Gordon Research Conferences
PI_Conferences PI_Conferences_Past
Conference Program
 
Malaria
Molecular and Cell Biology of Malaria
August 4-9, 2013
Renaissance Tuscany Il Ciocco Resort
Lucca (Barga), Italy
Chair:
Brendan Crabb

Vice Chair:
Robert Sauerwein

Related Meeting Information
The Malaria Gordon Research Conference was held in conjunction with the Malaria Gordon-Kenan Research Seminar. Please refer to the Malaria GKRS web page for more information.

The 2013 Malaria Gordon Research Conference in Tuscany, Italy will bring together leading international scientists from diverse disciplines to focus on the "Molecular and Cell Biology of Malaria". The Conference will present the most recent advances on the molecular and cellular aspects of the malaria parasite’s basic biology, immunology, host-parasite-vector interactions and pathogenic mechanisms. The meeting will provide a stimulating forum to discuss cutting edge fundamental and applied research on malaria, with an emphasis on programs that contribute to the development of vaccines and drugs.

This Malaria GRC is designed to be a highly interactive meeting that will provide a comprehensive overview of modern molecular malaria research. Invited speakers will be strongly encouraged to present unpublished results and will represent a variety of scientific disciplines, including biochemistry, medicinal chemistry, vaccine research, molecular genetics, structural, cell and systems biology. The format of the meeting will include extensive discussions after each presentation to be led by investigators who are at the forefront of their field. Most recent scientific advances will also be featured through the use of poster sessions and talks selected from submitted abstracts. The Conference will make special efforts to encourage participation by researchers from malaria endemic countries. This meeting offers an excellent opportunity to keep abreast of the most recent developments in both basic and applied research on malaria, and the potential for novel innovations to combat this disease worldwide.

It will provide an unique forum for talented early career researchers (graduate students and post-docs) to present and exchange new data and cutting edge ideas to foster wide ranging collaborations.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmDrugs and Drug Resistance
Discussion Leader: Xin-zhuan Su (NIH)
7:40 pm - 8:10 pmTim Anderson (Texas Biomedical Research Institute
"Malaria genomics in a public health crisis"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:40 pmElizabeth Winzeler (University of California)
"Using genomics to discover chemically-validated targets for an eradication agenda"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmGrazia Camarda (Istituto Superiore Di Sanita)
"Development of a Plasmodium falciparum in vitro screening assay for gametocytocidal compounds"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmPradip Rathod (University Of Washington)
"Parasite mutagenesis pathways that can challenge malaria eradication strategies"
9:25 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmVirulence Mechanisms
9:00 am - 9:10 amDiscussion Leader: Alexandra Rowe (University of Edinburgh)
9:10 am - 9:40 amKevin Kain (University of Toronto)
"Endothelial-pathogen interactions at the interface of severe malaria"
9:40 am - 9:50 amDiscussion
9:50 am - 10:10 amHernando del Portillo (CRESIB)
"Role of reticulocyte-derived exosomes in Plasmodium vivax malaria"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amGroup Photo / Coffee Break
10:50 am - 11:05 amSue Pierce (NIH, NIAID)
"Tipping the scale in severe malaria: the interplay of host genes and the environment in mouse models"
11:05 am - 11:10 amDiscussion
11:10 am - 11:25 amLars Hviid (University of Copenhagen)
"The role of non-specific IgM binding in PfEMP1-mediating resetting"
11:25 am - 11:30 amDiscussion
11:30 am - 11:45 amMichelle Wykes (Queensland Institute of Medical Research)
"Restoration of protection against malaria in mice without PD-1"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmSarah Hochman (Albert Einstein College Of Medicine)
"Fatal Pediatric Cerebral Malaria Pathology Reveals Intravascular Inflammation and Coagulation that is Exacerbated by HIV-1 Co-infection"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmIoannis Vakonakis (University Of Oxford)
"A molecular model of knob and PfEMP1 localization on the erythrocyte surface"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmMosquito Stages
5:30 pm - 5:40 pmDiscussion Leader: Marcelo Jacobs-Lorena (John Hopkins Bloomberg School of Health)
5:40 pm - 6:10 pmCarolina Barillas-Mury (NIAID)
"Malaria Transmission: a tale of mosquito immune activation and Plasmodium immune evasion"
6:10 pm - 6:20 pmDiscussion
6:20 pm - 6:40 pmGeorge Dimopoulos (Johns Hopkins Bloomberg School of Public Health)
"Exploiting transmission bottlenecks in the mosquito vector"
6:40 pm - 6:50 pmDiscussion
6:50 pm - 7:20 pmOliver Billker (Wellcome Trust Sanger Institute)
"Regulation of sexual development through signal transduction and transcription"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHost Cell Invasion
9:00 am - 9:10 amDiscussion Leader: Louis H. Miller (NIAID)
9:10 am - 9:40 amChetan Chitnis (ICGEB)
"Signaling pathways for regulation of microneme release during erythrocyte invasion by malaria parasites"
9:40 am - 9:50 amDiscussion
9:50 am - 10:10 amJulian Rayner (Wellcome Trust Sanger Institute)
"Receptor-ligand interactions during Plasmodium falciparum erythrocyte invasion"
10:10 am - 10:20 amDiscussion
10:20 amCoffee Break
10:50 am - 11:10 amPaul Gilson (Burnet Institute)
"A hierarchy of receptor-ligand interactions in malaria parasite invasion and their association with deformation, calcium influx and dehydration of host erythrocytes"
11:10 am - 11:20 amDiscussion
11:20 am - 11:40 amMike Blackman (National Institute for Medical Research)
"Advances in understanding of malaria parasite egress from its host cell"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmBruce Russell (Vivax Malaria Laboratory)
"Vivax Invasion and Development in Human Reticulocytes"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmMartin Boulanger (University of Victoria)
"Structural and biochemical characterization of Plasmodium falciparum 12 (Pf12) reveals a unique inter-domain organization and the potential for an antiparallel arrangement with Pf41"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmLiver Stage
5:30 pm - 5:40 pmDiscussion Leader: Maria Mota (University of Lisbon)
5:40 pm - 6:10 pmPhotini Sinnis (Johns Hopkins Bloomberg School of Public Health)
"Late liver stages: a role for falcipain-1 in hepatic merozoite infectivity"
6:10 pm - 6:20 pmDiscussion
6:20 pm - 6:40 pmSangeeta Bhatia (Massachusetts Institute of Technology)
"Hepatic Tissue Engineering for Modeling Liver Stage Malaria"
6:40 pm - 6:50 pmDiscussion
6:50 pm - 7:05 pmStefan Kappe (Seattle BioMed)
"Plasmodium vivax infection in mice with humanized livers"
7:05 pm - 7:10 pmDiscussion
7:10 pm - 7:25 pmMiles Davenport (UNSW, Centre For Vascular Research)
"Does blood stage P. falciparum suppress liver stage infection?"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmWhole Genome Analyses
9:00 am - 9:10 amDiscussion Leader: Jane Carlton (New York University)
9:10 am - 9:40 amDyann Wirth (Harvard School of Public Health)
"Harnessing genomics and genome biology to understand malaria biology"
9:40 am - 9:50 amDiscussion
9:50 amCoffee Break
10:30 am - 11:00 amDominic Kwiatkowksi (Wellcome Trust Sanger Institute)
"Watching the parasite genome evolve and trying to do something about it"
11:00 am - 11:10 amDiscussion
11:10 am - 11:25 amZybnek Bozdek (Nanynag Technological University)
"Transcriptome analyses of artemisinin resistant malaria emerging in the Greater Mekong Region"
11:25 am - 11:30 amDiscussion
11:30 am - 11:45 amKarine Le Roch (University of California)
"The spatial organization of the Plasmodium genome throughout its infectious cycle"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmLia Chappell (Wellcome Trust Sanger Institute)
"Directional, amplification-free RNA-seq of a Plasmodium knowlesi in vivo time course"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmHeather Painter (Lewis-Sigler Institute)
"Real-time Global Transcriptional Dynamics of Plasmodium falciparum Throughout Intraerythrocytic Development"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmImmunity
5:30 pm - 5:40 pmDiscussion Leader: Jean Langhorne (MRC National Institute for Medical Research)
5:40 pm - 6:00 pmKevin Marsh (Nuffield Dept of Clinical Medicine)
"Naturally acquired immunity to malaria in endemic populations"
6:00 pm - 6:10 pmDiscussion
6:10 pm - 6:30 pmEleanor Riley (LSHTM)
"Generation and maintenance of humoral immunity to malaria"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:00 pmBill Heath (University of Melbourne)
"Antigen presentation and development of T cell memory in murine malaria"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:25 pmChristian Engwerda (Queensland Institute of Medical Research)
"The regulation of CD4+ T cell responses during malaria"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
9:00 am - 12:30 pmMalaria Vaccine Development
9:00 am - 9:10 amDiscussion Leader: Robert Sauerwein (Radboud University Nijmegen Medical Centre)
9:10 am - 9:40 amMarcel Tanner (Swiss Tropical Institute)
"Status of RTS,S as malaria vaccine"
9:40 am - 9:50 amDiscussion
9:50 am - 10:05 amSimon Draper (University of Oxford)
"Malaria Vaccine Development against the Blood-Stage"
10:05 am - 10:10 amDiscussion
10:10 amCoffee Break
10:40 am - 11:00 amAnja Scholzen (Radboud University Nijmegen Medical Centre)
"Immune signatures induced by Chloroquine Prophylaxis and Sporozoite immunization in human volunteers"
11:00 am - 11:10 amDiscussion
11:10 am - 11:30 amMichael Good (Griffith University)
"Strategies for developing and testing chemically attenuated blood stage parasites as vaccines"
11:30 am - 11:40 amDiscussion
11:40 am - 12:00 pmToshihiro Horii (Osaka University)
"Phase 1b Randomized Trial and Follow-Up Study in Uganda of the Blood-Stage Malaria Vaccine Candidate BK-SE36"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmMary Galinski (Emory University)
"Malaria Host-Pathogen Interaction Center - MaHPIC"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmPhysiology and Biochemistry of Malaria
5:30 pm - 5:40 pmDiscussion Leader: Daniel Goldberg (Howard Hughes Medical Institute)
5:40 pm - 6:10 pmAndy Waters (University of Glasgow)
"Inducible, iterative and rapid protein inactivation in Plasmodium"
6:10 pm - 6:20 pmDiscussion
6:20 pm - 6:40 pmSylke Muller (University of Glasgow)
"Plasmodium falciparum phosphoenolpyruvate carboxylase identified as a key enzyme in redox maintenance and energy generation"
6:40 pm - 6:50 pmDiscussion
6:50 pm - 7:05 pmSujaan Das (MRC National Institute For Medical)
"Functional analysis of Plasmodium falciparum merozoite surface protein 1"
7:05 pm - 7:10 pmDiscussion
7:10 pm - 7:25 pmAndrew Tobin (University of Leicester)
"Progress towards targeting the malaria kinome"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
© 2014 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter