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Conference Program
 
Drug Metabolism
The Many Faces of Drug Metabolism
July 7-12, 2013
Holderness School
Holderness, NH

The 2013 Gordon Research Conference on Drug Metabolism will showcase the multidisciplinary nature of the field. Accordingly, the theme of this 43rd Drug Metabolism GRC is "The Many Faces of Drug Metabolism" and the program will cover both the "machinery" (enzymes, transporters) and the consequences of drug metabolism. The attendees of the meeting include scientists from academia, industry and regulatory groups. The presentations will focus on cutting-edge science including unpublished data, exploring the many facets of the field, including sessions on important biochemical processes (e.g., Phase II enzymes and non-CYP oxidases), the role of drug metabolism in etiology of cancer, including bioactivation, and PK/PD relationships. The program will also have a session on new and emerging technologies. To kick-off the meeting, a keynote address will take place on Sunday evening. There will be morning and evening sessions on each day; the morning sessions having four speakers and the evening sessions having three. In keeping with past tradition, the Wednesday evening session will feature six graduate students and/or postdoctoral fellows who will be selected from the many outstanding posters submitted. The poster sessions will be organized by Vice Chair Ken Korzekwa and participants are encouraged to submit poster presentations. With the afternoons free, the attendees are encouraged to enjoy the many outdoor recreational activities in the NH area. Some afternoon activities that are part of the Drug Metabolism GRC tradition will again take place, including tennis or hiking on Monday, the "Industry versus Academia" softball game on Tuesday (no experience required, bring your gloves) and a golf outing on Wednesday. The casual nature of the meeting and collegial atmosphere is highly conducive to informal interactions with ample time to get to know your colleagues, network and perhaps establish collaborations. As always, the registration fee includes housing and meals.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmThe Many Faces of Drug Metabolism
Discussion Leader: James Mangold (Novartis)
7:40 pm - 7:50 pm James Mangold (Novartis)
"Introduction: The Many Faces of Drug Metabolism"
7:50 pm - 9:00 pm Keynote Lecture: Stephen Hecht (University of Minnesota)
"Metabolism, DNA Adduct Formation and Carcinogenicity of Tobacco-specific Nitrosamine Enantiomers"
9:00 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmApplications of PK-PD and TK-TD Modeling in Drug Discovery and Development
Discussion Leader: Wade Adams (Metabolic Solutions Development Company)
9:00 am - 9:45 am Wade Adams (Metabolic Solutions Development Company)
"Prediction of Oxazolidinone Toxicity: A Retrospective"
9:45 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:15 am Harvey Wong (Genentech)
"From Mouse to Man and Back: Translational Pharmacokinetic-Pharmacodynamic Modeling in Oncology"
11:15 am - 11:30 am Discussion
11:30 am - 12:15 pm Wei-jian Pan (Amgen)
"Translational Pharmacology of AMG 181, a Human Anti-α4β7 Antibody Developed for Treating Inflammatory Bowel Diseases (IBD)"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAntibody-drug Conjugates
Discussion Leader: Jae Lee (Boehringer-Ingelheim)
7:30 pm - 8:00 pm Kedan Lin (Genentech)
"Exploring the Metabolism and Disposition of Antibody Drug"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Brooke VandenBrink (Amgen)
"The Impact of Linker Chemistry on the Activity of Antibody Drug Conjugates"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Steve Hansel (Pfizer)
"ADC Disposition: the Large and Small of It"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmConjugation Enzymes and In Vitro-In Vivo Correlations
Discussion Leader: Rory Remmel (University of Minnesota)
9:00 am - 9:30 am Ida Owens (National Institute of Child and Human Development, NIH)
"Endoplasmic reticulum-bound UDP-Glucuronosyltransferases Interact with Kinases in Order to Dictate Substrate Selections"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 am Nenad Menavski (University of Helsinki)
"The Albumin Effects on the Human UGTs are Enzyme and Substrate Dependent"
10:15 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:30 am Charles Falany (University of Alabama)
"Substrate Selectivity and Inhibition in Cytosolic Sulfotransferases"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pm Rory Remmel (University of Minnesota)
"Atypical Kinetics of the UGT1A Enzymes"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCarcinogen Metabolism and Bioactivation
Discussion Leader: Lisa Peterson (University of Minnesota)
7:30 pm - 8:00 pm XinXin Ding (New York Department of Health)
"Role of Metabolism in Chemical Carcinogenesis - Insights from Transgenic Mouse Models"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Lisa Peterson (University of Minnesota)
"Bioactivation Pathways of Furan, a Possible Human Carcinogen"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Arthur Grollman (Stony Brook University)
"The bioactivation of aristolochic acid"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe Other Oxidases
Discussion Leader: Michael Zientek (Pfizer)
9:00 am - 9:45 am Matthew Hutzler (Boehringer-Ingelheim)
"Understanding Aldehyde Oxidase Metabolism: Species Differences and Variability in Activity"
9:45 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 11:15 am John Cashman (Human BioMolecular Research Institute)
"A Story of Flavin-containing Monooxygenase 3 in Humans: Hidden in Plain Sight"
11:15 am - 11:30 am Discussion
11:30 am - 12:15 pm Dale Edmondson (Emory University)
"Differential Structures and Functions of Human Mitochondrial MAO A and MAO B"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmGraduate Student and Post-Doc Presentations
Discussion Leader: Henry Strobel (University of Texas - Houston Medical School)
7:30 pm - 7:45 pm Jason Baik (University of California - San Francisco)
"Simulating Drug Disposition Using Virtual Cell"
7:45 pm - 7:50 pm Discussion
7:50 pm - 8:05 pm John Barr (Washington State University)
"Evaluation of Azathioprine and Other Nitro-group Containing Compounds as Time Dependent inhibitors of Human Liver Aldehyde Oxidase"
8:05 pm - 8:10 pm Discussion
8:10 pm - 8:25 pm Ian Cook (Albert Einstein College of Medicine)
"Structure, Dynamics and Selectivity in the Cytosolic Sulfotransferase Family"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:45 pm Hong Lu (University of Rhode Island)
"Predicting Hepatic and Renal Clearance in Pediatric Populations Using Physiological and Biochemical Development Knowledge"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:05 pm Ryan Seguin (University of Washington)
"Fluoroquinoline Metabolism Leads to Mechanism-based Inhibition of Cytochrome P450 1A2"
9:05 pm - 9:10 pm Discussion
9:10 pm - 9:25 pm Kai Wang (Vanderbilt University)
"Reductive Detoxication of Carcinogenic Aromatic and Heterocyclic Aromatic Amines"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDrug Transporters: In"sights" Into Endogenous and Inflammatory Biomarkers
Discussion Leader: Imad Hanna (Novartis)
9:00 am - 9:30 am Daniel Bow (Abbvie Inc.)
"In Vivo Biomarkers of Drug Transporters"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 am Lauren Aleksunes (Rutgers University)
"Blood-Brain Barrier and Beyond: Efflux Transporter Regulation and Function During Neuroinflammation"
10:15 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:30 am Ryan Pelis (Dalhousie University)
"Renal organic anion transporter kinetics are influenced by aKG and NaDC3"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pm Manthena Varma (Pfizer)
"Mechanistic modeling of the transporter- and enzyme-mediated disposition and the complex drug interactions"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNew and Creative Applications of Technologies
Discussion Leader: Jimmy Flarakos (Novartis)
7:30 pm - 8:00 pm Gary Van Berkel (Oak Ridge National Laboratories)
"Laser Ablation and Liquid Extraction Surface Sampling Combinations for High Resolution Chemical Imaging of Drug Dosed Thin Tissue Sections"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Mohammad Ebrahimkhani (Massachusetts Institute of Technology)
"Human Body on a Chip"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Thomas Covey (AB Sciex)
"Development of a Differential Mobility Device for Ultra High Sensitivity Biologics Assays and Surface Analysis"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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