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Conference Program
 
Glial Biology: Functional Interactions among Glia & Neurons
March 3-8, 2013
Four Points Sheraton / Holiday Inn Express
Ventura, CA

The broad and long-term goal of the conference is to understand how glial cells interact with one another and with neurons and how the interplay between glia and neurons contributes to normal function and diseases of the brain. The biology of astrocytes and microglial cells, more than that of oligodendrocytes, is emphasized in this meeting.

Leaders in the field will discuss critical areas of glial research and emerging young scholars will have the opportunity to share new ideas.

The program will have nine sessions that broadly address glia cell involvement in synaptic structure and function, neurogenesis, brain energy metabolism, cerebral blood flow, and some neurological diseases. In addition, two poster sessions will permit all participants to contribute to discussion of these topics. The health relatedness of this meeting is that glial cells participate in many, possibly all, neurological and psychiatric diseases. Discussions about current research will advance our understanding of glial cells in both health and disease. In addition, specific presentations at this conference will focus on the involvement of glial cells in brain development, synaptic transmission, normal and deranged energy metabolism (e.g., stroke and hypoglycemia), tumor formation and spread and in the control of cerebral blood flow.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmGlia and Brain Development
Discussion Leader: Harry Sontheimer (University of Alabama at Birmingham)
7:40 pm - 8:05 pmBeth Stevens (Children's Hospital/Harvard University)
"Pruning CNS Synapses: An Active Role for Glia and Immune Molecules"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmCagla Eroglu (Duke University)
"Astrocytes Orchestrate Dendritic Spine Formation and Maturation"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmNicola Allen (Salk Institute)
"The role of astrocytes in synapse formation and maturation genesis"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmAstrocytes and Synaptic Communication
Discussion Leader: Vlad Parpura (University of Alabama at Birmingham)
9:00 am - 9:25 amRichard Robitalle (University of Montreal)
"Astrocytes detect and modulate basal synaptic transmission"
9:25 am - 9:30 amDiscussion
9:30 am - 9:55 amAndrea Volterra (University of Lausanne)
"Anatomical-functional organization of astrocyte-synapse communications in the adult hippocampus"
9:55 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:55 amDimitri Rusakov (University College London)
"Basic principles of Ca2+ signal integration by astrocytes"
10:55 am - 11:00 amDiscussion
11:00 am - 11:30 amStéphane Oliet (Inserm U862 - Neurocentre Magendie)
"Surface dynamics of astroglial glutamate transporter GLT-1"
11:30 am - 11:40 amDiscussion
12:00 pm - 12:10 pmTrainee Presentation: Catherine Christian (Stanford University)
"Thalamic astrocytes potentiate GABA transmission"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmTrainee Presentation: Dustin Hines (Tufts Med Sch)
"Inhibition of the SNARE sensitive pathway in astrocytes attenuates damage following stroke"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmNeuronal Metabolism and Glia
Discussion Leader: Gerald Dienel (University of Arkansas for Medical Sciences)
7:30 pm - 8:00 pmPierre Magistretti (King Abdullah University of Science and Technology (KAUST))
"Astrocyte-neuron metabolic cooperation"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmBruce Ransom (University of Washington)
"Metabolic support of white matter and myelinated axon function by glia"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmJeffery Rothstein (Johns Hopkins University)
"Oligodendroglia as central supporters of neurons/axons and participation in neurodegeneration"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmModel Approaches to Study Glia
Discussion Leader: Ken McCarthy (University of North Carolina)
9:00 am - 9:30 amMarc Freeman (UMass Med School)
"Cell-cell communication during astrocyte morphogenesis in Drosophila"
9:30 am - 9:35 amDiscussion
9:35 am - 10:05 amBruno Weber (University of Zurich)
"Two Photon Imaging of Energy Substrates in Neurons and Astrocyte"
10:05 am - 10:10 amDiscussion
10:10 amCoffee Break
10:40 am - 11:10 amDwight Bergles (Johns Hopkins Med Sch)
"In vivo imaging studies of astrocyte Ca2+ signaling"
11:10 am - 11:15 amDiscussion
11:15 am - 11:45 amBal Khakh (UCLA)
"Uncovering the rules for astrocyte engagement in neuronal circuits using optical and genetic approaches"
11:45 am - 11:50 amDiscussion
12:00 pm - 12:10 pmTrainee Presentation: Anna Molofsky (Langley Porter Psychiatric Institute/UCSF)
"An astrocyte encoded scaffold in the ventral spinal cord directs axon guidance and motor neuron subtype by secretion of Sema3a"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmTrainee Presentation: Lasse Dissing-Olesen (University of British Columbia)
"Activation of neuronal NMDA receptors triggers rapid microglial process outgrowth; evidence for neuron-microglia communication"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmEndocannabinoids and Glia
Discussion Leader: Jaideep Bains (University of Calgary)
7:30 pm - 8:00 pmXia Zhang (University of Ottawa)
"Glia and Memory"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmGiovanni Marsicano (University of Bordeaux)
"The roles of astroglial CB1 receptors"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmThomas Nevian (University of Bern)
"Astrocyte calcium signaling in synaptic plasticity"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGlia and Behavioral Control
Discussion Leader: Bruce Ransom (University of Washington)
9:00 am - 9:40 amPhil Haydon (Tufts Med Sch)
"Astrocytic regulation of purines in vivo and their impact on sleep homeostasis"
9:40 am - 9:55 amDiscussion
9:55 amCoffee Break
10:10 am - 10:50 amMaiken Nedergaard (University of Rochester)
"The Nightlife of Astrocytes"
10:50 am - 11:05 amDiscussion
11:05 am - 11:45 amChristian Giaume (College de France)
"The role of astroglial connexins in the regulation of sleep-wake cycle"
11:45 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmTrainee Presentation: Sophia Bardehle (Ludwig-Maximilians-Universität München)
"In vivo live imaging of reactive astrocytes after traumatic brain injury reveals heterogeneity with juxtavascular proliferation"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmTrainee Presentation: Maria Sild (McGill University)
"Radial glial process motility regulates excitatory synapse properties"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmBrain Disorders and Glia
Discussion Leader: Richard Ransohoff (Cleveland Clinic Foundation)
7:30 pm - 8:00 pmDavid Attwell (University College London)
"Ischaemia-evoked damage to oligodendrocytes: the roles of glutamate receptors and K+"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmJustin Lee (Korea Institute of Science & Technology)
"Mechanisms of glutamate release from astrocytes"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmMichael Sofroniew (UCLA)
"Reactive astrogliosis and the impact on brain function"
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMicroglia and Synaptic Stripping
Discussion Leader: Monica Carson (University of California Riverside)
9:00 am - 9:30 amRichard Ransohoff (Cleveland Clinic Foundation)
"Macrophages of the CNS: Provenance matters!"
9:30 am - 9:35 amDiscussion
9:35 am - 10:05 amCornelius Gross (EMBL)
"A role for microglia in neural circuit maturation"
10:05 am - 10:10 amDiscussion
10:10 amCoffee Break
10:40 am - 11:10 amShumin Duan (Zhejiang University School of Medicine)
"A novel pathway for purine-mediated macropinocytosis in microglia"
11:10 am - 11:15 amDiscussion
11:15 am - 11:45 amJonathan Kipnis (University of Virginia)
"Microglia - scavengers of Rett pathology"
11:45 am - 11:50 amDiscussion
12:00 pm - 12:10 pmTrainee Presentation: Long-Jun Wu (Rutgers, The State University of New Jersey)
"Microglia proton channel: pH regulation and beyond"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmTrainee Presentation: Stefanie Robel (University of Alabama at Birmingham)
"The role of reactive astrocytes in epilepsy"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmGlial Control of Blood Flow
Discussion Leader: Tailoi Chan-Ling (University of Sydney)
7:30 pm - 8:00 pmEric Newman (University of Minnesota)
"Glial regulation of the retinal vasculature in vivo"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmJessica Filosa (Georgia Health Sciences University)
"Role of TRPV4 channels in vasculo-glia--neuronal coupling"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmHarry Sontheimer (University of Alabama Birgmingham)
"Disruption of astrocyte-vascular coupling during tumor invasion"
9:20 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health under award number 1R13NS083353-01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

 
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