Gordon Research Conferences
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Conference Program
 
Molecular Pharmacology
New Opportunities with G-protein Coupled Receptors: From Single Molecules and Signaling Complexes to Physiology and Therapeutic Interventions
April 28 - May 3, 2013
Renaissance Tuscany Il Ciocco Resort
Lucca (Barga), Italy

Related Meeting Information
The Molecular Pharmacology Gordon Research Conference was held in conjunction with the Molecular Pharmacology Gordon Research Seminar. Please refer to the Molecular Pharmacology GRS web page for more information.

The Molecular Pharmacology Gordon Research Conference (GRC) has become a key event gathering scientists from basic, applied and clinical science in G protein coupled receptor (GPCR) research. This field has experienced major discoveries over the last 20 years, bringing or reinforcing new concepts that now apply to many other signaling molecules. The 2013 conference, 24th GRC edition, will emphasize both emerging and rapidly growing areas in the field, from receptor dynamics at molecular level to system-level analysis of receptor function. The 2013 program covers four main areas: i) structural dynamics of receptors and biologically relevant receptor complexes including studies at the single molecule level, ii) ligand-biased signaling in cellulo and in vivo, and novel approaches to physiology with an emphasis on animal models, (iii) novel opportunities for drug development and therapeutics and (iv) orphan and atypical GPCRs, revealing new mode of action of these important signaling proteins. Methodological aspects will include novel physical and computing approaches, the development of innovative biosensors and light-controlled processes, and innovative therapeutic strategies that shed new light on mechanisms of GPCR activation, biology and disease. Traditionally the GCR alternates between US west coast and Italy to encourage the international nature of the conference, and the meeting attracts some of the very best scientists from academic and industrial worlds to discuss major developments in the field. The 2013 conference will be held in Tuscany (Il Ciocco, Italy), and set as to encourage open discussions on latest and also controversial ideas in the field, facilitate collaborative work in areas of translational opportunity, and serve as a highly effective forum at which doctoral students, post-docs and junior scientists share their results and interact with more senior colleagues.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmNovel approaches to physiology
7:40 pm - 7:45 pmDiscussion Leader: Paul Insel (University of California San Diego, CA USA)
7:45 pm - 8:10 pmLief Fenno (Stanford University, Howard Hughes Medical Institute, Stanford, CA USA)
"GPCR tools for optogenetics"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmJurgen Wess (Lab. Bioorganic Chemistry, NIH-NIDDK, Bethesda, MD, USA)
"Muscarinic receptor-based designer receptors as novel tools to probe GPCR signaling and physiology"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmEhud Isacoff (University of California, Berkeley, CA USA)
"Light-gated glutamate receptors: synaptic transmission and plasticity"
9:20 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGPCR in physiology
9:00 am - 9:10 pmDiscussion Leader: Marc Caron (Duke University Medical Center, Durham, NC USA)
9:10 am - 9:35 amGiovanni Marsicano (INSERM, Bordeaux, France)
"Type-1 Cannabinoid Receptor Signaling in the Brain: the Where Matters"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amStefan Offermanns (Max-Planck-Institute for Heart & Lung Research, Bad Nauheim, Germany)
"Vascular and metabolic regulation through GPCRs"
10:10 am - 10:20 amDiscussion
10:20 am - 11:00 amGroup Photo / Coffee Break
11:00 am - 11:25 amStuart Sealfon (Mount Sinai Medical Center, New York, USA)
"GnRH Receptor Signaling Outside the Cell"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmYuri Ushkaryov (Medway School of Pharmacy, University of Kent, Kent, UK)
"Lasso and latrophilin: an air kiss"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmAlan Smrcka (University of Rochester Medical Center - NY USA)
"GPCR-dependent regulation of a novel perinuclear PI hydrolysis pathway in the heart"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmOrphan and atypical GPCRs
5:30 pm - 5:40 pmDiscussion Leader: Paul Insel (University of California San Diego, CA USA)
5:40 pm - 6:05 pmGeorge Gaitanaris (Omeros Corporation, Seattle, WA USA)
"High-throughput discovery of small molecules targeting orphan GPCRs"
6:05 pm - 6:15 pmDiscussion
6:15 pm - 6:40 pmKazushige Touhara (University of Tokyo, Tokyo, Japan)
"Chemosensory receptors in insects and vertebrates"
6:40 pm - 6:50 pmDiscussion
6:50 pm - 7:15 pmSarah Assmann (Penn State University, USA)
"Plant GPCRs"
7:15 pm - 7:30 pmDiscussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:20 amGPCRs and development
9:00 am - 9:10 pmDiscussion Leader: JoAnn Trejo (University of California San Diego, CA USA)
9:10 am - 9:35 amStacey Ogden (St. Jude Children's Research Hospital, Memphis, TN USA)
"Mechanisms of Smoothened Regulation and Signaling"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amAlejandro Aballay (Duke University Medical School, Durham, NC USA)
"Role of neuronal GPCR signaling in the control of immune homeostasis and longevity"
10:10 am - 10:20 amDiscussion
10:20 amBreak
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:00 pmPoster Session
5:00 pm - 12:30 pmGPCRs and development (continued)
Discussion Leader: JoAnn Trejo (University of California San Diego, CA USA)
5:00 pm - 5:25 pmXianhua Piao (Harvard Medical School, Boston, MA USA)
"GPR56 and cortical development"
5:25 pm - 5:35 pmDiscussion
5:35 pm - 5:50 pmHeike Biebermann (Charité University, Berlin, Germany)
"Hypothalamic GPCRs involved in body weight regulation: elucidation of new interacting partners"
5:50 pm - 5:55 pmDiscussion
5:50 pm - 7:30 pmBiased cellular signaling
5:55 pm - 6:00 pmDiscussion Leader: Brigitte Kieffer (IGBMC, Strasbourg, France)
6:00 pm - 6:25 pmMartin Beaulieu (Centre de recherche de l'Institut universitaire en santé mentale de Québec, Beauport, Québec, Canada)
"Going beyond functional selectivity, are mood stabilizers GPCR drugs?"
6:25 pm - 6:35 pmDiscussion
6:35 pm - 6:50 pmJan Steyaert (Vrije Universiteit Brussel - Belgium)
"Nanobodies as tools for the structural and functional investigation of GPCR transmembrane signaling"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:25 pmMark Von Zastrow (University of California San Francisco, CA USA)
"GPCR signaling along the endocytic pathway"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNew opportunities for treatment
9:00 am - 9:10 pmDiscussion Leader: Alan Smrcka (University of Rochester Medical Center - NY USA)
9:10 am - 9:35 amMartine Smit (VU University, Amsterdam, The Netherlands)
"Therapeutic targeting of the chemokine receptor system by llama-derived immunoglobulin single variable domains (Nanobodies)"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amMichel Bouvier (Université de Montréal, Canada)
"Exploring the pluridimensionality of GPCR signalling using BRET-based biosensor arrays"
10:10 am - 10:20 amDiscussion
10:20 am - 11:00 amCoffee Break
11:00 am - 11:25 amRalf Jockers (Institut Cochin, INSERM, Paris France)
"Exon sequencing of melatonin receptor genes: towards a personalized treatment of type 2 diabetes"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmLothar Lindemann (Hoffmann-La Roche, Basel Switzerland)
"Treatment of Fragile X Syndrome with mGlu5 inhibitors"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmRobert Lane (Monash University, Victoria, Australia)
"Identification of a bitopic ligand that acts allosterically across a dopamine D2 receptor dimer"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmKeynote Lectures
5:30 pm - 5:35 pmDiscussion Leader: Joël Bockaert (Institut de Génomique Fonctionnelle, Université de Montpellier, France)
5:35 pm - 6:25 pmBrian Kobilka (Beckman Center, Stanford University, CA USA)
"GPCR complexes: structure and dynamics"
6:25 pm - 6:35 pmDiscussion
6:35 pm - 6:55 pmRon Dror (D.E. Shaw Research, New York, NY USA)
"How drugs bind and control their targets: characterizing GPCR signaling through long-timescale simulation"
6:55 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmKaspar Hollenstein (Heptares Therapeutics, Hertfordshire, UK)
"Using thermostabilized receptors to obtain crystal structures of Family A and Family B G protein-coupled peptide receptors"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 8:00 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
8:50 am - 12:30 pmReceptor complexes and their dynamics
8:50 am - 9:00 pmDiscussion Leader: Martin Lohse (University of Wuerzburg, Germany)
9:00 am - 9:25 amDaniel Choquet (Institut Interdisciplinaire de Neurosciences, CNRS, Bordeaux, France)
"AMPA receptor surface trafficking: a new pharmaceutical target?"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amBernd Fakler (Institute of Physiology, University of Freiburg, Germany)
"Analysis of native GPCRs: Insights from functional proteomics"
10:00 am - 10:10 amDiscussion
10:10 am - 10:25 amCeline Ullrich (The Scripps Research Institute, Jupiter, FL USA)
"Molecular interaction between Gi-coupled 5-HT1B receptor and Gq/11-coupled GHSR1a receptor modulates serotonin-mediated signaling pathway"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amPhilippe Marin (Institut de Géomique Fonctionnelle, CNRS, Montpellier France)
"The 5-HT6 Receptor-Associated Complex: Role in Neuronal Differentiation and Cognition"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmTobias Langenhan (Institute of Physiology, University of Würzburg, Germany)
"Mechanisms of Adhesion-GPCR function and signaling"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmDavide Calebiro (Institute of Pharmacology, University of Würzburg, Germany)
"Direct visualization of individual GPCR interactions by single-molecule microscopy"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmGPCR structural dynamics
5:30 pm - 5:40 pmDiscussion Leader: Brian Kobilka (Beckman Center, Stanford University, CA USA)
5:40 pm - 6:05 pmNevin Lambert (Georgia Regents University, Augusta, GA, USA)
"Segregation of family A protomers in the plasma membrane"
6:05 pm - 6:15 pmDiscussion
6:15 pm - 6:40 pmMartin Lohse (University of Wuerzburg, Germany)
"GPCR dynamics"
6:40 pm - 6:50 pmDiscussion
6:50 pm - 7:15 pmMartha Sommer (Charité - University Medicine Berlin, Germany)
"Crystal structure of rhodopsin in its arrestin-interacting conformation"
7:15 pm - 7:25 pmDiscussion
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1 R13 DA035525-01 from the National Institute on Drug Abuse. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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