Gordon Research Conferences
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Conference Program
 
Mammalian DNA Repair
February 10-15, 2013
Four Points Sheraton / Holiday Inn Express
Ventura, CA
Chair:
Tanya T. Paull

Vice Chair:
Orlando D. Scharer

Related Meeting Information
The Mammalian DNA Repair Gordon Research Conference was held in conjunction with the Mammalian DNA Repair Gordon-Merck Research Seminar. Please refer to the Mammalian DNA Repair GMRS web page for more information.

The Mammalian DNA Repair Gordon Research Conference has met biannually since 1986. Unlike much larger conferences in this rapidly expanding field that meet less frequently, the Mammalian DNA Repair GRC does not attempt to be comprehensive in its coverage of the multiplicity of DNA repair processes and their biological importance, but rather seeks to highlight recent major advances in selected key areas. As evidenced by a number of rare human genetic diseases involving DNA repair defects, and by an ever expanding number of mouse models, DNA repair processes are now known to be critical for maintaining genetic integrity and stable genomic function in the face of abundant DNA damage. Such DNA damage is endogenously generated, and in addition is induced by environmental and clinical exposures to genotoxic agents. A number of recent research advances place DNA repair squarely at the crossroads of cancer, neurodegeneration and aging, and mechanistic understanding of key processes is progressing rapidly. The 2013 conference will emphasize the following topics: mechanisms of DNA repair (including double-strand breaks, base lesions, mismatches, and breaks incurred during replication); DNA damage signaling; roles of DNA repair proteins in cancer predisposition, neurodegeneration, and aging. Major emphasis is given to the importance of post-translational modifications and dynamic multi-protein interactions as regulatory mechanisms in all these areas.

Presentation of unpublished results will be strongly emphasized in instructions to all speakers, and interactive discussions involving all conferees will be actively encouraged. Broad participation will be facilitated through the selection of short talks from submitted abstracts, including those from postdocs and graduate students. This conference has frequently been over-subscribed in the past, so early application with submission of abstracts is strongly encouraged to aid in selection of conference participants and short platform talks.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Lectures
Discussion Leader: Tanya Paull (Univ. Texas at Austin)
7:40 pm - 8:20 pmWilliam Bonner (NIH)
"H2AX and Genome Stability"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmJan Hoejmakers (Erasmus Univ.)
"The impact of genome stability on health and disease"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmMechanisms of Excision Repair
Discussion Leader: Orlando Scharer (SUNY Stony Brook)
9:00 am - 9:20 amSam Wilson (NIEHS)
"Enzymology of mammalian base excision repair"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amOrlando Scharer (SUNY Stony Brook)
"Channeling ERCC1-XPF into nucleotide excision repair and interstrand crosslink repair"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:45 am - 11:05 amKiyoji Tanaka (Osaka Univ.)
"Non-canonical function of the nucleotide excision repair factor: Implication for XP/CS"
11:05 am - 11:15 amDiscussion
11:15 am - 11:35 amIvan Ahel (Univ. Manchester)
"Structure and catalytic mechanism of poly(ADP-ribose) glycohydrolases"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amJia Guo (Stanford)
"Comet-FISH reveals transcription-coupled repair of 8-oxoGuanine"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmPriscilla Cooper (LBNL)
"XPG Partners with BRCA2 to Promote Homologous Recombination and Maintain Genome Stability"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmMatthew Schellenberg (NIEHS)
"Mechanism of repair of 5'-topoisomerase II-DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session A (Even Numbers)
6:00 pmDinner
7:30 pm - 9:30 pmThe Molecular Dynamics of Mismatch Repair
Discussion Leader: Wei Yang (NIH)
7:30 pm - 7:50 pmLorena Beese (Duke Univ.)
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmTom Kunkel (NIEHS)
"Generating and repairing leading and lagging strand replication errors"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmWei Yang (NIH)
"From cons to pros: harnessing nature's power to beat cancer"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmAndrew Buermeyer (Oregon State)
"Impact of Pathogenic Mutations in Human MLH1 on MutLalpha Heterodimer Stability and Function in Mammalian Cells"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmEva Goellner (UC San Diego)
"Understanding the role of PCNA in DNA mismatch repair subpathways"
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe Repair of Breaks and Consequences for Genome Stability
Discussion Leader: Susan Lees-Miller (Univ. Calgary)
9:00 am - 9:20 amJohn Tainer (Scripps)
"Complexes and conformations at the replication-recombination interface"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amYunje Cho (Pohang Univ.)
"Structural dynamics of the Mre11-Rad50 complex"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:50 amSusan Lees-Miller (Univ. Calgary)
"Structural and functional studies on NHEJ complexes"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amDale Ramsden (UNC Chapel Hill)
"Fidelity of Nonhomologous End Joining"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amPenny Jeggo (Univ. Sussex)
"Regulation of DSB repair pathway choice"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmSteve West (Cancer Research UK)
"Co-operative actions of MUS81-EME1 and SLX1-SLX4 for Holliday junction resolution"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session A (Odd Numbers)
6:00 pmDinner
7:30 pm - 9:30 pmGenome Instability and Cancer
Discussion Leader: Thomas Helleday (Oxford Univ.)
7:30 pm - 7:50 pmThomas Helleday (Oxford Univ.)
"Novel DNA repair targets for anti-cancer treatments"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMark O'Connor (Astra Zeneca)
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmJacqueline Barlow (NIH)
"A novel class of early replicating fragile sites that contribute to genome instability in B cell lymphomas"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmKyle Miller (UT Austin)
"Systematic identification of functional residues in mammalian histone H2AX"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmPetr Cejka (Inst. Mol. Cancer Res.)
"The nuclease activity of Dna2 restrains its vigorous DNA helicase activity"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmWeihang Chai (Wash. St.)
"Mammalian DNA2 cleaves telomeric G4 to alleviate replication stress and maintain telomere integrity"
9:25 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDNA Damage Signaling
Discussion Leader: Karlene Cimprich (Stanford Univ.)
9:00 am - 9:20 amJohn Petrini (MSKCC)
"Genetic analysis of chromosome break metabolism in eukaryotic cells"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJunjie Chen (MD Anderson)
"Protein-protein interaction network in DNA damage signaling and tumorigenesis"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:50 amKarlene Cimprich (Stanford Univ.)
"Mechanisms for Maintaining Genome Stability at the Replication Fork"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amLee Zou (Harvard Univ.)
"Regulation of the ATR checkpoint pathway in human cells"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amMarkus Lobrich (Darmstadt Univ.)
"Plk3 regulates a non-homologous end-joining process involving CtIP-dependent resection and RPA binding"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmJames Borowiec (NYU)
"Phosphorylated RPA recruits the PALB2 tumor suppressor to stalled DNA replication forks to facilitate fork recovery"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmArmin Gamper (Univ. Pittsburgh)
"A novel role of ATR in G1 phase makes ATR a better drug target than ATM for radiosensitization"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session B (Even Numbers)
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmRelationships Between DNA Repair, Aging, and Neurodegeneration
Discussion Leader: Peter McKinnon (St. Jude)
7:30 pm - 7:50 pmLaura Niedernhofer (Univ. Pittsburgh)
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmPeter McKinnon (St. Jude)
"ATM and DNA damage signaling in the nervous system"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmSimon Boulton (Cancer Research UK)
"Mechanisms of DSB break repair pathway choice"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmOrsolya Kiraly (MIT)
"Interplay of genes, environment and tissue physiology controls the formation of genome rearrangements in vivo"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmRalph Scully (Beth Israel)
"Development of a bacterial replication terminator system to study homologous recombination at sites of replication fork arrest in mammalian cells"
9:25 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDNA Repair at Replication Forks
Discussion Leader: Jean Gautier (Columbia)
9:00 am - 9:20 amMaria Jasin (MSKCC)
"Double-strand break repair in mammalian cells"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJean Gautier (Columbia)
"Maintenance of genome stability: insights from a vertebrate cell-free system"
9:50 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 10:50 amVincenzo Costanzo (Cancer Research UK)
"Understanding the role of essential DNA damage response and repair genes in DNA replication"
10:50 am - 11:00 amDiscussion
11:00 am - 11:10 amRobert Fuchs (CNRS)
"The critical choice between Translesion Synthesis and Damage Avoidance"
11:10 am - 11:15 amDiscussion
11:15 am - 11:25 amRoger Woodgate (NIH)
"Ubiquitin mediates the physical and functional interaction between human DNA polymerases eta and iota"
11:25 am - 11:30 amDiscussion
11:30 am - 11:50 amPatricia Kannouche (IGR Cancer Inst.)
"New insights into the function of pol zeta (rev3) in mammalian cells"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmZvi Livneh (Weizmann)
"Effect of Nuclear Architecture on Translesion DNA Synthesis in Mammalian cells"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmKJ Myung (NIH)
"Two tales of ATAD5; One from DNA Repair and The Other from DNA Replication"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session B (Odd Numbers)
6:00 pmDinner
7:30 pm - 9:30 pmCrosslink Repair and Fanconi Anemia
Discussion Leader: Simon Boulton (Cancer Research UK)
7:30 pm - 7:50 pmAlan d'Andrea (Harvard Univ.)
"Regulation of the Fanconi Anemia/BRCA pathway"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmAgata Smorgozevska (Rockefeller Univ.)
"DNA crosslink repair and human disease"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmJulien Duxin (Harvard)
"Replication-coupled repair of a DNA-protein crosslink"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmLei Li (MD Anderson)
"FANCM and FAAP24 Maintain Genomic Stability through Cooperative as well as Unique Functions"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmWeidong Wang (NIH)
"Recruitment of the Fanconi Anemia core complex to DNA interstrand crosslinks is controlled by both replication -dependent and -independent pathways"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmGary Kupfer (Yale)
"A Role for RNA and the Transcriptional Machinery in the Pathophysiology of FA"
9:25 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13CA173883-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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