Gordon Research Conferences
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Conference Program
 
Chronobiology
Circadian Rhythms: From Molecule to Man
July 14-19, 2013
Salve Regina University
Newport, RI
Chair:
Michael Rosbash

Vice Chair:
Achim Kramer

Related Meeting Information
The Chronobiology Gordon Research Conference was held in conjunction with the Chronobiology Gordon-Kenan Research Seminar. Please refer to the Chronobiology GKRS web page for more information.

The 2013 Chronobiology GRC will present cutting-edge research on nearly all aspects of circadian biology: molecular, cellular, systems, neural, physiological and behavioral. The Conference will feature a wide range of organisms, from prokaryotes and lower eukaryotes to plants, animals and humans. Basic topics like systems vs cell-autonomous organization, circadian entrainment and basic clock mechanisms will feature alongside more translational topics like metabolic disease, cancer and aging. Invited speakers will represent many different subdisciplines, including biochemistry, molecular genetics, neurobiology, cell biology and physiology. The Conference will bring together invited speakers, which include many of the leading circadian rhythm investigators from across the globe, with more junior scientists, post-docs and graduate students. They will not only have the opportunity to meet and exchange ideas with the leaders in the field but also to present their work in poster format. Based on the submitted abstracts, a committee will choose some of these poster presentations for short talks. The collegial and informal atmosphere of the Conference, with ample discussion time as well as opportunities for informal gatherings in the afternoons and evenings, promotes brainstorming as well as new collaborations.

The 2013 Chronobiology GRC will offer for the first time a companion Gordon Research Seminar (GRS), organized along the same themes as the Conference. The GRS will be held immediately preceding the Chronobiology GRC at the same venue. More junior scientists, such as students, postdocs and newly established investigators, are encouraged to attend. They may seek more background in the field and/or the opportunity to present their work to an audience of peers Some of these presentations will be chosen for full talks at the GRC to follow.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmCircadian control of output, DNA repair (cancer) and physiology
Discussion Leader: Marina Antoch (Roswell Park)
7:40 pm - 8:00 pmMichael Brunner (Heidelberg)
"Functional Characterization of the FRQ-interacting RNA helicase"
8:00 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmAziz Sancar (UNC Chapel Hill)
"Control of DNA Repair and Cancer by the Circadian Clock"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmMukesh Jain (Case Western Reserve)
"KLF15 and circadian control of cardiac function"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:15 pmTBA (Selected from GRS)
9:15 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSystems vs. autonomous control of the clock
Discussion Leader: Hiroki Ueda (Riken)
9:00 am - 9:20 amRavi Allada (Northwestern)
"Neural clocks in Drosophila"
9:20 am - 9:25 amDiscussion
9:25 am - 9:45 amErik Herzog (Wash. U)
"GABA and VIP: A Yin-yang couple for circadian synchrony"
9:45 am - 9:50 amDiscussion
9:50 amGroup Photo / Coffee Break
10:20 am - 10:45 amSato Honma (Hokkaido Univ)
"The circadian system in the SCN; genes, development and environments"
10:45 am - 10:50 amDiscussion
10:50 am - 11:10 amMaria Ceriani (Fundacion Instituto Leloir Buenos Aires)
"Circadian period integrates network information through activation of the BMP signaling pathway"
11:10 am - 11:15 amDiscussion
11:15 am - 11:35 amMichael Hastings (MRC LMB Cambridge UK)
"Analysis and manipulation of cell-autonomous and network-level circadian pacemaking in the suprachiasmatic nucleus"
11:35 am - 11:40 amDiscussion
11:40 am - 12:00 pmTBA (Selected from GRS)
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:20 pmHot topic talk: Sebastian Kadener (The Hebrew University of Jerusalem)
"Clk RNA turnover control denoises circaidan transcription in time and space"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEntrainment: light, temperature, food and other entraining molecules
Discussion Leader: Michael Rosbash (Brandeis)
7:30 pm - 7:50 pmUeli Schibler (Geneva)
"Identification of circadian signaling pathways by synthetic tandem repeat promoter (STAR-PROM) screening"
7:50 pm - 7:55 pmDiscussion
7:55 pm - 8:15 pmSamer Hattar (Hopkins)
"From molecules to circuits to behavior: how light influences physiology"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:40 pmJoke Meijer (Leiden Univ Medical Center Holland)
"Light responsiveness and adaptive significance of the circadian system"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmCharlotte Helfrich-Förster (Universität Wuerzburg)
"Role of external and internal photoreceptors in timing Drosophila's daily activity"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmHot topic talk: Jeffrey Price (UMKC)
"Noncanonical FK506-binding Protein BDBT Binds DBT and Forms Foci at Night to Promote Circadian Rhythms"
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmClock mechanisms: transcription, protein turnover, structure, and post-transcriptional mechanisms
Discussion Leader: Paul Hardin (Texas A&M)
9:00 am - 9:20 amJoseph Takahashi (UT Southwestern)
"Transcriptional architecture of the circadian clock in mammals"
9:20 am - 9:25 amDiscussion
9:25 am - 9:45 amCharles Weitz (Harvard)
"Analysis of the PERIOD complex of the mammalian circadian clock"
9:45 am - 9:50 amDiscussion
9:50 am - 10:10 amJay Dunlap (Dartmouth)
"Genetic and molecular analysis of the Neurospora clock"
10:10 am - 10:15 amDiscussion
10:15 amCoffee Break
10:45 am - 11:05 amFelix Naef (École Polytechnique Fédérale De Lausanne)
"Mechanisms of phase-specific circadian transcription in mouse liver"
11:05 am - 11:10 amDiscussion
11:10 am - 11:30 amAchim Kramer (Charité Berlin)
"Posttranscriptional control of mammalian circadian rhythms"
11:30 am - 11:35 amDiscussion
11:35 am - 11:55 amHot topic talk: Frédéric Gachon (Nestlé Institute of Health Sciences)
"Post-transcriptional orchestration of the proteome in the mouse liver: is it a circadian matter?"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmHot topic talk: Carrie Partch (University of California Santa Cruz)
"A slow conformational switch regulates the 24-hour circadian clock"
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNon-transcriptional-translational oscillator mechanisms
Discussion Leader: Carl Johnson (Vanderbilt)
7:30 pm - 7:50 pmAkhilesh Reddy (Univ. Cambridge)
"Redox and metabolic oscillations in the clockwork"
7:50 pm - 7:55 pmDiscussion
7:55 pm - 8:15 pmSusan Golden (UC San Diego)
"Intrinsic input and output functions of the Kai oscillator of cyanobacteria"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:40 pmErin O'Shea (Harvard)
"Timekeeping with a Three-Protein Circadian Clock"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmJohn O'Neill (Univ Cambridge)
"Circadian rhythms in erythrocyte redox state, in vitro & in vivo"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEpigenetics and chromatin with an emphasis on aging
Discussion Leader: Paloma Mas (Center for Research in Agricultural Genomics, CRAG)
9:00 am - 9:20 amPaolo Sassone-Corsi (UC Irvine)
"Coordinated Epigenetic Control by the Clock"
9:20 am - 9:25 amDiscussion
9:25 am - 9:45 amSteve Brown (Univ. Zurich)
"Neural networking and epigenetics within the suprachiasmatic nucleus"
9:45 am - 9:50 amDiscussion
9:50 am - 10:05 amJürgen Ripperger (Univ Fribourg Switzerland)
"Role of circadian transcription factors in aging"
10:05 am - 10:10 amDiscussion
10:10 am - 10:30 amLeonard Guarente (MIT)
"Aging-sensitive control of central circadian rhythm by SIRT1"
10:30 am - 10:35 amDiscussion
10:35 amCoffee Break
11:05 am - 11:25 amSatchidananda Panda (Salk)
11:25 am - 11:30 amDiscussion
11:30 am - 11:50 amHot topic talk: Jerome Menet (Brandeis University)
"CLOCK:BMAL1 is a Pioneer-like Transcription Factor"
11:50 am - 11:55 amDiscussion
11:55 am - 12:15 pmTBA (Selected from GRS)
12:15 pm - 12:20 amDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmPlants including agriculturally or industrially interesting organisms
Discussion Leader: Susan Golden (UC San Diego)
7:30 pm - 7:50 pmPaloma Mas (Center for Research in Agricultural Genomics, CRAG)
"Chromatin and the Arabidopsis circadian clock: a question of time"
7:50 pm - 7:55 pmDiscussion
7:55 pm - 8:15 pmTakeshi Izawa (National Institute of Agrobiological Sciences)
"Time-keeping in rice under fluctuating field conditions"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:40 pmAlison Smith (John Innes Center)
"Timing starch consumption prevents starvation in Arabidopsis plants"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmDaniel Forger (Univ Michigan)
"Supermodels see the light of day: How high performance computing can help the next generation of circadian research"
9:05 pm - 9:25 pmAndrew Millar (Univ. Edinburgh)
"Models and infrastructure for systems chronobiology"
9:25 pm - 9:30 pm Combined Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
9:00 am - 12:30 pmMetabolic diseases II: metabolic syndrome, diabetes and aging
Discussion Leader: Amita Sehgal (UPenn)
9:00 am - 9:20 amCarla Green (Univ of Texas Southwestern Medical Center)
"Circadian post-transcriptional control of metabolism"
9:20 am - 9:25 amDiscussion
9:25 am - 9:45 amJoe Bass (Northwestern)
"Circadian Control of Bioenergetics and Fuel Selection in Mice"
9:45 am - 9:50 amDiscussion
9:50 am - 10:10 amGad Asher (Weizmann Institute of Science)
"A cross talk between metabolism and circadian rhythmicity"
10:10 am - 10:15 amDiscussion
10:15 amCoffee Break
10:45 am - 11:05 amTBA (Selected from GRS)
11:05 am - 11:10 amDiscussion
11:10 am - 11:30 amHot topic talk: Erik Musiek (Washington University School of Medicine)
"Impairment of the positive limb of the core circadian clock disrupts neuronal redox homeostasis and promotes neurodegeneration"
11:30 am - 11:35 amDiscussion
11:35 am - 11:55 amTBA (Selected from GRS)
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmMasashi Yanagisawa (UT Southwestern Medical Center/HHMI and Univ of Tsukuba)
"Forward genetic analysis of sleep in ENU-mutagenized mice: Identification of pedigrees with heritable sleep/wake abnormalities"
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSleep
Discussion Leader: Mike Young (Rockefeller) and Mehdi Tafti (Lausanne)
7:30 pm - 7:50 pmAmita Sehgal (UPenn)
"Molecular and cellular circuits underlying Drosophila behavior"
7:50 pm - 7:55 pmDiscussion
7:55 pm - 8:15 pmPaul Shaw (Washington Univ of St. Louis)
"Enhanced sleep reverses cognitive impairment in classic memory-mutants"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:40 pmLeslie Griffith (Brandeis Univ)
"Peptidergic regulation of sleep in Drosophila"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmPaul Franken (Univ Lausanne)
"Sleep homeostasis and circadian rhythms: shared molecular pathways?"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number R13NS083268. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

 
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