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Conference Program
 
Inhibition in the CNS
June 16-21, 2013
Les Diablerets Conference Center
Les Diablerets, Switzerland

Related Meeting Information
The Inhibition in the CNS Gordon Research Conference was held in conjunction with the Inhibition in the CNS Gordon Research Seminar. Please refer to the Inhibition in the CNS GRS web page for more information.

An international meeting on ‘Inhibition in the CNS’ as part of the Gordon Research Conference series will be held in Les Diablerets, Switzerland, June 16-21, 2013. The long-term goal of the Conference is to increase our understanding of the fundamental mechanisms underlying inhibitory synaptic transmission and the roles of GABAergic interneurons in regulating excitability of neuronal networks. A significant emphasis will be placed on the molecular and functional diversity of GABA and glycine receptors, on the mechanisms and regulation of GABA release, on the functional diversity of GABAergic interneurons and the way they enable nerve cells and neuronal networks to perform complex computations.

The aim of the meeting is to bring together junior and senior neuroscientists working on inhibition and to provide a forum for new directions and ideas in many aspects of inhibition. The five-day conference will combine research lectures by leading neuroscientists from Europe, North America and Australia with poster sessions and ‘short talks’ intended to encourage lively discussions and the free exchange of information and ideas. The meeting will contain two keynote lectures and six sessions that address current hot issues in the neurobiology of inhibition. One session will focus on the structural and functional diversity of GABAA and glycine receptors. Two sessions will discuss recent findings regarding the mechanisms of GABA release and the function and regulation of receptors in inhibitory synapses. Latest results regarding the passive and active electrical properties of GABAergic interneurons and the way they integrate synaptic inputs will also be presented in a specific session. Since interneurons comprise a very special cell population within neuronal networks, one session will bring together leading experts to present their data on how interneurons contribute to the generation of dynamic network behaviors and another session will reveal their roles in behaving animals. Finally, many opportunities will be provided for students and young postdoctoral scientists to present their results in a ‘short talk’ session as well as four afternoon poster sessions.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmProperties of GABAA receptors
Discussion Leader: Linda Overstreet-Wadiche (University of Alabama at Birmingham)
7:40 pm - 8:30 pmKeynote Lecture: Neil Harrison (Columbia University)
"Familiar Receptors in Unexpected Places"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:20 pmIstvan Mody (University of California, Los Angeles)
"Small, but significant: the HCO3- permeability of GABAA receptors"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStructure and function of GABAA receptors
Discussion Leader: Istvan Mody (University of California, Los Angeles)
9:00 am - 9:25 amCynthia Czajkowski (University of Wisconsin)
"Structural mechanisms underlying pentameric ligand-gated ion channel activation and drug modulation"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amAndrea Barberis (Italian Institute of Technology)
"Post-synaptic plasticity at GABAergic synapses"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:05 amMatt Jones (University of Wisconsin)
"Multidirectional intersubunit communication in the GABAA receptor"
11:05 am - 11:15 amDiscussion
11:15 am - 11:40 amTim Hales (University of Dundee)
"A role for open and closed GABAA receptor conformational selection in gating"
11:40 am - 11:50 amDiscussion
11:50 am - 12:15 pmRaimund Dutzler (University of Zurich)
"Activation and inhibition of prokaryotic pentameric ligand-gated ion channels"
12:15 pm - 12:25 pmDiscussion
12:30 pmGroup Photo / Lunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmModulation of inhibitory synaptic transmission
Discussion Leader: Jean-Marc Fritschy (University of Zurich)
5:30 pm - 5:55 pmJaideep Bains (University of Calgary)
"Bidirectional plasticity at GABA synapses after stress"
5:55 pm - 6:05 pmDiscussion
6:05 pm - 6:30 pmSteve Mennerick (Washington University)
"Receptor and non-receptor components of neurosteroid modulation of GABA-A transmission"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:05 pmHenrique von Gersdorff (Vollum Institute)
"Modulation of inhibitory interneurons in the retina"
7:05 pm - 7:15 pmDiscussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmInhibitory synaptic transmission
Discussion Leader: Jean-Marc Fritschy (University of Zurich)
9:00 am - 9:25 amJohn Bekkers (Australian National University)
"Odor-evoked responses of identified interneurons in the piriform cortex in vivo"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amLynn Dobrunz (University of Alabama at Birmingham)
"Transcriptional dysregulation in parvalbumin interneurons alters the dynamics of the excitation-inhibition balance"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:05 amPeter Jonas (IST Austria)
"Fast axonal signaling in parvalbumin-expressing GABAergic interneurons of the hippocampus"
11:05 am - 11:15 amDiscussion
11:15 am - 11:40 amScott Owen (Gladstone Institute, UCSF)
"Feed-forward inhibition in the striatum: mechanisms, modulation, and function"
11:40 am - 11:50 amDiscussion
11:50 am - 12:15 pmLinda Overstreet-Wadiche (University of Alabama at Birmingham)
"Distinct mechanisms maintain sparse firing of mature and immature dentate granule cells"
12:15 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmIntrinsic properties of GABAergic interneurons
Discussion Leader: Chris McBain (NIH)
5:30 pm - 5:55 pmDavid DiGregorio (Pasteur Institute)
"Multiplexed dendritic computations by calcium and voltage in cerebellar interneurons"
5:55 pm - 6:05 pmDiscussion
6:05 pm - 6:30 pmAngus Silver (University College London)
"Synaptic integration in GABAergic Golgi cells and their impact on granule cells"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:05 pmWade Regehr (Harvard University)
"Long-term regulation of the excitability of cerebellar Golgi cells"
7:05 pm - 7:15 pmDiscussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmInterneurons in dynamic neuronal networks
Discussion Leader: Chris McBain (NIH)
9:00 am - 9:25 amPeter Somogyi (MRC Unit, Oxford)
"Network and behavioral state-dependent firing of hippocampal GABAergic neurons"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amAttila Losonczy (Columbia University)
"Functional subdivisions in the GABAergic septohippocampal pathway of behaving mice"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:05 amPankaj Sah (University of Queensland, Brisbane)
"Excitatory and inhibitory GABAergic circuits in the basolateral amgydala"
11:05 am - 11:15 amDiscussion
11:15 am - 11:40 amIvan Soltesz (University of California, Irvine)
"Cell-type specific regulation of interneuronal microcircuits"
11:40 am - 11:50 amDiscussion
11:50 am - 12:15 pmLiset Menéndez de la Prida (Instituto Cajal, Madrid)
"Inhibitory control of normal and pathological ripples in the hippocampus"
12:15 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmShort Talks
Discussion Leader: Renata Batista-Brito (Yale University)
5:30 pm - 5:45 pmStephan Ciocchi (Medical University Vienna)
"Behaviour-dependent information routing in ventral hippocampal CA1 projection neurons"
5:45 pm - 5:50 pmDiscussion
5:50 pm - 6:05 pmCatherine Christian (Stanford University School of Medicine)
"Astrocytes potentiate GABAergic transmission in the thalamic reticular nucleus via endozepine signaling"
6:05 pm - 6:10 pmDiscussion
6:10 pm - 6:25 pmJulian Ammer (Ludwig-Maximilians-Universität München)
"Activity-dependent inhibition gates information in an echo suppression circuit"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 7:30 pmTBA (selected from GRS presenters)
7:30 pm - 8:00 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe role of inhibition in behavior
Discussion Leader: Tamas Freund (Inst. of Experimental Medicine, Budapest)
9:00 am - 9:25 amGilles Laurent (Max Planck Institute, Frankfurt)
"All-to-all feedback and optimization of sparse codes"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amAndreas Luthi (FMI, Basel)
"Inhibition in neuronal circuits of fear and anxiety"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:05 amJessica Cardin (Yale University)
"State-dependent recruitment and impact of cortical inhibition"
11:05 am - 11:15 amDiscussion
11:15 am - 11:40 amHuibert Mansvelder (University of Amsterdam)
"Experience-dependent adaptation of inhibition in prefrontal cortical circuits"
11:40 am - 11:50 amDiscussion
11:50 am - 12:15 pmMassimo Scanziani (University of California, San Diego)
"Cortical inhibitory circuits and visual processing"
12:15 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmTonic and phasic inhibition in the CNS
Discussion Leader: Zoltan Nusser (Inst. of Experimental Medicine, Budapest)
5:30 pm - 6:20 pmKeynote Lecture: Mark Farrant (University College London)
"'Tonic inhibition' - what, where and when?"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 7:10 pmChris McBain (NIH)
"Development and Maturation of Feed-forward Inhibition"
7:10 pm - 7:30 pmDiscussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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