Gordon Research Conferences
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Conference Program
 
Mechanisms of Membrane Transport
June 16-21, 2013
Mount Holyoke College
South Hadley, MA
Chair:
Nancy Carrasco

Vice Chair:
Lucy R. Forrest

The Gordon Research Conference on Mechanisms of Membrane Transport has been held for over 40 years. During this time, the membrane transporters and channels field has witnessed tremendous changes that have brought together scientists trained in various disciplines, such as biophysics, physiology, biochemistry, cell biology, structural biology, and computational biology. No meeting provides a better forum than this conference for investigators at all stages of their careers to engage in stimulating exchanges on the latest mechanistic breakthroughs in the membrane transport field.

A growing number of transporter and channel structures are becoming available, fundamentally changing our understanding of the mechanisms underlying the functioning of these remarkable molecules. Sessions will cover mechanistic studies (using structural, functional, thermodynamic, and computational methods) of a wide variety of transporters, including Na+- and H+-coupled transporters, CLC transporters and channels, cation channels, ABC transporters, and others. We will also discuss at length novel approaches to membrane protein structure and mechanisms.

The poster sessions will be a key component of the conference. All participants will be asked to bring posters, as they are an effective way to promote interactions and foster interdisciplinary collaborations. Abstracts will be chosen for short talks in sessions throughout the meeting. We especially encourage graduate students, postdocs, and junior faculty to attend.

The Conference on Mechanisms of Membrane Transport has a well-earned reputation for giving rise to numerous valuable insights into the structure, function, and mechanisms of transporters and channels, both during formal lectures and poster sessions and in the course of informal conversations. This is a tradition that we will continue.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmNa+-driven transporters
Discussion Leader: Satinder Singh (Yale)
7:40 pm - 8:10 pmErnie Wright (UCLA)
"Functional interrogation of SGLT structural models"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:50 pmChristine Ziegler (Max Planck, Frankfurt)
"Impact of coupling ions on secondary transport specificity and regulation"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:25 pmSeok-Yong Lee (Duke)
"Structural Basis of Concentrative Nucleoside Transport"
9:25 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:45 amGroup Photo
9:00 am - 12:30 pmChannels
Discussion Leader: Rachell Gaudet (Harvard)
9:00 am - 9:30 amFrancisco Bezanilla (U. Chicago)
"Voltage sensor kinetics that trace the molecular basis that make Na+ channels fast and K+ channels slow"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amRod Mackinnon (Rockefeller)
"Regulation of GIRK channel gating"
10:10 am - 10:20 amDiscussion
10:20 amCoffee Break
10:50 am - 11:20 amChris Miller (Brandeis)
"A new class of ion channels that resist toxicity of fluoride anion"
11:20 am - 11:30 amDiscussion
11:30 am - 12:00 pmRachell Gaudet (Harvard)
"Structural insights into TRPV channel function in health and disease"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmTBA
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTransporter regulation and disease
Discussion Leader: Geoffrey Abbott (UC Irvine)
7:30 pm - 8:00 pmSandra Gabelli (Hopkins)
"Cytoplasmic regulation of voltage-gated Na+ channels Nav1"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmPoul Nissen (Aarhus U., Denmark)
"Na+/K+ ATPase and neurotransmitter transporters"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmGeoff Abbott (UC Irvine)
"Ion channel-transporter crosstalk"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThermodynamics, kinetics, and conformational states during transport
Discussion Leader: Mario Amzel (Hopkins)
9:00 am - 9:30 amJosé Faraldo-Gómez (Max Planck, Frankfurt)
"Alternating access, proton coupling and cooperativity in the multi-drug resistance transporter ArcB"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amBaron Chanda (U. Wisconsin)
"Energetics of voltage-sensing in voltage-dependent ion channels"
10:10 am - 10:20 amDiscussion
10:20 amCoffee Break
10:50 am - 11:20 amLei Shi (Cornell)
"Allostery in the ion-controlled conformational dynamics of LeuT"
11:20 am - 11:30 amDiscussion
11:30 am - 12:00 pmHassane Mchaourab (Vanderbilt)
"The structural basis of mechanistic diversity in the LeuT fold"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmMario Amzel (Hopkins)
"Thermodynamic/kinetic analysis of the populations contributing to iodide transport by NIS"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThe latest on ABC transporters
Discussion Leader: Jue Chen (Purdue)
7:30 pm - 8:00 pmKasper Locher (ETH, Zurich)
"Mechanism of the B12 transporter BtuCD-F"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmMarkus Seeger (U. of Zurich)
"Structure-function relationships in heterodimeric ABC exporters"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmJue Chen (Purdue)
"Allosteric inhibition of the maltose transporter: atomic details of inducer exclusion"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSugar transport
Discussion Leader: Lucy Forrest (Max Planck, Frankfurt)
9:00 am - 9:30 amWolf Frommer (Stanford)
"Sensing transport"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amNieng Yan (Tsinghua U.)
"Structural and mechanistical investigation of proton-driven symporters"
10:10 am - 10:20 amDiscussion
10:20 amCoffee Break
10:50 am - 11:20 amLan Guan (Texas Tech)
"Structure and mechanism of a Na+-coupled sugar symporter"
11:20 am - 11:30 amDiscussion
11:30 am - 12:00 pmRon Kaback (UCLA)
"The Old Man and the Mechanism of Membrane Transport"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmTBA
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmHandling and transporting iron
Discussion Leader: Susan Buchanan (NIH)
7:30 pm - 8:00 pmPhilip Klebba (Kansas State U.)
"Active ion transport through an un-energized membrane"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmSusan Buchanan (NIH)
"Structural basis for iron piracy by pathogenic Neisseria"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmTBA
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmTBA
9:25 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
9:00 am - 12:30 pmHot topics in membrane transport
Discussion Leader: Nancy Carrasco (Yale)
9:00 am - 9:30 amAlessio Accardi (Cornell)
"Channeling your inner lipid"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amMing Zhou (Baylor)
"Structural basis of the alternate-access mechanism in a bile acid transporter"
10:10 am - 10:20 amDiscussion
10:20 amCoffee Break
10:40 am - 11:05 amStephen Long (Sloan Kettering)
"3D structure of the Ca2+ release-activated calcium channel Orai"
11:05 am - 11:15 amDiscussion
11:15 am - 11:35 amTBA
11:35 am - 11:45 amDiscussion
11:45 am - 12:15 pmShimon Schuldiner (Hebrew University)
"Alternate access in a neurotransmitter transporter"
12:15 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmUnusual Membrane Proteins
Discussion Leader: Chris Miller (Brandeis)
7:30 pm - 8:00 pmJoseph Mindell (NIH)
"Essential conformational changes in piston type transporters"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmBruno Gasnier (Université Paris Descartes)
"An unusual family of seven-helix amino acid transporters"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmFilippo Mancia (Columbia)
"The Crystal Structure of CysZ Reveals a Sulfate Transporter with a Remarkable Architecture"
9:20 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was supported by 1R13GM108287-01from the National Institutes of General Medical Science. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

 
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