Gordon Research Conferences
Meeting Details

Cell Contact and Adhesion (GRS)
Gordon-Merck Research Seminar

Intercellular Interactions in Development and Disease


June 1-2, 2013


Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy


Benjamin A. Nanes

Associate Chair:
Christine Chiasson-MacKenzie

Meeting Description

The Gordon Research Seminar on Cell Contact & Adhesion is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

This meeting will explore new insights into intercellular interactions through diverse adhesive structures and their important roles in development and disease. Topics covered will include cell-cell junction structure and regulation, tissue patterning and polarity, integration of adhesion and signaling, and other advances in the field. A broad range of approaches will be represented, including biochemistry, cell biology, structural biology, and engineering.

Related Meeting

This GRS was held in conjunction with the "Cell Contact and Adhesion" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.


Meeting Program

1:30 pm - 4:30 pmArrival and Check-in
3:00 pm - 3:15 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:15 pm - 4:00 pmCell Junctions and Disease Pathogenesis
Discussion Leaders: Carien Niessen (University of Cologne) and Adi Dubash (Northwestern University)
3:15 pm - 3:30 pmMichelle Rengarajan (Stanford University)
"Rho effectors regulate Listeria monocytogenes invasion in endothelial cells"
3:30 pm - 3:35 pmDiscussion
3:35 pm - 3:50 pmVanessa Andries (VIB & Ghent University)
"Role of NANOS family members in tumor progression"
3:50 pm - 4:00 pmDiscussion
4:00 pm - 5:30 pmPoster Session I
5:30 pm - 7:30 pmJunction Dynamics
Discussion Leaders: Elisabetta Dejana (FIRC Institute for Molecular Oncology) and Chantel Cadwell (Emory University)
5:30 pm - 5:45 pmNatalie Hudson (University College London)
"Paxillin mediates vascular endothelial cadherin internalization during lymphocyte transmigration"
5:45 pm - 5:50 pmDiscussion
5:50 pm - 6:05 pmAlejandro Adam (Albany Medical College)
"The many faces of the endothelial adherens junction"
6:05 pm - 6:10 pmDiscussion
6:10 pm - 6:25 pmSara Stahley (Emory University)
"Desmosome assembly and disassembly are membrane raft-dependent"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:45 pmMatthias Ruebsam (University of Cologne)
"Classical cadherins control epidermal barrier function: regulation through actomyosin?"
6:45 pm - 6:50 pmDiscussion
6:50 pm - 7:05 pmSelwin Wu (University of Queensland)
"Cadherin-actomyosin dynamics regulate force at the epithelia adherens junctions"
7:05 pm - 7:10 pmDiscussion
7:10 pm - 7:25 pmSabine Fischer (Goethe University)
"Intercellular adhesion determines the formation of three-dimensional cellular spheroids"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
7:30 am - 8:30 amBreakfast
9:00 am - 10:20 amCytoskeletal Attachments
Discussion Leaders: Alpha Yap (University of Queensland) and Koen Tyberghein (VIB & Ghent University)
9:00 am - 9:15 amLauren Albrecht (Northwestern University)
"The role of post-translational modification cascades in regulating desmoplakin interactions with intermediate filaments"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amChristopher Wilson (Genentech)
"Rasip1 Regulates Endothelial Junctional Actin Organization and Vascular Stability"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amAkila Surendran (National University of Singapore)
"Role of nitric oxide in cytoskeletal regulation during HGF-induced migration of epithelial cells"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amDavid Escobar (Northwestern University)
"Alpha-catenin-based adhesion relies on a dual-kinase phosphorylation mechanism"
10:15 am - 10:20 amDiscussion
10:20 am - 11:00 amCareer Panel: "Building a global scientific career: making connections and finding your niche"
  • Elisabetta Dejana (FIRC Institute for Molecular Oncology)
  • Alpha Yap (University of Queensland)
  • John Wallingford (University of Texas at Austin)
  • Carien Niessen (University of Cologne)
11:00 am - 12:30 pmPoster Session II
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmTissue Patterning and Development
Discussion Leaders: John Wallingford (University of Texas at Austin) and Abbye McEwen (Northwestern University)
1:30 pm - 1:45 pmShuichi Hayashi (Riken Center for Developmental Biology)
"Protocadherin-17 sustains amygdala axon extension by contact-dependent mechanisms"
1:45 pm - 1:50 pmDiscussion
1:50 pm - 2:05 pmTom Van Nieuwenhuysen (Ghent University)
"Embryonic wound healing requires activation of junctional actomyosin contractility by the catenin p0071"
2:05 pm - 2:10 pmDiscussion
2:10 pm - 2:25 pmGeorge Eisenhoffer (University of Utah)
"Desmoplakin buffers epithelia against mechanical tension during development to prevent cell shedding"
2:25 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill out GRS Evaluation Forms
3:00 pmGordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm.
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