Gordon Research Conferences
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Conference Program
 
Calcium Signalling
June 16-21, 2013
Renaissance Tuscany Il Ciocco Resort
Lucca (Barga), Italy
Chair:
Rosario Rizzuto

Vice Chair:
David I. Yule

Related Meeting Information
The Calcium Signalling Gordon Research Conference was held in conjunction with the Calcium Signalling Gordon Research Seminar. Please refer to the Calcium Signalling GRS web page for more information.

The 2013 Gordon Research Conference on Calcium Signaling will bring together the world’s leading researchers in this vibrant field at Il Ciocco Hotel in Tuscany, Italy. This spectacular site is located on two thousand acres of a natural park and provides an excellent setting for formal lectures and informal out-of-session discussions. The meeting will focus on the molecular and cellular mechanisms of calcium signaling together with the downstream physiological and pathological consequences of activation of these pathways. Specifically, the program will feature sessions focused on our current understanding of basic mechanisms including the role of intracellular and plasma membrane Ca2+ channels, the function of mitochondria in responding to, and shaping Ca2+ signals, and cross-talk between Ca2+ signaling and other signal transduction cascades. Sessions will also be devoted to the role of Ca2+ signals in controlling tissue-specific functions, including muscle contraction, exocytosis, and cell fate decisions. In addition, dedicated sessions will address the role of aberrant calcium signals in the pathogenesis of human diseases, including cardiovascular diseases, diabetes, cancer and neurodegeneration. Notably, an exciting session is planned addressing the long-standing controversy of calcium store dysfunction in Alzheimer’s disease. Informal afternoon sessions will allow all participants to present their work in a premier environment and to interact closely with prominent investigators in the field. Several poster presenters, including those with late-breaking findings will be invited to present short talks. Importantly, following the very successful experience of 2011, a Gordon Research Seminar will precede the meeting, providing students and postdocs with a forum to discuss current research results and interact with other scientists with similar experience levels and interests in a non-intimidating environment.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmCalcium and Neurodegeneration: an Unsolvable Controversy?
Discussion Leader: Katsuhiko Mikoshiba (RIKEN)
7:40 pm - 8:00 pmBeth Stutzmann (Rosalind Franklin University)
"Early Neuronal Calcium Signaling Alterations Underlying Later Alzheimer's Disease Pathology"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmIlya Bezprozvanny (University of Texas, Southwestern Medical Center)
"Presenilins, neuronal SOC and synaptic loss in AD"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmKevin Foskett (University of Pennsylvania)
"Role of exaggerated InsP3R-mediated Ca2+ signaling in Alzheimer's disease explored in a novel animal model"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmShort talk: Paola Pizzo (University of Padua)
"Presenilin-2 is essential in mediating Endoplasmic Reticulum-Mitochondria tethering and Ca2+ cross-talk"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCalcium and Cell Function
Discussion Leader: Ole Petersen (Cardiff University)
9:00 am - 9:25 amGuy Rutter (Imperial College, London)
"Role of mitochondrial calcium transport in the control of insulin secretion"
9:25 am - 9:35 amDiscussion
9:35 am - 9:45 amShort talk: Silvia Moreno (University of Georgia)
"Measurements of Ca2+ fluctuations during the lytic cycle of T. gondii using genetically encoded Ca2+ indicators"
9:45 am - 9:55 amDiscussion
9:55 amGroup Photo / Coffee Break
10:30 am - 10:55 amTobias Meyer (Stanford University)
"Coupling of Ca2+ and actin oscillations regulates cell migration and secretion"
10:55 am - 11:10 amDiscussion
11:10 am - 11:35 amYun Zhang (Harvard University)
"Compartmentalized calcium signaling in C. elegans neurons"
11:35 am - 11:50 amDiscussion
11:50 am - 12:15 pmMuthu Periasamy (Ohio State University)
"SR calcium cycling and muscle thermogenesis"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmCalcium in Inflammatory Diseases
Discussion Leader: Barbara Ehrlich (Yale University)
5:30 pm - 5:55 pmDaniela Riccardi (Cardiff University)
"The role of the extracellular calcium-sensing receptor in physiology and disease"
5:55 pm - 6:10 pmDiscussion
6:10 pm - 6:35 pmAlexei Tepikin (University of Liverpool)
"Signaling in borderlands: ER-PM junctions in cell physiology and pathophysiology"
6:35 pm - 6:50 pmDiscussion
6:50 pm - 7:15 pmAnant Parekh (Oxford University)
"CRAC channels and airway disease"
7:15 pm - 7:30 pmDiscussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCalcium Entry
Discussion Leader: Indu Ambudkar (NIH)
9:00 am - 9:25 amDonald Gill (Temple University)
"Distinct coupling domains in STIM1 and STIM2 define the Orai-activating site"
9:25 am - 9:40 amDiscussion
9:40 am - 9:50 amShort talk: Patrick Hogan (La Jolla Institute for Allergy)
"An siRNA screen identifies septins as coordinators of store-operated calcium entry"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:55 amTrevor Shuttleworth (University of Rochester)
"Contradictions in CRAC Channel Conformations"
10:55 am - 11:10 amDiscussion
11:10 am - 11:35 amPeter Stathopulos (Ontario Cancer Institute)
"Structural basis for STIM and Orai interactions in the regulation of SOCE"
11:35 am - 11:50 amDiscussion
11:50 am - 12:00 pmShort talk: Jonathan Soboloff (Temple University)
"Aberrant store-operated calcium entry (SOCE) in invasive melanoma"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmShort talk: Victoria Bolotina (Boston University)
"Ca2+ entry and Parkinson's disease"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmCalcium Entry and Disease
Discussion Leader: James Putney (NIEHS)
5:30 pm - 5:55 pmMohamed Trebak (Albany Medical College)
"Diversity of native ORAI Ca2+ entry channels and their contribution to vascular disease"
5:55 pm - 6:10 pmDiscussion
6:10 pm - 6:35 pmStefan Feske (New York University)
"ORAI and STIM proteins in the regulation of Ca2+ influx and immune responses"
6:35 pm - 6:50 pmDiscussion
6:50 pm - 7:15 pmAnnette Dolphin (University College, London)
"Neuronal voltage-gated calcium channels and the function of their auxiliary alpha2delta subunits"
7:15 pm - 7:30 pmDiscussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIntracellular Calcium Release
Discussion Leader: David Yule (University of Rochester)
9:00 am - 9:25 amColin Taylor (Cambridge University)
"Structure and function of IP3 receptors"
9:25 am - 9:40 amDiscussion
9:40 am - 9:50 amShort talk: Sandip Patel (University College London)
"Ancestral features of two-pore channels define a trajectory for evolution of voltage-gated Ca2+ and Na+ channels"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:55 amShmuel Muallem (NIH)
"IRBIT, A Third Messenger That Integrates and Synergizes Ca2+ and cAMP"
10:55 am - 11:10 amDiscussion
11:10 am - 11:35 amAntony Galione (Oxford University)
"New insights into NAADP-mediated calcium signaling"
11:35 am - 11:50 amDiscussion
11:50 am - 12:00 pmShort talk: Geert Bultynck (KU Leuven)
"Increased IP3R2 expression and chronic IP3 signaling renders B-cell lymphomas addicted to Bcl-2 at the endoplasmic reticulum"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmShort talk: Qiu-Xing Jiang (UT Southwestern)
"Ligand gating of the IP3 receptor: a structural view"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmIntracellular Calcium Release and Disease
Discussion Leader: Martin Bootman (The Open University)
5:30 pm - 5:55 pmJon Lederer (University of Maryland)
"Oxidation-dependent Calcium signaling in Heart"
5:55 pm - 6:10 pmDiscussion
6:10 pm - 6:35 pmLlewellyn Roderick (Babraham Institute)
"IP3-mediated calcium signalling in remodelling of cardiac physiology and hypertrophic growth"
6:35 pm - 6:50 pmDiscussion
6:50 pm - 7:15 pmSusan Hamilton (Baylor College of Medicine)
"Skeletal Muscle Regulation of Body Fat: Critical Role of Ca2+ Influx via CaV1.1"
7:15 pm - 7:30 pmDiscussion
7:30 pm - 8:00 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMitochondria
Discussion Leader: Andrew Thomas (New Jersey School of Medicine and Dentistry)
9:00 am - 9:25 amLuca Scorrano (University of Padua)
"Endoplasmic reticulum-specific variants of Mitofusin 2 tether it to mitochondria"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amMei-ling Joiner (University of Iowa)
"CaMKII and mitochondrial biology in heart"
10:00 am - 10:10 amDiscussion
10:10 amCoffee Break
10:40 am - 11:05 amJau-nian Chen (UCLA)
"Mitochondria and embryonic cardiac rhythmicity"
11:05 am - 11:15 amDiscussion
11:15 am - 11:40 amDiego De Stefani (University of Padua)
"The mitochondrial calcium uniporter (MCU)"
11:40 am - 11:50 amDiscussion
11:50 am - 12:00 pmShort talk: Madesh Muniswamy (Temple University)
"Discovery of Mitochondrial Ca2+ uniporter regulators"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmShort talk: Gyorgy Csordas (Thomas Jefferson University)
"MICU1 as a gatekeeper of MCU activity"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmKeynote Session
5:30 pm - 5:40 pmDiscussion Leader: Donald Gill (Temple University)
"Introduction"
5:40 pm - 6:20 pmMichael Berridge and Tullio Pozzan (Babraham Institute, CNR Neuroscience Institute)
"20 years from the first Calcium GRC: Where we were and how far we have gone"
6:20 pm - 6:35 pmDiscussion
6:35 pm - 7:20 pmKeynote Lecture: Anjana Rao (La Jolla Institute for Allergy and Immunology)
"New modulators of store-operated calcium entry identified through genome-wide RNAi screens"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible [in part] by 1 R13 AI107778-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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