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High Throughput Chemistry & Chemical Biology
June 2-7, 2013
Colby-Sawyer College
New London, NH
Chair:
Lisa A. Marcaurelle

Vice Chair:
Scott E. Wolkenberg
Application Deadline
The application deadline for this meeting was May 5, 2013. You may still submit an application. However, it will only be considered by the Conference Chair if more seats become available due to cancellations.
Related Meeting Information
The High Throughput Chemistry & Chemical Biology Gordon Research Conference will be held in conjunction with the High Throughput Chemistry & Chemical Biology Gordon Research Seminar. Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Please refer to the High Throughput Chemistry & Chemical Biology GRS web page for more information.

Dear Colleagues,

The 2013 GRC on High-Throughput Chemistry and Chemical Biology (HTCCB) will feature cutting edge talks bridging the disciplines of organic chemistry and chemical biology, covering a diverse range of topics. Invited speakers from both industry and academia will focus on the latest advances in synthetic methodology, reaction discovery, chemical biology, medicinal chemistry, library synthesis and screening. An overarching theme of the meeting is the application of high-throughput experimentation to research problems in these fields.

The HTCCB GRC will continue its tradition of excellent science in a relaxed atmosphere and will be held at Colby-Sawyer College in New London, NH. All conferees are encouraged to present a poster, as the afternoon poster sessions are an important part of the scientific and social exchange at the HTCCB GRC. The GRC has historically provided a unique gathering where colleagues and friends engage in informal discussion and exchange of ideas, and the 2013 meeting is set to provide likewise.

I am especially pleased to announce that the 3rd Gordon Research Seminar (GRS) for our conference will be held the weekend prior to the GRC on June 1-2. The HTCCB GRS is being organized by Jacqueline Wurst (The Broad Institute) and Joanna Loh (University of Kansas) and will provide an opportunity for trainees to share science and interact with leading researchers in an intimate setting. Graduate students and post-docs are encouraged to apply to both the GRS and GRC.

Along with the conference Vice-Chair, Scott Wolkenberg (Merck), I invite you to apply to what I hope to be an exciting and memorable meeting.

Lisa Marcaurelle
Chair 2013
GRC on High-Throughput Chemistry and Chemical Biology
H3 Biomedicine, Inc.

Contributors
SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmIntroductory Comments by GRC Site Staff / Chair's Welcome by Lisa Marcaurelle (H3 Biomedicine)
7:40 pm - 9:30 pmFrontiers in Chemical Biology
Discussion Leader: Paul Hanson (University of Kansas)
7:40 pm - 8:05 pm Emily Balskus (Harvard University)
"Gut Reactions: Understanding Disease-Associated Chemistry from the Human Microbiota"
8:05 pm - 8:10 pm Discussion
8:10 pm - 8:35 pm Jennifer Prescher (University of California, Irvine)
"Expanding the bioluminescent toolkit"
8:35 pm - 8:40 pm Discussion
8:40 pm - 9:25 pm Andrew Phillips (Yale University)
"Synthetic chemistry and mass-spectrometry: opportunities for impacting novel therapeutics"
9:25 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:30 amRapid Assembly of Complex Molecules
Discussion Leader: Jacqueline Wurst (Broad Institute)
9:00 am - 9:25 am Sarah Reisman (California Institute of Technology)
"The Development of New Synthetic Methods for the Rapid Construction of Molecular Complexity"
9:25 am - 9:30 am Discussion
9:30 am - 9:55 am Yujiro Hayashi (Tohoku University)
"One-pot reactions in total synthesis"
9:55 am - 10:00 am Discussion
10:00 am - 10:30 am Coffee Break
10:30 am - 12:30 pmPhenotypic Screening and Chemical Proteomics
Discussion Leader: Peter Fekkes (H3 Biomedicine)
10:30 am - 10:55 am Matthew Boxer (NIH/NCATS)
"Phenotypic Screen Identifies Potent Inhibitors of Lipid Droplet Formation"
10:55 am - 11:00 am Discussion
11:00 am - 11:25 am Sam Gerritz (Bristol-Myers Squibb)
"Small Molecules that Inhibit Influenza Virus Replication via Formation of Nucleoprotein Oligomers"
11:25 am - 11:30 am Discussion
11:30 am - 11:55 am Lyn Jones (Pfizer)
"Target engagement using chemical proteomics"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:25 pm Ivan Cornella-Taracido (Sanofi)
"Industrial Chemical Biology - hype or hope?"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSynthesis and Chemical Biology of Natural Products
Discussion Leader: Joshua Pierce (North Carolina State University)
7:30 pm - 7:55 pm Jiyong Hong (Duke University)
"Natural Product Synthesis at the Interface of Chemistry and Biology"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:30 pm Derek Tan (Memorial Sloan-Kettering Cancer Institute)
"Natural Product-based Strategies in Diversity-Oriented Synthesis"
8:30 pm - 8:35 pm Discussion
8:35 pm - 9:25 pm Dale Boger (Scripps Research Institute)
"Redesign of Vancomycin for Resistant Bacteria"
9:25 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:40 amCheminformatics
Discussion Leader: Donovan Chin (Novartis)
9:00 am - 9:25 am Meir Glick (Novartis)
"Perturbanomics: emergent discoveries from HTS Fingerprints of compounds or siRNA"
9:25 am - 9:30 am Discussion
9:30 am - 9:55 am Andrew Hopkins (University of Dundee)
"Encoding the creativity and beauty of drug design"
9:55 am - 10:00 am Discussion
10:00 am - 10:40 am Group Photo / Coffee Break
10:40 am - 12:30 pmLibrary Design, Synthesis and Screening
Discussion Leader: Aaron Beeler (Boston University)
10:40 am - 11:05 am Adam Nelson (University of Leeds)
"Towards the Systematic Exploration of Chemical Space"
11:05 am - 11:10 am Discussion
11:10 am - 11:35 am Andrei Yudin (University of Toronto)
"High-Throughput Synthesis Enabled by Amphoteric Molecules"
11:35 am - 11:40 am Discussion
11:40 am - 12:00 pm Stefan Gradl (Chiromics)
"Organocascade Catalysis: A new synthetic strategy is taking Affinity Screening Mass Spectrometry to the next level"
12:00 pm - 12:05 pm Discussion
12:05 pm - 12:25 pm Melvin Yu (Eisai)
"Application of Statistical Modeling to Library Building"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmIntegrated Chemical-Biological Approaches
Discussion Leader: Craig Thomas (NIH/NCATS)
7:30 pm - 7:45 pm 2011 Poster Winner: Albert Bowers (University of North Carolina, Chapel Hill)
"Bacterially-Encoded, Post-Translationally Modified Peptidomimetics for Drug Discovery"
7:45 pm - 7:50 pm Discussion
7:50 pm - 8:05 pm 2011 Poster Winner: Leslie Ofori (Stanford University)
"Strategies for sequence-selective RNA recognition"
8:05 pm - 8:10 pm Discussion
8:10 pm - 8:35 pm M.G. Finn (Georgia Institute of Technology)
"Function is All that Matters: Adventures in Target-Guided Assembly"
8:35 pm - 8:40 pm Discussion
8:40 pm - 9:25 pm Herbert Waldman (Max Plank Institute)
"Small molecule inhibition of KRas-Signaling - A systems approach"
9:25 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:30 amNew Approaches to Anti-Infective Drug Discovery
Discussion Leader: Paul Fleming (AstraZeneca)
9:00 am - 9:25 am Jared Shaw (University of California, Davis)
"Studies in Bacterial Cell Biology En Route to New Antibiotics"
9:25 am - 9:30 am Discussion
9:30 am - 9:55 am Jeremy Duvall (Broad Institute)
"Role of Next-Generation Synthesis in Anti-Infective Drug Discovery"
9:55 am - 10:00 am Discussion
10:00 am - 10:30 am Coffee Break
10:30 am - 12:30 pmCase Studies in Parallel Medicinal Chemistry
Discussion Leader: Kevin Woller (AbbVie)
10:30 am - 10:55 am Christopher Helal (Pfizer)
"Application of High-Speed Synthesis for the Identification of Sub-type Selective, Brain Penetrant, Phosphodiesterase Inhibitors"
10:55 am - 11:00 am Discussion
11:00 am - 11:25 am Zhi-Cai Shi (Merck)
"Accelerating the Discovery of DGAT1 inhibitors Through High Throughput Synthesis and Purification"
11:25 am - 11:30 am Discussion
11:30 am - 11:55 am Rene Lemieux (Agios)
"Optimization and Characterization of Mutant IDH Inhibitors for the Treatment of Cancer"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:25 pm David Maloney (NIH/NCATS)
"Discovery of ML323, A Potent and Selective Inhibitor of the USP1/UAF1 Deubiquitinase Complex"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmNew Platforms for Reaction Discovery and Optimization
Discussion Leader: Corey Stephenson (Boston University)
7:30 pm - 8:05 pm Tim Jamison (Massachusetts Institute of Technology)
"Continuous Multistep Synthesis"
8:05 pm - 8:10 pm Discussion
8:10 pm - 8:45 pm Spencer Dreher (Merck)
"Micro-scale high-throughput chemistry: enabling modern chemistry in real-world synthesis"
8:45 pm - 8:50 pm Discussion
8:50 pm - 9:25 pm John Hartwig (University of California, Berkeley)
"High Throughput Experimentation for Catalyst Discovery, Development, and Application"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:30 amNew Catalytic Methods for Synthesis
Discussion Leader: Alessandra Bartolozzi (Boehringer Ingelheim)
9:00 am - 9:25 am Abigail Doyle (Princeton University)
"Design of New Transition Metal-Catalyzed Synthetic Methods"
9:25 am - 9:30 am Discussion
9:30 am - 9:55 am Thomas Nielsen (Technical University of Denmark)
"Synthesis of Heterocycles through Metal-Catalyzed Isomerization Reactions"
9:55 am - 10:00 am Discussion
10:00 am - 10:30 am Coffee Break
10:30 am - 12:30 pmSmall Molecule Modulation of Gene Expression
Discussion Leader: Ann Rowley (Infinity Pharmaceuticals)
10:30 am - 10:55 am James Bradner (Dana Farber Cancer Institute)
"Chemical Control of Chromatin Structure and Function"
10:55 am - 11:00 am Discussion
11:00 am - 11:25 am Richard Cummings (Constellation Pharmaceuticals)
"Translating chromatin modulation into drug discovery: EZH2"
11:25 am - 11:30 am Discussion
11:30 am - 11:55 am Richard Chesworth (Epizyme)
"Drug Discovery and Histone Methyl Transferases"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:25 pm Stefan Kubicek (CeMM Research Center for Molecular Medicine)
"Chemical Epigenetics - Small molecule modulators of cell fate"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThe Science of Therapeutics
Discussion Leader: Mike Foley (Broad Institute)
7:30 pm - 7:55 pm Martin Drysdale (Beatson Institute for Cancer Research)
"Fragments, shape and protein-protein interactions"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:30 pm Markus Warmuth (H3 Biomedicine)
"Translating the Cancer Genome into Therapeutics: Key Challenges and Hurdles"
8:30 pm - 8:35 pm Discussion
8:35 pm - 9:25 pm Stuart Schreiber (Harvard University)
"Human Biology, Chemical Biology and the Science of Therapeutics"
9:25 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture
Last Updated: May 21, 2013
 
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