Gordon Research Conferences
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Conference Program
 
Atherosclerosis
Translating the Biology of Atherosclerosis
June 16-21, 2013
Stoweflake Resort and Conference Center
Stowe, VT
Chairs:
Elaine W. Raines & Daniel Rader

Vice Chair:
Klaus Ley

Atherosclerosis and its complications remain the major cause of mortality in the Western World. It is a unique form of chronic inflammation involving both genetic and environmental mechanisms and many diverse cellular and molecular processes. The 2013 Atherosclerosis Gordon Research Conference will provide a comprehensive overview of current research on atherosclerosis with a focus on the latest and most exciting developments in the field. Novel observations will be presented regarding well-established contributors to atherogenesis, such as endothelial dysfunction, imbalanced lipid metabolism and clearance, maladaptive immune responses and the interplay between inflammation and thrombosis. In addition, emerging areas with particular promise to shift these "imbalances" will be discussed, such as altering the phenotypes of macrophage subsets, modulating circulating microRNAs to modify disease progression, and probing epigenetics in assessment of human disease progression.

The conference enjoys a worldwide reputation, and brings together participants from all career levels and from a variety of backgrounds for high-quality, intensive discussions of research at the frontiers of knowledge in atherosclerosis. Deliberate selection of a wide variety of participants has enabled a cross-fertilization among scientists from different disciplines that is unusual in other forums. It is the goal of the conference organizers that nearly every person attending the conference participates either as a speaker, discussion leader or poster presenter.

Promoting interactions among young investigators, trainees and established investigators has been a strength of this Gordon Conference, and we will continue to foster this tradition. For every session, one to two speaking slots will be left open for late-breaking developments and selection of talks from the submitted abstracts. This latter effort will particularly target participation from more junior investigators and trainees. Prizes in the form of registration and/or travel refund, will be given for the highest-rated posters in the student and fellow categories. Throughout the conference, interactions between senior and young investigators will be promoted in both formal and informal settings. The overall goal of the conference organizers is to provide extraordinary opportunities for learning and for developing relationships and collaborations.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmGenetics and Cardiovascular Disease
Discussion Leader: Sekar Kathiresan (Harvard University)
7:40 pm - 8:00 pmSekar Kathiresan (Harvard University)
"Next-gen genetics yields 'old school' discoveries: Lipoprotein lipase pathway genes and risk for coronary artery disease"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmMarlys Koschinsky (University of Windsor)
"Lipoprotein(a): A riddle wrapped in a mystery inside an enigma"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmHugh Watkins (Radcliffe Department of Medicine, Oxford University)
"Life after GWAS: what can we expect to learn about atherosclerosis?"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmShort Talk: Arya Mani (Yale University)
"Wnt signaling in early atherosclerosis"
9:20 pm - 9:25 pmDiscussion
9:30 pmReception
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmEndothelial activation and dysfunction
Discussion Leader: Myron Cybulsky (University of Toronto)
9:00 am - 9:20 amMark Feinberg (Harvard Medical School)
"MicroRNAs and endothelial cell activation and dysfunction"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJason Fish (University of Toronto)
"Feedback regulation of endothelial activation by microRNA"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amCynthia Reinhart-King (Cornell University)
"Age-related aortic stiffening and endothelial dysfunction"
10:20 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:20 amJorge Plutzky (Harvard Medical School)
"Epigenetic repression of endothelial inflammatory genes"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amStefanie Dimmeler (University of Frankfurt)
"Atheroprotective communication via miRNAs"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk: Hong Chen (Oklahoma Medical Research Foundation)
"The novel role of epsins in Atherosclerosis"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort Talk: Kristen Leslie (University of Pittsburgh)
"EBP50 actiates NF-kappaB via PKCzeta and participates in the feed-forward loop for vascular inflammation"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session: Endothelial activation, Stem cells, Leukocyte cell trafficking, Adaptive Immunity
6:00 pmDinner
7:30 pm - 9:30 pmStem cells, stem cell genes and cardiovascular disease
Discussion Leader: Stefanie Dimmeler (University of Frankfurt)
7:30 pm - 7:50 pmMatthias Nahrendorf (Harvard Medical School)
"Liberation of hematopoietic stem cells during myocardial infarction"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMark Majesky (Seattle Children's Research Institute)
"Adventitial progenitor cells and vascular remodeling"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmKathleen Martin (Yale University Medical Center)
"Stem cell gene regulation and SMC plasticity"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmShort Talk: Changche Zhou (University of Kentucky)
"IKKβ links vascular inflammation to obesity and atherosclerosis"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk: Peter Psaltis (University of Adelaide)
"Identification of resident adventitial macrophage precursor cells (AMPCs) with angiogenic potential"
9:25 pm - 9:30 pmDiscussion
9:30 pmReception
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLeukocyte cell trafficking and innate immunity in atherosclerosis
Discussion Leader: Gwen Randolph (Washington University)
9:00 am - 9:20 amGwen Randolph (Washington University)
"Myeloid cell trafficking in atherosclerosis"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amMyron Cybulsky (University of Toronto)
"Aortic CCR7-dependent reverse transmigration of dendritic cells is inhibited by hypercholesterolemia"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amShort Talk: Clinton Robbins (Harvard University)
"Local proliferation dominates lesional macrophage accumulation in atherogenesis"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amShort Talk: Tanja Pedersen (University of Copenhagen)
"HIF-1 alpha expression in macrophages promotes development of atherosclerosis"
10:25 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:20 amChristoph J. Binder (CeMM Center for Molecular Medicine of Austrian Academy of Sciences)
"Complement factor H and atherosclerosis"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amKathryn J. Moore (New York University)
"Role of netrin-1 in promoting chronic inflammation"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk: Masanori Aikawa (Harvard University)
"Dll4-Notch signaling promotes macrophage activation, atherosclerotic vascular diseases, and metabolic disorders"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort Talk: Orina Belton (University College Dublin)
"Alteration of monocyte function in the regression of atherosclerosis"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session: Endothelial activation, Stem cells, Leukocyte cell trafficking, Adaptive Immunity
6:00 pmDinner
7:30 pm - 9:30 pmAdaptive Immunity in Atherosclerosis
Discussion Leader: Klaus Ley (La Jolla Institute for Allergy and Immunology)
7:30 pm - 7:50 pmKlaus Ley (La Jolla Institute for Allergy and Immunology)
"T cell-APC interactions"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmAndrew Lichtman (Harvard University)
"Regulation of T cell responses"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmElena Galkina (Eastern Virginia Medical School)
"IL-17 and atherosclerosis"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmShort Talk: Xuchu Que (University of California San Diego)
"Transgenic Ldlr-/- mice expressing an oxidation-specific antibody have less atherosclerosis decreased hepatosteatosis"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk: Matthew Butcher (Eastern Virginia Medical School)
"Conversion of murine peripheral T regulatory cells to a novel Foxp2+ IFN-γ+ phenotype in atherogenesis"
9:25 pm - 9:30 pmDiscussion
9:30 pmReception
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEpigenetics and atherosclerosis
Discussion Leader: Gary K. Owens (University of Virginia)
9:00 am - 9:20 amGary K. Owens (University of Virginia)
"Tracking chromatin signatures in individual cells to trace vascular SMC lineage in human atherosclerotic lesions"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amSilvio Zaina (University of Guanajuato)
"The methylome of atherosclerosis"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amTapan Chatterjee (University of Cincinatti)
"HDAC9 in atherosclerosis"
10:20 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:20 amAndriana Margariti (King's College London)
"Therapeutic potential of epigenetic rejuvenated vascular cells in cardiovascular disease"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amMenno de Winther (University of Amsterdam)
"Macrophage phenotype regulation by histone-modifying enzymes"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk: Erik Van Kampen (Leiden Academic Center for Drug Research)
"Diet-induced changes in bone marrow augment atherosclerosis"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort Talk: Sylvia Nuernberg (Stanford University)
"The coronary heart disease-associated transcription factor TCF21 regulates genes involved in vascular development and disease"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session: Genetics, Epigenetics, Thrombosis, Lesion Dynamics and Macrophage Phenotype
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmThrombosis, microparticles and cardiovascular disease
Discussion Leader: Chantal Boulanger (INSERM)
7:30 pm - 7:50 pmChantal Boulanger (INSERM)
"Microparticles and Atherothrombosis"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmNigel Mackman (University of North Carolina Chapel Hill)
"Tissue factor and plaque rupture"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmSteffen Massberg (Ludwig-Maximillians University)
"Crosstalk between thrombosis and innate immunity"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmShort Talk: Esther Lutgens (University of Amsterdam)
"Expression of platelet CD40 promotes platelet-induced atherogenesis by enhancing leukocyte recruitment"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk: Adrienne Mueller (ETH Zurich)
"Detecting plaque vulnerability in human carotid arteries with PET probes"
9:25 pm - 9:30 pmDiscussion
9:30 pmReception
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLesion Dynamics
Discussion Leader: Ira Tabas (Columbia University)
9:00 am - 9:20 amIra Tabas (Columbia University)
"Macrophage ER stress response and lesion dynamics"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amAthan Kuliopulos (Tufts University)
"MMP-1 activation of PAR1 with smooth muscle injury"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amEdward Plow (Cleveland Clinic)
"Thrombospondin 4 human genetic mutants associated with CAD"
10:20 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:20 amRick Assoian (University of Pennsylvania)
"Mechanisms and consequences of arterial stiffening in injury and atherosclerosis"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amShort Talk: Babak Razani (Washington University)
"p62-enriched inclusion bodies in macrophages play a protective role in atherosclerosis"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amShort Talk: Andrew Lau (University Health Network Toronto)
"The role of ASC in atherosclerosis"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk: Daniel Goldstein (Yale University)
"Aging enhances atherosclerosis via hematopoietic and non-hematopoietic factors"
12:10 pm - 12:15 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session: Genetics, Epigenetics, Thrombosis, Lesion Dynamics and Macrophage Phenotype
6:00 pmDinner
7:30 pm - 9:30 pmMacrophage phenotype and plasticity
Discussion Leader: Catherine (Lynn) Hedrick (La Jolla Institute for Allergy and Immunology)
7:30 pm - 7:50 pmCatherine Hedrick (La Jolla Institute for Allergy and Immunology)
"Mechanisms of macrophage polarization"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmIrina Udalova (Kennedy Institute of Rheumatology, Oxford University)
"Master switches regulating macrophage phenotype"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 9:20 pmKeynote Address: Christopher Glass (University of California San Diego)
"Genomics and Lipidomics of Macrophage Foam Cell Formation"
9:20 pm - 9:30 pmDiscussion
9:30 pmReception
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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