Gordon Research Conferences
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Conference Program
 
Biological Mechanisms in Evolution
In Basic Biology, Cancer, Infectious Disease and Medicine
June 2-7, 2013
Stonehill College
Easton, MA

Application Deadline
The application deadline for this meeting was May 5, 2013. You may still submit an application. However, it will only be considered by the Conference Chair if more seats become available due to cancellations.

Application Deadline Update: There is still space available! You may still submit an application. Apply Now!

The goal of this meeting is to bring current understanding of biological mechanisms, including molecular mechanisms of genome plasticity, mutagenesis, protein- and RNA-based inheritance, epigenetics, stress, stress responses, stochasticity, and phenotypic variation and plasticity (among others), to bear on understanding of evolution, and the many medical and basic-science problems driven by evolution. We hope to unite what have been disparate fields: evolutionary biology and mechanistic molecular genetics, genomics and molecular biology, focusing on the contributions of the latter to our understanding of evolution. The "modern synthesis" of the early twentieth century, which gave birth to current evolutionary biology, predated the molecular biology revolution. Traditional evolutionary biology has not always kept pace with changes to the basic assumptions of genetic inheritance and discoveries of non-genetic inheritance that have come from studies on molecular mechanisms. Similarly, molecular biology has often ignored the critical roles of evolution in important medical and basic-biological problems. This meeting is aimed at the growing body of investigators attempting to bring molecular biological mechanisms to bear on understanding of evolution. The goals are to catalyze integrated, mechanistic views of mechanisms of evolution operating today and their consequences in medicine and basic biology. Although molecular biology is only recently beginning to penetrate the arena of evolutionary biology, integration of these disciplines is crucial for deeper understanding of evolution and biology in general. This meeting will give a home and community to researchers doing this.

Support Available: We are offering $500 in support for the registration fees for new student applicants who register for a double room (this support would reduce the registration fee to $430). The financial support will be allocated upon acceptance of each new student application, from now until the budget for this is exhausted; so please apply right away. Although students will be supported first, postdocs with special financial needs may apply for support with a brief note in their applications justifying their financial need.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmIntroductory Comments by GRC Site Staff / Welcome: Susan Rosenberg and Christine Queitsch
7:40 pm - 9:30 pmKeynote Presentations: Pioneers in Stress-Inducible Evolution
Discussion Leader: Susan Rosenberg (Baylor College of Medicine, Houston)
7:40 pm - 8:20 pm Susan Lindquist (Massachusetts Institute of Technology)
"How protein Folding Sculpts the Inheritance of New Traits"
8:20 pm - 8:35 pm Discussion
8:35 pm - 9:15 pm Miroslav Radman (Necker Institute, Paris, and Mediterranean Institute for Life Sciences)
"Concepts in Cell Biology of Survival: Evolving Interplay Between Biological Function and Information"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStress-Inducible Genetic Change Mechanisms
Discussion Leader: Ivan Matic (INSERM, Paris)
9:00 am - 9:30 am Ivan Matic (INSERM, Paris)
"Induction of Stress Responses and Mutagenesis by Sub-inhibitory Concentrations of Antibiotics"
9:30 am - 9:40 am Discussion
9:40 am - 10:05 am Peter Glazer (Yale University)
"Hypoxic-stress-induced Genomic Instability in Human Cancer Cells: Accelerated Adaptation to the Tumor Microenvironment"
10:05 am - 10:15 am Discussion
10:15 am Group Photo / Coffee Break
10:45 am - 11:10 am Philip Hastings (Baylor College of Medicine)
"Stress-Induced Gene Amplification in E. coli: A Paradigm for Human Copy-Number Variation"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 am Marlene Belfort (SUNY Albany)
"Introns and Inteins as Sensors of Stress and Mediators of Evolutionary Adaptation"
11:45 am - 11:55 am Discussion
11:55 am - 12:08 pm TBA (short talk selected from abstracts)
12:08 pm - 12:13 pm Discussion
12:13 pm - 12:26 pm TBA (short talk selected from abstracts)
12:26 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStress and Evolution / Non-Random Mutagenesis in Genomes
Discussion Leader: Lilach Hadany (Tel Aviv University)
7:30 pm - 7:55 pm Lilach Hadany (Tel Aviv University)
"The Evolution of Stress-Induced Mutation and Recombination: Population Genetic Models"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:30 pm Amar Al Mamun (Baylor College of Medicine)
"A Protein Network Underlying Mutagenic Repair of DNA Breaks Under Stress"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:05 pm Lynn Caporale (St. John's University)
"Evolutionary Theory Predicts that Mutations are Not Random"
9:05 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm TBA (short talk selected from abstracts)
9:25 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNon-Random Mutagenesis in Genomes
Discussion Leader: John W. Drake (National Institute of Environmental Health Sciences, Research Triangle Park)
9:00 am - 9:25 am John W. Drake (National Institute of Environmental Health Sciences, Research Triangle Park)
"The Decay of the Non-Random Cliché"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Laura Landweber (Princeton University)
"RNA-Medicated Epigenetic Inheritance in the Ciliate Oxytricha"
10:00 am - 10:10 am Discussion
10:10 am Coffee Break
10:40 am - 11:05 am Ben Taylor (MRC, Cambridge, UK)
"Kataegic mutation showers through the action of APOBEC family DNA deaminases"
11:05 am - 11:15 am Discussion
11:15 am - 11:40 am Anna Malkova (Indiana University Purdue University Indianapolis)
"Consequences of Break-Induced Replication in Yeast"
11:40 am - 11:50 am Discussion
11:50 am - 12:03 pm TBA (short talk selected from abstracts)
12:03 pm - 12:10 pm Discussion
12:10 pm - 12:23 pm TBA (short talk selected from abstracts)
12:23 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNon-Genetic Inheritance
Discussion Leader: Christine Queitsch (University of Washington)
7:30 pm - 7:55 pm Christine Queitsch (University of Washington)
"Genomic Footprints of the Evolutionary Capacitors Hsp90 and RNA Polymerase V"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:30 pm Leah Cowen (University of Toronto)
"Coupling Protein Homeostasis and Regulatory Circuitry: Hsp90 Modulates the Evolution of Drug Resistance"
8:30 pm - 8:40 pm Discussion
8:40 pm - 8:50 pm TBA (short talk selected from abstracts)
8:50 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Joanna Masel (University of Arizona)
"Evolutionary Capacitance, Complex Adaptations, and Evolvability"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStochastic Non-Genetic Inheritance and Adaptation
Session Chair: Herbert Levine (Rice University)
Discussion Leader: David Dubnau (Public Health Research Institute, Newark)
9:00 am - 9:30 am David Dubnau (Public Health Research Institute, Newark)
"Chance and Necessity in the Regulation of Bacillus subtilis Competence"
9:30 am - 9:40 am Discussion
9:40 am - 10:05 am Stanislas Leibler (Rockefeller University)
"Stochastic Switching and Adaptation of Populations in Varying Environments"
10:05 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 11:10 am Christophe Herman (Baylor College of Medicine)
"Transcription Errors and Epigenetic Inheritance in Bacteria"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 am Arjun Raj (University of Pennsylvania)
"Stochastic Epigenetics at the Single Chromosome Level"
11:45 am - 11:55 am Discussion
11:55 am - 12:08 pm TBA (short talk selected from abstracts)
12:08 pm - 12:13 pm Discussion
12:13 pm - 12:26 pm TBA (short talk selected from abstracts)
12:26 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmCancer as Evolution
Discussion Leader: Lawrence Loeb (University of Washington)
7:30 pm - 7:55 pm Lawrence Loeb (University of Washington)
"Cancer, an Evolving Challenge"
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:30 pm Thea Tlsty (University of California San Francisco)
"Social Evolution of Cellular Communities Under Stress: Driving Forces of Dynamic Heterogeneity"
8:30 pm - 8:40 pm Discussion
8:40 pm - 9:05 pm Carlo Maley (University of California San Francisco)
"Ecology and Evolution of Cancer"
9:05 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Franziska Michor (Harvard University)
"Cancer Genomes and Evolution"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEvolution of Antibiotic Resistance
Discussion Leader: Yousif Shamoo (Rice University)
9:00 am - 9:30 am Yousif Shamoo (Rice University)
"Evolution of Daptomycin Resistance: the Lab Mimics the Clinic"
9:30 am - 9:40 am Discussion
9:40 am - 10:05 am Kim Lewis (Northeastern University)
"Dormancy Rules: Stochastic and Deterministic Mechanisms of Persister Formation"
10:05 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 11:10 am Robert Austin (Princeton University)
"Re-thinking the Speeds of Evolution in Complex Ecologies"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 am Erika Shor (Princeton University)
"Stress-Response Control of Resistance Mutagenesis in Yeast"
11:45 am - 11:55 am Discussion
11:55 am - 12:08 pm TBA (short talk selected from abstracts)
12:08 pm - 12:13 pm Discussion
12:13 pm - 12:26 pm TBA (short talk selected from abstracts)
12:26 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTransmissable Genomic Instability Mechanisms
Discussion Leader: Barbara Hohn (Friedrich Miescher Institute of Biomedical Research)
7:30 pm - 7:38 pm Barbara Hohn (Friedrich Miescher Institute of Biomedical Research)
"Transmissable Genomic Instability Mechanisms"
7:38 pm - 7:40 pm Discussion
7:40 pm - 8:05 pm Carmel Mothersill (McMaster University)
"Horizontal Transmission of Genomic Instability in the Bystander Effect and Evolvability"
8:05 pm - 8:15 pm Discussion
8:15 pm - 8:28 pm TBA (short talk selected from abstracts)
8:28 pm - 8:33 pm Discussion
8:33 pm - 9:00 pm Yuri Dubrova (University of Leicester)
"Vertical Non-Genetic Transmission of Genomic Instability in Mice"
9:00 pm - 9:10 pm Discussion
9:10 pm - 9:23 pm TBA (short talk selected from abstracts)
9:23 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Last Updated: May 14, 2013
 
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