Gordon Research Conferences
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Conference Program
 
Cell Biology of Metals
July 28 - August 2, 2013
Salve Regina University
Newport, RI

The 2013 Cell Biology of Metals Gordon Research Conference provides a highly interactive and collegial forum for junior and senior investigators alike to learn of the latest advances in our understanding of metal homeostasis, metabolism, and utilization in cells and organisms. The cell biology of metals is an emerging field of active research and this conference is the key venue for exciting unpublished work on nutrient metals (primarily iron, copper, zinc, and manganese), with presentations of research in humans and mice as well as plants, nematodes, and single-celled organisms. The meeting will bring together an outstanding and diverse group of molecular and structural biologists, biochemists, geneticists, cell biologists, and clinicians to bridge the gap between basic and applied research. Highlights include discussions of how dysregulation of metal homeostasis and utilization underscores human disease and how bacterial pathogens work to exploit host metal supplies to enhance their virulence in humans. Other sessions will address metalloproteomics and metallogenomics, intracellular metal trafficking, metal cofactor assembly, and metallosensor proteins and the regulation of gene expression. Oral presentations will be given by both new investigators and established leaders in the field and will be complemented by several poster sessions; some speakers will be selected from submitted poster abstracts. The broad and integrated coverage of topics will allow for extensive "cross-fertilization" of ideas among researchers studying metal nutrients from a multi-disciplinary perspective.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmOpening Keynote Session: Metals and Disease
Discussion Leader: Tim Stemmler (Wayne State University)
7:40 pm - 8:20 pmAshley Bush (University of Melbourne)
"Metallostasis in Alzheimer's and Parkinson's diseases"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmAdam Linstedt (Carnegie Mellon University)
"Metal-induced block of a deadly food and water-borne disease"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMetalloproteomics and Metallogenomics
Discussion Leader: Val Culotta (Johns Hopkins University)
9:00 am - 9:25 amChris Dupont (J. Craig Venter Institute)
"Genome encoded metallomes of cultivated and uncultivated marine microbes"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amVadim Gladyshev (Harvard University)
"Comparative genomics and ionomics of metals"
10:00 am - 10:10 amDiscussion
10:10 am - 10:20 amSharon Ruthstein (Bar-Ilan University)
"The missing link in the copper cycle: exploring biological pathways using EPR spectroscopy"
10:20 am - 10:25 amDiscussion
10:25 amGroup Photo / Coffee Break
11:00 am - 11:25 amJohn Tainer (Scripps Research Institute)
"Defining metallo-proteins and proteomes"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmDavid Mendoza-Cozatl (University of Missouri)
"Ionome dynamics in Arabidopsis and the transporters behind it"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmNicole Beauchene (University of Wisconsin-Madison)
"Influence of O2 on the ferric uptake regulator (Fur) regulon in Escherichia coli K12"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmMetals and Microbial Pathogenesis
Discussion Leader: Jonathan Gitlin (Marine Biological Laboratory)
7:30 pm - 7:55 pmManuela Rafatellu (University of California-Irvine)
"Host-microbe competition for metal nutrients in the inflamed gut"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:15 pmArati Ramesh (University of Texas Southwestern)
"Structure and mechanism of a transition-metal-sensing regulatory RNA"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmMichael Petris (University of Missouri)
"Mouse models of tissue-specific copper dyshomeostasis via conditional deletion of ATP7A"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmSusan Buchanan (NIDDK, NIH)
"Structural basis for iron piracy by pathogenic Neisseria"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIntracellular Metal Trafficking and Utilization
Discussion Leader: Mary Lou Guerinot (Dartmouth College)
9:00 am - 9:25 amAmy Medlock (University of Georgia)
"Ferrochelatase: A window into mitochondrial iron utilization and heme transport"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amJerry Kaplan (University of Utah)
"The ins and outs of mitochondrial iron"
10:00 am - 10:10 amDiscussion
10:10 am - 10:20 amCarine White (University of Maryland)
"Control of metazoan heme homeostasis by a conserved ABC transporter-dependent efflux pathway"
10:20 am - 10:25 amDiscussion
10:25 amCoffee Break
11:00 am - 11:25 amDeborah Chiabrando (University of Torino)
"Regulation of heme trafficking by FLVCR1 isoforms"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmAmy Palmer (University of Colorado-Boulder)
"Dissecting zinc homeostasis using fluorescent sensors"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmJaekwon Lee (University of Nebraska - Lincoln)
"Copper limitation inhibits growth signal pathways toward combating cancer"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmMetal Cofactor Assembly
Discussion Leader: Dennis Winge (University of Utah)
7:30 pm - 7:55 pmFlorian Bittner (Technische Universitat Braunschweig)
"Molybdenum metabolism in eukaryotes and crosstalk to iron"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:15 pmKatherine Vest (Auburn University)
"Transport of copper across the mitochondrial inner membrane"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmDavid Barondeau (Texas A&M University)
"Macromolecular juggling for building iron-sulfur clusters"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmRoland Lill (Philipps Universitat Marburg)
"Mechanisms and diseases of eukaryotic iron-sulfur protein biogenesis"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMetals in Physiology and Disease
Discussion Leader: Robert Fleming (Saint Louis University)
9:00 am - 9:25 amPatricia Jennings (University of California-San Diego)
"The role of NEET proteins in maintaining mitochondrial integrity and iron homeostasis"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amDe-liang Zhang (NICHD, NIH)
"Polycythemia and pulmonary hypertension of Irp1-/- mice suggest an essential role of Irp1 in iron hemostasis and hypoxia response"
10:00 am - 10:10 amDiscussion
10:10 am - 10:20 amRichard Eisenstein (University of Wisconsin-Madison)
"The IRP1-HIF-2a axis: coordinating iron and oxygen sensing with erythropoiesis and iron absorption"
10:20 am - 10:25 amDiscussion
10:25 amCoffee Break
11:00 am - 11:25 amThomas O'Halloran (Northwestern University)
"Zinc Fluxes in Control of Ooctye Maturation, Fertilization and Mammalian Development"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmRobert Cousins (University of Florida)
"Altered physiology associated with a murine Zip14 knockout"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmMitchell Knutson (University of Florida)
"The metal-ion transporter Zip14 is essential for iron loading of the liver"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chairs; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chairs
7:30 pm - 9:30 pmMetallosensors and Homeostasis
Discussion Leader: Ralf Mendel (Technische Universitat Braunschweig)
7:30 pm - 7:55 pmDavid Giedroc (Indiana University)
"Transition metal homeostasis and resistance in the human pathogen Streptococcus pneumoniae"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:15 pmPeng Chen (Cornell University)
"Direct substitution and assisted dissociation pathways for turning off transcription by a MerR-family metalloregulator"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmSimon Labbe (University of Sherbrooke)
"Iron homeostasis in the model eukaryote S. pombe"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmCaryn Outten (University of South Carolina)
"Fe-S clusters as sensors of cellular iron status in yeast"
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMetal Homeostasis in Higher Eukaryotes
Discussion Leader: Caroline Enns (Oregon Health & Science University)
9:00 am - 9:25 amKerry Kornfeld (Washington University)
"Zinc storage and excretion in C. elegans"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amTerri Long (North Carolina State University)
"Molecular mechanisms of the iron deficiency response in plants"
10:00 am - 10:10 amDiscussion
10:10 am - 10:20 amAnshika Jain (University of South Carolina)
"Role of ferric-reductases and transporters in mitochondrial iron homeostasis in Arabidopsis thaliana"
10:20 am - 10:25 amDiscussion
10:25 amCoffee Break
11:00 am - 11:25 amJodie Babitt (Harvard Medical School)
"New insights into iron homeostasis regulation by the BMP pathway"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmHelena Öhrvik (Duke University)
"Function and regulation of the mammalian Ctr1 copper importer"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmThomas Chi (University of California - San Francisco)
"Evidence that zinc may play an essential role in the initiation of kidney stone formation"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmClosing Keynote Session: Emerging Areas in the Cell Biology of Metals
Discussion Leader: Jose Arguello (Worcester Polytechnic University)
7:30 pm - 8:10 pmNigel Robinson (Durham University)
"A cells contribution to metal-protein speciation"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmSabeeha Merchant (University of California-Los Angeles)
"Bioavailable Cu is sequestered in microcompartments"
9:10 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1 R13 DK98827 from NIDDK. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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