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Epigenetics
Gordon Research Conference

Mechanisms and Implications

Dates

August 4-9, 2013

Location

Bryant University
Smithfield, RI

Organizers

Chairs:
Eric J. Richards & Emma Whitelaw

Vice Chairs:
William G. Kelly & Ortrun Mittelsten Scheid

Meeting Description

The field of epigenetics covers the diverse processes through which non-genetic information, encoded outside DNA nucleotide sequence, is regulated and transmitted through cell divisions, and, in some cases, vertically across generations. Since the first meeting in 1995, the Epigenetics GRC has been an important forum for sharing new results and fostering the development of this rapidly advancing field. Throughout its sixteen-year history, this conference series has focused on the molecular mechanisms that underlie epigenetic phenomena in a broad range of eukaryotes. The 2013 Epigenetics conference will continue this emphasis on underlying mechanisms, including RNA-directed chromatin modification, DNA modification dynamics, RNA inheritance, three-dimensional nuclear organization, and prions. In addition, selected sessions will explore active subtopics, such as epigenomics, transgenerational inheritance, and the intersection of epigenetics and the environment.

The conference will bring together leaders from a variety of disciplines working on diverse experimental platforms. Space in each session will be reserved for presentations to be selected from submitted abstracts, and will include talks from both younger scientists and established researchers with new, exciting findings. Poster presentations are invited from all participants.

Bryant University, located close to Providence, RI, will be the venue for this conference.

Contributors

Meeting Program

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmEpigenetic Phenomena and Mechanisms
Discussion Leader: Eric Richards (Boyce Thompson Institute)
7:40 pm - 7:50 pmEmma Whitelaw (La Trobe University)
"Nuancing Epigenetics"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:30 pmTim Bestor (Columbia University)
"DNA modification and chromatin-based epigenetic systems"
8:30 pm - 8:45 pmDiscussion
8:45 pm - 9:15 pmYury Chernoff (Georgia Institute of Technology)
"Protein-based inheritance systems"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmEstablishment of Epigenetic States
9:00 am - 9:10 amDiscussion Leader: Marjori Matzke (Academia Sinica)
"Session introduction and data highlights"
9:10 am - 9:35 amSteve Jacobsen (UCLA)
"Gene silencing in Arabidopsis"
9:35 am - 9:45 amDiscussion
9:45 am - 10:00 amMaria Gutierrez-Arcelus (University of Geneva)
"Passive and active DNA methylation and the interplay with genetic variation in gene regulation"
10:00 am - 10:05 amDiscussion
10:05 amCoffee Break
10:30 am - 10:45 amKim Nguyen (University of Minnesota)
"TALE architecture in chimeric proteins of TALE and DNMT3A-CCD methyltransferase (TALEM-D) mediated in vivo unique methylation patterns"
10:45 am - 10:50 amDiscussion
10:50 am - 11:15 amErica Larschan (Brown University)
"The CLAMP protein links MSL complex to the X-chromosome during Drosophila dosage compensation"
11:15 am - 11:25 amDiscussion
11:25 am - 11:40 amEmilie Castonguay (University of Edinburgh)
"Identification of novel inhibitors of heterochromatin integrity through a chemical screen in fission yeast"
11:40 am - 11:45 amDiscussion
11:45 am - 12:10 pmLars Jansen (Instituto Gulbenkian de Ciência)
"Stable retention of nucleosomes at active genes"
12:10 pm - 12:20 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session A
6:00 pmDinner
7:30 pm - 9:30 pmErasure & Dynamics of Epigenetic States
Discussion Leader: Wolf Reik (Babraham Institute)
7:30 pm - 7:55 pmWolf Reik (Babraham Institute)
"The role of DNA modifications in epigenetic reprogramming and signalling"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmAlexander Meissner (Harvard University)
"Epigenetic dynamics in stem cells and development"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmMiguel Ramalho-Santos (University of California - San Francisco)
"Tets can dance: Vitamin C is an epigenetic missing link in embryonic stem cells and beyond"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmAmnon Koren (Harvard University)
"Random replication of the inactive X chromosome"
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNuclear Organization
Discussion Leader: Edith Heard (Institut Curie)
9:00 am - 9:25 amEdith Heard (Institut Curie)
"The nuclear and chromosome dynamics of X-chromosome inactivation"
9:25 am - 9:35 amDiscussion
9:35 am - 9:50 amFred Berger (Temasek Life Sciences Laboratory)
"A new class of histone variant induces heterochromatin and promotes chromatin condensation"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:55 amPeter Fraser (Babraham Institute)
"Exploration of functional genetic and epigenetic landscapes in 3D chromosome structures"
10:55 am - 11:05 amDiscussion
11:05 am - 11:20 amJack Bateman (Bowdoin College)
"Comparing enhancer action in cis and in trans"
11:20 am - 11:25 amDiscussion
11:25 am - 11:40 amMaria-Elena Torres-Padilla (IGBMC)
"Heterochromatin establishment at mouse pericentromeres depends on nuclear position"
11:40 am - 11:45 amDiscussion
11:45 am - 12:10 pmJason Brickner (Northwestern University)
"Mechanism and conservation of nuclear pore-dependent transcriptional memory"
12:10 pm - 12:20 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session B
6:00 pmDinner
7:30 pm - 9:30 pmRNA-Based Epigenetic Mechanisms
7:30 pm - 7:40 pmDiscussion Leader: Frédéric Chédin (University of California - Davis)
"Session introduction and data highlights"
7:40 pm - 8:05 pmAlyson Ashe (University of Cambridge)
"Multigenerational Epigenetic Memory in the Germline of C. elegans"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmRob Martienssen (Cold Spring Harbor Laboratory)
"Germline reprogramming and epigenetic inheritance mediated by small RNA"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmAdele Murrell (University of Cambridge)
"Genomic imprinting and cotranscriptional splicing"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmLeah Matzat (National Institutes of Health)
"Messenger RNA is a functional component of a chromatin insulator complex"
9:25 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEpigenomics
Discussion Leader: Joseph Ecker (Salk Institute)
9:00 am - 9:25 amKhai Luong (PacBio)
"Epigenomic profiling using SMRT technology"
9:25 am - 9:35 amDiscussion
9:35 am - 9:50 amSoojin Yi (Georgia Institute of Technology)
"Evolution of human brains and DNA methylation"
9:50 am - 9:55 amDiscussion
10:00 amCoffee Break
10:30 am - 10:55 amJoseph Ecker (Salk Institute)
"Methylation on the brain"
10:55 am - 11:05 amDiscussion
11:05 am - 11:30 amDirk Schübeler (Friederich Miescher Institute)
"Instructing the epigenome in stem and differentiated cells"
11:30 am - 11:40 amDiscussion
11:40 am - 12:10 pmHenk Stunnenberg (NCMLS)
"The epigenome of groundstate mouse embryonic stem cells"
12:10 pm - 12:20 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session C
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmEpigenetic Inheritance
Discussion Leader: Bill Kelly (Emory University)
7:30 pm - 7:55 pmBill Kelly (Emory University)
"Memory of transcription past"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmVincent Colot (Institut de Biologie de l'Ecole Normale Supérieure)
"Inheritance patterns of DNA methylation and transposable element mobilization in Arabidopsis"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmCraig Pikaard (Indiana University)
"Molecular memory, silent locus identity and epigenetic inheritance in Arabidopsis"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmJiang Liu (Beijing Institute of Genomics, CAS)
"Sperm, but not oocyte, DNA methylome is inherited by Zebrafish early embryos"
9:25 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEnvironmental Interactions
9:00 am - 9:10 amDiscussion Leader: Jean Finnegan (CSIRO)
"Session introduction and data highlights"
9:10 am - 9:35 amShunsuke Ishii (RIKEN)
"Inheritance of stress-induced chromatin alterations"
9:35 am - 9:45 amDiscussion
9:45 am - 10:00 amStephen Santoro (Harvard University)
"The activity-dependent histone variant H2B.E modulates the life span of olfactory neurons"
10:00 am - 10:05 amDiscussion
10:05 amCoffee Break
10:30 am - 10:55 amOrtrun Mittelsten Scheid (Gregor Mendel Institute)
"Stress and epigenetic response"
10:55 am - 11:05 amDiscussion
11:05 am - 11:30 amUeli Grossniklaus (University of Zurich)
"Is there epigenetic memory of heat stress?"
11:30 am - 11:40 amDiscussion
11:40 am - 12:05 pmSally Mackenzie (University of Nebraska)
"Organelle-mediated elicitation of heritable epigenetic variation in plant development"
12:05 pm - 12:15 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session D
6:00 pmDinner
7:30 pm - 9:30 pmEpigenetics and Disease
Discussion Leader: Anne Ferguson-Smith (University of Cambridge)
7:30 pm - 7:55 pmSarah Clinton (University of Alabama - Birmingham)
"Epigenetics, Neurodevelopment and Risk for Anxiety and Depression in Model Rats"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:20 pmJiemin Wong (East China Normal University)
"The UHRF Family Proteins Negatively Regulate De Novo DNA Methylation and Their Overexpression Causes DNA Hypomethylation in Cancer"
8:20 pm - 8:25 pmDiscussion
8:25 pm - 8:50 pmRichard Festenstein (Imperial College London)
"Antagonising heterochromatin formation in Friedreich's ataxia: a novel therapy for a prototypic position-effect disease?"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmAnne Ferguson-Smith (University of Cambridge)
"Meeting synthesis"
9:20 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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