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Bioenergetics
Gordon Research Conference

Molecular Mechanisms and Fundamental Principles to Cellular Energetics in Health and Disease

Dates

June 23-28, 2013

Location

Proctor Academy
Andover, NH

Organizers

Chair:
Ulrich Brandt

Vice Chair:
Karlett J. Parra

Meeting Description

Celebrating its 50th anniversary, the 2013 Gordon Conference on Bioenergetics will bring together scientists interested in molecular aspects of energy converting processes in procaryotes and mitochondria. The mission is to stimulate exchange of ideas between investigators interested in Bioenergetics from a broad range of scientific disciplines. It is anticipated that participants will include investigators actively engaged in research aimed at determining the high resolution structures of macromolecules, enzymatic and ion translocation mechanisms, the regulation of metabolic rates, mitochondrial morphology, and mitochondrial disease processes. The scope of the meeting also extends to participants interested in other related oxidation-reduction systems, mitochondrial transporters and ion translocating ATPases. The meeting will provide a platform for active researchers to present their most recent findings in formal scientific sessions and poster sessions. Ample free time will be scheduled for unfettered conversation between participants. One focus of the meeting will be the rapidly advancing developments in the structure, function and regulation of the membrane integral multiprotein complexes of biological energy conversion, like Complexes I-IV of the electron transport chain and F1F0 ATP synthases and closely related V1V0-ATPases. The second focus will be on the impact of function and dysfunction of bioenergetic systems on cells and organisms as a whole. Thus the program will include sessions emphasizing mitochondrial dysfunction in aging, neural disorders, and the genetics of disease related mutations. The poster sessions and the poster discussion session have traditionally been a highlight of Bioenergetics Gordon Conferences. The posters offer an opportunity for junior investigators to actively participate in the meeting by presenting their own research. Finally, the meeting seeks to generate an environment most conducive for young scientists to interact with established investigators in the field.

Contributors

Meeting Program

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmMechanisms and Energetics of ATP-Synthesis
Discussion Leader: Wayne Frasch (Arizona State University)
7:55 pm - 8:40 pmJohn Walker (MRC Mitochondrial Biology Unit)
"Bioenergetics research over the past 50 years: what next?"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmDavid Mueller (Rosalind Franklin University)
"The structural basis of drug binding and disease as related to the mitochondrial ATP synthase"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStructure and Function of Complex I
Discussion Leader: Thorsten Friedrich (University of Freiburg)
9:20 am - 9:45 amLeonid Sazanov (MRC Mitochondrial Biology Unit)
"Structure and mechanism of complex I"
9:45 am - 9:55 amDiscussion
9:55 am - 10:20 amVolker Zickermann (Goethe-University)
"The structure of mitochondrial complex I"
10:20 am - 10:30 amDiscussion
10:30 amCoffee Break
10:55 am - 11:20 amHideto Miyoshi (Kyoto University)
"Identification of the binding site of amilorides, inhibitors of proton-pumping machinery of complex I"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amJudy Hirst (MRC Mitochondrial Biology Unit)
"Inhibition of complex I"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmOscar Juarez (Rensselaer Polytechnic Institute)
"Aspartate 397 in subunit B of Vibrio cholerae Na+-NQR forms part of the sodium binding site, is involved in cation selectivity and affect cation binding site cooperativity"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmMargareta Blomberg (Stockholm University)
"Energetic requirements for proton pumping in heme-copper oxidases - a theoretical study"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmDiversity of Bioenergetic Systems
Discussion Leader: Manuela Pereira (University of Lisbon)
7:50 pm - 8:15 pmRolf Thauer (MPI for Terrestric Microbiology)
"Flavin-based electron bifurcation in anaerobic bacteria and archaea: a novel mechanism of energy coupling"
8:15 pm - 8:25 pmDiscussion
8:25 pm - 8:50 pmPia Ädelroth (University of Stockholm)
"Proton transfer in the diverse members of the heme-copper oxidase superfamily"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:25 pmAnthony Moore (University of Sussex)
"Structure and function of the alternative oxidases in plants and human pathogens"
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmEmerging Techniques
Discussion Leader: Les Dutton (University of Pennsylvania)
9:10 am - 9:50 amLes Dutton (University of Pennsylvania)
"In Memory of Britton Chance: An electrical engineers approach to bioenergetics from quantum mechanics to quantitative diagnostics"
9:50 am - 10:00 amDiscussion
10:00 am - 10:25 amPetra Fromme (Arizona State University)
"Time resolved femtosecond nanocrystallography opens a new era in structural biology"
10:25 am - 10:35 amDiscussion
10:35 amCoffee Break
11:00 am - 11:25 amManuela Zoonens (CNRS Paris)
"Amphipols: versatile tools to stabilize and study membrane proteins in aqueous solutions"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmMichael Börsch (Friedrich Schiller University Jena)
"Monitoring conformational changes in individual FoF1-ATP synthases by advanced single-molecule FRET imaging in solution"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmRoger Springett (Dartmouth College)
"Quantitation of the mitochondrial membrane potential and pH gradient in living cells"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmRespiratory Complexes in Health and Disease
Discussion Leader: Gary Cecchini (San Francisco VA Medical Center)
7:50 pm - 8:15 pmArtur Osyczka (Jagiellonian University)
"A new perspective on the mechanism of quinol oxidation catalyzed by the cytochrome bc1 complex"
8:15 pm - 8:25 pmDiscussion
8:25 pm - 8:50 pmPeter R. Rich (University College London)
"Functions of the hydrophilic channels in mitochondrial cytochrome c oxidase"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:25 pmÓlöf Einarsdóttir (University of California)
"Protein tuning of ligand pathways and metal centers in heme-copper oxidases"
9:25 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMechanisms and Functions of V-type and A-type ATPases
Discussion Leader: Volker Müller (Goethe-University Frankfurt)
9:20 am - 9:45 amPatricia Kane (SUNY Upstate Medical University)
"Multiple modes of V-ATPase regulation"
9:45 am - 9:55 amDiscussion
9:55 am - 10:20 amGerhard Grüber (Nanyang Technological University)
"Structural and mechanistic diversities and similarities of the coupling domains in A-ATP synthases and eukaryotic V-ATPases"
10:20 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:25 amDennis Brown (Massachusetts General Hospital)
"Regulation of the V-ATPase in proton secreting epithelial cells"
11:25 am - 11:35 amDiscussion
11:35 am - 11:50 amTakeshi Murata (Chiba University)
"Rotation mechanism of Enterococcus hirae V1-ATPase based on asymmetric crystal structures"
11:50 am - 11:55 amDiscussion
11:55 am - 12:10 pmLaura Preiss (Max Planck Institute for Biophysics)
"Life in a proton desert: Adaptations of the Bacillus pseudofirmus OF4 ATP synthase rotor ring"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmSupramolecular Organization of Bioenergetic Complexes
Discussion Leader: Rosemary Stuart (Marquette University)
7:50 pm - 8:15 pmCristina Ugalde (University Hospital Madrid)
"Assembly of mitochondrial respirasomes in human cellular models in health and disease"
8:15 pm - 8:25 pmDiscussion
8:25 pm - 8:50 pmAntonio Enriquez (Centro Nacional de Investigaciones Cardiovasculares)
"Functional role of respiratory supercomplexes"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:25 pmCharles L. Hoppel (Case Western Reserve University)
"Respiratory supercomplexes in disease"
9:25 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPoster Oral Discussion Session
Discussion Leaders: Karlett Parra (University of New Mexico) and Susanne Arnold (Nijmegen Center for Mitochondrial Disorders)
9:00 am - 10:15 amTBA (Selected from Poster Presentations)
10:15 amCoffee Break
10:45 am - 12:15 pmTBA (Selected from Poster Presentations)
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSystems Biology and Mitochondrial Diseases
Discussion Leader: Jan Smeitink (Nijmegen Center for Mitochondrial Disorders)
7:55 pm - 8:20 pmSalvatore DiMauro (Columbia University)
"Mitochondrial medicine"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:55 pmMassimo Zeviani (National Institute of Neurology)
"Networking proteins and mechanisms by studying mitochondrial disease"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:20 pmMarleen Forkink (Radboud University Nijmegen Medical Center)
"Mitochondrial hyperpolarization during complex I inhibition requires active ETC complexes and modulates calcium signaling"
9:20 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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