The Gordon Research Seminar on Lysosomal Diseases is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.
The focus of this meeting is the presentation of cutting-edge research on a wide range of diseases resulting from lysosomal dysfunction. This meeting will encompass diverse areas of research including, but not limited to, basic lysosomal biology, autophagy, lysosomal disease pathogenesis and the introduction of novel therapies for the treatment of lysosomal disorders.
Seed funding for this new Gordon Research Seminar has been provided by Merck Research Laboratories.
|1:30 pm - 4:30 pm||Arrival and Check-in|
|3:00 pm - 3:15 pm||Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair|
|3:15 pm - 4:00 pm||Disease Models|
|Discussion Leader: Christopher Wassif (NIH/NICHD)|
|3:15 pm - 3:30 pm||Leigh Paton (University of Oxford)
"Novel ENU mouse model of Mucolipidosis II"
|3:30 pm - 3:38 pm||Discussion|
|3:38 pm - 3:53 pm||Abdulfatah Alayoubi (University of Toronto)
"Gene Therapy of Farber Disease with Mechanistic Implications"
|3:53 pm - 4:00 pm||Discussion|
|4:00 pm - 5:30 pm||Poster Session I|
|5:30 pm - 7:30 pm||Lysosomal Disease Pathogenesis and Therapies|
|Discussion Leader: Anatalia Labilloy (University of Pittsburgh)|
|5:30 pm - 5:50 pm||Allison Bradbury (Auburn University)
"Dramatic Therapeutic Response of Intracranial AAV Gene Therapy in Feline GM2 Gangliosidosis"
|5:50 pm - 6:00 pm||Discussion|
|6:00 pm - 6:20 pm||Cristin Davidson (Albert Einstein College of Medicine)
"Efficacy of different cyclodextrins in the treatment of a murine model of Niemann-Pick type C disease"
|6:20 pm - 6:30 pm||Discussion|
|6:30 pm - 6:50 pm||Tamar Farfel-Becker (Weizmann Institute of Science)
"The pathogenesis of neuronopathic Gaucher disease: glucosylceramide accumulation, neuroinflammation and neurodegeneration"
|6:50 pm - 7:00 pm||Discussion|
|7:00 pm - 7:20 pm||Oscar Chen (University of Oxford)
"Defective transition metal ion homeostasis and hematological abnormalities in lysosomal storage disease animals and their clinical implications"
|7:20 pm - 7:30 pm||Discussion|
|7:30 am - 8:30 am||Breakfast|
|9:00 am - 11:00 am||Lysosomes in Health and Disease|
|Discussion Leader: Heather Gray-Edwards (Auburn University)|
|9:00 am - 9:20 am||Martina Malnar (Rudjer Boskovic Institute)
"Cholesterol levels modulate trafficking of APP and BACE1 in Niemann-Pick type C cells"
|9:20 am - 9:30 am||Discussion|
|9:30 am - 9:50 am||Katrijn Coen (Catholic University of Leuven)
"Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells"
|9:50 am - 10:00 am||Discussion|
|10:00 am - 10:20 am||Luis Tecedor (University of Iowa)
"Membrane microdomain properties, caveolin-1 transport and caveolae-related functions are impaired in brain endothelial lacking the Batten disease protein, CLN3"
|10:20 am - 10:30 am||Discussion|
|10:30 am - 10:50 am||Ruth Milkereit (University of Toronto)
"Investigating the trafficking of LAPTM4 proteins"
|10:50 am - 11:00 am||Discussion|
|11:00 am - 12:30 pm||Poster Session II|
|Coffee will be served in the poster area from 11:00 am - 11:30 am|
|1:30 pm - 2:30 pm||Career Progression Workshop|
|Discussion Leader: Andres Klein (Weizmann Institute of Science)|
- Frances Platt (University of Oxford)
- Steven U. Walkley (Albert Einstein College of Medicine)
- Tony Futerman (Weizmann Institute of Science)
|2:30 pm - 3:00 pm||Evaluation Period|
|Fill out GRS Evaluation Forms|
|3:00 pm||Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm.|
Research reported in this publication was supported by the National Institute of Neurological Disorders And Stroke of the National Institutes of Health under Award Number R13NS083199. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Last Updated: March 26, 2013