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Conference Program
 
Fibronectin, Integrins & Related Molecules
February 10-15, 2013
Ventura Beach Marriott
Ventura, CA

Related Meeting Information
The Fibronectin, Integrins & Related Molecules Gordon Research Conference was held in conjunction with the Fibronectin, Integrins & Related Molecules Gordon Research Seminar. Please refer to the Fibronectin, Integrins & Related Molecules GRS web page for more information.

The 2013 Gordon Research Conference on Fibronectin, Integrins and Related Molecules will be held February 10th - 15th at the Ventura Beach Marriott, Ventura, California. This conference has emerged as a key scientific meeting for those interested in integrins and the interactions between cells with the extracellular matrix in development, homeostasis and disease. The program encompasses a full range of topics, from studies in whole organisms to single molecules. The conference seeks to encourage those who attend the meeting to explore new research directions, by showcasing the latest developments in imaging, modelling, biosensors, mechanobiology and clinical translation. We look forward to including in the program approximately 20 short talks from the applicants, and two poster sessions. Graduate students and postdoctoral scientists are encouraged to also apply to the associated Gordon Research Seminar.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmBuilding Animals
Discussion Leaders: Richard Hynes (MIT) and Srikala Raghavan (NCBS, Bangalore)
7:40 pm - 8:10 pmDavid Sherwood (Duke University)
"Cell Invasion through basement membrane: the anchor cell breaches the barrier"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:30 pmSophie Astrof (Thomas Jefferson University)
"Cell specific functions of fibronectin during cardiovascular development"
8:30 pm - 8:35 pmDiscussion
8:35 pm - 9:05 pmDoug De Simone (University of Virginia)
"Adhesion-dependent mechanical signaling in morphogenesis"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmMatthew Naylor (University of Sydney)
"Dissecting integrin signalling in glandular epithelium"
9:25 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMaintaining Health
Discussion Leaders: Jean Schwarzbauer (Princeton University) and Arnoud Sonnenberg (Netherlands Cancer Institute)
9:00 am - 9:30 amJane Sottile (University of Rochester Medical Center)
"Consequences of fibronectin dependent extracellular matrix remodeling"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amAmbra Pozzi (Vanderbilt University)
"A role for integrin α1β1 as a negative regulator of TGF-β activation in the context of fibrosis"
9:55 am - 10:00 amDiscussion
10:00 amGroup Photo / Coffee Break
10:30 am - 11:00 amMary Beckerle (University of Utah)
"Interface between cytoskeletal dynamics and tumor biology"
11:00 am - 11:10 amDiscussion
11:10 am - 11:25 amWhitney Longmate (Albany Medical College)
"Integrin α3β1 as a regulator of laminin-332 processing & basement membrane organization during wound healing"
11:25 am - 11:30 amDiscussion
11:30 am - 12:00 pmRonen Alon (Weizmann Institute of Science)
"Roles of focal adhesion adaptors in lymphocyte motility and arrests"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmJie Chen (LSU Health Sciences Center)
"Shear stress-induced proinflammatory responses require αv integrins but not α5"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 1
6:00 pmDinner
7:30 pm - 9:30 pmIntegrating Force
Discussion Leaders: Alexander Dunn (Stanford University) and Jari Ylanne (University of Jyvaskyla)
7:30 pm - 8:00 pmMichael Lampson (University of Pennsylvania)
"Sensing centromere tension: mechanical force and chromosome segregation"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmChristophe Le Clainche (CNRS Gif-sur-Yvette)
"In vitro reconstitution of focal adhesion mechanosensitivity controlled by the self-assembly of actomyosin cables"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 9:00 pmMartin Humphries (University of Manchester)
"Force and signal relays through adhesion complexes"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmMatthew Rubashkin (University of California - San Francisco)
"The nanoscale organization of focal adhesion signaling complexes can reflect changes in cellular contractility and motility on fibronectin matrices"
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLinking to the cytoskeleton
Discussion Leaders: David Critchley (University of Leicester) and Ellen Van Obberghen-Schilling (University of Nice)
9:00 am - 9:30 amClare Waterman (National Institutes of Health)
"The role of actomyosin assembly in focal adhesion maturation"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amCharles Streuli (University of Manchester)
"How integrins control epithelial polarity"
9:55 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:00 amReinhard Fässler (Max Planck Institute, Martinsreid)
"Genetic analysis of integrin signalling"
11:00 am - 11:10 amDiscussion
11:10 am - 11:25 amBenjamin Klapholz (University of Cambridge)
"Talin mediates integrin function by adopting tissue-specific conformations"
11:25 am - 11:30 amDiscussion
11:30 am - 12:00 pmMarie-France Carlier (CNRS Gif-sur-Yvette)
"Control of actin assembly in coordinated polymerization machineries"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmTBA (Short talk selected from the GRS)
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 2
6:00 pmDinner
7:30 pm - 9:30 pmContributions to Disease
Discussion Leaders: Takao Sakai (Cleveland Clinic) and Dean Sheppard (University of California, San Francisco)
7:30 pm - 8:00 pmRichard Hynes (The David H Koch Institute for Integrative Cancer Research)
"Fibronectin and the ECM universe"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmInaam Nakchbandi (MPI of Biochemistry and University of Heidelberg)
"Circulating fibronectin controls tumor growth"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 9:00 pmCatherine Park (University of California, San Francisco)
"Integrins: a multifaceted target for cancer therapy"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmRoman Bogorad (MIT)
"siRNA mediated knockdown of all hepatic integrins in vivo affects transformed but not normal hepatocytes"
9:25 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDynamic Contacts in Migration
Discussion Leaders: Maddy Parsons (King's College London) and Roy Zent (Vanderbilt Medical Center)
9:00 am - 9:30 amGaudenz Danuser (Harvard University)
"Force-regulated assembly of actin filaments and adhesions"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amPatrick Oakes (University of Chicago)
"Regulation of Focal Adhesion Maturation by the Actin Cytoskeleton"
9:55 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:00 amGregory Giannone (University of Bordeaux)
"The inner life of adhesion sites: Integrin dynamics at the nano-scale"
11:00 am - 11:10 amDiscussion
11:10 am - 11:25 amLorraine Santy (Pennsylvania State University)
"Phosphoinositide specificity determines which cytohesins regulate β1 integrin recycling"
11:25 am - 11:30 amDiscussion
11:30 am - 12:00 pmAnne Huttenlocher (University of Wisconsin-Madison)
"Imaging invasive migration"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmJulie Kadrmas (University of Utah)
"Regulating Integrin adhesion and signaling in Drosophila melanogaster"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 3
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmSubstrate Mechanics
Discussion Leaders: Michael DiPersio (Albany Medical College) and Valerie Weaver (University of California, San Francisco)
7:30 pm - 8:00 pmAndrés J. Garcia (Georgia Institute of Technology)
"May the force be with you: engineering cell adhesive forces"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmSarah Calve (Purdue University)
"Biomechanical regulation of skeletal muscle regeneration"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmMatthew Paszek (Cornell University)
"The slimy story of metastasis, the cancer cell glycocalyx mechanically activates integrin function"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmCorinne Albiges-Rizo (Institut Albert Bonniot CNRS INSERM)
"BMP-2 signaling is associated with integrin mediated mechanotansduction pathway"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmXiaoping Du (University of Illinois at Chicago)
"A mechanism for directional switch of integrin signaling and the concept of selective inhibition of outside-in signaling as a new anti-thrombotic strategy"
9:25 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRegulation and Activation
Discussion Leaders: Magdalena Chrzanowska-Wodnicka (Bloodcenter of Wisconsin) and Jim Norman (Beatson Institute for Cancer Research)
9:00 am - 9:30 amJohanna Ivaska (University of Turku)
"Regulation of integrin activity and traffic in cell migration"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amAntje Schaefer (Sanquin Institute, Amsterdam)
"The force from within - leukocyte transendothelial migration requires high endothelial stiffness which is regulated by α-Actinin 4"
9:55 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:00 amMark Ginsberg (University of California, San Diego)
"Regulation of integrin activation"
11:00 am - 11:10 amDiscussion
11:10 am - 11:25 amGuido Serini (University of Torino School of Medicine)
"The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via ECM bound/active integrin endocytosis and Rac signaling"
11:25 am - 11:30 amDiscussion
11:30 am - 12:00 pmDavid Calderwood (Yale University)
"Novel pathways of integrin activation"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmBernhard Wehrle-Haller (University of Geneva)
"Integrin-dependent signaling; a new solution for an old problem"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session 4
6:00 pmDinner
7:30 pm - 9:30 pmStructure
Discussion Leaders: Simon Goodman (Merck KGAA) and Motomu Shimaoka (MIE University Medical School)
7:30 pm - 8:00 pmJunichi Takagi (Osaka University)
"Multi-faceted approach to analyze structure and function of integrins"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmMehmet Sen (Harvard Medical School)
"Structural basis for relay of allostery in aI-domain containing integrins"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 9:00 pmTitus Boggon (Yale University)
"Structure and function of cytosolic modulators of integrin signaling"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmBen Goult (University of Leicester)
"Conformational changes in the talin R2R3 rod domains determines whether RIAM or vinculin joins the party"
9:25 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13CA174204-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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