Gordon Research Conferences
Meeting Details

Oxidative Stress & Disease (GRS)
Gordon Research Seminar

Brain Aging and Neurodegeneration


April 13-14, 2013


Les Diablerets Conference Center
Les Diablerets, Switzerland


Jia Yao

Associate Chair:
Fei Yin

Meeting Description

The Gordon Research Seminar on Oxidative Stress & Disease is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is to provide a platform for an outstanding and diverse group of young investigators to present and communicate their researches in brain aging and neurodegenerative diseases. Research topics include basic science discoveries of the underlying mechanisms of brain aging as well as translational investigations for therapeutic development to prevent and treat age-related neurodegenerative diseases.

Related Meeting

This GRS was held in conjunction with the "Oxidative Stress & Disease" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.


Meeting Program

1:30 pm - 4:30 pmArrival and Check-in
3:00 pm - 3:15 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:15 pm - 4:00 pmAging Brain in Motion: An Imaging Strategy for Disease Diagnosis and Monitoring
Discussion Leader: Enrique Cadenas (University of Southern California, USA)
3:15 pm - 3:50 pmAgneta Nordberg (Karolinska Institute, Sweden)
"Dynamic changes in PET amyloid and FDG imaging at different stages of Alzheimer's disease"
3:50 pm - 4:00 pmDiscussion
4:00 pm - 5:30 pmPoster Session I
5:30 pm - 7:30 pmCommon Mechanisms Underlying Brain Aging and Neurodegeneration
Discussion Leader: Roberta Diaz Brinton (University of Southern California, USA)
5:30 pm - 5:50 pmAna Ledo (Universidade de Coimbra, Portugal)
"Oxygen and nitric oxide concentration profiles linked to NMDA receptor activity in the hippocampus of a model of Alzheimer's disease"
5:50 pm - 5:55 pmDiscussion
5:55 pm - 6:15 pmDimitrije Krstic (University of Zurich)
"Degenerating neurites as cause of Aß accumulation and amyloid plaque formation"
6:15 pm - 6:20 pmDiscussion
6:20 pm - 6:40 pmGabriella Leonarduzzi (University of Turin, Italy)
"Interaction between lipid oxidation products and amyloid-β in amplifying neuronal damage in Alzheimer's disease"
6:40 pm - 6:45 pmDiscussion
6:45 pm - 7:05 pmLauren Klosinski (University of Southern California, USA)
"Mechanistic link between mitochondrial dysfunction and white matter degeneration in the normal mammalian aging female brain: Proof of concept"
7:05 pm - 7:10 pmDiscussion
7:10 pm - 7:25 pmArvind Goswami (Indian Institute of Science, India)
"Understanding the contribution of variants of mtHsp70 leading to mitochondrial dysfunction in Parkinson's disease"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amPrevention and Treatment for Brain Aging and Neurodegeneration: Translational Approaches
Discussion Leader: Agneta Nordberg (Karolinska Institute, Sweden
9:00 am - 9:20 amTianyi Jiang (University of Southern California)
"Lipoic Acid Restores Age-Associated Impairment of Brain Energy Metabolism"
9:20 am - 9:25 amDiscussion
9:25 am - 9:45 amHarsh Sancheti (University of Southern California)
"Lipoic Acid as a Therapeutic/Nutraceutical Agent in Alzheimer's Disease"
9:45 am - 9:50 amDiscussion
9:50 am - 10:10 amNatalie Noe (Institute for Genetics, Germany)
"Bezafibrate improves mitochondrial function in the CNS of a mouse model of mitochondrial encephalopathy"
10:10 am - 10:15 amDiscussion
10:15 am - 10:35 amJamaica Rettberg (University of Southern California, USA)
"Development of metabolic and physiological biomarker profiles for early detection of women at risk for Alzheimer's disease"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amCatia Lourenco (Universidade de Coimbra, Portugal)
"Neuronal-nitric oxide dynamics and coupled neurovascular coupling in Alzheimer Disease and Aging"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session II
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmCareer Development
Discussion Leaders: Jia Yao (University of Southern California, USA) and Fei Yin (University of Southern California, USA)
1:30 pm - 2:15 pmLadora Thompson (University of Minnesota, USA)
"Negotiating The First Academic Position & Identifying Career Development Applications for Success"
2:15 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill out GRS Evaluation Forms
3:00 pmGordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm.

Funding for this conference was made possible, in part by 1 R13 AG 044908-01 from the National Institute on Aging (NIA) and the National Institute of Neurological Disorders and Stroke (NINDS). 'The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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