The 2013 GRC on Catecholamines will focus on cutting-edge developments in catecholamine research. In recent years, catecholamines have been the focus of investigations using a broad range of approaches from molecular biology to behavior and clinical studies. One of the characteristics of the field is that neuronal systems using catecholamines have much in common, although investigators who focus on particular catecholamines or on different actions of the same catecholamine are often unaware of complementary aspects of catecholamine research. It is increasingly apparent that continued progress will require increasingly integrated approaches in studies of catecholamine biology, function and dysfunction. Thus, molecular biologists are being drawn to more integrated systems approaches and behavioral biologists are exploiting many molecular approaches. In addition, because DA, NE and epinephrine serve as neurotransmitters and hormones throughout the phylogenetic scale, studies are possible in simple organisms where powerful genetic tools are available. Finally, recent innovative work allows the elucidation of catecholamine neurotransmission during natural animal behaviors, an important focus of the 2013 sessions. Thus, in the 2013 meeting talks will range from very basic research on mechanisms of catecholamine neurotransmission to talks integrating catecholamine physiology, pharmacology and behavior. Furthermore, the past few years have witnessed a tremendous advance in our understanding of mental and neurological disorders, including drug abuse and Parkinson’s disease. Sophisticated behavioral measures combined with elegant molecular, cellular and systems approaches, along with powerful imaging studies in humans, have produced a large number of high-profile reports that are likely to have a positive impact on health issues. For example, the biological bases of reward processes are implicating several catecholamines and a variety of brain regions and signaling mechanisms. We plan to highlight these new advances by including some of the researchers at the forefront of this field (and many of them can be considered junior scientists) in an attempt to provide a unique opportunity to discuss recent advances in the understanding of how catecholamine systems may contribute to the pathophysiology and treatment of those conditions.