| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff and Chair Karl Kadler (University of Manchester) |
| 7:40 pm - 9:30 pm | Emerging Technologies in Cell-Matrix Research |
| 7:40 pm - 8:00 pm | Discussion Leader: John Bateman (Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Australia)
"Introductory Remarks" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:30 pm | Martin Humphries (University of Manchester, UK)
"What's in an adhesion complex, and how does it work?"
|
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:00 pm | Melinda Duer (University of Cambridge, UK)
"Heavy mice and lighter things: using NMR spectroscopy to elucidate molecular structures in tissues"
|
| 9:00 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | TBA (Selected from Submitted Abstracts or GRS) |
| 9:25 pm - 9:30 pm | Discussion |
| 9:30 pm - 10:30 pm | Reception |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Collagen Biosynthesis, Structure and Assembly |
| 9:00 am - 9:20 am | Discussion Leader: David Hulmes (Institute for the Biology and Chemistry of Proteins, Lyon, France)
"Introductory Remarks" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | David Eyre (University of Washington, Seattle)
"Prolyl 3-hydroxylation, molecular assembly and cross-linking"
|
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Michael Rape (University of California, Berkeley)
"Ubiquitin-dependent regulation of collagen secretion"
|
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:55 am | Coffee Break |
| 10:55 am - 11:15 am | Tak Mak (University of Toronto, Canada)
"Regulation of collagen synthesis by onco-metabolite 2-hydroxyglutarate"
|
| 11:15 am - 11:25 am | Discussion |
| 11:25 am - 11:45 am | Maria Antonietta De Matteis (Telethon Institute of Genetics and Medicine, Napes, Italy)
"Role of TRAPP complex in procollagen trafficking"
|
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:10 pm | TBA (Selected from Submitted Abstracts or GRS) |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | TBA (Selected from Submitted Abstracts or GRS) |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Collagen-Protein Interactions and Signaling |
| 7:30 pm - 7:50 pm | Discussion Leader: Hilary Ashe (University of Manchester, UK)
"Introductory Remarks" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Amy Bradshaw (Medical University of South Carolina)
"Procollagen processing in hearts and periodontal ligament - collagen-binding proteins that affect fibril assembly and deposition"
|
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Johanna Myllyharju (University of Oulu, Finland)
"Collagen prolyl 4-hydroxylases in skeletogenesis"
|
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | TBA (Selected from Submitted Abstracts or GRS) |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | TBA (Selected from Submitted Abstracts or GRS) |
| 9:25 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Developmental Biology of the Matrix |
| 9:00 am - 9:20 am | Discussion Leader: Ronen Schweitzer (Shriners Research Center, Portland, OR)
"Introductory Remarks" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Elazar Zelzer (Weizmann Institute of Science, Israel)
"Building the bone-tendon attachment unit"
|
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | David Birk (University of South Florida)
"Regulation of extracellular matrix assembly during development"
|
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:55 am | Group Photo / Coffee Break |
| 10:55 am - 11:15 am | Delphine Duprez (Université Pierre et Marie Curie, Paris)
"Transcription and growth factors during tendon formation and repair"
|
| 11:15 am - 11:25 am | Discussion |
| 11:25 am - 11:45 am | Audrey McAlinden (Washington University, St. Louis)
"Mis-expression of embryonic Col2a1 isoforms affects cartilage matrix assembly and post-natal bone development"
|
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:10 pm | TBA (Selected from Submitted Abstracts or GRS) |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | TBA (Selected from Submitted Abstracts or GRS) |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Genetic Mechanisms of Disease |
| 7:30 pm - 7:50 pm | Discussion Leader: Leena Bruckner-Tuderman (Freiburg Institute for Advanced Studies)
"Introductory Remarks" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Cristina Has (University of Freiburg, Germany)
"Focal adhesions and skin fragility disorders"
|
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Qing Jun Meng (University of Manchester, UK)
"Circadian rhythms of matrix-secreting cells"
|
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | TBA (Selected from Submitted Abstracts or GRS) |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | TBA (Selected from Submitted Abstracts or GRS) |
| 9:25 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Collagen Regulation and Dysregulation |
| 9:00 am - 9:20 am | Discussion Leader: Sergey Leikin (National Institute of Child Health & Human Development, NIH)
"Introductory Remarks" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Peter Byers (University of Washington, Seattle)
"Lessons learned: cis- and trans-acting effects on collagen production and structure identified from heritable disorders"
|
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Kazuhiro Nagata (Kyoto Sangyo University, Japan)
"Regulation of collagen synthesis by Hsp47 and P4H in combination with specific inhibitors"
|
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:55 am | Coffee Break |
| 10:55 am - 11:15 am | Joan Marini (NICHD, NIH)
"Identification of a causative mutation for bone dysplasia"
|
| 11:15 am - 11:25 am | Discussion |
| 11:25 am - 11:45 am | Giorgio Galli (Boston Children's Hospital)
"Prdm5-dependent regulation of collagen genes transcription"
|
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:10 pm | TBA (Selected from Submitted Abstracts or GRS) |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | TBA (Selected from Submitted Abstracts or GRS) |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
| 7:30 pm - 9:30 pm | Stem Cells, Repair and Regenerative Medicine |
| 7:30 pm - 7:50 pm | Discussion Leader: Pamela G. Robey (NIDCR, NIH)
"Introductory Remarks" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Fiona Watt (King's College London, UK)
"Dermal remodelling mediated by epidermal signals"
|
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Matthias Lutolf (Swiss Federal Institute of Technology Lausanne (EPFL))
"Deciphering stem cell-ECM interactions using artificial niches"
|
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | TBA (Selected from Submitted Abstracts or GRS) |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | TBA (Selected from Submitted Abstracts or GRS) |
| 9:25 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Matrix Mechanobiology |
| 9:00 am - 9:20 am | Discussion Leader: Boris Hinz (University of Toronto)
"Introductory Remarks" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Janine Erler (BRIC, University of Copenhagen)
"Lysyl oxidases in cancer progression"
|
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Michael Kjaer (Bispebjerg Hospital, Copenhagen)
"Mechanical loading and collagen turnover in tendon and skeletal muscle - how dynamic is it?"
|
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:55 am | Coffee Break |
| 10:55 am - 11:15 am | Dennis Discher (University of Pennsylvania)
"From matrix to nucleus - Scaling results in polymer biophysics"
|
| 11:15 am - 11:25 am | Discussion |
| 11:25 am - 11:45 am | Valerie Weaver (UC Berkeley/UCSF) |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:10 pm | TBA (Selected from Submitted Abstracts or GRS) |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | TBA (Selected from Submitted Abstracts or GRS) |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Future Directions of Collagen Matrix Research |
| 7:30 pm - 7:50 pm | Discussion Leader: Collin Stultz (Harvard-MIT Division of Health Sciences and Technology)
"Introductory Remarks" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Natalia Nieto (Mount Sinai School of Medicine, NYC)
"Osteopontin, collagen and liver fibrosis"
|
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Markus Buehler (Massachusetts Institute of Technology)
"In silico mechanobiology of collagen: mutations, defects and mechanics"
|
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | TBA (Selected from Submitted Abstracts or GRS) |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | TBA (Selected from Submitted Abstracts or GRS) |
| 9:25 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |