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Elastin, Elastic Fibers and Microfibrils (GRS)
Gordon Research Seminar

From Basic Concepts to Translational Applications

Dates

July 20-21, 2013

Location

University of New England
Biddeford, ME

Organizers

Chair:
Katja Schenke-Layland

Associate Chair:
Sandeep M. Khatri

Meeting Description

The Gordon Research Seminar on Elastin, Elastic Fibers & Microfibrils is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is to bring together young scientists at the forefront of elastic fiber-related research to discuss ideas among peers and a selected group of established scientific mentors. The latest advances in elastic fiber and microfibril research, including the biology of the elastin-associated matrix, fiber assembly, disease mechanisms, and applications in regenerative medicine will be discussed. There will be strong emphasis on mentoring, including a panel discussion about finding a job in elastic fiber-related research and ample opportunities for networking.

Related Meeting

This GRS was held in conjunction with the "Elastin, Elastic Fibers and Microfibrils" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

SATURDAY
1:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmElastic Fibers - Past and Future
3:45 pm - 4:15 pmDiscussion Leaders: Katja Schenke-Layland (Fraunhofer IGB Stuttgart, Germany) and Sandeep M. Khatri (University of Pittsburgh, USA)
3:45 pm - 4:15 pmKeynote Speaker: Elaine Davis (McGill, Montreal, Canada)
"Elastic fiber assembly: Insights from the electron microscope"
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmElastin
Discussion Leaders: Robert Mecham (Washington University, Seattle, USA) and Kristin Kumashiro (University of Hawai, USA)
7:30 pm - 7:50 pmLisa Muiznieks (The Hospital for Sick Children, Toronto, Canada)
"Understanding elastin self-assembly: maturation of the elastin coacervate"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmYoshito Yamashiro (UT Southwestern Medical Center, USA)
"Identification of Key Modulators Involved In Aortic Aneurysm Formation In Fibulin-4 Deficient Mice"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmCharu Munjal (Cincinnati Childrens Hospital Medical Center, USA)
"Elastase mediated p-Erk1/2 activation in Emilin1 deficient model of Aortic Valve Disease"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmMareike Dabisch-Ruthe (Heart and Diabetes Center Bad Oeynhausen, Germany)
"Characterization of cellular pyrophosphate homeostasis as cause of ectopic calcification in Pseudoxanthoma elasticum"
9:20 pm - 9:30 pmDiscussion
SUNDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:00 amPanel Discussion: "Where to find a job and how to be successful in it"
Abhay Pandit (NUI Galway, Ireland), Tony Weiss (Sydney, Australia), Scott Goldmann (DSM Biomedical, Exton, USA), Todd McDevitt (Georgia Tech, Atlanta, USA)
10:00 am - 11:00 amElastin Associated Proteins and Microfibrils
Discussion Leaders: Brigida Bochicchio (University of Basilicata, Italy) and Hiromi Yanasigawa (UTSW, USA)
10:00 am - 10:20 amRachael Andrie (Oregon Health & Science University, USA)
"The role of fibrillin-1 in emphysema"
10:20 am - 10:30 amDiscussion
10:30 am - 10:50 amAlexander Wohl (University of Cologne, Germany)
"Molecular requirements for the regulation of BMP growth factor activity by fibrillin"
10:50 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session II
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmElastin, Elastic fibers and Microfibrils in Regenerative Medicine
Discussion Leaders: Katja Schenke-Layland (Fraunhofer IGB Stuttgart, Germany) and Gerhard Sengle (University of Cologne, Germany)
1:30 pm - 1:50 pmGiselle Yeo (University of Sydney, Australia)
"Biological and structural properties of human tropoelastin with a revived 'fossil' domain 22"
1:50 pm - 2:00 pmDiscussion
2:00 pm - 2:20 pmSvenja Hinderer (Fraunhofer IGB Stuttgart, Germany)
"Upregulation of (tropo-)elastin expression in a 3D dynamic bioreactor system"
2:20 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill out GRS Evaluation Forms
3:00 pmGordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm.

Funding for this conference was made possible (in part) by 1R13HL1120348-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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