Gordon Research Conferences
PI_Conferences PI_Conferences_Past
Conference Program
 
Cannabinoid Function in the CNS
Cannabinoids in Synapses, Circuits and the Human Brain
August 4-9, 2013
Waterville Valley Resort
Waterville Valley, NH

Related Meeting Information
The Cannabinoid Function in the CNS Gordon Research Conference was held in conjunction with the Cannabinoid Function in the CNS Gordon Research Seminar. Please refer to the Cannabinoid Function in the CNS GRS web page for more information.

The 2013 Gordon Research Conference on "Cannabinoid Function in the CNS", the fifth in this series, will feature presentation of the latest findings on cannabinoid and endocannabinoid roles in neurophysiology, pathophysiology and human neurological and neuropsychiatric disorders. Participants will discuss new findings and ideas about the endocannabinoid system and its roles in synaptic plasticity and human brain function/disease states marked by alterations in neuroplasticity. Pathological processes (i.e. pain, addiction, epilepsy and neurological/neuropsychiatric disorders) linked to alterations in synaptic plasticity/endocannabinoid signaling will be evaluated from multiple levels of analysis (i.e. from molecules to man). This focus is warranted based upon widespread recreational as well as medicinal use of cannabinoid-based preparations. The conference will bring together established investigators from various disciplines, such as chemistry, biochemistry, pharmacology, physiology, imaging, neurology and psychiatry, but will also provide opportunities to young investigators and students from around of the world, with the aim of attracting new prospective leaders to this exciting research area. Poster presentations will be held on all conference days, and speakers for podium presentations will be selected from among those submitting poster presentations, to provide opportunities for early career-stage investigators to present their results to all conference attendees. All speakers will focus presentations on unpublished results, thus stressing novel/cutting edge research. In the opening keynote talk, Dr. Bernardo Sabatini (Harvard Medical School) will discuss optical methods for observing and controlling neural circuits, including work on neuromodulators, topics that are relevant to much of the work discussed throughout this meeting. Endocannabinoid roles and cannabinoid effects in the human brain will be a particular focus of the conference. Potential therapeutic uses of cannabinoids and endocannabinoid modulators will also be featured. The collegial atmosphere at the conference, with opportunities for informal gatherings during leisure time and long poster sessions, will promote cross-disciplinary discussion and collaboration with the goal of unifying different disciplines in the study of cannabinoid function in the CNS.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Lecture
7:30 pm - 7:50 pmDiscussion Leader: Pablo Castillo (Albert Einstein College of Medicine)
"Introduction"
8:00 pm - 9:00 pmBernardo Sabatini (Harvard Medical School)
"Imaging and Controlling Neural Circuits with Light"
9:00 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEndocannabinoids and Neurological/Neuropsychiatric Diseases
9:00 am - 9:10 amDiscussion Leader: Beat Lutz (University of Mainz)
"Introduction"
9:10 am - 9:30 amMatthew Hill (University of Calgary)
"CRH regulation of endocannabinoid signaling as a bridge between stress and anxiety"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amOzge Gunduz-Cinar (NIH/NIAAA)
"Anandamide modulation of fear rescue in a mouse model of impaired extinction"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amGroup Photo / Coffee Break
10:30 am - 10:50 amCecilia Hillard (Medical College of Wisconsin)
"Circulating Endocannabinoids: Signature of Psychiatric Disease"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amMarkus Leweke (University of Heidelberg)
"New insights into endocannabinoid functioning in schizophrenia, personality and post traumatic stress disorder"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amNephi Stella (University of Washington)
"Targeting Endocannabinoid Signaling for the Treatment of Huntington's Disease and Epilepsy"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmWim Vandenberghe (Leuven Research Institute for Neurodegenerative Diseases)
"CB1 in Huntington's disease: in vivo imaging in human brain"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEndocannabinoid-Dependent Synaptic Plasticity and Epilepsy
Discussion Leader: F. Edward Dudek (University of Utah)
"Introduction"
7:30 pm - 7:50 pmThomas Nevian (University of Berne)
"Retrograde signalling in spike-timing dependent plasticity"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmCatherine Woolley (Northwestern University)
"Sex-specific regulation of synaptic inhibition in the hippocampus"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmIvan Soltesz (University of California Irvine School of Medicine)
"Cell-type specific organization of CB1R-expressing interneurons in the control and epileptic hippocampus"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmKarolien Goffin (Katholieke Universiteit Leuven)
"Imaging of the cannabinoid system in epilepsy"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEndocannabinoids, Endovanilloids and the Endocannabinoid Metabolome
9:00 am - 9:10 amDiscussion Leader: Vincenzo Di Marzo (Endocannabinoid Research Group)
"Introduction"
9:10 am - 9:30 amQing-Song Liu (Medical College of Wisconsin)
"Endocannabinoid signaling in stress and depression"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amJulian Romero (Hospital Universitario Fundacion Alcorcon)
"In vivo modulation of astrocytic and microglial activity in neuroinflammation by endocannabinoids"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amCoffee Break
10:30 am - 10:50 amSachin Patel (Vanderbilt University School of Medicine)
"So FAAH so good... but COX next: Substrate-selective COX-2 inhibition for endocannabinoid augmentation"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amHeather Bradshaw (Indiana Univeristy)
"The impact of ABHD12, MGL, or CB2 deletion on the endocannabinoid-related lipidome: implications for TRPV signaling"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amAndres Chavez (Albert Einstein College of Medicine)
"New insights on TRPV1 channels as modulators of synaptic function"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmPedro Grandes (Basque Country University)
"TRPV1 in hippocampal circuits of the rodent brain"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEndocannabinoids in the Basal Ganglia and Learning and Memory
Discussion Leader: Raffaella Tonini (Istituto Italiano di Tecnologia)
"Introduction"
7:30 pm - 7:50 pmRui Costa (Champalimaud Centre for the Unknown)
"Endocannabinoids and habit formation"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmYasumasa Ueda (Kyoto Prefectural University of Medicine)
"A Role of eCB signaling in the control of primate basal ganglia function"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmSteven Laviolette (University of Western Ontario)
"Cannabinoid Control of Rewarding and Aversive Memory Formation Through Mesocorticolimbic Interactions"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmJoseph Cheer (University of Maryland School of Medicine)
"CB1 receptor activation modulates the neural timing functions of dopamine"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe Endocannabinoid System and Pain: From the Bench to the Bedside
9:00 am - 9:10 amDiscussion Leader: Victoria Chapman (The University of Nottingham Medical School)
"Introduction"
9:10 am - 9:30 amDaniele Piomelli (University of California, Irvine)
"Dual FAAH-Cox inhibitors - potent analgesic and anti-inflammatory agents devoid of Cox-mediated toxicity"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amAron Lichtman (Virginia Commonwealth University)
"Dual blockade of endocannabinoid catabolic enzymes produces augmented antinociceptive effects with reduced cannabimetic side effects"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amCoffee Break
10:30 am - 10:50 amVolker Neugebauer (University of Texas Medical Branch/Galveston)
"Modulation of medial prefrontal cortical output by CB1 interacting with mGluR5 in pain"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amDavid Finn (National University of Ireland Galway)
"The endocannabinoid system in affective and cognitive regulation of pain"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amRuth Ross (University of Toronto)
"Characterization of a positive allosteric modulator of the CB1 receptor that alleviates allodynia in a neuropathic pain model without cannabimimetic side effects in mice"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmMark Ware (McGill University Health Centre)
"Lost in translation? Clinical perspectives on cannabinoids and pain"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmCB1 Receptor Trafficking
Discussion Leader: Ken Mackie (Indiana University)
"Introduction"
7:30 pm - 7:50 pmJeremy Henley (University of Bristol)
"Mechanisms Underlying CB1 Axonal Polarisation"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmIstvan Katona (Hungarian Academy of Sciences)
"Cell type-and synapse-specific STORM super-resolution imaging of CB1 receptors in the hippocampus"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmGuillermo Yudowski (University of Puerto Rico)
"The dynamics of CB1R endocytosis in neurons: One coated pit at a time"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmJingJing Wu (The Johns Hopkins School of Medicine)
"Cannabinoid signaling in the mammalian inner ear"
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe Endocannabinoid System in Reward, Substance Abuse and Addiction
9:00 am - 9:10 amDiscussion Leader: Miriam Melis (Universita degli studi di Cagliari)
"Introduction"
9:10 am - 9:30 amGeoffrey Vargish (NICHD)
"Persistent inhibitory defects dollowing chronic in utero exposure to exogenous cannabinoids"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amLoren Parsons (The Scripps Research Institute)
"Influence of disrupted endocannabinoid metabolism on the motivational effects of nicotine"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amCoffee Break
10:30 am - 10:50 amDaniela Parolaro (The University of Insurbia)
"Adolescent THC exposure as a developmental insult favouring the onset of psychiatric diseases later in life"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amTherese Jay (Ecole des Neurosciences Paris Ile de France)
"Chronic cannabinoid exposure during adolescence is associated with negative consequences in adult structural and synaptic plasticity in the rat prefrontal cortex"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amYasmin Hurd (Mount Sinai School of Medicine)
"The in utero and cross-generational continuum of the neurobiological effects of cannabis"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmJussi Hirvonen (University of Turku)
"Imaging cannabinoid CB1 receptors in addictive disorders using positron emission tomography"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCannabinoid Receptor Signaling
Discussion Leader: Heather Bradshaw (Indiana University)
"Introduction"
7:30 pm - 7:50 pmMichelle Glass (The University of Auckland)
"Allosteric modulators of CB1 lead to rapid 'desensitization' of signalling"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmKen Mackie (Indiana University)
"Mechanisms involved in CB1 tolerance"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmGiovanni Marsicano (Inserm Bordeaux)
"Quantity is not quality: functional importance of low levels CB1 expression in the brain"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmHot Topics From Posters: Brian Shonesy (Vanderbilt University)
"CAMKII regulates diacylglycerol lipase alpha and striatal endocannabinoid signaling"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmHot Topics From Posters: Matthew Buczynski (The Scripps Research Institute)
"Enhanced nicotine reward in a mouse model of the P129T FAAH gene polymorphism"
9:25 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1 R13 DA035550-01A1 from the National Institute on Drug Abuse. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
© 2014 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter