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Immunology of Fungal Infections (GRS)
Gordon-Merck Research Seminar

Dates

January 12-13, 2013

Location

Hotel Galvez
Galveston, TX

Organizers

Chair:
Michael K. Mansour

Associate Chair:
Teresa Zelante

Meeting Description

The Gordon Research Seminar on Immunology of Fungal Infections is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

There has been an unprecedented rise in invasive fungal disease owing to an expanding immunocompromised patient population. Our need to understand the precise molecular mechanisms that govern successful immune responses to fungal pathogens is greater than ever. This inaugural Gordon Research Seminar on the Immunology of Fungal Infections will provide the platform for young investigators to present their research in a non-intimidating environment while building a rich scientific network with their peers and leading researchers in the field of fungal immunity. Discussions will span diverse topics such as innate immune recognition of fungal pathogens, adaptive immune responses, as well as newly emerging fields such as fungal-microbiota interactions, and host-fungus microenvironment. To foster networking and provide guidance, leading senior faculty from around the world have been chosen as Discussion Leaders. This seminar serves as an ideal setting to cross-pollinate researchers with broad interests, engage in cutting-edge discussions and form novel collaborations among the young fungal immunology community.

Related Meeting

This GRS was held in conjunction with the "Immunology of Fungal Infections" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

SATURDAY
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Address
3:45 pm - 4:15 pmBruce Klein (University of Wisconsin)
"A Wisconsin soil fungus reveals surprising twists and turns: where BAD begets good and DARK casts light on fungal disease"
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmInnate Immunity: Recognition and Response
Discussion Leaders: Gordon Brown (University of Aberdeen), Jatin Vyas (Massachusetts General Hospital) and Stuart M. Levitz (University of Massachusetts)
7:30 pm - 7:45 pm Alison Coady (University of California, San Francisco)
"MyD88 signaling is required for inflammatory cell influx, cytokine response, and host survival during infection with Histoplasma capsulatum"
7:45 pm - 7:50 pm Discussion
7:50 pm - 8:05 pm Camaron Hole (University of Texas at San Antonio)
"STAT1 Activation is Critical to the Recruitment of Plasmacytoid Dendritic Cells During the Protective Immune Response to Experimental Pulmonary Cryptococcus neoformans Infection"
8:05 pm - 8:10 pm Discussion
8:10 pm - 8:25 pm Chelsea Bueter (University of Massachusetts)
"Spectrum and Mechanisms of NLRP3 Inflammasome Activation by Chitosan"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:45 pm Kerstin Huenniger (ZIK Septomics)
"C5a enhances antifungal activity of human neutrophilic granulocytes in human blood"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:05 pm Michael Davis (University of Michigan)
"Lysosome damage facilitates intracellular parasitism by Cryptococcus neoformans"
9:05 pm - 9:10 pm Discussion
9:10 pm - 9:25 pm Kelly Shepardson (Geisel School of Medicine at Dartmouth)
"Hypoxia Inducible Factor 1 Alpha is Required for Pulmonary Innate Immune Response to Aspergillus fumigatus"
9:25 pm - 9:30 pm Discussion
SUNDAY
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amAdaptive Immunity
Discussion Leaders: Luigina Romani (University of Perugia), Liise-anne Pirofski (Albert Einstein College of Medicine) and Bruce Klein (University of Wisconsin)
9:00 am - 9:15 am Rossana Iannitti (University of Perugia)
"CD4/CD8 T cell-targeted vaccination in aspergillosis: the molecular basis of personalized vaccines"
9:15 am - 9:20 am Discussion
9:20 am - 9:35 am Darin Wiesner (University of Minnesota)
"Cryptococcus neoformans Titan Cells Influence the Pulmonary Immune Response"
9:35 am - 9:40 am Discussion
9:40 am - 9:55 am Rebecca Drummond (University of Aberdeen)
"The Role of Dectin-1 on Antigen Specific CD4+ T-cell trafficking to the GI Tract during Murine Systemic Candidiasis"
9:55 am - 10:00 am Discussion
10:00 am - 10:15 am YaFeng Qui (University of Michigan)
"Scavenger receptor A modulates the immune response to pulmonary Cryptococcus neoformans infection"
10:15 am - 10:20 am Discussion
10:20 am - 10:35 am Daniela Ifirm (Raboud University Nijmegen Medical Center)
"The role of dectin-2 in host defense against fungal infections"
10:35 am - 10:40 am Discussion
10:40 am - 10:55 am Akash Verma (Cincinnati Children's Hospital)
"IL-33, a novel downstream target of IL-4 during Histoplasma capsulatum infection"
10:55 am - 11:00 am Discussion
11:00 am - 12:30 pmPoster Session II
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:40 pmEmerging Fields in Fungal Immunity
Discussion Leaders: Arturo Casadevall (Albert Einstein College of Medicine), Jean-Paul Latgé (Institut Pasteur) and Mihai Netea (Raboud University Nijmegen Medical Center)
1:30 pm - 1:45 pm Shih-Chin Cheng (Raboud University Nijmegen Medical Center)
"The unique structural features and distinct biological function of Candida hyphal glucan"
1:45 pm - 1:50 pm Discussion
1:50 pm - 2:05 pm Jörg Linde (Hans-Knöll-Institute)
"Systems-based analysis of fungal infections by small- and large-scale network analysis"
2:05 pm - 2:10 pm Discussion
2:10 pm - 2:25 pm Fabien Cottier (Singapore Immunology Network)
"How does our microbiota protect us from Candida albicans?"
2:25 pm - 2:30 pm Discussion
2:30 pm - 2:40 pm Concluding Remarks
2:40 pm - 3:00 pmEvaluation Period
Fill out GRS Evaluation Forms
3:00 pmGordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm.
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