The Gordon Research Seminar on Cell Contact & Adhesion is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.
This meeting will explore new insights into intercellular interactions through diverse adhesive structures and their important roles in development and disease. Topics covered will include cell-cell junction structure and regulation, tissue patterning and polarity, integration of adhesion and signaling, and other advances in the field. A broad range of approaches will be represented, including biochemistry, cell biology, structural biology, and engineering.
|1:30 pm - 4:30 pm||Arrival and Check-in|
|3:00 pm - 3:15 pm||Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair|
|3:15 pm - 4:00 pm||Cell Junctions and Disease Pathogenesis|
|Discussion Leaders: Carien Niessen (University of Cologne) and Adi Dubash (Northwestern University)|
|3:15 pm - 3:30 pm||Michelle Rengarajan (Stanford University)
"Rho effectors regulate Listeria monocytogenes invasion in endothelial cells"
|3:30 pm - 3:35 pm||Discussion|
|3:35 pm - 3:50 pm||Vanessa Andries (VIB & Ghent University)
"Role of NANOS family members in tumor progression"
|3:50 pm - 4:00 pm||Discussion|
|4:00 pm - 5:30 pm||Poster Session I|
|5:30 pm - 7:30 pm||Junction Dynamics|
|Discussion Leaders: Elisabetta Dejana (FIRC Institute for Molecular Oncology) and Chantel Cadwell (Emory University)|
|5:30 pm - 5:45 pm||Natalie Hudson (University College London)
"Paxillin mediates vascular endothelial cadherin internalization during lymphocyte transmigration"
|5:45 pm - 5:50 pm||Discussion|
|5:50 pm - 6:05 pm||Alejandro Adam (Albany Medical College)
"The many faces of the endothelial adherens junction"
|6:05 pm - 6:10 pm||Discussion|
|6:10 pm - 6:25 pm||Sara Stahley (Emory University)
"Desmosome assembly and disassembly are membrane raft-dependent"
|6:25 pm - 6:30 pm||Discussion|
|6:30 pm - 6:45 pm||Matthias Ruebsam (University of Cologne)
"Classical cadherins control epidermal barrier function: regulation through actomyosin?"
|6:45 pm - 6:50 pm||Discussion|
|6:50 pm - 7:05 pm||Selwin Wu (University of Queensland)
"Cadherin-actomyosin dynamics regulate force at the epithelia adherens junctions"
|7:05 pm - 7:10 pm||Discussion|
|7:10 pm - 7:25 pm||Sabine Fischer (Goethe University)
"Intercellular adhesion determines the formation of three-dimensional cellular spheroids"
|7:25 pm - 7:30 pm||Discussion|
|7:30 am - 8:30 am||Breakfast|
|9:00 am - 10:20 am||Cytoskeletal Attachments|
|Discussion Leaders: Alpha Yap (University of Queensland) and Koen Tyberghein (VIB & Ghent University)|
|9:00 am - 9:15 am||Lauren Albrecht (Northwestern University)
"The role of post-translational modification cascades in regulating desmoplakin interactions with intermediate filaments"
|9:15 am - 9:20 am||Discussion|
|9:20 am - 9:35 am||Christopher Wilson (Genentech)
"Rasip1 Regulates Endothelial Junctional Actin Organization and Vascular Stability"
|9:35 am - 9:40 am||Discussion|
|9:40 am - 9:55 am||Akila Surendran (National University of Singapore)
"Role of nitric oxide in cytoskeletal regulation during HGF-induced migration of epithelial cells"
|9:55 am - 10:00 am||Discussion|
|10:00 am - 10:15 am||David Escobar (Northwestern University)
"Alpha-catenin-based adhesion relies on a dual-kinase phosphorylation mechanism"
|10:15 am - 10:20 am||Discussion|
|10:20 am - 11:00 am||Career Panel: "Building a global scientific career: making connections and finding your niche"|
- Elisabetta Dejana (FIRC Institute for Molecular Oncology)
- Alpha Yap (University of Queensland)
- John Wallingford (University of Texas at Austin)
- Carien Niessen (University of Cologne)
|11:00 am - 12:30 pm||Poster Session II|
|Coffee will be served in the poster area from 11:00 am - 11:30 am|
|1:30 pm - 2:30 pm||Tissue Patterning and Development|
|Discussion Leaders: John Wallingford (University of Texas at Austin) and Abbye McEwen (Northwestern University)|
|1:30 pm - 1:45 pm||Shuichi Hayashi (Riken Center for Developmental Biology)
"Protocadherin-17 sustains amygdala axon extension by contact-dependent mechanisms"
|1:45 pm - 1:50 pm||Discussion|
|1:50 pm - 2:05 pm||Tom Van Nieuwenhuysen (Ghent University)
"Embryonic wound healing requires activation of junctional actomyosin contractility by the catenin p0071"
|2:05 pm - 2:10 pm||Discussion|
|2:10 pm - 2:25 pm||George Eisenhoffer (University of Utah)
"Desmoplakin buffers epithelia against mechanical tension during development to prevent cell shedding"
|2:25 pm - 2:30 pm||Discussion|
|2:30 pm - 3:00 pm||Evaluation Period|
|Fill out GRS Evaluation Forms|
|3:00 pm||Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm.|