| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Frontiers of Structure and Function - Tools for Studies of Complex Systems |
| Discussion Leader: Catherine Drennan (MIT/HHMI) |
| 7:40 pm - 8:10 pm | Vicki Wysocki (Ohio State University)
"Characterizing protein complexes by ion mobility and surface induced dissociation MS"
|
| 8:10 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:50 pm | Donald Hamelberg (Georgia State University)
"Probing functional dynamics in enzymes using computer simulations"
|
| 8:50 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:25 pm | Francisco Asturias (Scripps)
"Regulation of ribonucleotide reductases through quaternary structure rearrangements"
|
| 9:25 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Catalysis and Regulation in Medicine |
| Discussion Leader: Mark Hixon (Takeda) |
| 9:00 am - 9:30 am | Tom Meek (GSK)
"The dependence of the rate-limiting step(s) of cathepsin C on amino acid substituents of its peptide substrates"
|
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Ruma Banerjee (University of Michigan)
"Enzymology of H2S signaling"
|
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Group Photo / Coffee Break |
| 10:50 am - 11:20 am | Stuart Licht (Sanofi US)
"Mechanistic studies of nicotinamide phosphoribosyltransferase"
|
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:45 am | TBA (Poster Presentation) |
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:05 pm | TBA (Poster Presentation) |
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | TBA (Poster Presentation) |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Enzymology of Alternative Energy |
| Discussion Leader: TBA |
| 7:30 pm - 8:00 pm | Rolf Thauer (MPI Marburg)
"Flavin-based electron bifurcation: a novel mechanism of energy coupling in anaerobes"
|
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Anne Jones (Arizona State University)
"Defining directionality and aerotolerance of soluble, multimeric [NiFe]-hydrogenases: How do you make a redox enzyme run backwards?"
|
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Markus Ribbe (UC Irvine)
"Hydrocarbon formation by nitrogenases"
|
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Molecular Mechanisms of Complex Biosynthetic Transformations |
| Discussion Leader: TBA |
| 9:00 am - 9:30 am | Squire Booker (Penn State University)
"Radical mechanisms of post-transcription and post-translational modification"
|
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Chaitan Khosla (Penn State University)
"Polyketide assembly lines: Mechanistic insights and unsolved problems"
|
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:20 am | Ben Shen (Scripps Florida)
"Polyketide assembly lines: Mechanistic insights and unsolved problems"
|
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:00 pm | Wendy Kelly (Georgia Tech)
"Thiostrepton: Engineering new tricks for an old antibiotic"
|
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | TBA (Poster Presentation) |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Fundamentals of Enzyme Catalysis |
| Discussion Leader: TBA |
| 7:30 pm - 8:00 pm | Richard Wolfenden (UNC Chapel Hill)
"Benchmarks for transition state affinity and enzyme evolution"
|
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | John Richard (University of Buffalo)
"Triosephosphate isomerase: a paradigm for enzyme-catalyzed proton transfer at carbon"
|
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Karen Allen (Boston University)
"Specificity and promiscuity in a superfamily of phosphatases"
|
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Flavoenzymes |
| Discussion Leader: TBA |
| 9:00 am - 9:30 am | Dewey McCafferty (Duke University)
"The flavoenzyme histone demethylase LSD1: Mechanism, biology, and emerging role in breast cancer" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Amnon Kohen (University of Iowa)
"Mechanistic studies of flavin-dependent thymidylate synthase"
|
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:20 am | Giovanni Gadda (Georgia State University)
"How a single electron and a flavin save lives: the case of nitronate monooxygenase"
|
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:45 am | TBA (Poster Presentation) |
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:05 pm | TBA (Poster Presentation) |
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | TBA (Poster Presentation) |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
| 7:30 pm - 9:30 pm | Enzyme Mechanisms and Function |
| Discussion Leader: TBA |
| 7:30 pm - 8:00 pm | Tadhg Begley (Texas A&M University)
"Radical SAM enzymes in cofactor biosynthesis"
|
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Chris Whitman (UT Austin)
"The accidental assignment of function in the tautomerase superfamily"
|
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Lana Saleh (New England Biolabs)
"Biochemical insight into the oxidation of DNA 5-methylcytosine by an iron(II)/a-ketoglutarate-dependent dioxygenase"
|
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Chemical Biology Tools: Development and Application |
| Discussion Leader: TBA |
| 9:00 am - 9:30 am | Virginia Cornish (Columbia University)
"Expanding the synthetic capabilities of yeast" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Minkui Luo (Memorial Sloan Kettering Cancer Center)
"Expanding biochemical reactivity of S-adenosyl-L-methionine to interrogate methyltransferases"
|
| 10:10 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break |
| 10:50 am - 11:20 am | Pieter Dorrestein (UC San Diego)
"GoogleMAP"-type view of specialized molecules from microbes, their communities and hosts including people"
|
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:00 pm | Anna Mapp (University of Michigan)
"Caught in the act: capturing coactivator assemblies in vitro and in vivo" |
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | TBA (Poster Presentation) |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Amazing Enzymology |
| Discussion Leader: Vahe Bandarian (University of Arizona) |
| 7:30 pm - 8:20 pm | JoAnne Stubbe (MIT)
"Radicals: your life in their hands"
|
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 9:15 pm | Chris Walsh (Harvard Medical School)
"Seeking biosynthetic simplicity on the far side of complexity: peptidyl alkalois synthases of aspergilli"
|
| 9:15 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |