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Lipids, Molecular & Cellular Biology of
Gordon Research Conference

Dates

July 21-26, 2013

Location

Waterville Valley
Waterville Valley, NH

Organizers

Chair:
Rosalind A. Coleman

Vice Chair:
Suzanne Jackowski

Meeting Description

The Gordon Research Conference on Molecular and Cellular Biology of Lipids brings together outstanding scientists in the field to present and discuss their research on lipid metabolism, emphasizing the roles of lipids in health and disease at the molecular, cellular, and organismal levels. The 2013 meeting will be held from July 21-26 at the Waterville Valley Resort in Waterville Valley, New Hampshire. First organized in 1955, the Molecular and Cellular Biology of Lipids conference is among the oldest continuous Gordon Conference meetings. The 2013 meeting will include nine lecture sessions and four afternoon poster sessions that cover a broad range of topics, including lipid signals that regulate cell metabolism, new roles for lipases and acyltransferases in obesity, atherosclerosis and inflammation, membrane biogenesis and turnover, cellular lipid metabolism, fatty acid uptake and metabolism, transcriptional control of lipids, novel roles for phosphatidic acid, and genetic regulation of lipid enzymes by miRNAs. Over 35 speakers will highlight lipid biochemistry and metabolism in a variety of organisms, including yeast, bacterial pathogens, viruses, and mammals. Several speakers will be chosen based on submitted abstracts. The invited speakers will represent both well-established senior investigators and energetic junior investigators who are pioneering new approaches, thereby generating an atmosphere guaranteed to stimulate lively discussions. The biochemists, structural biologists, cell biologists, physiologists, nutrition scientists, and geneticists who attend this conference will derive synergistic benefit from the high quality of the speakers, the diverse experimental expertise of the participants, the abundant opportunities for interactions, and the resplendent natural surroundings of the White Mountain National Forest. Because lipid metabolism is fundamental to normal growth and development, to cellular responses to external stimuli, and to disorders related to obesity, atherosclerosis, aging, inflammation, and the metabolic syndrome, basic research in this field has a far ranging impact with profound consequences for many other fields.

Contributors

Meeting Program

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Lectures: Lipids from Membranes to Metabolic Disease
Discussion Leader: Rosalind Coleman (University of North Carolina, Chapel Hill, NC)
7:40 pm - 8:25 pmJames Rothman (Yale University, New Haven, CT)
"The molecular mechanism of membrane fusion and Its cellular regulation"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 9:20 pmHenry Ginsberg (Columbia University, NYC, NY)
"There are many ways to get a fatty liver, or not"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLipid Signals that Regulate Cell Metabolism
Discussion Leader: David Bernlohr (University of Minnesota)
9:00 am - 9:30 amDagmar Kratky (Medical University of Graz, Austria)
"C16 ceramide triggers apoptosis in adipose triglyceride lipase-deficient macrophages"
9:30 am - 9:35 amDiscussion
9:35 am - 10:05 amJames Ntambi (University of Wisconsin, Madison, WI)
"Hepatic de novo lipogenesis and regulation of metabolism"
10:05 am - 10:10 amDiscussion
10:10 am - 10:45 amGroup Photo / Coffee Break
10:45 am - 11:15 amJennifer Watts (Washington State University)
"Physiological roles of dietary and endogenously synthesized PUFAs in C. elegans"
11:15 am - 11:20 amDiscussion
11:20 am - 11:35 amJ. Kalervo Hiltunen (University of Oulu, Finland)
"Mitochondrial fatty acid synthesis - lipoic acid or more?"
11:35 am - 11:40 amDiscussion
11:40 am - 12:20 pmRichard Gross (Washington University, St. Louis, MO)
"Pleiotropic roles of the patatin-like family of phospholipases in cellular signaling and bioenergetics revealed through lipidomics"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNew Roles for Lipases and Acyltransferases
Discussion Leader: Hei Sook Sul (University of California-Berkeley)
7:30 pm - 8:00 pmJudy Storch (Rutgers University, New Brunswick, NJ)
"Monoacylglycerol lipase and the regulation of body weight and obesity"
8:00 pm - 8:05 pmDiscussion
8:05 pm - 8:35 pmRichard Lehner (University of Alberta, Edmonton, Canada)
"Hepatic triacylglycerol lipases and lipoprotein metabolism"
8:35 pm - 8:40 pmDiscussion
8:40 pm - 8:55 pmSaskia Neher (University of North Carolina - Chapel Hill)
"Mechanistic insights into lipoprotein lipase regulation"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:25 pmDaniel Nomura (University of California-Berkeley)
"Mapping Dysregulated Lipid Signaling Pathways in Disease using Functional Metabolomics"
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMembrane Lipids, Biogenesis and Turnover
Discussion Leader: Daniel Raben (Johns Hopkins University, Baltimore, MD)
9:00 am - 9:30 amMelanie Ott (University of California-San Francisco)
"Lipid droplets and hepatitis C virus infection"
9:30 am - 9:35 amDiscussion
9:35 am - 10:05 amRussell DeBose-Boyd (University of Texas-Southwestern, Dallas, TX)
"Regulation of HMG CoA reductase degradation in the liver"
10:05 am - 10:10 amDiscussion
10:10 am - 10:25 amNils Faergeman (University of Southern Denmark, Denmark)
"Impaired epidermal barrier function compromises SREBP-mediated lipogenic gene expression in liver"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amTim Osborne (Sanford-Burnham Medical Research Institute, Orlando, FL)
"New roles and regulation for SREBPs in mammalian metabolism"
11:30 am - 11:35 amDiscussion
11:35 am - 12:05 pmTodd Graham (Vanderbilt University, Nashville, TN)
"The Flip Side of Membrane Biogenesis: Creating Asymmetry with P4-ATPases"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmAnn Wehman (Rudolf-Virchow-Zentrum, University of Würzburg, Germany)
"The lipid flippase TAT-5 prevents the budding of extracellular vesicles"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCellular Lipid Metabolism
Discussion Leader: Clay Semenkovich (Washington University, St. Louis, MO)
7:30 pm - 8:00 pmTobias Walther (Yale University, New Haven, CT)
"Cell biology of lipid droplet formation and growth"
8:00 pm - 8:05 pmDiscussion
8:05 pm - 8:35 pmHiroyuki Arai (University of Tokyo, Japan)
"A new role for glycerol-3-phosphate acyltransferase in mitochondrial fusion"
8:35 pm - 8:40 pmDiscussion
8:40 pm - 8:55 pmHongying (Hoy) Shen (Yale University, New Haven, CT)
"Sphingosine kinase 1 in endocytic membrane trafficking"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:25 pmSarah Spiegel (Virginia Commonwealth University, Richmond, VA)
"Role of sphingosine-1-phosphate in signaling and metabolism"
9:25 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFatty Acid Metabolism
Discussion Leader: James Ntambi (University of Wisconsin, Madison, WI)
Introduction: Teresa Garrett (Vassar College, Poughkeepsie, NY)
9:00 am - 9:35 amChuck Rock (St. Jude Children's Research Hospital, Memphis, TN)
"Lipid Metabolism in Bacterial Pathogens: Unique biochemistry and therapeutic opportunities"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amJessica Ellis (Johns Hopkins University, Baltimore, MD)
"Acot7 protects neurons from excess fatty acid metabolism and neurodegeneration"
9:55 am - 10:00 amDiscussion
10:00 am - 10:25 amCoffee Break
10:25 am - 10:55 amNada Abumrad (Washington University, St. Louis, MO)
"Fatty acid uptake, lipid remodeling and cardiac adaptation"
10:55 am - 11:00 amDiscussion
11:00 am - 11:30 amValerie O'Donnell (Cardiff University, UK)
"Oxidized phospholipids enzymatically generated by human innate immune cells"
11:30 am - 11:35 amDiscussion
11:35 am - 12:05 pmDavid E. Cohen (Harvard Medical School, Boston, MA)
"Acyl-CoA thioesterase-mediated control of lipid and glucose metabolism"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmMatthew Watt (Monash University, Melbourne, Australia)
"Perilipin 5 deficiency in mice alters metabolism and causes skeletal muscle insulin resistance"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTranscriptional Control Of Lipids
Discussion Leader: Steve Farber (Carnegie Institute, Baltimore, MD)
7:30 pm - 8:00 pmDouglas Mashek (University of Minnesota, St. Paul, MN)
"Lipolysis as an important mediator of hepatic energy metabolism"
8:00 pm - 8:05 pmDiscussion
8:05 pm - 8:35 pmAmy Walker (University of Massachusetts, Worcester, MA)
"Lipolysis as an important mediator of hepatic energy metabolism"
8:35 pm - 8:40 pmDiscussion
8:40 pm - 8:55 pmPeter Espenshade (Johns Hopkins University, Baltimore, MD)
"Transcriptional Regulation of Sterol Homeostasis in Fungi"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:25 pmVikas Chandra (Sanford-Burnham Medical Research Institute, Orlando, FL)
"Structural-functional studies of nuclear receptors as drug targets"
9:25 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
9:00 am - 12:30 pmSpotlight On Phosphatidate
Discussion Leader: Miriam Greenberg (Wayne State University, Detroit, MI)
9:00 am - 9:30 amGeorge Carman (Rutgers University, New Brunswick, NJ)
"Regulation of phosphatidate phosphatase and Its impact on lipid metabolism"
9:30 am - 9:35 amDiscussion
9:35 am - 10:05 amBrian Finck (Washington University, St. Louis, MO)
"Lipin 1 modulates cAMP-mediated signaling by regulating cellular phosphatidic acid concentrations"
10:05 am - 10:10 amDiscussion
10:10 am - 10:25 amGregory Fairn (St. Michael's Hospital, University of Toronto, Canada)
"Phosphatidic Acid produced by diacylglycerol kinases is required for constitutive ruffling, macropinocytosis and its synthesis attenuates superoxide production in phagocytes"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amHongyuan Rob Yang (University of New South Wales, Sidney, Australia)
"Seipin, phosphatidic acid and 'supersized' lipid droplets"
11:30 am - 11:35 amDiscussion
11:35 am - 12:05 pmSusan Henry (Cornell University, Ithaca, NY)
"Regulatory mechanisms controlling channeling of phosphatidic acid into phospholipids vs. triacylglycerol during active growth in yeast"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmShirin Bahmanyar (Ludwig Institute for Cancer Research, University of California-San Diego, CA)
"Spatial regulation of phospholipid flux by the lipin activation pathway controls mitotic reorganization of the nuclear envelope"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGenetic Regulation Of Lipids
Discussion Leader: Carol Sztalryd (University of Maryland, Baltimore MD)
7:30 pm - 8:00 pmKathryn J. Moore (NYU Medical Center, NYC, NY)
"MicroRNA regulation of lipid metabolism"
8:00 pm - 8:05 pmDiscussion
8:05 pm - 8:35 pmKasey Vickers (NHLBI, NIH)
"Lipid-based carriers of extracellular microRNAs in intercellular communication"
8:35 pm - 8:40 pmDiscussion
8:40 pm - 8:55 pmEyleen O'Rourke (Harvard Medical School, Boston, MA)
"MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:25 pmDaniel Raben (Johns Hopkins University, Baltimore, MD)
"DGKθ and endocytosis"
9:25 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1 R13 DK 98861 - 01 from NIDDK and NIGMS. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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