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Conference Program
 
Cancer Genetics & Epigenetics
April 21-26, 2013
Renaissance Tuscany Il Ciocco Resort
Lucca (Barga), Italy
Chair:
Joseph F. Costello

Vice Chair:
Ricky Johnstone

Mutations and epimutations interact reciprocally to drive unrestrained growth and malignant progression of cancer. Specific genetic mutations of epigenetic regulators may cause widespread epigenetic alterations, and epimutations similarly predispose to genetic alterations either locally or across the genome. This GRC series focuses on the discovery and function of novel recurrent genetic and epigenetic alterations, the mechanisms that predispose to them, and their functional consequence on tumor cell behavior, therapeutic response and numerous cancer phenotypes. More comprehensive and integrative analysis of cancers has been enabled and significantly advanced by genomic technologies. Such profiling and analyses are now possible on impressively small amounts of tissue or potentially on single cells, allowing heterogeneity to be addressed at the regional and cellular level. From the discovery of the alterations, along with significant structural biology and chemistry, new agents with therapeutic potential have arisen. The translational value of these discoveries and promising therapeutic agents is being put to the test internationally in preclinical and clinical settings, and will be discussed in depth. Personalized genetic and epigenetic therapies for cancer patients are being taken to a new level. Sessions in this meeting will focus on distinguishing driver from passenger mutations and epimutations, the mechanistic links between genetic mutations and epimutations, and the identification of actionable defects in primary cancers. Novel therapies that target specific genetic alterations or aim to reverse epigenetic alterations more globally will be discussed by leaders from academic and industry laboratories.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: The Importance of Cancer Genetics and Epigenetics to the Future of Oncology
Discussion Leaders: Joe Costello (University of California San Francisco) and Sue Clark (The Garvan Institute of Medical Research)
7:40 pm - 8:10 pmStephen Baylin (Johns Hopkins)
"Targeting Epigenetic Abnormalities in Cancer - From the Lab to Therapeutic Promise"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:45 pmPeter Campbell (Sanger Institute)
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmJeffrey Settleman (Genentech)
"Chromatin Modification as a Mechanism of Reversible Tolerance to Cancer Drugs"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChromatin Regulators
Discussion Leader: Peter Jones (USC)
9:00 am - 9:25 amStefan Pfister (DKFZ, The German Cancer Research Center)
"Recurrent H3.3 Mutation in Childhood Glioblastoma - A Genetic Hit with Epigenetic Consequences"
9:25 am - 9:30 amDiscussion
9:30 am - 9:55 amSteve Mack (SickKids Hospital, University of Toronto)
"Epigenomics of Childhood Brain Tumors"
9:55 am - 10:00 amDiscussion
10:00 amGroup Photo / Coffee Break
10:30 am - 11:00 amMark Dawson (Wellcome Trust Cruk Gurdon Institute)
"Targeting Epigenetic Readers in Leukaemia"
11:00 am - 11:10 amDiscussion
11:10 am - 11:40 amChristoph Plass (DKFZ, The German Cancer Research Center)
"Epigenetic Reprogramming in Cancer"
11:40 am - 11:50 amDiscussion
11:50 am - 12:20 pmChristine Chaffer (MIT)
"Poised chromatin at the ZEB1 promoter enables cell plasticity and enhances tumorigenicity"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmTransposons
Discussion Leader: Henk Stunnenberg (Radboud University Nijmegen Medical Centre)
5:30 pm - 5:55 pmJohn V. Moran (University of Michigan)
"Studies of a Human Retrotransposon"
5:55 pm - 6:00 pmDiscussion
6:00 pm - 6:25 pmTing Wang (Washington University)
"Transposable Element Family-specific DNA Hypomethylation Contributes to Tissue-Specific Enhancer Landscapes"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:55 pmPaula Vertino (Emory University)
"Chromatin Determinants of Aberrant DNA Methylation in Cancer"
6:55 pm - 7:00 pmDiscussion
7:00 pm - 7:25 pmPeter Kharchenko (Dana Farber Cancer Institute)
"Transposable Element and other Somatic Insertions in Human Cancers"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFunctional Genetics
Discussion Leader: Boris Bastian (University of California San Francisco)
9:00 am - 9:25 amKeith Killian (National Cancer Institute, USA)
"Succinate dehydrogenase: Krebs-cycle guardian of the epigenome"
9:25 am - 9:30 amDiscussion
9:30 am - 9:55 amBruno Amati (SEMM Fondazione Istituto Italiano di Tecnologia (IIT) and IEO)
"Epigenome and Transcriptome Regulation in Myc-Driven Tumors"
9:55 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:00 amJay Bradner (Dana Farber Cancer Institute)
"Clinical Translation of Bromodomain Inhibitors"
11:00 am - 11:10 amDiscussion
11:10 am - 11:40 amRicky Johnstone (The Peter MacCallum Cancer Institute)
"Using Genetically Engineered Mouse Models of Cancer to Identify New Tumor Suppressor Genes and Therapies"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmAdele Murrell (University of Cambridge)
"Hydroxymethylation - anticipating methylation change?"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmTing Wang (Washington University)
"Visualizing epigenomes from the NIH Roadmap, ENCODE and beyond"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmCancer Epigenetics, Inflammation and Premalignancy
Discussion Leader: Jean Pierre Issa (Temple University)
5:30 pm - 5:55 pmPeter Jones (USC)
"DNA Methylation Drivers and Passengers"
5:55 pm - 6:00 pmDiscussion
6:00 pm - 6:25 pmSusan Clark (The Garvan Institute of Medical Research)
"Replication Timing and Epigenetic Reprogramming in Cancer"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:55 pmToshikazu Ushijima (Japan National Cancer Center Research Institute)
"Aberrant H3K27me3 and DNA Methylation Induced by Chronic Inflammation"
6:55 pm - 7:00 pmDiscussion
7:00 pm - 7:25 pmThea Tlsty (University of California San Francisco)
"Epigenetic and Phenotypic Plasticity"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEpigenetic Regulation, Polycomb and Pluripotency
Discussion Leader: Peggy Farnham (USC)
9:00 am - 9:25 amWinston Timp (Johns Hopkins)
"A Unified View of Cancer as a Disease of Epigenetic Instability"
9:25 am - 9:30 amDiscussion
9:30 am - 9:55 amChris Oakes (DKFZ, The German Cancer Research Center)
"Heterogeneity and Evolution of DNA Methylation are Linked to Genetic Aberrations in Chronic Lymphocytic Leukemia"
9:55 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:00 amKristian Helin (University of Copenhagen)
"Mechanisms Regulating Polycomb Recruitment to Target Genes"
11:00 am - 11:10 amDiscussion
11:10 am - 11:40 amGiuseppe Zardo (University of Rome)
"Polycomb Proteins and microRNAs: Partners in Cell Fate Determination"
11:40 am - 11:50 amDiscussion
11:50 am - 12:20 pmHenk Stunnenberg (Radboud University, Nijmegen)
"Distinct epigenomic states of Mouse Pluripotent Stem Cells"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmEpigenetic Mechanisms and Clinical Correlations
Discussion Leader: Paula Vertino (Emory University)
5:30 pm - 5:55 pmPeggy Farnham (USC)
"The Interplay of DNA Methylation and Epigenetic Histone Modifications"
5:55 pm - 6:00 pmDiscussion
6:00 pm - 6:25 pmPatrick Trojer (Constellation Pharmaceuticals)
"Discovery of EZH2 Small Molecule Inhibitors and their Therapeutic Application"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:55 pmManel Esteller (Bellvitge Biomedical Research Institute, Barcelona)
"Human Cancer Epigenetics: From Knowledge to Application"
6:55 pm - 7:00 pmDiscussion
7:00 pm - 7:25 pmJean Pierre Issa (Fels Institute, Temple University)
"Genetic and Epigenetic Interactions"
7:25 pm - 7:30 pmDiscussion
7:30 pm - 8:00 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGenomics and Personalized Oncology
Discussion Leader: Kristian Helin (University of Copenhagen)
9:00 am - 9:25 amBoris Bastian (University of California San Francisco)
"Genotypes and Phenotypes of Melanocytic Neoplasia"
9:25 am - 9:30 amDiscussion
9:30 am - 9:55 amTimour Baslan (Cold Spring Harbor Laboratories)
"High Throughput Single Cell Sequencing of Breast Cancers Reveals Insights into Tumor Evolution and Heterogeneity"
9:55 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:00 amBrett Johnson (University of California San Francisco)
"Early Ancestral Origins and Therapy driven Evolution of Tumor Recurrence"
11:00 am - 11:10 amDiscussion
11:10 am - 11:40 amXiaole Shirley Liu (Harvard University, Dana Farber Cancer Institute)
"Chromatin Dynamics in Development and Cancer"
11:40 am - 11:50 amDiscussion
11:50 am - 12:20 pmRoy Pollock (Epizyme, Inc.)
"Targeting Histone Methyltransferases in Cancer Therapy"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmNovel Targets and Therapies
Discussion Leader: Ricky Johnstone (The Peter MacCallum Cancer Institute)
5:30 pm - 5:55 pmPeter J. Tummino (GlaxoSmithKline Pharmaceuticals)
"Prospects for Bromodomain Inhibitors in Solid Tumors"
5:55 pm - 6:00 pmDiscussion
6:00 pm - 6:25 pmKen Nephew (Indiana University & Simon Cancer Center)
"Novel DNMT Inhibitors as Chemosensitizers in Malignancy"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:55 pmJolanta Grembecka (University of Michigan, Ann Arbor)
"Development of Novel Targeted Therapy for MLL Leukemias"
6:55 pm - 7:00 pmDiscussion
7:00 pm - 7:25 pmSaverio Minucci (IEO, Milan)
"Chromatin Alterations and Targets in Leukemogenesis"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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