Gordon Research Conferences
Meeting Details

CAG Triplet Repeat Disorders (GRS)
Gordon Research Seminar


June 22-23, 2013


Waterville Valley
Waterville Valley, NH


Edward W. Green

Meeting Description

The Gordon Research Seminar on CAG Triplet Repeat Disorders is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is to bring together early career scientists from around the world to discuss cutting-edge research on the molecular and cellular mechanisms of CAG repeat disorders, and the various therapeutic strategies which are being developed to combat them. In addition, there will be a session showcasing emerging methods and models in neurodegenerative research, and the chance to speak to discussion leaders drawn from academia, clinical practice, and the therapeutics industry.

Related Meeting

This GRS was held in conjunction with the "CAG Triplet Repeat Disorders" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.


Meeting Program

1:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmIntroductory Session: "The History of HD"
Discussion Leader: Emily Sontag (Stanford, USA)
3:45 pm - 4:15 pm David Housman (MIT, USA)
"Selected vignettes in HD Research carried out by the young and the restless"
4:15 pm - 4:30 pm Discussion
4:30 pm - 6:00 pmPoster Session I (Surnames A-K)
6:00 pmDinner
7:30 pm - 9:30 pmEmerging Methods and Models: Illuminating New Paths to Therapeutics
Discussion Leader: Lisa Ellerby (Buck Institute, USA)
7:30 pm - 7:50 pm Anna Parievsky (UCLA, USA)
"Alterations of thalamostriatal and corticostriatal projections in the R6/2 mouse model of Huntington's disease using optogenetics"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Jintang Du (Scripps Research Institute, USA)
"CTG·CAG triplet-repeat instability in DM1 iPSCs"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Laura Bowie (McMaster University, Canada)
"Using high content image analysis to identify potential drug treatments for Huntington's disease"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Megan Keiser (University of Iowa, USA)
"Gene therapies for spinocerebellar ataxia type 1"
9:20 pm - 9:30 pm Discussion
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amMolecular Mechanisms of Disease
Discussion Leader: Vahri Beaumont (CHDI Foundation Inc., USA)
9:00 am - 9:20 am Leora Fox (Columbia University, USA)
"Elimination of Alfy in an inducible model of Huntington's disease"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Chiara Scaramuzzino (Italian Institute of Technology, Italy)
"Pathogenic interaction of PRMT6 and polyglutamine androgen receptor in SBMA"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 am Joseph Ochaba (University of California Irvine, USA)
"SUMOylation regulates the formation of insoluble mutant Huntingtin: relevance to HD pathogenesis"
10:20 am - 10:30 am Discussion
10:30 am - 10:50 am Andreas Neuder (King's College London, UK)
"Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease"
10:50 am - 11:00 am Discussion
11:00 am - 12:30 pmPoster Session II (Surnames L-Z)
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:45 pmPathophysiology of Neurodegeneration
Discussion Leader: Andy Lieberman (University of Michigan, USA)
1:30 pm - 1:45 pm Davina Hensman Moss (UCL, UK)
"The C9orf72 expansion is the most frequent genetic cause of HD-like disorders in a UK based population"
1:45 pm - 1:55 pm Discussion
1:55 pm - 2:10 pm Rana Soylu (Lund University, Sweden)
"Long-term metabolic effects of huntingtin expression in the hypothalamus"
2:10 pm - 2:20 pm Discussion
2:20 pm - 2:35 pm Bindu Diana Paul (Johns Hopkins University School of Medicine, USA)
"Depletion of cystathionine gamma lyase, the biosynthetic enzyme for cysteine, mediates neurodegeneration in Huntington's disease"
2:35 pm - 2:45 pm Discussion
2:45 pm - 3:00 pmEvaluation Period
Fill out GRS Evaluation Forms
3:00 pmGordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm.
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