Gordon Research Conferences
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Conference Program
 
Metals in Biology
January 20-25, 2013
Four Points Sheraton / Holiday Inn Express
Ventura, CA

Related Meeting Information
The Metals in Biology Gordon Research Conference was held in conjunction with the Bioinorganic Chemistry Gordon Research Seminar. Please refer to the Bioinorganic Chemistry GRS web page for more information.

Metal ions are essential for the function of over one third of all proteins, and are involved in a number of key biological processes including respiration, photosynthesis, nitrogen and carbon cycling, biosynthesis of antibiotics, gene regulation, replication and repair of DNA, antioxidant defense, and neurotransmission. Understanding how metal ions function in these systems requires multidisciplinary approaches that span the broad fields of inorganic chemistry, biochemistry, cell biology, and physics. The Metals in Biology (MIB) GRC, one of the longest running GRCs, is an important forum for discussion of research at the forefront of this field. Fostering new collaborations among researchers from diverse backgrounds with complementary skills and goals is a hallmark of this conference. In addition to lectures covering a wide range of topics, poster sessions facilitate discussions in an open atmosphere.

The Gordon Research Seminar (GRS) in Bioinorganic Chemistry is closely associated with the MIB GRC. This meeting typically draws graduate and postdoctoral students from a variety of laboratories studying metals in biology. The GRS overlaps with the MIB GRC meeting for one evening session on Thursday, including a poster session that allows students to meet and interact with established scientists. We specifically encourage graduate students and postdocs to take advantage of these unique educational opportunities and to participate in either the MIB GRC conference or the Bioinorganic Chemistry GRS or both.

Typical topics for lectures and posters include: biochemical and biophysical characterization of new metal containing proteins, enzymes, nucleic acids, factors, and chelators from all forms of life; synthesis, detailed characterization, and reaction chemistry of biomimetic compounds; novel crystal and solution structures of biological molecules and synthetic metal-chelates; discussions of the roles that metals play in medicine, maintenance of the environment, and biogeochemical processes; metal homeostasis; application of theory and computations to the structure and mechanism of metal-containing biological systems; and novel applications of spectroscopy to metals in biological systems.

Joan Broderick will chair the 2014 conference and James Mayer will chair the 2015 conference.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmProton and Electron Transfer in Bioinorganic Chemistry
Discussion Leader: Harry Gray (California Institute of Technology)
7:40 pm - 8:20 pmJames Mayer (University of Washington)
"Moving Protons and Electrons in Biomimetic Systems"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmJudith Klinman (University of California, Berkeley)
"Linking Protein Motions to C-H Activation in Enzymes"
9:15 pm - 9:30 pmDiscussion
9:30 pmPoster Session I / Chair's Reception
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmMetalloenzymes and Biofuels
Discussion Leader: John Lipscomb (University of Minnesota)
9:00 am - 9:30 amMichael Marletta (The Scripps Research Institute)
"Oxidative Degradation of Cellulose"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amPaul Walton (University of York)
"Copper Active Sites of Polysaccharide Oxygenases: Structural and Spectroscopic Studies"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amJ. Martin Bollinger, Jr. (Penn State University)
"The Mechanism of the Cryptically-Redox Oxygenation Reaction Catalyzed by Aldehyde Deformylating Oxygenase (Formerly Aldehyde Decarbonylase)"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmSaltman Lecture: Michelle Chang (University of California, Berkeley)
"Exploring the Bioinorganic Chemistry of Microbial Lignin Degradation"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmMetals and Pathogens
Discussion Leader: Alejandro Vila (University of Rosario)
7:30 pm - 8:00 pmElizabeth Nolan (Massachusetts Institute of Technology)
"Metal-Chelating Host-Defense Proteins in Human Innate Immunity"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmCelia Goulding (University of California, Irvine)
"Investigation of the Unique Mycobacterial Heme Uptake System"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmDavid Wright (Vanderbilt University)
"Hemozoin: Crystal Engineering, Heme Homeostasis and Drug Discovery in the Malaria Parasite"
9:20 pm - 9:30 pmDiscussion
9:30 pmPoster Session I
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmManganese Oxygen Chemistry
Discussion Leader: Andrew Borovik (University of California, Irvine)
9:00 am - 9:30 amJoAnne Stubbe (Massachusetts Institute of Technology)
"The Class Ib RNRs: Metallo-cofactor Identification and Mechanism of Assembly"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amBradley Tebo (Oregon Health and Science University)
"Unraveling the Mechanism of Mn Biomineralization by Mn(II) Oxidizing Bacteria"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amStiefel Lecture: Theodor Agapie (California Institute of Technology)
"Synthetic Models of the Oxygen Evolving Complex in Photosystem II"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmJulie Kovacs (University of Washington)
"Metastable Mn-Peroxo Intermediates. Correlation Between Structure and Reactivity"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmEnvironmental Bioinorganic Chemistry
Discussion Leader: Alison Butler (University of California, Santa Barbara)
7:30 pm - 8:00 pmStephen Lippard (Massachusetts Institute of Technology)
"Control of Substrate Access to the Active Sites of Diiron Monooxygenases"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmJoachim Reimann (Radboud University, Nijmegen)
"Anaerobic Methane Oxidation by Nitrite Reducing Bacteria: A New Role for NO"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmMak Saito (Woods Hole Oceanographic Institution)
"Metalloproteins in the Ocean: Strategies for Coping with Extreme Metal Scarcity"
9:20 pm - 9:30 pmDiscussion
9:30 pmPoster Session II
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMetal Homeostasis
Discussion Leader: Elizabeth Theil (Children's Hospital Oakland Research Institute)
9:00 am - 9:30 amDavid Giedroc (Indiana University)
"Bacterial Transition Metal Homeostasis"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amRichard Bruick (University of Texas Southwestern Medical Center)
"A Mammalian Iron and Oxygen Sensor - New Dog, Old Trick?"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amSabeeha Merchant (University of California, Los Angeles)
"Recycling Cu and Fe in Chloroplasts"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmJosé Argüello (Worcester Polytechnic Institute)
"CtpC: An Uncommon P1B-type Mn2+ Transport ATPase Required for Secreted Protein Metallation in Mycobacteria"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmHeme Protein Structure and Function
Discussion Leader: Liliya Yatsunyk (Swarthmore College)
7:30 pm - 8:00 pmDavid Goldberg (Johns Hopkins University)
"High-Valent Metal-Oxo Corrolazines: Mechanisms and Catalysis Involving HAT, OAT and O2"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmEkaterina Pletneva (Dartmouth College)
"Interplay Between Redox Chemistry and Protein Conformational Dynamics: Stories of Heme Proteins"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmAngela Wilks (University of Maryland)
"A Histidine-Switch Primes the Cytoplasmic Heme Chaperone of P. aeruginosa for Heme Release to Heme Oxygenase"
9:20 pm - 9:30 pmDiscussion
9:30 pmPoster Session II / Reception in honor of Saltman and Stiefel Lecturers
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmReactivity and Biogenesis of Iron-Sulfur Clusters
Discussion Leader: Timothy Stemmler (Wayne State University)
9:00 am - 9:30 amWayne Outten (University of South Carolina)
"The Co-Evolution of Oxygen Metabolism and Fe-S cluster Biogenesis: Insights from the Suf Pathway"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amMarkus Ribbe (University of California, Irvine)
"Biosynthesis of Nitrogenase FeMoco"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amSquire Booker (Penn State University)
"Methylation of an sp2-Hybridized Carbon center in rRNA Leading to Antibiotic Resistance"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmJacqueline Barton (California Institute of Technology)
"DNA Signaling among Proteins with 4Fe-4S Clusters
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pmJoint Session with Gordon Research Seminar
Discussion Leader: Stephen Lippard (Massachusetts Institute of Technology)
7:30 pm - 8:30 pmChuan He (University of Chicago)
"Oxidative Demethylation and Selective Metal Recognition in Biology"
8:30 pm - 8:45 pmDiscussion
8:45 pmPoster Session (Joint Poster Session with Gordon Research Seminar)
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

This material is based upon work supported by the Department of Energy under Award Number DE- SC0008369. This report was prepared as an account of work sponsored by an agency of the United States Government. Neither the United States Government nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process or service by trade name, trademark, manufacturer, or otherwise does not necessarily constitute or imply its endorsement, recommendation, or favoring by the United States Government or any agency thereof. The views and opinions of authors expressed herein do not necessarily state or reflect those of the United States Government or any agency thereof.

Funding for this conference was made possible (in part) by 5R13GM096436-03 from the National Institutes of General Medical Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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