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Carbohydrates
Gordon Research Conference

Dates

June 16-21, 2013

Location

Mount Snow
West Dover, VT

Organizers

Chairs:
Joseph J. Barchi & George O'Doherty

Vice Chairs:
Jeffrey C. Gildersleeve & Alexei V. Demchenko

Meeting Description

The science of carbohydrates has been studied for well over one hundred years, but it is only in the last few that the myriad roles played by cellular sugars in normal development and disease have been fully appreciated. This importance of carbohydrates is succinctly illustrated in the recent commissioned report by the National Academy of Sciences that outlines a roadmap for the future of glycoscience research and means to reach some of those goals. The 2013 Gordon Research Conference on Carbohydrates will bring together some of the most important players in transformative glycoscience, and serve as a forum for discussions on progress in those areas of glycoscience that are most in need of improvement: Glycan synthesis, analysis, detection, structure and informatics. The meeting will highlight the work of both established and younger glycoscientists through a nearly equal number of invited and short talks, including rapid "poster" talks to direct the audience to work presented at each of the poster sessions. Included will be a session entitled "Lessons from the Consortium for Functional Glycomics" that will bring together group leaders form the various core laboratories that comprised the consortium and discuss ways forward for the future of the technology that evolved from that experiment. The goal of this meeting will be to bring together both the primary players and those up and coming in the field to consider the most critical aspects of glycoscience and as a result make informed suggestions as to the way forward for the entire field.

Contributors

Meeting Program

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmChemical Glycobiology
Discussion Leader: Chris Cairo (University of Alberta)
7:40 pm - 8:05 pmAmit Basu (Brown University)
"Chemical Glycobiology of Pollen Tube Extension"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmDavid Jakeman (Dalhousie U)
"Carbohydrate phosphonates, multi-functional enzyme probes"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmValentin Wittmann (University of Konstanz)
"Two color glycan labeling of live cells by a combination of Diels-Alder and click chemistry"
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmPoster Highlight Talk: Roger Ashmus (University of Alberta)
"Progress towards understanding the biosynthesis of phosphoramidates in Campylobacter jejuni"
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLessons from the CFG (Consortium for Functional Glycomics)
Discussion Leader: Joe Barchi (National Cancer Institute at Frederick)
9:00 am - 9:20 amPamela Marino (National Institute of General Medical Sciences)
"Challenges of an Omic's Era - seeking partners and finding opportunities"
9:20 am - 9:25 amDiscussion
9:25 am - 9:50 amJames Paulson (Scripps Research Institute)
"Decoding the glycome: A central paradigm of the CFG"
9:50 am - 10:00 amDiscussion
10:00 am - 10:25 amGroup Photo / Coffee Break
10:25 am - 10:50 amAnne Dell (Imperial College)
"Glycosylation of mouse and human immune cells: insights emerging from glycomics analysis"
10:50 am - 11:00 amDiscussion
11:00 am - 11:25 amDavid Smith (Emory U.)
"Application of Glycan Microarrays to Deciphering the Structure and Function of the Human Glycome"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmRahul Raman (MIT)
"Informatics for Glycomics at the CFG"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmBrief Talk: Wesley Zandberg (Simon Fraser University of Konstanz)
"Trojan horse inhibition of glycosyltransferases in cells: controlling cell surface expression of glycans"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I (1-55)
6:00 pmDinner
7:30 pm - 9:30 pmCarbohydrate Synthesis and Biosynthesis
Discussion Leader: Jennifer Koviach-Cote (Bates College)
7:30 pm - 7:55 pmHung-wen (Ben) Liu (University of Texas)
"Exploiting sulfur carrier proteins from primary metabolism for 2-thiosugar biosynthesis"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmTodd Lowary (University of Alberta)
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:50 pmShort Talk: Matthew Pratt (University of Southern California)
"Development of a highly selective metabolic chemical reporter of O-GlcNAc modifications"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmLinda Hsieh-Wilson (Cal Tech)
"Using Chemistry to Discover Carbohydrate Mechanisms in Biology and Disease"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCarbohydrate Immunology and Immunotherapy
Discussion Leader: Jeff Gildersleeve (National Cancer Institute)
9:00 am - 9:25 amPeter Andreana (University of Toledo)
"PS A1 as a Covalent Adjuvant in Immune Stimulation"
9:25 am - 9:35 amDiscussion
9:35 am - 9:45 amShort Talk: Saddam Muthana (National Cancer Institute, Frederick)
"Studying immunogenicity of blood group antigens and developing a new method for blood typing"
9:45 am - 9:50 amDiscussion
9:50 am - 10:15 amKate Rittenhouse-Olson (University of Buffalo)
"Unique immunization strategies for Thomsen Friedenreich Antigen"
10:15 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
Discussion Leader: Isaac Krauss (Brandeis University)
10:55 am - 11:05 amShort Talk: Roberto Adamo (Novartis Vaccines and Diagnostics)
"Site selective conjugation at tyrosines on CRM197 as a general approach to well-defined conjugate vaccines"
11:05 am - 11:10 amDiscussion
11:10 am - 11:35 amHorst Kunz (University of Mainz)
"Synthetic Antitumor Vaccines - an Interplay of Carbohydrate and Peptide Antigen Structures"
11:35 am - 11:45 amDiscussion
11:45 am - 11:50 amPoster Highlight Talk: Nathaniel Schocker (University of Texas El Paso)
"Potential use of synthetic alpha-galactosyl and alpha-rhamnosyl containing glycotopes of the parasite Trypanosoma cruzi as new diagnostic biomarkers for Chagas Disease"
11:50 am - 11:55 amPoster Highlight Talk: Cristina Zamora (Tufts University)
"Fluorogenic sialic acid glycosides for quantification of sialidase activity upon natural substrates"
11:55 am - 12:20 pmLai-Xi Wang (University of Maryland)
"Synthetic Carbohydrate Antigens for HIV Vaccine Design"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II (56-106)
6:00 pmDinner
7:30 pm - 9:30 pmGlycans and Natural Products
Discussion Leader: Daniel Werz (University of Goettingen)
7:30 pm - 7:55 pmJurgen Rohr (University of Kentucky)
"Enzymatic Total Syntheses of TDP-deoxysugars and Their Use for Studying Glycosyltransfer Reactions of Antitumor Antibiotic Biosyntheses"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmRodrigo Andrade (Temple University)
"Total Synthesis and Biological Evaluation of Desmethyl Macrolide Antibiotics"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:50 pmShort Talk: Thomas Beale (University of Toronto)
"Regioselective glycosylations of natural products using borinic acid catalysts"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:10 pmClay Bennett (Tufts University)
"Reagent controlled chemical glycosylation"
9:10 pm - 9:25 pmIsaac Krauss (Brandeis University)
"Directed Evolution of Carbohydrate Clusters in Design of HIV Vaccine Candidates"
9:25 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMolecular Structure and Recognition in Glycan Drug Design
Discussion Leader: Susanne Striegler (University of Arkansas)
9:00 am - 9:25 amRobert Woods (University of Georgia)
"Computational screening of virtual glycan arrays: a new tool for specificity prediction and validation"
9:25 am - 9:35 amDiscussion
9:35 am - 9:45 amShort Talk: France Isabelle Auzanneau (University of Guelph)
"Synthesis of LeALeX oligosaccharide fragments and molecular modeling of the LeALeX Tumor Associated Carbohydrate Antigen"
9:45 am - 9:50 amDiscussion
9:50 am - 10:15 amDev Arya (Clemson University)
"Shape Recognition of Nucleic Acids by Carbohydrates"
10:15 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
Discussion Leader: Yann Chevolot (Institut des Nanotechnologie, Lyon)
10:55 am - 11:05 amShort Talk: Alexander Titz (University of Konstanz)
"Discovery of two classes of potent and drug-like glycomimetic inhibitors of Pseudomonas aeruginosa LecB with distinct binding modes"
11:05 am - 11:10 amDiscussion
11:10 am - 11:35 amChang-Chun Lin (University of Calgary)
"Targeting Clostridium Difficile Toxins: Challenges and Recent Developments"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amShort Talk: Miao He (Emory University)
"Using an N-linked tetrasaccharide as a biomarker for the diagnosis of ALG1-CDG (CDG-lk)"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk: Danielle Dube (Bowdoin College)
"Chemical tools to discover and target Helicobacter pylori's glycoproteins"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort Talk: Alexandre Driguez (Sanofi Aventis)
"Synthesis of new and non-natural specific FGFR4-agonists heparin octasaccharides"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session III (All posters)
6:00 pmDinner
7:30 pm - 9:30 pmGlycosylation and Anomeric Chemistry
Discussion Leader: Alexei Demchenko (University of Missouri)
7:30 pm - 7:55 pmScott Rychnovsky (University of California Irvine)
"Reactivity next to heteroatoms: anomeric effects beyond carbohydrates"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmToshiki Nokami (Tottori University)
"Electrochemistry as an enabling tool for glycosylation"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:50 pmShort Talk: Takayuki Furukawa (Wayne State University)
"Development of a cation clock reaction for determining relative kinetics of glycosylation reactions"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmSuvarn Kulkarni (Indian Institute of Technology, Bombay)
"Expeditious synthesis of bacterial glycoconjugates"
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
9:00 am - 12:30 pmGlycan and Glycoconjugate Synthesis: Enzymes and Beyond
Discussion Leader: Eugene Cioffi (University of South Alabama)
9:00 am - 9:25 amKelley Moremen (University of Georgia)
"Production and use of mammalian glycosylation enzymes for enzymatic and structural studies"
9:25 am - 9:35 amDiscussion
9:35 am - 9:45 amShort Talk: Luigi Panza (University of Piemonte)
"Synthetic approaches to glycosphingolipids"
9:45 am - 9:50 amDiscussion
9:50 am - 10:15 amXi Chen (University of California Davis)
"Chemoenzymatic synthesis of carbohydrates and glycoconjugates"
10:15 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
Discussion Leader: Yasuhiro Kajihara (Osaka University)
10:55 am - 11:05 amShort Talk: Xuechen Li (University of Hong Kong)
"New methods in glycopeptides/glycoprotein synthesis"
11:05 am - 11:10 amDiscussion
11:10 am - 11:35 amRobert Linhardt (Renssalear Polytechnic University)
"Chemoenzymatic synthesis of heparins"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amShort Talk: Srinivas Hotha (Indian Institute of Science Education and Research, Pune)
"Oligoarabinans by gold catalyzed glycosylations"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk: Steven Sucheck (University of Toledo)
"Mycobacterium tuberculosis GIgE: Structure, mechanism and inhibition of an essential maltosyltransferase"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort Talk: Xinyu Liu (University of Pittsburgh)
"New tactics and strategies in oligosaccharide assembly"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session IV (All posters)
6:00 pmDinner
7:30 pm - 9:30 pmNanomaterials, Sensors and Diagnostics
Discussion Leader: Suri Iyer (Georgia State University)
7:30 pm - 7:55 pmTheresa Reineke (University of Minnesota)
"Sugar-coated nanocomplexes: designed block copolymers for therapeutic delivery"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmXuewei Liu (Nanyang Technological University)
"Glycosciences: From Synthetic Methods to Glycobiology"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:50 pmShort Talk: Cornelius Boerkoel (National Institutes of Health)
"Detection of glycosylation abnormalities among individuals with undiagnosed diseases: The NIH Undiagnosed Disease Program experience"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmNicola Pohl (Indiana University)
"Challenges in Carbohydrate Library Synthesis"
9:20 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13GM109242-01 from NIGMS. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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