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Conference Program
 
Directed Cell Migration
January 20-25, 2013
Hotel Galvez
Galveston, TX
Chair:
Peter Friedl

Vice Chair:
Carole Parent

Related Meeting Information
The Directed Cell Migration Gordon Research Conference was held in conjunction with the Directed Cell Migration Gordon-Merck Research Seminar. Please refer to the Directed Cell Migration GMRS web page for more information.

The 2013 Gordon Research Conference on Directed Cell Migration (formerly known as: Gradient Sensing and Directed Cell Migration) will provide a discussion forum for the question of how eukaryotic cells or cell groups polarize and migrate directionally. Mechanisms include chemical gradients (chemotaxis, haptotaxis) and physical guidance by cell and tissue structures. This is a unique interdisciplinary conference that focuses on diverse systems including development, neuronal path finding, leukocyte trafficking, wound healing, tissue repair, model organisms and cancer. The conference is also relevant for researchers interested in the development of therapeutics aimed at disorders where cell migration is involved such as cardiovascular diseases, rheumatic and allergic diseases, asthma, and cancer.

Our program includes established researchers and rising stars working on directional cell migration and will highlight the commonality and differences of molecular and physical mechanisms that regulate migration processes. The conference will emphasize basic molecular mechanisms, new concepts and models, and will also explore links between cell migration during development, immune cell trafficking, and cancer. It further will focus on novel engineered devices to test particular cell functions, mathematical modeling and the similarities and differences between single-cell and collective migration processes. The combination of speakers and topics has been selected with the specific intention of stimulating new ideas across disciplines, discuss needs for developing new methodologies as well as promoting collaborations in the field of cell polarization and migration. The session speakers, selected from a variety of fields, will emphasize novel, unpublished results directly related to gradient sensing and directed cell migration. Young investigators will be encouraged to present and discuss their findings in a supportive environment through the invitation of up to 20 additional speakers, selected from submitted abstracts, and by participation in the posters sessions. Throughout the conference, interactions between senior and young investigators will be promoted in both formal and informal settings.

This conference will be preceded by a Gordon Research Seminar highlighting keynote talks by an established and a young leader in the field and include presentations by participants and in-depth discussions on the evolution of key concepts in directed cell migration over the past few decades.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Lectures
Discussion Leader: Peter Friedl (Radboud Universtiy Nijmegen / MD Anderson Cancer Center)
7:40 pm - 8:20 pmPaul Kubes (University of Calgary, Calgary, Canada)
"Interstitial Leukocyte Migration and Function in Vivo"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmDavid Sherwood (Duke University)
"Invadopodia in Vivo for Penetration of Basement Membranes"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmBasic Mechanisms of Cell Migration
Discussion Leader: Peter Devreotes (Johns Hopkins School of Medicine, Baltimore)
9:00 am - 9:20 amEva Paluch (Max Planck Institute, Dresden)
"Cell Polarization through Blebbing"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amOrion Weiner (University of California, San Francisco, CA, USA)
"Decisions at the Leading Edge"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amAnna Kashina (Univerity of Pennsylvania, USA)
"Beta-actin Arginylation and Cell Motility"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amJason Haugh (North Carolina State University, USA)
"Modeling Adhesion and Integrin Signaling"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amMonica Skoge (University of California San Diego, San Diego, USA)
"Role of Memory in the Dynamics of Ras Activation in Chemotaxing Cells"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amRobert Kay (MRC Laboratory of Molecular Biology, Cambridge, UK)
"Bleb-driven Chemotaxis of Dictyostelium Cells"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmDang Irene (CNRS, Gif-sur-Ivette, FR)
"Arpin, a Novel Protein that Inhibits the Arp2/3 Complex at the Leading Edge, Steers Cell Migration"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmFlash Talks (selected from abstracts to highlight posters)
  • Junsang Doh (Pohang University of Science and Technology, Pohang, South Korea)
    "Dynamic modulation of multi-cellular clusters using a cell-friendly photoresponsive polymer"
  • Daniel Irimia (Harvard Medical School, Boston, MA, USA)
    "Restoring Neutrophil Chemotaxis Improves Survival after Burn Injuries"
  • Eva Kiermaier (Austrian Institute for Technology, Vienna, Austria)
    "Polysialylation of CCR7 is Required for Chemokine Sensing and Directed Migration in Dendritic Cells"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMigration in Defined Environments (Microdevices)
Discussion Leader: David Beebe (Wisconsin Institute for Medical Research, University of Wisconsin, Masison, WI)
7:30 pm - 7:50 pmDave Beebe (Wisconsin Institute for Medical Research, University of Wisconsin, Masison, WI)
"Microdevices to Study Cell Migration & Signaling"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmAndre Levchenko (Signal Transduction & Cell-Cell Communication Lab Clark, Johns Hopkins University, Baltimore, MD, USA)
"Nanodevices & Modeling to Address Polarized Signaling"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmXavier Trepat (Institute for Bioengineering of Catalonia, Spain)
"Integrating Forces in Cell-Cell and Cell-Matrix Adhesion"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmWolfgang Losert (University of Maryland, College Park, MD, USA)
"Unidirectional Contact Guidance of Ameboid Cell Migration via Surface Nanotopography"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmRunchi Gao (Johns Hopkins University, Baltimore, MD, USA)
"Large Scale High Throughput Screen Reveals Pianissimo As an Essential Mediator of Electrotaxis of Dictyostelium Discoideum"
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCollective Cell Migration
Discussion Leader: Erik Sahai (London Research Institute, London, UK)
9:00 am - 9:20 amDouglas DeSimone (Department of Cell Biology, School of Medicine, University of Virginia Health System, Charlottesville, VA, USA)
"Balancing Cell-Cell Junctions in Collective Migration"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amAndy Ewald (Johns Hopkins School of Medicine, Baltimore, MD, USA)
"Mammary Gland Development - Implications for Cancer"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amDenise Montell (Johns Hopkins School of Medicine, Baltimore, MD, USA)
"Collective Migration in Drosophila"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amRoberto Mayor (Department of Cell & Developmental Biology, University College, London, UK)
"Collective Migration of Neural Crest Cells"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amErika Dona (European Molecular Biology Laboratories, Heidelberg, GER)
"Protein Turnover Imaging Unravels Self-Generated Directionality during Collective Cell Migration"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amLoic Dupre (INSERM U1043, Toulouse, FRA)
"Collective Cell Migration Overcomes Endocytosis-Mediated Receptor Deactivation"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmErik Danen (Leiden University, Leiden, NL)
"Integrins control breast cancer cell migration and dissemination through TGFß/miR200/ZEB signaling network"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmFlash Talks (selected from abstracts to highlight posters)
  • Maureen Bjerke (Charlottesville, VA, USA)
    "Focal Adhesion Kinase is Required for Polarity of Collectively Migrating Cells"
  • Viviana Gallardo (NIH, Bethesda, MD, USA)
    "Directed Migration of the Zebrafish Lateral Line as a Model for Metastasis"
  • Arnold Hayer (Stanford University, Stanford, CA, USA)
    "Asymmetric Adherens Junctions as Guidance Signals for Collective Endothelial Cell Migration"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPolarity and Steering of Migration
Discussion Leader: Denise Montell (Johns Hopkins School of Medicine, Baltimore, MD, USA)
7:30 pm - 7:50 pmDaniel Lew (Department of Pharmacology & Cancer Biology, Duke University)
"Yeast Polarity and Small GTP Binding Proteins"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmTobias Meyer (Stanford University)
"Integrating Signaling Networks"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmRobert Insall (Beastson, Glasgow, UK)
"From Cells to Modeling - and Back"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmChuan-Hsiang Huang (Johns Hopkins University, Baltimore, MD, USA)
"Coupling of Excitable Signaling and Oscillatory Cytoskeletal Networks Mediates Cell Migration"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmBjörn Hegemann (ETH, Zürich, CH)
"A Two-Step Mechanism for Gradient Sensing in Yeast"
9:25 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIn Vivo Migration of Leukocytes and Stem Cells
Discussion Leader: Anna Huttenlocher (Madison School of Public Health, Madison, WI, USA)
9:00 am - 9:20 amRuth Lehmann (Skirball Institute, New York University, New York, USA)
"Germ Cell Migration in Drosophila"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amCarole Parent (National Institutes of Health, Washington D.C., USA)
"Steering in Dictyostelium - Lessons for Leukocytes"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amAndrew Luster (Massachusetts General Hospital CIID/Rheumatology, Allergy & Immunology, Charlestown, MA, USA)
"Chemokines and Directed Leukocyte Migration"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amFrederick Geissmann (Guy's Campus, London, UK)
"Leukocyte Trafficking and Function"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amRemco Mentink (Hubrecht Institute, Utrecht, NL)
"Three Sequentially Acting Wnt Pathways are Required to Position Migrating Neuroblast Descendants along the C. Elegans A-P Axis"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amDianne Cox (Albert Einstein School of Medicine, Bronx, NY, USA)
"Phospho-Dependent Interaction between Wiskott-Aldrich Syndrome Protein and Intersectin-2L Regulates Macrophage Chemotaxis via a Positive Feedback Mechanism"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmTim Lämmermann (NIH, Bethesda, MD, USA)
"Molecular control of innate immune cell chemotaxis at sites of cell damage in vivo"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmFlash Talks (selected from abstracts to highlight posters)
  • Karolina Rzeniewicz (King's College, London, UK)
    "Investigating a Role for L-selectin in Regulating Transendothelial Migration"
  • Ved Sharma (Albert Einstein College of Medicine, Bronx, NY, USA)
    "Macrophage-Tumor Cell Migration, Pairing and Streaming Motility Reconstituted in One-Dimensional Environment"
  • Qian Zhang (LHD/NIAID/NIH, Bethesda, MD, USA)
    "DOCK8 Coordinately Regulates Cytoskeletal Functions for T Cell Migration and Survival within Confined Spaces"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmCytoskeletal Control and Mechanotransduction
Discussion Leader: Michael Sixt (Austrian Institute of Technology, Vienna)
7:30 pm - 7:50 pmMartin Schwartz (Yale University)
"Mechanosensing"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmChristopher Chen (University of Pennsylvania, PA, USA)
"Adhesion Forces of Cell Matrix Interaction"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmMaria Celeste Aragona (Padua, Italy)
"Force Sensing and Gene Expression"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmMargaret Titus (University of Minnesota, Minneapolis, MN, USA)
"Chemotactic Signaling in Dictyostelium Requires a MyTH/FERM Myosin"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmChun-Lin Chen (National Sun Yat-Sen University, Taiwan)
"PIP3-Binding Myosin I as a Signal Transducer in Phagocytosis and Cell Migration"
9:25 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCell Migration and Function
Discussion Leader: Carole Parent (NIH, Washington D.C., USA)
9:00 am - 9:20 amAnna Huttenlocher (Madison School of Public Health, Madison, WI, USA)
"Neutrophil Migration and Tissue Damage"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amPaul Frenette (Albert Einstein College of Medicine, New York City, NY, USA)
"Chemokin-induced Polarization and Trafficking"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amWolfgang Weninger (Centenary Institute of Cancer Medicine & Cell Biology, University of Sydney, Australia)
"Leukocyte Trafficking and Effector Functions"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amErik Sahai (London Research Institute, London, UK)
"Plasticity of Migration and Signaling"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amLaura Mutch (University of Birmingham, Birmingham, UK)
"The role of vesicle trafficking in chemotaxis"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amVerena Niggli (University of Bern, Bern, CH)
"Uropod formation in chemokine-stimulated T-cells"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmAlbrecht Schwab (University of Münster, Münster, GER)
"Role of TRPC6 Channels in Neutrophil Recruitment and Chemotaxis"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmFlash Talks (selected from abstracts to highlight posters)
  • Xuehua Xu (NIH, Bethesda, MD, USA)
    "G Protein Coupled Receptor Controls Neutrophil Chemotaxis by Novel PLCg2/PKCbII/PKD Signaling Pathway"
  • Jun Nakanishi (National Institute for Material Science, JP)
    "Photoactivatable Nanopatterned Substrate for Analyzing Collective Cell Migration"
  • Veronika te Boekhorst (MD Anderson Cancer Center, Houston, TX, USA)
    "Hypoxia-Induced Filopodial and Blebby Amoeboid Dissemination in Epithelial Cancer Cells"
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTherapeutic Targeting of Cell Migration
Discussion Leader: Jeffrey Segall (Albert Einstein School of Medicine, NYC)
7:30 pm - 7:50 pmStephanie Alexander (The University of Texas, MD Anderson Cancer Center, Houston, TX, USA)
"Targeting integrins in cancer invasion in vivo"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmAmanda Proudfoot (Merck Serono, Geneva)
"Therapeutic targeting of chemokines"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmBarbara Sennino (University of California, San Francisco, CA, USA)
"How to combat tumor escape from angiogenesis inhibitors"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmWill Wood (University of Bath, Bath, UK)
"Calcium Flashes Orchestrate the Wound Inflammatory Response through DUOX Activation and Hydrogen Peroxided Release"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmAnne Bresnick (Albert Einstein College of Medicine, Bronx, NY, USA)
"S100A4-based Reagents to Target Breast Cancer Metastasis"
9:25 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1 R13 GM105343-01 from the National Institute of General Medical Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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