The Gordon Research Seminar on Matrix Metalloproteinases is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.
The focus of this meeting is to highlight recent developments in the field of protease biology focusing on MMPs, ADAMs, ADAMTSs, astacin metalloproteinases, and their specific inhibitors. The discussions will center on the role of these enzymes in regulating the complex biological processes involved in development, homeostasis, and diseases such as cardiovascular disease, connective tissue disorders, lung injury, and cancer. The meeting will also feature a career panel to advise on and discuss the range of career paths available to graduate students and postdoctoral fellows.
|1:30 pm - 4:30 pm||Arrival and Check-in|
|3:00 pm - 3:15 pm||Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair|
|3:15 pm - 4:00 pm||Keynote Presentation|
|Discussion Leader: Sean Gill (Western University/Lawson Health Research Institute)|
|3:15 pm - 3:45 pm||Gillian Murphy (University of Cambridge)
"The metalloprotease roller coaster: what lies ahead?"
|3:45 pm - 4:00 pm||Discussion|
|4:00 pm - 5:30 pm||Poster Session I|
|5:30 pm - 7:30 pm||Regulation of metalloproteinase localization and function in development and disease|
|Discussion Leaders: Johanne Dubail (Cleveland Clinic Lerner Research Institute) and Trista Robichaud (University of Texas Health Science Center)
|5:30 pm - 5:45 pm||Sarah Dombernowsky (University of Copenhagen)
"A functional genomic screen identifies a novel regulator of ADAM17 subcellular localization and ectodomain shedding activity"
|5:45 pm - 5:50 pm||Discussion|
|5:50 pm - 6:05 pm||Mary Dear (Vanderbilt University)
"Drosophila MMPs regulate trans-synaptic signaling, synaptic architecture and neurotransmission strength"
|6:05 pm - 6:10 pm||Discussion|
|6:10 pm - 6:25 pm||Salvatore Santamaria (Imperial College London)
"Isolation of inhibitory antibodies of ADAMTS-5 from a phage display library"
|6:25 pm - 6:30 pm||Discussion|
|6:30 pm - 6:45 pm||Antoine Cominelli (Universite catholique de Louvain - de Duve Institute)
"Matrix Metalloproteinase-27 is retained in the endoplasmic reticulum by its specific C-terminal extension"
|6:45 pm - 6:50 pm||Discussion|
|6:50 pm - 7:05 pm||Ashley Weiss (University of Toronto)
"Quadruple Timp deficiency impacts post-natal survival, skeletal homeostasis and hematopoiesis"
|7:05 pm - 7:10 pm||Discussion|
|7:10 pm - 7:25 pm||Matthew Deberge (Geisel School of Medicine at Dartmouth College)
"MAPK/ERK-dependent T-cell receptor signaling induces ADAM17 proteolytic processing of TNF receptor 2"
|7:25 pm - 7:30 pm||Discussion|
|7:30 am - 8:30 am||Breakfast|
|9:00 am - 11:00 am||From Cocaine to Cancer: Metalloproteinases in Disease|
|Discussion Leaders: Antoine Dufour (University of British Columbia) and Alisha Mendonsa (Vanderbilt University)
|9:00 am - 9:15 am||Alexander Smith (Medical University of South Carolina)
"MMPs-2 and -9 mediate synaptic plasticity accompanying relapse to cocaine seeking"
|9:15 am - 9:20 am||Discussion |
|9:20 am - 9:35 am||Stephanie Gauci (Murdoch Childrens Research Institute)
"Blocking collagenolysis prevents aggrecan loss more effectively than blocking aggrecanolysis in the aggrecan interglobular domain, in vitro and in vivo"
|9:35 am - 9:40 am||Discussion |
|9:40 am - 9:55 am||Tobias Zech (Beatson Institute for Cancer Research)
"Actin-hotspot mediated reversible clustering of MT1-MMP at invasive pseudopods is required to drive breast cancer cell invasion"
|9:55 am - 10:00 am||Discussion |
|10:00 am - 10:15 am||Roosmarijn Vandenbroucke (VIB - Ghent University)
"Role of matrix metalloproteinases in inflammation-induced epithelial barrier disruption"
|10:15 am - 10:20 am||Discussion |
|10:20 am - 10:35 am||Beatriz Morancho (Vall D'Hebron Institute of Oncology)
"ADAM17 mediates the pro-tumorigenic effect of p95HER2-induced senescent cells"
|10:35 am - 10:40 am||Discussion |
|10:40 am - 10:55 am||Catherine Ong (Imperial College London)
"Neutrophil MMP-8/-9 cause matrix destruction in human TB and are regulated by an AMPK-dependent pathway"
|10:55 am - 11:00 am||Discussion |
|11:00 am - 12:30 pm||Poster Session II|
|Coffee will be served in the poster area from 11:00 am - 11:30 am|
|1:30 pm - 2:30 pm||Career Panel: "To Infinity and Beyond: A glimpse into what you can do with a graduate education!"|
|Discussion Leader: Gillian Murphy (University of Cambridge)|
- Howard Crawford (Mayo Clinic Florida)
- Marie Kveiborg (University of Copenhagen)
- Jonathan Larkin (GlaxoSmithKline)
|2:30 pm - 3:00 pm||Evaluation Period|
|Fill out GRS Evaluation Forms|
|3:00 pm||Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm.|
Funding for this conference was made possible (in part) by 1R13CA176706-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
Last Updated: May 9, 2013