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Cell Biology of Megakaryocytes and Platelets (GRS)
Gordon Research Seminar

Paths to a Research Career in Platelet Biology and Hemostasis/Thrombosis

Dates

March 9-10, 2013

Location

Hotel Galvez
Galveston, TX

Organizers

Chair:
Jonathan N. Thon

Associate Chair:
Bethany Kerr

Meeting Description

The Gordon Research Seminar on Cell Biology of Megakaryocytes and Platelets is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is to bring together young investigators to present their latest innovative work towards advancing our understanding of megakaryocyte and platelet formation and function. Through career oriented presentations and round table discussion with both academic and pharmaceutical leaders in their field, this GRS will also provide young investigators with valuable career advice from experts conducting basic, translational and pharmaceutical research.

Related Meeting

This GRS was held in conjunction with the "Cell Biology of Megakaryocytes and Platelets" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

SATURDAY
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:40 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:40 pm - 4:30 pmIntroduction to Megakaryocyte and Platelet Biology
Discussion Leaders: Jonathan Thon (Harvard University) and Milka Koupenova (University of Massachusetts)
3:40 pm - 4:10 pmKeynote Lecture: Jack Levin (University of California, San Francisco)
"Studies of the megakaryocyte/platelet lineage: A historical perspective"
4:10 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmMegakaryocyte and Platelet Biology I
Discussion Leaders: Milka Koupenova (University of Massachusetts) and Anthony D'Souza (Yale School of Medicine)
7:30 pm - 7:45 pmIan Macaulay (Weatherall Institute of Molecular Medicine)
"Platelet-biased stem cells reside at the apex of the hematopoietic stem cell hierarchy
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmVishal Salunkhe (University College Dublin)
"The MEIS1 interactome in megakaryocytes reveals a role in cell cycle regulation"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmSabrina Zeddis (Sanquin Research)
"The RNA-binding protein ATAXIN-2 regulates megakaryocytic differentiation"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmJustin Hamilton (Monash University)
"The Class II PI3K, PI3K-C2a, regulates platelet adhesion receptor function under shear and is important for the in vivo function of mouse platelets"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmMartina Lundberg (Queen Mary University of London)
"Synergistic platelet inhibition by prostacyclin, nitric oxide and the P2Y12 inhibitor prasugrel"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmMatthew Harper (University of Bristol)
"Coincident stimulation activates canonical transient receptor potential channels in platelets"
9:25 pm - 9:30 pmDiscussion
SUNDAY
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amMegakaryocyte and Platelet Biology II
Discussion Leaders: Shinobu Matsuura (Boston University Medical School) and Bethany Kerr (Cleveland Clinic, Ohio)
9:00 am - 9:15 amNatalie Poulter (University of Birmingham)
"Dynamic imaging of actin nodules in platelet adhesion"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amRobert Goggs (University of Bristol)
"Defining the role of RhoG in platelets"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amAnnachiara Mitrugno (Royal College of Surgeons in Ireland)
"Inhibition of Syk-PKC pathway in platelets impairs prostate cancer cells induced platelet secretion: Novel insights into platelet-cancer cell cross-talk"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amJessica Cedervall (Uppsala University)
"HRG regulates tumor progression, epithelial to mesenchymal transition and metastasis via platelet-induced signaling in the pre-tumorigenic microenvironment"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amKelly Metcalf Pate (Johns Hopkins University School of Medicine)
"Platelet activation and platelet-monocyte aggregate formation contribute to platelet decline during acute SIV infection in pigtailed macaques"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amAmie Waller (University of Reading)
"The role of Staphylococcus aureus wall teichoic acid in potentiating activation of human platelets"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session II
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmCareer Development Round Table Discussion
Discussion Leaders: Leslie Parise (University of North Carolina at Chapel Hill), Katya Ravid (Boston University), Joseph Italiano (Harvard University), Steve Watson (University of Birmingham) and Robert Tressler (Cellerant Therapeutics, Inc.)
1:30 pm - 1:45 pm Career Talk: Leslie Parise (University of North Carolina at Chapel Hill)
"Balancing acts: towards an academic career in platelet biology"
1:45 pm - 2:00 pm Robert Tressler (Cellerant Therapeutics, Inc.)
"A pharmaceutical approach to platelet translational research"
2:00 pm - 2:30 pm Round Table Discussion
2:30 pm - 3:00 pmEvaluation Period
Fill out GRS Evaluation Forms
3:00 pmGordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm.

Funding for this conference was made possible (in part) by 1R13HL117369-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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