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Conference Program
 
Cilia, Mucus & Mucociliary Interactions
April 7-12, 2013
Renaissance Tuscany Il Ciocco Resort
Lucca (Barga), Italy

The transport of mucus and other fluids by motile cilia is fundamental to human health and development. Disruption of this process in the respiratory tract due to ciliary dysfunction (as a result of primary ciliary dyskinesia) or alterations in the viscoelastic properties of mucus leads to severe pulmonary diseases such as cystic fibrosis and bronchitis. Similarly, alterations in cilia-driven fluid flow and disruption of extracellular signaling gradients during embryogenesis can result in a broad array of devastating developmental disorders (ciliopathies). This conference provides the unique opportunity for basic scientists and clinical researchers interested in these inter-related areas to discuss their latest findings and learn about new technologies that provide novel approaches to current challenges. This conference attracts a broad array of scientists ranging from biophysicists and biochemists to physiologists and geneticists. In addition, the conference format provides excellent opportunities for junior scientists to present their work and exchange ideas in a collegial atmosphere with leaders in the field. The meeting will begin on the Sunday evening with two keynote lectures by eminent scientists from the fields of cilia and mucus who will set out the current paradigms within these areas and provide insight into the key challenges for the future. This will be followed by eight sessions that will include a combination of invited presentations and short talks on the latest results selected from the abstracts received. Each session will be chaired by two discussion leaders who will provide brief overviews of the topics to be covered. These formal sessions will also include significant time for discussion. Furthermore, there will be additional opportunities for informal discussions during the afternoons and evenings. In addition, there will be two poster sessions which will allow for the in-depth presentation of new results.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Talks on Cilia and Mucus
Discussion Leaders: Martina Brueckner (Yale University School of Medicine) and David Thornton (University of Manchester)
7:40 pm - 8:20 pmGeorge Witman (University of Massachusetts Medical School)
"Cilia Assembly and Function"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmJeffrey Wine (Stanford University School of Medicine)
"Mucus, Secretion and Cystic Fibrosis"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCiliary Assembly and Mucus Production
Discussion Leader: Winfield Sale (Emory University School of Medicine) and Mary Rose (Children's National Medical Center)
9:00 am - 9:20 amEszter Vladar (Stanford University School of Medicine)
"Centriole Assembly"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amDavid Erle (University of California San Francisco)
"Intracellular Assembly of Mucins"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amEsben Lorentzen (Max Planck Institute, Martinsried)
"Structural Mechanisms of Ciliary Assemby"
10:20 am - 10:30 amDiscussion
10:30 amGroup Photo / Coffee Break
11:00 am - 11:20 amC. William Davis (University of North Carolina, Chapel Hill)
"Mucus Secretion and Synthesis: Regulated versus Basal Pathways"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amElizabeth Smith (Dartmouth College)
"Ciliary Motility"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmMichael McGuckin (University of Queensland)
"Cytokines, Inflammation and Mucus Production"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmBiophysics of Cilia/Mucus Interactions
Discussion Leader: Stephen King (University of Connecticut Health Center) and Richard Superfine (University of North Carolina, Chapel Hill)
5:30 pm - 5:50 pmHiroaki Ishikawa (University of California, San Francisco)
"Primary Cilia Respond to Uniaxial Strain by Reorienting and Elongating Along the Axis of Stretch"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmRichard Cone (John's Hopkins University)
"Biophysics of Mucus"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmBrian Button (University of North Carolina, Chapel Hill)
"Mucin Effects on the Peri-ciliary Layer"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmJulien Vermot (Institut de Génétique et de Biologie Moléculaire et Cellulaire)
"Cilia-driven Fluid Flow and Morphogenesis"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDifferentiation of Multiciliated and Secretory Cells
Discussion Leader: Michael McGuckin (University of Queensland) and Susan Dutcher (Washington University School of Medicine)
9:00 am - 9:20 amChristopher Kintner (Salk Institute for Biological Studies)
"Control of Multiciliated Cells"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amThad Stappenbeck (Washington University School of Medicine)
"Autophagy and Mucus Cell Function"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amPascal Barbry (CNRS, Institut de Pharmacologie Moléculaire et Cellulaire)
"Impact of micro RNAs on Vertebrate Multiciliogenesis in the Airway"
10:20 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:20 amJayaraj Rajagopal (Massachusetts General Hospital)
"Notch Signaling in Airway Mucus Metaplasia and Alveolar Development"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amBrian Mitchell (Northwestern University)
"Deuterosome-mediated Centriole Biogenesis"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmLei Wang (Shanghai Institutes for Biological Sciences)
"MiR-34b Regulates Multiciliogenesis during Organ Formation in Zebrafish"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmCilia, Flow and Tissue Development
Discussion Leader: Iain Drummond (Massachusetts General Hospital) and Steven Brody (Washington University School of Medicine)
5:30 pm - 5:50 pmZhaoxia Sun (Yale University School of Medicine)
"Kidney Development"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmDominic Norris (MRC Harwell)
"Left-right Asymmetry"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmJoseph Loturco (University of Connecticut)
"Dyslexia-related Gene Function and Ciliary Activity"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmEamon Dubaissi (University of Manchester)
"The Development and Function of Secretory Cells in the Mucociliary Embryonic Frog Skin"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGenomic, Proteomic and Glycomic Approaches to Cilopathies and Muco-ciliary Disease
Discussion Leader: Heymut Omran (Universitätsklinikum Münster) and Alessandra Livraghi-Butrico (University of North Carolina, Chapel Hill)
9:00 am - 9:20 amMichael Knowles (University of North Carolina, Chapel Hill)
"Filling the Genomic Gap in MUC5AC: Characterization of Genetic Variation that Modifies Cystic Fibrosis Lung Disease Phenotypes"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amAnne Dell (Imperial College London)
"Glycomics of Mucus"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amSusan Dutcher (Washington University School of Medicine)
"Chlamydomonas Genomics/Proteomics to Understand Ciliogenesis"
10:20 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:20 amGunnar Hansson (University of Gothenberg)
"The Mucus Proteome"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amHannah Mitchison (University College London)
"Genetics of Primary Ciliary Dyskinesia"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmAmelia Shoemark (Royal Brompton Hospital)
"Bardet Biedl Syndrome Respiratory Cilia Structure and Function"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmCilia/Fluid Interactions
Discussion Leader: Lawrence Ostrowski (University of North Carolina, Chapel Hill) and Peter Satir (Albert Einstein College of Medicine)
5:30 pm - 5:50 pmRichard Superfine (University of North Carolina, Chapel Hill)
"Mucociliary Interactions - Insights from a Vertical Clearance Model"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmMartin Blum (University of Hohenheim)
"Flow at the Left-Right Organizer"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmRaymond Goldstein (University of Cambridge)
"Ciliary Coordination and Metachronal Synchrony"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmIain Drummond (Massachusetts General Hospital)
"Novel Factors Required for Ciliary Motility"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 8:00 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNew Approaches to the Study of Cilia and Muco-ciliary Interactions
Discussion Leaders: Elizabeth Smith (Dartmouth College) and C. William Davis (University of North Carolina, Chapel Hill)
9:00 am - 9:20 amShiaulou Yuan (Yale University School of Medicine)
"The Ciliary Axoneme is a Calcium Signaling Compartment Required for Determination of LR Asymmetry"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amMaxence Nachury (Stanford University)
"Gating Ciliary Protein Entry"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amNajl Valeyev (University of Exeter)
"Ciliary Systems Model for Ca2+, cAMP and Membrane Potential Regulation"
10:20 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:20 amCamille Ehre (University of North Carolina, Chapel Hill)
"The Muc5ac Mucus Over-expression Model"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amClaudius Werner (Universitätsklinikum Münster)
"Bridging Bench to Bedside in Primary Ciliary Dyskinesia"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmAlessandra Livraghi-Butrico (University of North Carolina, Chapel Hill)
"Phenotypic Consequences of Muc5b Deletion in a Mouse Model of Defective Airway Mucus Clearance"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmFrom Protists to Mammals - Understanding Ciliary Function and Muco-ciliary Disease
Discussion Leader: George Witman (University of Massachusetts Medical School) and Jeffrey Wine (Stanford University School of Medicine)
5:30 pm - 5:50 pmTakashi Ishikawa (Paul Scherrer Institute)
"Three-dimensional Molecular Arrangement of Dynein, Tubulins and Regulatory Proteins in Flagella/Cilia"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmMustafa Khokka (Yale University School of Medicine)
"Xenopus for the study of Cilia"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmMark Hoegger (University of Iowa)
"Mucociliary Transport in Newborn Pigs"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmLawrence Ostrowski (University of North Carolina, Chapel Hill)
"Axonemal Dynein Function in Mice"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13HL117367-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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