Gordon Research Conferences
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Conference Program
 
Hormone-Dependent Cancers
Development and Progression
July 28 - August 2, 2013
Bryant University
Smithfield, RI
Chair:
Karen E. Knudsen

Vice Chair:
Wayne Tilley

The Gordon Research Conference (GRC), focused on Hormone-Dependent Cancers: Development and Progression will be held on July 28th-August 2nd, 2013 at Bryant College in Rhode Island. Developing means to prevent and treat hormone-dependent cancers is of critical importance, give the significant impact these malignancies have on human health. Recent evidence suggests that hormones influence a large number of heretofore unappreciated processes associated with cancer development, including not only cell signaling and transcriptional regulation, but also aggressive tumor phenotypes (e.g. tumor cell dissemination, stem cell function, response to chemotherapy and DNA damaging agents, tumor metastasis, and alterations of the tumor microenvironment). It is also now clear that the role of hormones extends far beyond breast and prostate cancer, and that a multitude of both peptide and steroid hormones have a major impact on human malignancies not previously known to be hormone sensitive.

A thorough understanding of hormone action in regulating these cellular processes and cancer phenotypes is essential for the advancing understanding of hormone action in the most basic sense, translating these new findings into potential nodes for novel treatment strategies, and for coupling existing hormone associated therapies to new treatments. Toward this end, the 2013 GRC is designed to maximize interaction between the basic science test, investigators with expertise in chromatin regulation, transcription control, cell signaling, translational scientists with expertise in modeling human disease, and physician scientists who stand at the forefront of improving treatment for hormone dependent malignancies. The goal of the 2013 GRC will be to provide a format for this necessary interaction and fruitful exchange of scientific ideas common to overlapping research fields, such that novel concepts emerge, scientific collaborations are formed, and new translational opportunities are revealed.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:35 pmWelcome / Introductory Comments by GRC Site Staff
7:35 pm - 9:30 pmHormone Action & Cancer Development
Discussion Leaders: Karen Knudsen (Thomas Jefferson University) and Wayne Tilley (U. Adelaide)
7:35 pm - 8:00 pmKeynote Speaker: Charles Perou (University of North Carolina at Chapel Hill)
"Molecular Genetics and Genomics of Hormone Receptor Positive Breast Cancers for Therapy Selection"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:20 pmJustin Drake (University of California, Los Angeles)
"Defining kinase targets in castration resistant prostate cancer"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmGail Prins (University of Illinois at Chicago)
"Hormonal Regulation of Prostate Stem and Progenitor Cells"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmGeoffrey Greene (University of Chicago)
"Nuclear Receptor Cross Talk and Targeting in Breast Cancer Prevention and Treatment"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmChromatin Regulation in Cancer Development and Progression: Seq and you will find...
Discussion Leaders: Vasan Yegnasubramanian (Johns Hopkins University) and Geoffrey Greene (University of Chicago)
9:00 am - 9:20 amPeter Jones (University of Southern California)
"Cancer Genetics and Epigenetics - Two Sides of the Same Coin?"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amW. Lee Kraus (UT Southwestern Medical Center)
"Comprehensive Transcriptional Profiling in Breast Cancer Cells"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:20 am - 10:40 amCarol Lange (University of Minnesota)
"Mechanisms of Altered Progesterone Receptor (PR) Promoter Selection in Breast Cancer Models"
10:40 am - 10:50 amDiscussion
10:50 am - 11:10 amEdwin Cheung (Genome Institute of Singapore)
"Global Regulation of Chromatin Structure and Transcription by Nuclear Hormone Receptors"
11:10 am - 11:20 amDiscussion
11:20 am - 11:35 amJindan Yu (Northwestern University)
"Role of FoxA1 in androgen receptor signaling and prostate cancer"
11:35 am - 11:45 amDiscussion
11:45 am - 12:00 pmQianben Wang (The Ohio State University)
"GATA2-dependent transcription programs and prostate cancer initiation"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmLaura Cato (Dana-Farber Cancer Center)
"Bag-1L and the androgen receptor"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCross Talk of Hormone Receptor and DNA Damage Response Pathways
Discussion Leaders: Edwin Cheung (Genome Institute of Singapore) and Steve Balk (Harvard Medical School)
7:30 pm - 7:50 pmVasan Yegnasubramanian (Johns Hopkins University)
"The double-edged sword of androgen-induced double strand breaks in prostate cancer"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmFelix Feng (University of Michigan)
"Lnc-RNAs, an unexplored frontier in the DNA damage response and cancer phenotypes"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmMatthew Scheiwer (Thomas Jefferson University/Kimmel Cancer Center)
"Targeting nuclear receptor-DNA damage crosstalk in cancer therapy"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:00 pmDan Gioeli (University of Virginia)
"Checkpoint signaling and AR function in cancer"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmRobert Den (Thomas Jefferson University)
"Effectors of the DNA damage and radiotherapy response in cancer"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStem Cells & Cancer Development
Discussion Leaders: Gail Prins (University of Illinois at Chicago) and Leslie Gold (New York University)
9:00 am - 9:20 amGeoffrey Lindeman (University of Melbourne)
"Mammary stem cells and breast cancer - taking cues from steroid hormones"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amDean Tang (University of Texas)
"Understanding prostate cancer cell heterogeneity and its clinical implications"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:20 am - 10:40 amMichael Shen (Columbia University)
"Androgen receptor function in prostate epithelial stem cells"
10:40 am - 10:50 amDiscussion
10:50 am - 11:10 amGail Risbridger (Monash University)
"Prostate cancer, stem cells and hormone regulated micro-environment"
11:10 am - 11:20 amDiscussion
11:20 am - 11:35 amScott Cramer (University of Colorado)
"Tak1 and CHD1 intersection with AR signaling"
11:35 am - 11:45 amDiscussion
11:45 am - 12:00 pmSuzanne Fuqua (Baylor College of Medicine)
"Role of AR in Hormone Resistance"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmOmar Franco (Vanderbilt)
"Role of Androgen Receptor in Prostate Cancer Stroma During Tumor Progression"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMicroenvironment & Metastasis
Discussion Leaders: Elahe Mostaghel (University of Washington) and William Ricke (University of Wisconsin)
7:30 pm - 7:50 pmKornelia Polyak (Harvard Medical School)
"Therapeutic relevance of epithelial-stromal cell interactions"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmNora Navone (University of Texas)
"Fibroblast Growth Factor axis in the signaling crosstalk between Prostate Cancer cells and Bone"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmTheresa Hickey (University of Adelaide)
"Androgen and Estrogen Action in a Complex Cellular Environment"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:10 pmAlessandro Fatatis (Drexel University)
"New models of bone disease"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmDaniel Frigo (University of Houston)
"Functional Role of Autophagy in Prostate Cancer"
9:25 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEndocrine Therapy Resistance
Discussion Leaders: Beatrice Knudsen (Cedars-Sinai Medical Center) and Carol Lange (U. Minnesota)
9:00 am - 9:20 amHoward Scher (Memorial Sloan-Kettering)
"Understanding And Targeting Resistance To Androgen Receptor Signaling Inhibitors In Castration Resistant Prostate Cancer"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJoyce Slingerland (University of Miami)
"How cross talk with Src modifies ligand activated ER transcription coupled proteolysis"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:50 amJason Carroll (Cancer Research UK)
"Understanding estrogen receptor transcription in breast cancer"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amLeonie Young (Royal College of Surgeons Ireland)
"SRC-1 is a driver of tumour adaptability in endocrine resistant breast cancer"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amStephen Plymate (University of Washington)
"Androgen Receptor Splice Variants: A New Set of AR Co-Activators"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:15 pmAna Aparicio (MD Anderson)
"A Molecular Characterization of the Anaplastic Prostate Carcinomas"
12:15 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmHormone Action in Cancers Beyond Breast & Prostate
Discussion Leaders: Michael Shen (Columbia University) and Joyce Slingerland (University of Miami)
7:30 pm - 7:50 pmCheryl Walker (Texas A&M)
"Epigenetic 'Readers, Writers and Erasers' as Targets for Developmental (re)Programming of Tumor Suppressor Gene Penetrance"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJill Siegfried (University of Pittsburgh)
"Role of Estrogen Receptor in Growth of Lung Cancer"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmElahe Mostaghel (University of Washington)
"Does the Androgen Receptor Play a Role in Mantle Cell Lymphoma"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:10 pmXuesen Dong (University of British Columbia)
"Mechanisms of the androgen receptor splicing in prostate cancer cells"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmZhaoyu Li (Mayo Clinic)
"Estrogen action in liver cancer"
9:25 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHormones in Translation
Discussion Leaders: Theresa Hickey (University of Adelaide) and Robert Den (Thomas Jefferson University, Kimmel Cancer Center)
9:00 am - 9:25 amKeynote Speaker: Johann deBono (Royal Marsden Hospital)
"Prostate cancer: Just can't get enough (hormones)?"
9:25 am - 9:35 amDiscussion
9:35 am - 9:50 amTrevor Penning (University of Pennsylvania)
"Androgen biosynthetic enzymes in castrate resistant prostate cancer"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:50 amCliff Hudis (Memorial Sloan-Kettering)
"The role of the Androgen Receptor in Metastatic Breast Cancer"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amSteve Balk (Harvard Medical School)
"Androgen Receptor Function in Prostate Cancer Development and Progression"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amEvan Simpson (Prince Henry’s Institute of Australia)
"Obesity and breast cancer - role of aromatase"
11:45 am - 11:55 amDiscussion
11:55 am - 12:10 pmSteffi Oesterreich (University of Pittsburgh)
"Unique Estrogen Signaling in Lobular Breast Cancer: Translational Significance?"
12:10 pm - 12:20 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThe Future of Targeted Therapy
Discussion Leaders: Felix Feng (University of Michigan) and Leonie Young (Royal College of Surgeons Ireland)
7:30 pm - 7:50 pmGanesh Raj (University of Texas Southwestern)
"Targeting the functional social network of steroid receptors"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:15 pmJun Luo (Johns Hopkins University)
"Clinical relevance of AR splice variants"
8:15 pm - 8:25 pmDiscussion
8:25 pm - 8:40 pmFrank Claessens (Leuven University)
"Genetic variation in the androgen responsiveness of TMPRSS2/T2E fusion"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:10 pmRobert Clarke (Georgetown University)
"Application of Systems Biology to Explore Targeted Therapies for Endocrine Resistant Breast Cancers"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmFinal Wrap-up and Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13CA-177078-01A1 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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