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Conference Program
 
Insulin-Like Growth Factors in Physiology & Disease
(This meeting is currently known as "IGF & Insulin System in Physiology & Disease")
March 17-22, 2013
Ventura Beach Marriott
Ventura, CA
Chair:
Robert J. Smith

Vice Chair:
Briony E. Forbes

The 2013 Gordon Conference on Insulin like Growth Factors (IGFs) in Physiology and Disease will present cutting-edge research on the role of IGFs and their signaling pathways in development, maintenance of life and in major diseases. IGFs have essential functions in promoting normal growth as well as cell survival and tissue repair. IGFs and their signaling pathways are also implicated in cancer progression, neurodegeneration, and ageing, and are therefore being actively explored as points of therapeutic intervention for these conditions. This Conference will cover the physiological and molecular aspects of IGF ligands, receptors, binding proteins and signaling pathways in somatic cell growth, stem cells, differentiation, cancer progression, neurogenesis and neurodegeneration, stress and ageing. The goal of the Conference is to bring together investigators who are at the forefront of their field to discuss the key aspects of IGF function in different tissues and diseases. It will provide opportunities for junior scientists and graduate students to present their work and exchange ideas with leaders in the field. Abstracts will be selected for presentation as short talks. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings will provide an avenue for scientists from different disciplines to brainstorm and promote collaborations ultimately aimed at understanding and potentially manipulating IGF functions to enhance normal tissue function or to suppress disease progression.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:10 pmKeynote Lecture
Discussion Leader: Briony Forbes (University of Adelaide)
7:40 pm - 8:40 pmLinda Partridge (Max Planck Institute for Biology of Aging and University College London)
"Nutrient Sensing Pathways and Aging"
8:40 pm - 9:10 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIGF Signaling and Functions in Cell Renewal and Proliferation
Discussion Leader: Marc Tatar (Brown University)
9:00 am - 9:25 amLeanne Jones (Salk Institute for Biological Studies)
"Regulation of Stem Cell Behavior and Homeostasis by InR Signaling in Drosophila"
9:25 am - 9:40 amDiscussion
9:40 am - 9:55 amDoaa Aboalola (Western Ontario University)
"The Role of Insulin-Like Growth Factor Binding Protein-6 in the Differentiation of Placental Mesenchymal Stem Cells into Skeletal Muscle"
9:55 am - 10:00 amDiscussion
10:00 amGroup Photo / Coffee Break
10:30 am - 10:55 amPierre De Meyts (Hagedorn Research Institute)
"Cell Cycle Regulation by IGF-I, Insulin, and Insulin Analogues"
10:55 am - 11:10 amDiscussion
11:10 am - 11:30 amCunming Duan (University of Michigan)
"TRP Channel-Dependent Activation of IGF1R-PI3K-Akt Signaling Regulates Calcium Deficiency-Induced Epithelial Growth"
11:30 am - 11:40 amDiscussion
11:40 am - 11:55 amAmy Lyons (University College Cork)
"IGF-1R Signaling is Essential for Mitochondrial Maintenance and Function"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmAntonino Belfiore (University of Catanzaro)
"Functional Interaction Between Discoidin Domain Receptor 1 and Insulin Receptor Isoform A"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmSignaling Pathways and Regulation
Discussion Leader: Rosemary O'Connor (University College Cork)
7:30 pm - 7:55 pmDavid Clemmons (University of North Carolina)
"Metabolic Actions of IGF-I"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmLeonard Girnita (Karolinska Institute)
"Biasing IGF-I Receptor Signaling Through G-Protein Coupled Receptors"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmJohn Menting (Walter and Eliza Hall Institute)
"Insulin and IGF1 Signaling - The Structural Details of Ligand Binding to Site 1"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmJiri Jiracek (Institute of Organic Chemistry and Biochemistry, Czech Republic)
"Recent Advances in Insulin Structural Research and Plans for the Expansion to the Field of IGF-1 and 2"
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIGFs in Growth, Regeneration, and Aging Processes
Discussion Leader: Pinchas Cohen (UC Davis)
9:00 am - 9:25 amPatrice Delafontaine (Tulane University School of Medicine)
"Aging, Atherosclerosis, and IGF-I"
9:25 am - 9:40 amDiscussion
9:40 am - 9:55 amChristian Sell (Drexel University College of Medicine)
"A Global Reduction in Mammalian IGF-1 Levels Does Not Produce a Consistent Increase in Lifespan"
9:55 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:55 amCarien Niessen (University of Cologne)
"Insulin/IGF-I Mediated Regulation of Skin Morphogenesis, Homeostasis, and Regeneration"
10:55 am - 11:10 amDiscussion
11:10 am - 11:30 amGang Xi (University of North Carolina)
"Plasma Membrane Localized Nox4-Derived ROS Alters IGF-I-Stimulated Src Activation and Biological Actions"
11:30 am - 11:40 amDiscussion
11:40 am - 11:55 amMara Fornaro (Novartis Institutes for Biomedical Research)
"E-Peptides Derived from an Isoform of IGF-1 Have No Apparent Effect on Muscle Cell Growth"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmZee Upton (Queensland University)
"Effectiveness of an Acellular Synthetic Vitronectin: IGF-I Matrix in the Treatment of Hard-to-Heal Leg Ulcers"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmIGF Binding Proteins
Discussion Leader: Cheryl Conover (Mayo Clinic)
7:30 pm - 7:55 pmDavid Flint (University of Strathclyde)
"IGFBP-5 Enhances the Host Response to Tumors to Limit Metastatic Potential"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmSue Firth (Kolling Institute of Medical Research)
"IGFBP-3 and Cancer Cell Survival"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmAllyson Agostini-Dreyer (Rutgers University)
"Nuclear Localization of IGFBP-3 in Response to Intrinsic Apoptotic Stress"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmClaus Oxvig (Aarhus University)
"Pregnancy-Associated Plasma Protein-A (PAPP-A) Modulates Early Developmental Rate in Zebrafish Independent of Its Proteolytic Activity"
9:25 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGenetics and Epigenetics
Discussion Leader: Ron Rosenfeld (Stat 5 Consulting)
9:00 am - 9:25 amJan-Maarten Wit (Leiden University Medical Center)
"Genetic Causes of IGF-I Deficiency and Insensitivity"
9:25 am - 9:40 amDiscussion
9:40 am - 9:55 amMarc Becker (Mayo Clinic)
"IGF-2 is Overexpressed in Bowel Metastases of Primary Patient Ovarian Cancer Tumorgrafts"
9:55 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:55 amHaim Werner (Sackler School of Medicine, Tel Aviv University)
"Transcriptional and Epigenetic Control of IGF-I Receptor Action: Implications in Metabolism and Cancer"
10:55 am - 11:10 amDiscussion
11:10 am - 11:25 amAnyonya Guntur (Maine Medical Center)
"Impaired Oxygen Consumption in Osteoblasts Leads to Reduced Bone Formation and Low Bone Mass in IRS1 Mutant Mice"
11:25 am - 11:35 amDiscussion
11:35 am - 11:50 amVinodh Kumar Radhakrishnan (Loma Linda University)
"Differential Mechanisms in the Regulation of IGF-II Expression in Breast Cancer"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmMichal Marzec (Children's Hospital of Philadelphia)
"Modulation of Maturation and Secretion of IGF-1 and -2 by Genetic Variants of Glucose Regulated Protein 94 Found in Human Populations"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmIGF Mechanisms and Functions in Specific Target Tissues
Discussion Leader: Shoshana Yakar (New York University College of Dentistry)
7:30 pm - 7:55 pmElizabeth Barton (University of Pennsylvania)
"IGF Anabolic Actions in Skeletal Muscle"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmKeith Baar (UC Davis)
"IGF-I and Other Growth Factors in Engineered Human Ligaments"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmSara Harstad (Mayo Clinic)
"Preferential Impact of Pregnancy-Associated Plasma Protein-A Deficiency on Visceral Fat"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmVictoria DeMambro (Maine Medical Center)
"IGFBP-2 and Estrogen as Co-regulators of Body Composition and Energy Expenditure"
9:25 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIGFs in Neuronal Growth, Survival, and Function
Discussion Leader: Terri Wood (New Jersey Medical School)
9:00 am - 9:25 amIgnacio Torres Aleman (Cajal Institute)
"The Puzzle of IGF-I Signaling in the Brain: Antagonism and Cooperativity Among Insulin Family Members"
9:25 am - 9:40 amDiscussion
9:40 am - 9:55 amDerek Huffman (Albert Einstein College of Medicine)
"Central Insulin and IGF-1 Signaling in the Regulation of Peripheral Metabolism with Aging"
9:55 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:55 amAdrian Krainer (Cold Spring Harbor Laboratory)
"Circulating IGF-I Deficiency in Spinal Muscular Atrophy"
10:55 am - 11:10 amDiscussion
11:10 am - 11:30 amFriedrich Metzger (F. Hoffmann-La Roche)
"PEGylated Insulin-like Growth Factor I Treatment Efficacy in Rodent Models of Neuromuscular Disorders Depends on Age and Disease Severity"
11:30 am - 11:40 amDiscussion
11:40 am - 11:55 amIsabel Varela-Nieto (CSIC-UAM, Spain)
"Insulin-like Growth Factor I Deficiency and Hearing Loss in Mice: Molecular Clues and Clinical Implications"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmSteven Levison (UMDNJ-NJMS)
"IGF-II Is Required to Maintain Neural Stem Cells Across the Lifespan"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmIGFs in Cancer
Discussion Leader: Derek LeRoith (Mt. Sinai School of Medicine)
7:30 pm - 7:55 pmMichael Pollak (McGill University)
"How Anti-Ligand Antibodies Differ from Anti-Receptor Antibodies as Drug Candidates"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmStephen Hursting (M.D. Anderson and University of Texas at Austin)
"Energy Balance, Metabolism, and Cancer: The Role of IGF-I Signaling"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmMarina Guvakova (University of Pennsylvania)
"The Onset of Carcinoma Cell Motility by IGF-I Requires IGF-IR-Mediated Endocytosis and the Transient Activation of the Small GTPase Rap1"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmRoberta Malaguarnera (University of Magna Graecia)
"Metformin Inhibits the Androgen Mediated Up-Regulation of Insulin-like Growth Factor-I Receptor Through Multiple Mechanisms"
9:25 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible, in part by (R13AG033456) from the National Institute on Aging. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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