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Conference Program
 
Cell Biology of Megakaryocytes & Platelets
March 10-15, 2013
Hotel Galvez
Galveston, TX
Chair:
Katya Ravid

Vice Chair:
Joe Italiano

Related Meeting Information
The Cell Biology of Megakaryocytes & Platelets Gordon Research Conference was held in conjunction with the Cell Biology of Megakaryocytes & Platelets Gordon Research Seminar. Please refer to the Cell Biology of Megakaryocytes & Platelets GRS web page for more information.

The Gordon Research Conference (GRC) on the Cell Biology of Megakaryocytes and Platelets is the premier scientific meeting focused on the biology of megakaryocytes and the platelets that arise from them. This will be the 5th biennial meeting that was first organized by Steve Watson and Jon Frampton in 2005 to bring together two groups of scientists with complimentary goals and interests.

Our meeting will begin with processes governing megakaryopoiesis and thrombopoiesis, including from inducible pluripotent and embryonic stem cells, moving to novel computational and screening methods to study theses processes, transitioning to the cell biology of these cells in the context of the cytoskeleton, and then to newly identified signaling, inflammatory and immune functions in megakaryocytes and platelets. This plan then leads smoothly to a session centered on discoveries related to megakaryocyte and platelet pathology. In addition, there is a whole session devoted to presentations of Hot Topics, selected form submitted abstracts. The sessions cover within the same cluster processes that govern megakaryocyte and platelet development and function, thus, allowing convergence of two audiences with overlapping interests, further increasing exchange of perspectives. The translational potential is illustrated in a new session titled: From Bench to Bed Side, and talks, such as on novel therapeutic options for thrombocytosis associated with myeloproliferative neoplasm. Lastly, the program will include, for the first time, a session titled: Breaking Paradigms in Megakaryocyte and Platelet Biology, thus providing opportunities to learn about, and discuss new paradigms that challenge older concepts in the field. Keynote speakers at the end of the conference, Drs. Kenneth Kaushansky and Denisa Wagner, will further discuss ongoing challenges and new findings and perspectives.

This GRC is tied in with a two-day Gordon Research Seminar (GRS) for trainees interested in this field and will give them the opportunity to present their research as well as gain insights from senior academic and industry investigators in this area. A Keynote talk will focus on a historical overview of discovery in megakaryocyte/platelet biology. Abstracts submitted by trainees will be scored by a panel, and selected for oral presentations, of which some will also present under Hot Topics in the GRC. Round table discussions with investigators will provide mentoring related to careers in academia and in pharmaceutical companies.

The GRS and GRC meetings take place from March 9-10th and 10-15th, 2013, respectively, at the beautiful, historic Hotel Galvez, Galveston Island, Texas, located on the Gulf of Mexico. With the unique surroundings of wide beaches and numerous attractions on and near the island, this will be an exciting and memorable venue for all attendees.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmInduced Pluripotent Stem Cells towards Megakaryopoiesis and Thrombopoiesis
7:40 pm - 7:45 pm Discussion Leader: Andrew Leavitt (University of California San Francisco)
7:45 pm - 8:10 pmCedric Ghevaert (University of Cambridge)
"Generation of mature megakaryocytes from human pluripotent stem cells by a transcription factor mediated forward programming approach"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmGeorge Murphy (Boston University)
"Pluripotent stem cell modeling of normal and abnormal megakaryocyte development"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmMortimer Poncz (University of Pennsylvania)
"Induced pluripotent stem cells and inherited platelet disorders"
9:20 pm - 9:30 pmDiscussion
9:30 pmRefreshments
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmScreening and Computational Approaches to Decoding Megakaryopoiesis and Thrombopoiesis
9:00 am - 9:05 amDiscussion Leader: Willem H. Ouwehand (University of Cambridge, UK)
9:05 am - 9:30 amPaul Bray (Jefferson College)
"Master MiRs that regulate megakaryocyte and platelet development"
9:30 am - 9:45 amDiscussion
9:45 am - 10:10 amJun Lu (Yale University)
"A screen for novel micro RNAs in control of megakaryopoiesis and thrombopoiesis"
10:10 am - 10:25 amDiscussion
10:25 am - 11:05 amCoffee Break
11:05 am - 11:30 amAna Cvejic (University of Cambridge, UK)
"Functional Genomic screen of identified GWAS hits towards understanding megakaryopoiesis"
11:30 am - 11:45 amDiscussion
11:45 am - 12:10 pmBenjamin Kile (The Walter and Eliza Hall Institute)
"A mouse ENU mutagenesis screen reveals novel regulators of platelet production and function"
12:10 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmCell Biologists New Views of the Cytoskeleton in Megakaryocyte and Platelet Biology
7:30 pm - 7:35 pmDiscussion Leader: Diane Krause (Yale University)
7:35 pm - 8:00 pmHana Raslova (INSERM, France)
"RUNX1 control of cytoskeletal components and megakaryocyte ploidy"
8:00 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmOwen McCarty (Oregon Health Science University)
"Regulation of the Rac axis in platelets"
8:40 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmJoseph Italiano (Harvard Medical School)
"New cytoskeletal mechanisms that power platelet production"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCommon and Distinct Signaling in Megakaryocyte and Platelet Biology
9:00 am - 9:05 amDiscussion Leader: Lawrence (Skip) Brass (University of Pennsylvania)
9:05 am - 9:30 amMark Ginsberg (University of California San Diego)
"New Insights on regulation of platelet adhesive signaling"
9:30 am - 9:45 amDiscussion
9:45 am - 10:10 amPeter Newman (Blood Center of Wisconsin)
"Integrin/ITAM connections in platelets"
10:10 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:20 amSusan Smyth (The Gill Heart Institute)
"Lipid signaling and platelet function"
11:20 am - 11:35 amDiscussion
11:35 am - 12:00 pmSidney Whiteheart (University of Kentucky)
"New signals to platelet secretion"
12:00 pm - 12:15 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmBreaking Paradigms in Megakaryocyte and Platelet Biology
7:30 pm - 7:35 pmDiscussion Leader: Steve Watson (University of Birmingham)
7:35 pm - 8:00 pmYumiko Matsubara (Keio University, Japan)
"Generation of megakaryocytes and platelets from adult fat, non-hematopoietic cells"
8:00 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmAndy Weyrich (University of Utah)
"Platelets do divide"
8:40 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmRobert Flaumenhaft (Harvard Medical School)
"New 'secretes' about platelet granules"
9:20 pm - 9:30 pmDiscussion
9:30 pmRefreshments
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPlatelets and Megakaryocytes as Inflammatory and Immune Cells
9:00 am - 9:05 amDiscussion Leader: Jane Freedman (University of Massachusetts)
9:05 am - 9:30 amCraig Morrel (University of Rochester)
"Platelet and T cell interaction"
9:30 am - 9:45 amDiscussion
9:45 am - 10:10 amScott Crist (Purdue University)
"Platelets and megakaryocytes as inflammatory and immune cells"
10:10 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:20 amJane Freedman (University of Massachusetts)
"Innate immunity and platelet function"
11:20 am - 11:35 amDiscussion
11:35 am - 12:00 pmThomas McIntyre (Cleveland Clinic)
"Watching platelets and their pro-inflammatory IL-1b-rich microparticles"
12:00 pm - 12:15 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session III
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmHot Topics
Discussion Leader: Leslie Parise (University of North Carolina at Chapel Hill)
7:30 pm - 7:40 pmSjoert Jansen (University of Cambridge)
"The red blood cell GWAS gene SMIM1 underlies the Vel blood group and is a regulator of red blood cell and platelet formation"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmThomas Mercher (INSERM, Institut Gustave Roussy)
"ETO2-GLIS2 is a novel fusion oncogene in pediatric acute megakaryoblastic leukemia"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmAnita Eckly-Michel (INSERM)
"Biogenesis of the Demarcation Membrane System in Megakaryocytes: a 3D Evaluation"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmAntonina Risitano (University of Massachusetts and Boston University)
"Influence of platelet activation and miRNA transfer to endothelial cells on vascular homeostasis"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmTimothy Stalker (University of Pennsylvania)
"Mapping Thrombus Architecture to the Platelet Signaling Network"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmNiamh Moran (Royal College of Surgeons in Ireland)
"Inhibition of Syk-PKC pathway in platelets impairs Prostate Cancer Cells Induced Platelet Secretion: Novel insights into Platelet- Cancer cell crass-talk"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmTBA (Selected from GRS)
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmTBA (Selected from GRS)
9:25 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMegakaryocytes and Platelets: from Bench to Bed-Side
9:00 am - 9:05 amDiscussion Leader: John Crispino (Northwestern University)
9:05 am - 9:30 amJohn Crispino (Northwestern University)
"Aberrant megakaryopoiesis in the myeloproliferative neoplasms"
9:30 am - 9:45 amDiscussion
9:45 am - 10:10 amDavid Kuter (Harvard Medical School)
"Romiplostim for the treatment of thrombocytopenia: Development, physiology and clinical effects"
10:10 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:20 amRoss Levine (Memorial Sloan Kettering Cancer Center)
"Jak mutations and megakarocyte-induced myelofibrosis"
11:20 am - 11:35 amDiscussion
11:35 am - 12:00 pmRonald Hoffman (Mount Sinai School of Medicine)
"Novel therapeutic options for thrombocytosis associated with myeloproliferative neoplasms"
12:00 pm - 12:15 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session IV
6:00 pmDinner
7:30 pm - 8:55 pmKeynote Talks: Megakaryopoiesis Thrombopoiesis and Thrombosis: Now and Tomorrow
7:30 pm - 7:35 pmDiscussion Leader: Kenneth Kaushansky (Stony Brook University)
7:35 pm - 8:00 pmDenisa Wagner (Harvard Medical School)
"New insight into innate immune response and thrombosis: the role of Neutrophile Extracellular Traps"
8:00 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmKenneth Kaushansky (Stony Brook University)
"Thrombopoietin and megakaryocyte/platelet development: From Enigmatic to Mimetics"
8:40 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmJose Lopez (Puget Sound Blood Center)
"Megakaryopoiesis and thrombopoiesis in Bioengineered vessel systems"
9:20 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13HL117369-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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