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Immunology of Fungal Infections
Gordon Research Conference

Dates

January 13-18, 2013

Location

Hotel Galvez
Galveston, TX

Organizers

Chairs:
Stuart M. Levitz & Luigina Romani

Vice Chairs:
Bruce S. Klein & Bernhard Hube

Meeting Description

Fungal diseases have emerged as major causes of morbidity and mortality in healthy and immune-compromised individuals. A fine-tuned immune response is critical, as either insufficient or exaggerated responses compromise the host's ability to eradicate fungal infection. Remarkable advances have been made in our understanding of the innate and adaptive components underlying the protective and non-protective mechanisms of immunity. Moreover, emerging evidence suggests that the indigenous microbiota that inhabits the human body shapes the host immune system and renders fungal interaction with the host more complex than previously appreciated. These discoveries allow a better understanding of the risk factors predisposing to disease susceptibility, including genetic variants of immune-related genes, and provide a means to develop novel approaches for immunotherapy and vaccination. Similarly important is the contribution of fungi to the plasticity of the immune system, from tolerance to autoimmunity. This conference will bring together the world's leading researchers investigating antifungal immunity, in a setting ideal for promoting cross-disciplinary discussions and collaborations. This will provide a compelling and informative meeting covering the latest advances in the field and the most pressing issues to be tackled.

Related Meeting

This GRC was held in conjunction with the "Immunology of Fungal Infections" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmPAMPered Fungi
Discussion Leader: Arturo Casadevall (Albert Einstein College of Medicine)
7:40 pm - 8:15 pmKeynote Address: Gordon Brown (University of Aberdeen)
"Pattern recognition receptors, fungal infections and the 2011 Nobel Prize"
8:15 pm - 8:25 pmDiscussion
8:25 pm - 8:50 pmGerald Fink (Whitehead Institute/MIT)
"Recognition of Candida albicans by receptors in vitro and in vivo"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmNeil Gow (University of Aberdeen)
"Pro- and anti-inflammatory molecules of the Candida cell wall"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmAdaptive Immunity
Discussion Leader: Liise-anne Pirofski (Albert Einstein College of Medicine)
9:00 am - 9:20 amGeorge Deepe (University of Cincinnati College of Medicine)
"Trace metals and the adaptive immune system in histoplasmosis"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amVera Calich (Universidade de São Paulo)
"The role of indoleamine dioxygenase (IDO) in the resistance and susceptibility to Paracoccidioides brasiliensis infection"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:50 amTerry Wright (University of Rochester School of Medicine and Dentistry)
"Lung macrophage phenotype influences host defense against Pneumocystis"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amBorna Mehrad (University of Virginia, Charlottesville)
"Neutrophil-dendritic cell interactions in host response to Aspergillus"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amCory Hogaboam (University of Michigan Medical School)
"The role of Gas6 and its cognate receptor Axl in severe fungal asthma"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmAmariliz Rivera (UMDNJ-New Jersey Medical School)
"Requisite role for CCR2+ Inflammatory monocytes in defense against Invasive Aspergillosis"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmTobias Hohl (Fred Hutchinson Cancer Research Center)
"CCR2+ inflammatory monocytes mediate innate defense against systemic candidiasis"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMoving From Bench to Bedside and From Bedside to Community
Discussion Leader: Margaret Hostetter (Cincinnati Children's Hospital Medical Center)
7:30 pm - 7:50 pmMihai Netea (Radboud University Nijmegen Medical Center)
"Integrating functional genomics and immunology to understand host defense against Candida infections"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmThomas Harrison (St. Georges Hospital Medical School)
"Short course adjunctive interferon gamma in HIV-associated cryptococcal meningitis"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmThomas Walsh (Weill Cornell Medical College)
"Immunopharmacology of antifungal agents"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmDimitrios Kontoyiannis (M. D. Anderson Cancer Center)
"Immunopharmacology of echinocandins"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMaking Sense Of Fungi
Discussion Leader: David Underhill (Cedars-Sinai Medical Center)
9:00 am - 9:20 amAmy Hise (Case Western Reserve University)
"Innate inflammasome activation by Candida albicans"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amKarl Kuchler (Medical University of Vienna)
"A novel signaling mechanism regulating the cross-talk of innate and adaptive immunity during fungal infections"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:50 amMichael Brenner (Harvard Medical School)
"Role of NKT cells in fungal infection"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amDan Kaplan (University of Minnesota)
"How skin DC subsets determine the adaptive response to infection with C. albicans"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amBetty Wu-Hsieh (National Taiwan University College of Medicine)
"Modulation of innate cell cytokine response to Histoplasma"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmMichael Mansour (Massachusetts General Hospital)
"Control of fungal phagosome maturation"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmJoshua Obar (Montana State University)
"IL-1R1 and inflammasome mediated limitation of pulmonary Aspergillus fumigatus growth"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmBeyond PAMPs: Fungal adaptation and metabolic regulation
Discussion Leader: Neil Gow (University of Aberdeen)
7:30 pm - 7:50 pmArturo Casadevall (Albert Einstein College of Medicine)
"Non-lytic exocytosis of Cryptococcus neoformans from macrophages"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmRobert Cramer (Geisel School of Medicine at Dartmouth)
"In vivo Hypoxia fungal adaptation/metabolism impacts pulmonary innate immune responses"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmAxel Brakhage (Hans-Knoell-Institute)
"Immune evasion of Aspergillus fumigatus"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmJean Paul Latgé (Institut Pasteur)
"Aspergillus sugars are not always sweet"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmC-type Lectins
Discussion Leader: Gordon Brown (University of Aberdeen)
9:00 am - 9:20 amTeunis Geijtenbeck (University of Amsterdam)
"C-type lectins in anti-fungal immunity"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJürgen Ruland (Technische Universität München)
"New insights into C-type lectin receptor signaling for anti-fungal immunity"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:50 amKazuyoshi Kawakami (Tohoku University Graduate School of Medicine)
"C-type lectin receptors and memory T cell response in cryptococcal infection"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amChad Steele (University of Alabama)
"Dectin-1 and immunopathogenesis during fungal allergy"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amGeorgios Chamilos (University of Crete)
"Dissecting the role of autophagy in immunity against Aspergillus"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amSalomé Leibundgut-Landmann (ETH Zürich)
"IL-17-secreting innate lymphoid cells, and not Th17 cells, are essential for host defense against fungal infection"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmAlana Sterkel (University of Wisconsin, Madison)
"Interactions with macrophages help instead of hinder Blastomyces dermatitidis"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmJudith Bain (University of Aberdeen)
"Molecular live cell imaging tools to study Candida albicans interference in phagosome maturation"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmFungal Vaccines
Discussion Leader: George Deepe (University of Cincinnati College of Medicine)
7:30 pm - 7:50 pmJay Kolls (University of Pittsburgh School of Medicine)
"Host Immune requirements to prevent Pneumocystis infection"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMarcel Wüthrich (University of Wisconsin, Madison)
"Regulation of vaccine-induced anti-fungal Th17 immunity"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmFloyd Wormley (University of Texas at San Antonio)
"Potential vaccine strategies for the treatment of pulmonary cryptococcosis"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmJack Edwards (Harbor-UCLA Medical Center)
"Strategies for a vaccine against Candida"
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmImmunogenetics of Fungal Diseases
Discussion Leader: Mihai Netea (Radboud University Nijmegen Medical Center)
9:00 am - 9:20 amSteven Holland (National Institutes of Health)
"GATA2 and STAT1: Critical determinants of human mycosis"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amOliver Kurzai (Hans-Knoell-Institute)
"Addressing the genetic risk for invasive aspergillosis - from single loci to genome wide association"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:50 amAgostinho Carvalho (University of Perugia)
"Humoral immunity and immunogenetics in aspergillosis: old friends revisited"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amFrank van de Veerdonk (Radboud University Nijmegen Medical Center)
"Functional genomics of Aspergillus infection"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amCristina Cunha (University of Perugia)
"NLRP3 and susceptibility to pulmonary aspergillosis"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amJessica Quintin (Radboud University Nijmegen Medical Center)
"'Training' of the innate immunity by Candida albicans"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmNydiaris Hernandez-Santos (University of Pittsburgh)
"Th17 cells confer long term adaptive immunity to oral mucosal Candida albicans infections"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmChristopher Mody (University of Calgary)
"Enhanced fungicidal lymphocyte activity within the microenvironment of a cryptococcoma"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThe Host/Microbioma/Fungus Triad
Discussion Leader: Jean-Paul Latgé (Institut Pasteur)
7:30 pm - 7:50 pmDavid Underhill (Cedars-Sinai Medical Center)
"Immune mechanisms for sensing commensal intestinal fungal populations"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMartin Schaller (Klinikum der Universität Tübingen)
"Alternative strategies in antifungal therapies"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmTeresa Zelante (Singapore Immunology Network)
"Tryptophan, the microbiota and fungi: an intriguing ménage à trois"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmJunko Yano (Louisiana State University Health Sciences Center)
"Identification of innate immune factors and their biological role in the immunopathogenesis of vulvovaginal candidiasis"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmJeremy McAleer (Children's Hospital of Pittsburgh of UPMC)
"Regenerating islet-derived III-gamma regulates pulmonary Th17 immunity by alterning the gut microbiome"
9:25 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible [in part] by 1 R13 AI103989-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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