| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | DRUGS, DESIGNS, THERAPIES |
| Discussion Leader: Doug Johnson (Pfizer) |
| 7:40 pm - 8:10 pm | David Ehmann (AstraZeneca)
"Avibactam and DBO beta-Lactamase Inhibitors: A New Class with an Unusual Mechanism"
|
| 8:10 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:35 pm | Poster Talk: Eranthie Weerapana (Boston College)
"Targeting Reactive Cysteines with Modular Chemical Probes"
|
| 8:35 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:15 pm | Jeff Kelly (Scripps)
"Adapting Proteostasis to Ameliorate Misfolding Diseases"
|
| 9:15 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | STUDYING NUCLEIC ACID PROCESSES WITH MIMETICS & DESIGN |
| Discussion Leader: Eranthie Weerapana (Boston College) |
| 9:00 am - 9:30 am | Julie Strauss-Soukup (Creighton)
"Structural Characterization of a Mammalian Riboswitch in the Spermine Biosynthetic Pathway"
|
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Bruce Armitage (Carnegie Mellon)
"Heteroquadruplex Formation by Guanine-Rich PNA: An Alternative Recognition Mode for Nucleic Acids"
|
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:20 am | Scot Wolfe (University of Massachusetts Medical School)
"Engineering Homeodomains and Zinc Fingers for Targeted Genome Modification"
|
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:00 pm | Ming Hammond (University of California, Berkeley)
"Privileged RNA Scaffolds for in vivo Function"
|
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Poster Talk: Simon Friedman (University of Missouri)
"The Photoactivated Insulin Depot"
|
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | BIOLOGICAL IMPLICATIONS OF NOVEL COMPOUNDS |
| Discussion Leader: Dan Harki (University of Minnesota) |
| 7:30 pm - 8:00 pm | Shana Kelley (University of Toronto)
"Mitochondria-specific Delivery of Bioactive Cargo"
|
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Doug Mitchell (University of Illinois at Urbana-Champaign)
"Unconventional Strategies to Suppress the Rise of Drug Resistance"
|
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Neil Marsh (University of Michigan)
"Fluorinated Proteins: F is for Folding and Mis-Folding"
|
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | BUILDING IMAGING METHODS TO UNDERSTAND BIOLOGY |
| Discussion Leader: Violeta Marin (AbbVie) |
| 9:00 am - 9:30 am | Young-Tae Chang (National University of Singapore)
"Bioimaging Probe and Sensor Development: Hypothesis Driven or Diversity Driven?"
|
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Paul Thompson (Scripps Florida)
"Picking the PADlock: Chemical Probes to Image and Isolate Biomarkers of Disease"
|
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:20 am | Peter Beal (University of California, Davis)
"Controlling Duplex RNA Properties with Nucleobase Modifications" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:45 am | Poster Talk: Jennifer Prescher (University of California, Irvine)
"Expanding the Bioorthogonal Chemistry Toolkit"
|
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:05 pm | Poster Talk: Zev Gartner (University of California, San Francisco)
"Building Relationships between the Structure and Function of Human Tissues"
|
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Poster Talk: TBA |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CHEMICAL APPROACHES FOR FIGHTING DISEASE |
| Discussion Leader: Adrian Whitty (Boston University) |
| 7:30 pm - 8:00 pm | Michelle Arkin (University of California, San Francisco)
"Site-Directed Lead Discovery: Thinking Outside the Active Site"
|
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | John Vederas (University of Alberta)
"Recent Exploration of Structures and Mechanisms of Antimicrobial Peptides from Bacillus sp."
|
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Jeff Cirillo (Texas A&M Health Science Center)
"Strategies for Real-Time Analysis of Mycobacterial Infections"
|
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | UNDERSTANDING PROTEINS & PUTTING THEM TO WORK |
| Discussion Leader: Alan Kennan (Colorado State University) |
| 9:00 am - 9:30 am | Dan Herschlag (Stanford University)
"How Enzymes Work and Why We Can't Design Them (Yet)"
|
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Joelle Pelletier (University of Montreal)
"Harnessing Enzymes for Biocatalysis, Antibiotic Discovery and Understanding Drug Resistance"
|
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:20 am | Tom Moody (Almac)
"SelectAZyme Biooxidation Applications in Accessing New Chemicals"
|
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:45 am | Poster Talk: Wenshe Liu (Texas A&M)
"A Fascinating Chemistry of a Genetically Encoded Acrylamide"
|
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:05 pm | Poster Talk: Champak Chatterjee (University of Washington)
"Chemical Approaches to Investigate Chromatin Modification by the Small Ubiquitin-like Modifier (SUMO)"
|
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Poster Talk: Brian McNaughton (Colorado State University)
"Engineering Bacteriophage for Targeted Delivery of Therapeutic Proteins"
|
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
| 7:30 pm - 9:30 pm | OPEN FORUM: COMPETITION & PRE-COMPETITIVE SHARING |
| Discussion Leader: Suzanne Stokes (Vertex Pharmaceuticals) |
| 7:30 pm - 8:00 pm | David Drewry (GlaxoSmithKline)
"Catalyzing Chemical Biology and Drug Discovery by Sharing Strategic Compound Sets"
|
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Zhi-Fu Tao (AbbVie)
"Targeting Bcl-2 Family Proteins with Highly Potent and Selective Small Molecule Inhibitors"
|
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Gretchen Schroeder (Bristol-Myers-Squibb)
"Met Kinase Inhibitors for Oncology: Two Clinical Candidates with Differing Kinase Selectivity Profiles"
|
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | CHEMICAL & SYSTEMS BIOLOGY: TOOLS, INSIGHTS, & DISCOVERIES |
| Discussion Leader: Margot Paulick (Union College) |
| 9:00 am - 9:30 am | Hiraoki Suga (University of Tokyo)
"Non-Traditional Peptide Drug Leads Discovery Accelerated by the RaPID System"
|
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Angela Koehler (Broad Institute)
"Small-Molecule Probes of Transcriptional Regulation"
|
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:20 am | Gitte Neubauer (Cellzome)
"Chemoproteomics-based Drug Discovery"
|
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:00 pm | Lara Mahal (New York University)
"Sweet Patterns: Revelations from Systems-Based Glycan Analysis"
|
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Poster Talk: Isaac Krauss (Brandeis University)
"Directed Evolution of Glycoclusters in the Design of HIV Vaccines"
|
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | IMAGING, DESIGNING, & UNDERSTANDING BIOMOLECULES |
| Discussion Leader: Terry Sheppard (Nature Chemical Biology) |
| 7:30 pm - 8:00 pm | Jon Clardy (Harvard Medical School)
"Molecular foundations of evolved and primitive agriculture" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Bob Copeland (Epizyme)
"Protein Methyltransferase Inhibitors as Personalized Cancer Therapeutics" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Steve Benner (Foundation for Applied Molecular Evolution)
"Redesigning Nucleic Acids"
|
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |