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Glycobiology
Gordon Research Conference

Dates

March 3-8, 2013

Location

Ventura Beach Marriott
Ventura, CA

Organizers

Chair:
Kelley W. Moremen

Vice Chair:
Markus Aebi

Meeting Description

The Glycobiology GRC is one of the most exciting and important meetings in the field and offers a unique opportunity to both contribute to and keep abreast of the latest developments in our multidisciplinary field in a collegial setting. Carbohydrates harbor biological information and many new glycan functions are rapidly emerging from the studies of tissues and organs of humans and model systems, as well as in the area of microbial glycobiology. These advances are fueled by equally dramatic developments in the structural analysis of glycans and proteins interacting with carbohydrates as well as in analytical technologies. This meeting will focus on the roles of glycans in a variety of living systems and processes, including human physiology and pathology. An outstanding and diverse group of international scientists working at the forefront of research will present at the meeting. Twelve scientific sessions will cover diverse areas of the field, including structural glycomics, structural glycobiology of enzymes and receptors, chemical glycobiology, glycobiology of viruses, microbes, and parasites, host-microbe interactions, mechanisms of glycosylation and catabolism, epigenetic regulation, glycan diversity, roles of glycobiology in immunology and cancer, and human genetic disorders and vertebrate pathology. In addition to the approximately 31 invited talks, 21 short talks have been selected from poster abstracts, and six Conference Awards will be given for outstanding abstracts submitted by graduate students and post-docs. For the first time, a Glycobiology Gordon Research Seminar will also be held in advance of the GRC that will foster interactions between graduate students, post-docs and established researchers as mentors.

Related Meeting

This GRC was held in conjunction with the "Glycobiology" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmGlycan diversity: biochemistry, regulation and enzymology
Discussion Leader: Robert Haltiwanger (Stonybrook University)
7:40 pm - 8:04 pmJeff Esko (U California, San Diego)
"Degrading Heparan Sulfate"
8:04 pm - 8:11 pmDiscussion
8:11 pm - 8:21 pmPoster Talk: Yanzhuang Wang (U Michigan)
"Golgi cisternal stacking is required for accurate glycosylation"
8:21 pm - 8:26 pmDiscussion
8:26 pm - 8:50 pmHenrik Clausen (U Copenhagen)
"Functional glycomics using Zinc Finger nuclease engineered human cell lines"
8:50 pm - 8:57 pmDiscussion
8:57 pm - 9:21 pmSteve Withers (U British Columbia)
"Chemistry and glycobiology: a rewarding relationship"
9:21 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:50 amGlycosylation and Quality Control
Discussion Leaders: Reid Gilmore (U Mass Med School) and Karen Colley (U Ill Collge of Med)
9:00 am - 9:05 amIntroduction: Reid Gilmore (U Mass Med School) and Karen Colley (U Ill Collge of Med)
9:05 am - 9:28 amReid Gilmore (U Mass Med School)
"The role of oligosaccharyltransferase isoforms in mammalian cells"
9:28 am - 9:35 amDiscussion
9:35 am - 9:58 amStuart Moore (INSERM, Paris)
"Glycosylation and quality control: a view from the trash can"
9:58 am - 10:05 amDiscussion
10:05 am - 10:35 amGroup Photo / Coffee Break
10:35 am - 10:45 amPoster Talk: Cecilia D'Alessio (Foundacion Instituto Leloir)
"Structure of the MRH domain of glucosidase II, a key enzyme in glycoprotein folding quality control"
10:45 am - 10:50 amDiscussion
10:50 am - 12:30 pmGlycomics
Discussion Leader: Stuart Haslam (Imperial College)
10:50 am - 10:55 amIntroduction: Stuart Haslam (Imperial College)
10:55 am - 11:18 amCarlito Lebrilla (U California, Davis)
"Rapid throughput Glycome and Glycoproteome analysis and its implications to Glycobiology"
11:18 am - 11:25 amDiscussion
11:25 am - 11:48 amKay-Hooi Khoo (Academia Sinica)
"Sulfoglycomics: Technical development and applications to immune cells"
11:48 am - 11:55 amDiscussion
11:55 am - 12:05 pmPoster Talk: Rodrigo Ortiz-Meoz (Harvard Medical School)
"Identification of Novel Cellular Targets of O-GlcNAc Transferase"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmPoster Talk: Vanessa Dehennaut (CNRS)
"O-GlcNAcylation, a novel regulator of cell signaling and cell cycle"
12:20 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStructure and Biochemistry
Discussion Leader: Steve Withers (U British Columbia)
7:30 pm - 7:35 pmIntroduction: Steve Withers (U British Columbia)
7:35 pm - 7:57 pmKaspar Locher (ETH, Zurich)
"Structure and reaction mechanism of bacterial oligosaccharyltransferase"
7:57 pm - 8:03 pmDiscussion
8:03 pm - 8:13 pmPoster Talk: Shunsuke Matsumoto (Kyoto University)
"Crystal structure of an archaeal oligosaccharyltransferase"
8:13 pm - 8:18 pmDiscussion
8:18 pm - 8:40 pmKoichi Kato (National Institutes of Natural Sciences, Okazaki)
"Molecular and structural basis for N-glycan-dependent determination of glycoprotein fates in cells"
8:40 pm - 8:46 pmDiscussion
8:46 pm - 8:56 pmPoster Talk: David Rose (U Waterloo)
"Structural analysis of α-glucosidase I"
8:56 pm - 9:01 pmDiscussion
9:01 pm - 9:24 pmKaren Colley (U Ill Coll of Medicine)
"Structural basis for protein-specific polysialylation"
9:24 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:50 amChemistry
Discussion Leader: Geert-Jan Boons (U Georgia)
9:00 am - 9:05 amIntroduction: Geert-Jan Boons (U Georgia)
9:05 am - 9:28 amCarolyn Bertozzi (U California, Berkeley)
"Imaging glycans in microbes"
9:28 am - 9:35 amDiscussion
9:35 am - 9:58 amSabine Flitsch (Univ of Manchester)
"Investigation of glycoenzyme activity using glycoarrays"
9:58 am - 10:05 amDiscussion
10:05 am - 10:35 amCoffee Break
10:35 am - 10:45 amPoster Talk: Leslie Revoredo (Case Western Reserve)
"Independently profiling the function of the catalytic and lectin domains of the UDP: GalNAc Polypeptide α-N-Acetylgalactosaminyltransferases (ppGalNAc-Ts) via novel glycopeptide substrates"
10:45 am - 10:50 amDiscussion
10:50 am - 12:30 pmGlycobiology of Viruses
Discussion Leader: James Paulson (Scripps Res Inst)
10:50 am - 10:55 amIntroduction: James Paulson (Scripps Res Inst)
10:55 am - 11:18 amThierry Hennet (University of Zurich)
"Giant virus glycosylation"
11:18 am - 11:25 amDiscussion
11:25 am - 11:35 amPoster Talk: Michela Tonetti (U Genova)
"Structural characterization of the N-linked glycans associated to the capsid protein of the giant DNA virus PBCV-1"
11:35 am - 11:40 amDiscussion
11:40 am - 12:02 pmYoshihiro Kawaoka (University of Tokyo, U Wisconsin, Madison)
"Pandemic influenza"
12:02 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmPoster Talk: Helen Blanchard (Griffith University)
"Rotavirus recognition of, and interactions with, sialic acid-containing receptors"
12:20 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmParasite & Microbial Glycobiology
Discussion Leader: Chris West (U Oklahoma Coll of Med)
7:30 pm - 7:35 pmIntroduction: Chris West (U Oklahoma Coll of Med)
7:35 pm - 7:57 pmTamara Doering (Washington U Med Sch)
"Polysaccharide capsule synthesis in the pathogenic yeast Cryptococcus neoformans"
7:57 pm - 8:03 pmDiscussion
8:03 pm - 8:25 pmMichael Ferguson (University of Dundee)
"Sugar nucleotide metabolism in Trypanosoma brucei"
8:25 pm - 8:31 pmDiscussion
8:31 pm - 8:54 pmSonja-Varena Albers (Max Planck Institute)
"N-glycosylation in crenarchaea"
8:54 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmPoster Talk: Michel Riviere (U of Toulouse France)
"O-mannosylation of bacterial proteins is crucial for virulence of Myco-bacterium tuberculosis"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmPoster Talk: Julia Anzengruber (U Natural Res & Life Sci, Austria)
"Evidence of species-wide general O-glycosylation of extracellular proteins in Lactobacillus buchneri"
9:25 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:50 amGlycoconjugate biosynthesis and catabolism
Discussion Leader: Jeff Esko (U California, San Diego)
9:00 am - 9:05 amIntroduction: Jeff Esko (U California, San Diego)
9:05 am - 9:28 amRobert Linhardt (Rensselaer Polytech Institute)
"Proteoglycan biochemistry, synthesis, and analysis"
9:28 am - 9:35 amDiscussion
9:35 am - 9:58 amHarry Brumer (Univ of British Columbia)
"CAZymology of the human gut microbiome"
9:58 am - 10:05 amDiscussion
10:05 am - 10:35 amCoffee Break
10:35 am - 10:45 amPoster Talk: Ding Xu (U California, San Diego)
"Heparan Sulfate-Dependent Oligomerization of the Receptor for Advanced Glycation End Products (RAGE) is Essential for Signal Transduction"
10:45 am - 10:50 amDiscussion
10:50 am - 12:30 pmEpigenetic regulation and glycan diversity
Discussion Leader: John A. Hanover (NIDDK)
10:50 am - 10:55 amIntroduction: John A. Hanover (NIDDK)
10:55 am - 11:18 amKelth Vosseller (Drexel College of Medicine)
"O-GlcNAc signaling as metabolic sensor; implications in disease"
11:18 am - 11:25 amDiscussion
11:25 am - 11:48 amTetsuya Okajima (Nagoya Univ School of Medicine)
"Biochemical and biological analysis of O-GlcNAc modification of extracellular proteins"
11:48 am - 11:55 amDiscussion
11:55 am - 12:05 pmPoster Talk: Francesco Rao (U of Dundee)
"The human O-GlcNAcase C-terminal domain is a pseudo histone acetyltransferase"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmPoster Talk: Frederic Bard (Inst Mol Cell Biol, Singapore)
"Encoding the glycome: the role of Golgi organization"
12:20 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmImmunology and Cancer
Discussion Leader: Michael Pierce (U Georgia)
7:30 pm - 7:35 pmIntroduction: Michael Pierce (U Georgia)
7:35 pm - 7:57 pmRichard Cummings (Emory Sch of Med)
"Tn and SialylTn Antigens in Human Cancer: Genetic Regulation and Contributions to Cancer Phenotypes"
7:57 pm - 8:03 pmDiscussion
8:03 pm - 8:25 pmKevin Campbell (U of Iowa Sch of Med)
"Genetics and Glycobiology of Dystroglycanopathies"
8:25 pm - 8:31 pmDiscussion
8:31 pm - 8:54 pmDennis Kasper (Harvard)
"Revising our understanding of the role of carbohydrates in immunity"
8:54 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmPoster Talk: Francis Jacob (University Hospital, Basel)
"The glycosphingolipid P1 expressed on ovarian cancer cells shows correlated A4GALT expression and matches with novel Exon2a genotype"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmPoster Talk: Yuko Naito-Matsui (Kyoto U)
"Regulation of immune system by the activation-dependent alteration of sialic acid species in lymphocytes"
9:25 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:50 amHost-microbe interactions
Discussion Leader: Richard Cummings (Emory Sch Med)
9:00 am - 9:05 amIntroduction: Richard Cummings (Emory Sch Med)
9:05 am - 9:28 amLora Hooper (UT Southwestern)
"Lectin-mediated immune defense of the intestine"
9:28 am - 9:35 amDiscussion
9:35 am - 9:58 amJonathan Hodgkin (Oxford)
"Glycosylation and bacterial infection in the nematode C. elegans"
9:58 am - 10:05 amDiscussion
10:05 am - 10:35 amCoffee Break
10:35 am - 10:45 amPoster Talk: Therese Wohlschlager (ETH, Zurich)
"Methylated glycans as targets of Tectonin: a nematotoxic fungal lectin of novel specificity"
10:45 am - 10:50 amDiscussion
10:50 am - 12:30 pmGenetic Disorders and Vertebrate Pathology
Discussion Leader: Hudson Freeze (Sanford Burnham)
10:50 am - 10:55 amIntroduction: Hudson Freeze (Sanford Burnham)
10:55 am - 11:18 amGordon Lauc (U of Zagreb)
"Genes affecting N-glycosylation of human proteins show pleiotropy with autoimmune diseases, cancer, diabetes and neuropsychiatric disorders"
11:18 am - 11:25 amDiscussion
11:25 am - 11:48 amPeter Roach (Indiana School of Medicine)
"Glycogen Metabolism and Lafora Disease"
11:48 am - 11:55 amDiscussion
11:55 am - 12:05 pmPoster Talk: Onno Holleboom (U Amsterdam)
"Genetic defects in protein glycosylation as cause of dyslipidemia"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmPoster Talk: Lianchun Wang (U Georgia)
"Heparan sulfate is required for prostate cancer initiation and progression"
12:20 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGenetic Disorders and Development
Discussion Leader: Lance Wells (U Georgia)
7:30 pm - 7:35 pmIntroduction: Lance Wells (U Georgia)
7:35 pm - 7:57 pmFrancois Foulquier (University of Lille)
"Contribution of CDG-II to the understanding of the molecular mechanisms of N-linked protein glycosylation"
7:57 pm - 8:03 pmDiscussion
8:03 pm - 8:13 pmPoster Talk: Duy Tran (NIDCR, NIH)
"Real time imaging of dynamic secretory events to define the role of protein O-glycosylation in regulated secretion"
8:13 pm - 8:18 pmDiscussion
8:18 pm - 8:28 pmPoster Talk: Flavio Schwarz (U California San Diego)
"Modulation of innate immune responses in the central nervous system by Siglec-11 and Siglec-16"
8:28 pm - 8:33 pmDiscussion
8:33 pm - 8:55 pmLinda Baum (UCLA)
"O-glycans as master switches to regulate leukocyte migration, function and survival"
8:55 pm - 9:01 pmDiscussion
9:01 pm - 9:23 pmRichard Steet (U Georgia)
"Elucidating ML-II Pathogenesis and GlcNAc-1-Phosphotransferase Function Using Zebrafish"
9:23 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1 R13 GM 105060 - 01 from National Institute of General Medical Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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