Gordon Research Conferences
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Conference Program
 
Cell Growth & Proliferation
June 23-28, 2013
Mount Snow Resort
West Dover, VT
Chair:
David Pellman

Vice Chair:
Anindya Dutta

Related Meeting Information
The Cell Growth & Proliferation Gordon Research Conference was held in conjunction with the Cell Growth & Proliferation Gordon Research Seminar. Please refer to the Cell Growth & Proliferation GRS web page for more information.

The 2013 Gordon Research Conference on Cell Growth and Proliferation will focus on the molecular mechanisms underlying eukaryotic cell division and their impact on cancer biology. The cell cycle involves a complex series of events, including cell growth, genome duplication, and mitosis. Dramatic progress in these areas has come from experiments performed in organisms ranging from yeast to mammals using approaches spanning high resolution structure determination to systems-level analysis. To continue this interdisciplinary tradition, an elite group of international researchers using diverse experimental approaches and systems will discuss their latest findings at this meeting. Sessions will focus on basic events underlying cell division. Topics will include: how cells regulate their size and metabolism; how they transit through G1; the molecular machines that carry out DNA replication and how they contend with chromatin structure; how cells sense, signal, and repair DNA damage inside and outside of S phase; how cells prepare for and execute mitosis; and the mechanical events underlying chromosome segregation and cytokinesis. A constant theme throughout these discussions will be how these processes go awry in cancer. Uniting experts in these diverse, yet related topics is expected to provide an integrated view of the cell cycle and cancer biology fields and fertilize future investigation. In addition to invited speaker talks, short talks will be selected from the submitted abstracts. Students and Post-docs are encouraged to attend the associated Gordon Research Seminar that will immediately precede the research conference.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Telomeres and Tumour Suppressors
Discussion Leaders: David Pellman (Dana-Farber Cancer Institute) and Anindya Dutta (University of Virginia)
7:40 pm - 8:20 pmJoan Brugge (Harvard Medical School)
"Lessons learned from Models of Morphogenesis and Tumorigenesis"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmDavid Sabatini (Whitehead Institute)
"Regulation of growth by the mTOR pathway"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCell Growth and Metabolism
Discussion Leader: Gustavo Leone (Ohio State University Medical Center)
9:00 am - 9:20 amMary Lilly (NICHD/NIH)
"Npr2 and Npr3: New inhibitors of TOR kinase activity in Drosophila"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amBruce Edgar (Center for Molecular Biology Heidelberg (ZMBH))
"Control of Regenerative Growth in the Drosophila Intestine"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amYuh-Hwa Wang (Wake Forest School of Medicine)
"DNA breaks at fragile sites generate oncogenic RET/PTC rearrangements in human thyroid cells"
10:10 am - 10:15 amDiscussion
10:15 am - 10:45 amGroup Photo / Coffee Break
10:45 am - 11:05 amJan Skotheim (Stanford School of Medicine)
"Setting the DNA:cytoplasm threshold for the Xenopus mid-blastula transition"
11:05 am - 11:15 amDiscussion
11:15 am - 11:35 amCeleste Simon (University of Pennsylvania School of Medicine)
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmDanny Lew (Duke University)
"Polarity establishment in the yeast cell cycle"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmPayal Bhatia (University of Lausanne)
"Mechanism of Pom1-dependent cell size regulation and division site positioning through dual regulation of Cdr2 in fission yeast"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmG1 Progression and Cell Cycle Engines
Discussion Leader: Bruce Edgar (Center for Molecular Biology Heidelberg (ZMBH))
7:30 pm - 7:50 pmGustavo Leone (Ohio State University Medical Center)
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJackie Lees (Koch Institute)
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmPeter Sicinski (Dana-Farber Cancer Institute)
"Cell cycle machinery in development and in cancer"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmRan Kafri (Harvard Medical School)
"Specification of cell size and control of size heterogeneity by mTOR-dependent modulation of growth rate"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSabrina Spencer (Stanford University)
"The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit"
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChromosome Duplication
Discussion Leader: Karen Oegema (UC San Diego)
9:00 am - 9:20 amAnindya Dutta (University of Virginia)
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amSteve Bell (Massachusetts Institute of Technology)
"Mechanisms Controlling the Initiation of Eukaryotic DNA Replication"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amAmity Manning (MGH Cancer Center/Harvard Medical)
"Replication changes following pRB loss corrupt chromatin structure and promote CIN"
10:10 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:05 amJohn Diffley (Cancer Research UK)
"Loading and activation of the eukaryotic replicative helicase"
11:05 am - 11:15 amDiscussion
11:15 am - 11:35 amNick Dyson (Massachusetts General Hospital Cancer Center)
"Connecting the dots between pRB inactivation and CIN"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmBob Duronio (University of North Carolina at Chapel Hill)
"A Drosophila Genetic Platform for Determining the Function of Histone Post Translational Modifications in Cell Proliferation"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmJeanette Cook (University of North Carolina)
"A positive role for histone H3K4 di-methylation in DNA replication"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGetting In and Out of Mitosis
Discussion Leader: Todd Stukenberg (University of Virginia)
7:30 pm - 7:50 pmKaren Oegema (UC San Diego)
"RhoA flux Mediated by M-Phase GAP Controls the Timing, but Not the Dimensions, of the Cytokinetic RhoA Zone"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmBrian Dynlacht (New York University Medical School)
"The centriole to cilium transition and cell cycle control"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmEric Weiss (Northwestern University)
"Structure and substrate docking of a conserved Ndr/LATS kinase complex"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmHongtao Yu (University of Texas Southwestern Medical Center)
"Bub1 installs a tension-regulated switch at kinetochores for proper chromosome segregation"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmDan Foltz (University of Virginia)
"Centromeric chromatin assembly and posttranslational modification"
9:25 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe DNA Damage Response and Checkpoints
Discussion Leader: Don Cleveland (University of California, San Diego)
9:00 am - 9:20 amTanya Paull (University of Texas)
"Regulation of DNA double-strand break repair and signaling"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amMike Yaffe (Massachusetts Institute of Technology)
"Cross-Talk between Mitotic Kinase Signaling and DNA Damage Response-New Insights into Mitotic Regulation"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amMark Hall (Purdue University)
"A novel function for Cdc14 phosphatase in promoting genome stability"
10:10 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:05 amSteve Elledge (Harvard Medical School)
"Haploinsufficiency in cancer"
11:05 am - 11:15 amDiscussion
11:15 am - 11:35 amMaria Jasin (Memorial Sloan-Kettering Cancer Center)
"Protecting the genome by homologous recombination"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmJim Haber (Brandeis University)
"Autophagy regulates the yeast DNA damage response and cell cycle progression"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmBrian Calvi (Indiana University)
"Drosophila endocycling cells do not apoptose in response to genotoxic stress: A response of cancer cells to therapy?"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmChromosome Stability
Discussion Leader: Maria Jasin (Memorial Sloan-Kettering Cancer Center)
7:30 pm - 7:50 pmTodd Stukenberg (University of Virginia)
"EB1 and microtubules generate chromosome autonomous signaling at kinetochores by controlling the inner centromeric pool of Aurora B in prometaphase"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJan van Deursen (Mayo Clinic)
"Aneuploidy in Health and Aging"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmRong Li (Stowers Institute for Medical Research)
"Segregation of aging determinants during yeast asymmetric cell division"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmSusana Godinho (Dana-Farber Cancer Institute/Harvard Medical)
"Oncogene-like induction of invasive behavior by centrosome amplification"
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
9:00 am - 12:30 pmOncogenes, Tumor Suppressors and Therapeutics
Discussion Leader: Celeste Simon (University of Pennsylvania School of Medicine)
9:00 am - 9:20 amTak Mak (Ontario Cancer Institute)
"Metabolic Adaptation in Tumor Growth"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amPeter Jackson (Genentech)
"Taming the Hedgehog: GPR161 and basal repression of Shh signaling"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amFranziska Michor (Dana-Farber Cancer Institute)
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:10 amElizaveta Leshchiner (Dana-Farber Cancer Institute)
"Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices"
11:10 am - 11:15 amDiscussion
11:15 am - 11:25 amAllan Gurtan (Massachusetts Institute of Technology)
"An unexpected genomic binding profile for the proto-oncogene HMGA2"
11:25 am - 11:30 amDiscussion
11:30 am - 11:50 amAlan D'Andrea (Dana-Farber Cancer Institute)
"Ubiquitin Control of the Fanconi Anemia/BRCA Pathway"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmZhewei Shen (University of Pennsylvania)
"YAP requires AMOT-p130 for hepatic cell proliferation and carcinogenesis"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmPhilipp Kaldis (IMCB)
"Loss of Cdk2 and cyclin A2 impairs tumorigenesis"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmOncogenes, Cell Survival and Metabolism
Discussion Leader: Peter Sicinski (Dana-Farber Cancer Institute)
7:30 pm - 7:40 pmSusanne Rafelski (University of California, Irvine)
"Proper Inheritance of Mitochondrial Content in Budding Yeast Through Coordination of Mitochondrial Biogenesis, Redistribution, and Cell Growth"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmAlain DeBruin (Utrecht University)
"Surgical resection and radiofrequency ablation initiate cancer in bile duct cells deficient for p53 and Rb"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmEmily Foley (Memorial Sloan Kettering)
"The B56-PP2A phosphatase is required for the formation of stable attachments between kinetochores and microtubule plus-ends"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmQuincey Justman (Harvard University)
"How does the S. cerevisiae cell cycle respond to environmental change?"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmGalit Lahav (Harvard Medical School)
"Encoding Cellular Information through p53 Dynamics in Single Cell"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmSally Kornbluth (Duke University)
"Killing cancer cells through inhibition of fatty acid synthesis"
9:20 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by (Insert Grant/Cooperative Agreement # 1R13CA177028-01) from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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