Gordon Research Conferences
PI_Conferences PI_Conferences_Past
Conference Program
 
Cardiac Arrhythmia Mechanisms
February 17-22, 2013
Four Points Sheraton / Holiday Inn Express
Ventura, CA
Chair:
Mario Delmar

Vice Chair:
Peter Kohl

The 2013 Gordon Research Conference (GRC) on Cardiac Arrhythmia Mechanisms will focus on integrating basic and translational science with clinically relevant topics. This is the 6th GRC on Cardiac Arrhythmia Mechanisms. Every two years since 2003, this international meeting has provided a venue for scientific discourse on the mechanisms that underlie disturbances in cardiac rhythm and lethal arrhythmias, and the novel approaches to therapy and prevention. The meeting draws broad participation from the national and international communities of graduate students, postdoctoral fellows and senior faculty, working in academia or in industry, that share a common interest in the fight against cardiac arrhythmias and sudden cardiac death. Since its inception, this GRC meeting has provided a unique, collegial environment to foster cross-disciplinary collaborations between investigators in various fields including molecular biology, molecular genetics, stem cell biology, cellular electrophysiology, biophysics, imaging, biomedical engineering, mathematics, and clinical cardiology. In this gathering, leading experts and young promising investigators will present and together discuss the most exciting, cutting-edge research, from the gene/molecule to the bedside, that seeks to improve our understanding of the mechanisms, diagnosis and treatment of cardiac arrhythmias.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 8:15 pmKeynote Presentation
7:40 pm - 8:00 pmJose Jalife (University of Michigan)
"The Na-K Channelosome Controls the Frequency and Stability of Cardiac Fibrillation"
8:00 pm - 8:15 pmDiscussion
8:15 pm - 9:30 pmCalcium and the Control of Heart Rhythm
Discussion Leader: Isabelle Deschenes (Case Western Reserve University)
8:15 pm - 8:35 pmJames Weiss (UCLA)
"Experimental/computer models of calcium dynamics"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:10 pmJonathan Satin (University of Kentucky)
"L-type Calcium Channel Multi-protein Complex Includes An Auto-regulatory Transcription Factor"
9:10 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmSubcellular Structures/macromolecular complexes as arrhythmogenic substrates
Discussion Leader: Kalliopi Pilichou (University of Padua)
9:00 am - 9:20 amGail Robertson (University of Wisconsin-Madison)
"Role of hERG channel subunits in cardiac repolarization"
9:20 am - 9:35 amDiscussion
9:35 am - 9:55 amFadi Akar (Mount Sinai School of Medicine)
"Mitochondrial Function and Cardiac Arrhythmias"
9:55 am - 10:10 amDiscussion
10:10 amCoffee Break
10:40 am - 11:00 amRobert Ross (UCSD)
"The costamere, cell-matrix interactions, and cardiac arrhythmias"
11:00 am - 11:15 amDiscussion
11:15 am - 11:35 amRobert Gourdie (Virginia Tech)
"The perinexus as a niche for protein interactions at the intercalated disc"
11:35 am - 11:50 amDiscussion
11:50 am - 12:10 pmMark Ellisman (UCSD)
"Multiscale Imaging of Cells: From Organelle Systems to Molecular Complexes"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNovel experimental approaches to study macromolecular complexes
Discussion Leader: Michele Miragoli (University of Parma)
7:30 pm - 7:50 pmLori Isom (University of Michigan)
"Na+ channel β1 subunits: multi-functional cell adhesion molecules and channel modulators at the cardiac intercalated disc"
7:50 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmEli Rothenberg (New York University)
"Super-resolution Fluorescent Microscopy to Study Macromolecular Complexes in Cardiac Myocytes"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmJulia Gorelik (Imperial College of London)
"Scanning Ion Conductance Microscopy in Cardiac Biology"
9:00 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmTrainee Presentation: Pan Li (UCSD)
"Multiscale Modeling of the Purkinje-Ventricular System"
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNovel experimental approaches to the study of cardiac electrophysiology
Discussion Leader: Guy Salama (University of Pittsburgh)
9:00 am - 9:20 amPhilipp Sasse (Bonn University)
"Exciting Light: Optogenetics in Cardiovascular Research"
9:20 am - 9:35 amDiscussion
9:35 am - 9:55 amCalum MacRae (Harvard University)
"Zebrafish: A Simple Model to Study Complex Arrhythmias"
9:55 am - 10:10 amDiscussion
10:10 amCoffee Break
10:40 am - 11:00 amBum-Rak Choi (Brown University)
"Transgenic rabbit models provide new insight on the mechanisms of arrhythmia initiation in LQT1 and LQT2 syndromes"
11:00 am - 11:15 amDiscussion
11:15 am - 11:35 amGlenn Fishman (New York University)
"A novel model of sodium channelopathy"
11:35 am - 11:50 amDiscussion
11:50 am - 12:10 pmHenry Halperin (Johns Hopkins University)
"Patient-Specific Imaging/Modeling to Predict Sites of VT Ablation"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCell-cell Communication in the Heart
Discussion Leader: Nenad Bursac (Duke University)
7:30 pm - 7:50 pmRobin Shaw (UCSF)
"New Insights into the Regulation of the Cx43 Life Cycle"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmToon van Veen (Utrecht University)
"Intercellular communication and the progression of cardiac fibrosis"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmBruce Smaill (Auckland University)
"Infarct Structure and Electrical Activation"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmFarah Sheikh (UCSD)
"Mechanical Junction Proteins and the Function of the Sinus Node"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCardiomyopathies, Heart Failure and Arrhythmias
Discussion Leader: Michael Rosen (Columbia University)
9:00 am - 9:20 amIgor Efimov (Washington University)
"Electrophysiological Properties of the Human Normal and Failing Heart"
9:20 am - 9:35 amDiscussion
9:35 am - 9:55 amSteven Houser (Temple University)
"Cardiac Remodeling in Heart Failure"
9:55 am - 10:10 amDiscussion
10:10 amCoffee Break
10:40 am - 11:00 amDouglas Zipes (Indiana University)
"Spinal Chord Stimulation and Arrhythmias in Heart Failure"
11:00 am - 11:15 amDiscussion
11:15 am - 11:35 amCristina Basso (Padua University)
"Arrhythmogenic Mechanisms in Arrhythmogenic Cardiomyopathy"
11:35 am - 11:50 amDiscussion
11:50 am - 12:10 pmAngeliki Asimaki (Harvard University)
"The Wnt signaling pathway as a therapeutic target in arrhythmogenic cardiomyopathy"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmArrhythmia Treatment and Assessment of Arrhythmia Risk (Part I)
Discussion Leader: Natalia Trayanova (Johns Hopkins University)
7:30 pm - 7:50 pmPeng-Sheng Chen (Indiana University)
"Vagal Stimulation and Atrial Arrhythmias"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmGregory Morley (New York University)
"Spinal Chord Stimulation in AF"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmDavid Spragg (Johns Hopkins)
"Ablation versus drugs in the treatment of AF"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmTrainee Presentation: Jason Constantino (Johns Hopkins)
"Role of the infarct scar in ventricular dyssynchrony. An image-based electromechanical model study"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmTrainee Presentation: Jonathan Moreno (Cornell University)
"Cardiac Dynamics in silico: Pharmacology through high performance computing"
9:25 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmArrhythmia Treatment, and Assessment of Arrhythmia Risk (Part II)
Discussion Leader: Penelope Boyden (Columbia University)
9:00 am - 9:20 amWilliam Stevenson (Harvard University)
"Current Status on the Efficacy of Ventricular Ablation"
9:20 am - 9:35 amDiscussion
9:35 am - 9:55 amSumeet Chugh (Cedar Sinai)
"Clinical Genomics of Sudden Death"
9:55 am - 10:10 amDiscussion
10:10 amCoffee Break
10:40 am - 11:00 amArthur Wilde (Amsterdam Medical Center)
"Assessment of Arrhythmia Risk in Inherited Diseases"
11:00 am - 11:15 amDiscussion
11:15 am - 11:35 amAlfred George (Vanderbilt University)
"Novel Arrhythmia Genes Discovered by Exome Sequencing"
11:35 am - 11:50 amDiscussion
11:50 am - 12:10 pmBernd Fleischmann (University of Bonn)
"Stem cells as a model to study cardiac development and function"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmArrhythmia Treatment and Assessment of Arrhythmia Risk (Part III)
Discussion Leader: Tim Kamp (University of Wisconsin, Madison)
7:30 pm - 7:50 pmMichael LaFlamme (University of Washington)
"Human ESC-Derived Cardiomyocytes Electrically Couple and Suppress Arrhythmias in a Guinea Pig Infarct Model"
7:50 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmEduardo Marban (Cedar Sinai)
"Stem Cells and the treatment of Heart Disease"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmSean Wu (Mass General)
"Reprogramming into Cardiomyocytes: Potentials and Pitfalls"
9:00 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmPanel Discussion: "A realistic view of the future of gene/cell therapy in the treatment of cardiac arrhythmias"
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13HL117370-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
© 2014 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter