Gordon Research Conferences
PI_Conferences PI_Conferences_Past
Conference Program
 
Apoptotic Cell Recognition & Clearance
June 23-28, 2013
University of New England
Biddeford, ME

Related Meeting Information
The Apoptotic Cell Recognition & Clearance Gordon Research Conference was held in conjunction with the Apoptotic Cell Recognition & Clearance Gordon Research Seminar. Please refer to the Apoptotic Cell Recognition & Clearance GRS web page for more information.

About 50-200 billion of our cells die daily by apoptosis or programmed cell death in the human body. The mechanisms of apoptosis have been extensively studied, but those of the elimination of apoptotic cells are much less understood. Apoptotic cells are rapidly engulfed and digested by their neighbors or by professional phagocytes in a process known as phagocytosis, clearance or efferocytosis. During development this process plays a key role in tissue morphogenesis and renewal. It also allows for the maintenance of tissue homeostasis in adults and promotes the resolution of inflammation. Failure to clear apoptotic cells can result in developmental defects, chronic inflammatory disorders, autoimmune and neurodegenerative diseases. For example, it has been associated with Lupus, a chronic inflammatory autoimmune disease, and with retinal degeneration. Dying cells can be cleared before completion of their programmed death, and failure in this process may result in cancer. A thorough understanding of efferocytosis is essential to design new therapies to prevent or treat chronic inflammation, autoimmune and neurodegenerative diseases, and cancer. Some of the molecular mechanisms of apoptotic cell clearance are shared with those of pathogen clearance, and thus studying efferocytosis will also lead to new therapies to fight infections. This is critical since pathogens are becoming resistant to current treatments.

At this Gordon Research Conference on Apoptotic Cell Recognition & Clearance and its associated Gordon Research Seminar, we will discuss the latest advances made in our understanding of the molecular mechanisms of apoptotic cell recognition and clearance in all model organisms, from worm, fly, fish and mouse, to mammalian (including human) cells in the context of both healthy and disease states.

The conference will bring together investigators who are at the forefront of the field, and provide opportunities for post-docs and graduate students to present and discuss their work in poster format and exchange ideas with leaders in the field. Some poster presenters will be selected for short talks at the GRC. The accompanying GRS provides further opportunity for students and post-docs to orally present their work and network amongst themselves, as well as to prepare and encourage them to attend and participate at the GRC.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Lectures on Phagocytosis, and Tumor Immunology
Discussion Leader: Dror Mevorach (The Medical School Hadassah and the Hebrew University, Jerusalem)
7:40 pm - 8:20 pmKeynote speaker: Sergio Grinstein (Hospital for Sick Children, University of Toronto)
"Imaging phagocytosis: receptors, phospholipids and the cytoskeleton"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmKeynote speaker: Guido Kroemer (INSERM, Paris XI University, Villejuif)
"Recognition of stressed and dying cancer cells by innate immune effectors"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCell killing, Extrusion, Competition in Tissue Homeostasis and Regeneration
Discussion Leader: Adam Lacy-Hulbert (Massachusetts General Hospital, Harvard Medical School, Boston)
9:00 am - 9:25 amJody Rosenblatt (Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City)
"Unconventional trafficking drives a cell to extrude from an epithelium"
9:25 am - 9:40 amDiscussion
9:40 am - 9:55 amSelected from poster abstracts: Noelia Alonso-Gonzalez (Centro Nacional Investigaciones Cardiovasculares, Madrid, Spain)
"Homeostatic clearance of aged neutrophils in the bone marrow and peripheral tissues"
9:55 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:55 amSilvia Finnemann (Fordham University, New York)
"Daily clearance phagocytosis in the retina: molecular mechanisms"
10:55 am - 11:10 amDiscussion
11:10 am - 11:35 amRichard Lang (Cincinnati Children's Hospital Medical Center, Cincinnati)
"Macrophages in development and regeneration"
11:35 am - 11:50 amDiscussion
11:50 am - 12:15 pmZsuzsanna Szondy (Debrecen University, Debrecen)
"Macrophages engulfing apoptotic cells produce a novel retinoid to regulate phagocytosis and apoptosis in the thymus"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmApoptotic Cell Lipids-Associated Molecular Patterns and Signaling
Discussion Leader: Silvia Finnemann (Fordham University, New York)
7:30 pm - 7:55 pmXiaochen Wang (National institute of Biological Sciences, Beijing)
"Secreted Lipid-binding proteins mediate cell corpse recognition in C. elegans"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmShigekazu Nagata (Kyoto University, Kyoto)
"Exposure of phosphatidylserine to cell surface"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmDonna Bratton (National Jewish Health Center, Denver)
"Final directives of the dying cell: phospholipid signals for corpse clearance"
9:15 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMolecular Mechanisms of Recognition, Engulfment and Degradation of Apoptotic Corpses
Discussion Leader: Donna Bratton (National Jewish Health Center, Denver)
9:00 am - 9:25 amKodi Ravichandran (University of Virginia, Charlottesville)
"Rethinking death: unexpected signals initiated via apoptotic cells"
9:25 am - 9:40 amDiscussion
9:40 am - 9:55 amSelected from posters abstracts: Shefali Krishna (Memorial Sloan-Kettering Cancer Center, New York)
"Nutrient export and lysosome reformation during phagocytosis and entosis"
9:55 am - 10:00 amDiscussion
10:00 amGroup Photo / Coffee Break
10:30 am - 10:55 amChonglin Yang (Institute of Genetics and Developmental Biology, Beijing)
"Clathrin-dependent phagocytic clearance of apoptotic cells"
10:55 am - 11:10 amDiscussion
11:10 am - 11:35 amAkiko Shiratsuchi (Kanazawa University, Kanazawa)
"Phagocytosis of apoptotic cells and bacteria with a common mechanism in Drosophila"
11:35 am - 11:50 amDiscussion
11:50 am - 12:15 pmZheng Zhou (Baylor College, Houston)
"Burying the corpse, clearance of apoptotic cells in the nematode C. elegans"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmApoptotic Cell Recognition Receptor Signaling
Discussion Leader: John Savill (University of Edinburgh, Edinburgh)
7:30 pm - 7:55 pmEstee Kurant (Technion Israel Institute of Technology, Haifa)
"Mechanisms of apoptotic cell clearance in Drosophila CNS"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmKim McCall (Boston University, Boston)
"Engulfment by epithelial follicle cells in the Drosophila ovary"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmRay Birge (University of Medicine and Dentistry of New Jersey, Newark)
"Recognition of apoptotic cells by TAM receptors"
9:15 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmInflammatory Consequences of Apoptotic Cell Clearance
Discussion Leader: Kodi Ravichandran (University of Virginia, Charlottesville)
9:00 am - 9:25 amDmitri Krysko (University of Ghent, Ghent)
"Immunogenic cell death and DAMPs"
9:25 am - 9:40 amDiscussion
9:40 am - 9:55 amSelected best abstract from GRS talks: Luis Munoz (Friedrich-Alexander University of Erlangen-Nuremberg)
"Sialylation of anti-histone IgG autoantibodies determines their capabilities to participate in the clearance of late apoptotic cells"
9:55 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:55 amDavid Ucker (University of Illinois College of Medicine, Chicago)
"Characterization of apoptotic determinants for recognition and immunosuppression"
10:55 am - 11:10 amDiscussion
11:10 am - 11:35 amAdam Lacy-Hulbert (Massachusetts General Hospital, Harvard Medical School, Boston)
"Eating your way out of trouble: how apoptotic cells reprogram the immune response"
11:35 am - 11:50 amDiscussion
11:50 am - 12:15 pmIan Dransfield (University of Edinburgh, Edinburgh)
"Control of apoptotic cell clearance in mammalian macrophages by glucocorticoids"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmTissue Homeostasis in Inflammation and Self-Tolerance
Discussion Leader: Peter Henson (National Jewish Health Center, Denver)
7:30 pm - 7:55 pmSelected Talk from GRS: Anna Zagorska (Salk Institute, La Jolla)
"Axl Tyrosine Kinase is a Phagocytic Receptor for Apoptotic Cells during inflammation"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmSteven Bensinger (UCLA, Los Angeles)
"LXRs as integrators of lipid metabolism and self tolerance"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmWilliam Janssen (National Jewish Health Center, Denver)
"Differential regulation of survival versus death in resident and recruited macrophages during resolving inflammation"
9:15 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmApoptotic Cell Clearance in Neurogenesis and Neurodegeneration
Discussion Leader: Martin Herrmann (University Hospital Erlangen, Erlangen)
9:00 am - 9:25 amMary Logan (Oregon Health and Science University, Portland)
"Insulin-like signaling networks regulate glial responses to axon injury"
9:25 am - 9:40 amDiscussion
9:40 am - 9:55 amSelected from posters abstracts: Guy Brown (Cambridge University, Cambridge)
"Phagoptosis: cell death by primary phagocytosis in the inflamed, ischaemic and neurodegenerating brain"
9:55 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:55 amFrancesca Peri (EMBL, Heidelberg)
"Neuronal cell death goes live: how microglia find dying neurons"
10:55 am - 11:10 amDiscussion
11:10 am - 11:35 amLaura Johnston (Columbia University, New York)
"Fitness-sensing and competition during growth in Drosophila"
11:35 am - 11:50 amDiscussion
11:50 am - 12:15 pmJonathan Kipnis (University of Virginia, Charlottesville)
"Mecp2 and phagocytosis - implications for Rett syndrome"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNecroptosis, Oncogenesis and Tumor Immunology
Discussion Leader: Luciana Dini (University of Salento, Lecce)
7:30 pm - 7:55 pmPeter Vandenabeele (University of Ghent, Ghent)
"Molecular mechanisms of necroptosis execution"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmChristopher Gregory (University of Edinburgh, Edinburgh)
"Oncogenic effects of apoptotic-cell clearance"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmMartin Herrmann (University Hospital Erlangen, Erlangen)
"Apoptotic cells modulate tumor immunology and autoimmunity"
9:15 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible [in part] by 1 R13 AI105920-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
© 2014 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter