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Conference Program
 
Mycotoxins & Phycotoxins
June 16-21, 2013
Stonehill College
Easton, MA

Related Meeting Information
The Mycotoxins & Phycotoxins Gordon Research Conference was held in conjunction with the Mycotoxins & Phycotoxins Gordon Research Seminar. Please refer to the Mycotoxins & Phycotoxins GRS web page for more information.

Fungal, algal, and cyanobacterial toxins adversely affect the health of humans, animals, and the environment. The occurrence and toxicity of these mycotoxins and phycotoxins, which may be present in food, water, and air, is often impacted by multiple factors including environmental change and human activity. Given the ecological and societal importance of this field, exchange of ideas and collaboration among numerous disciplines (e.g., biology, analytical chemistry, toxicology, ecology, plant pathology, epidemiology, genomics/proteomics, meteorology, economics/trade, risk assessment/hazard management, and public health) is critical for assessing risks and developing sustainable management practices for these natural toxins.

The 16th Gordon Research Conference (GRC) on Mycotoxins and Phycotoxins provides an interdisciplinary and international forum of pioneering research for academic, governmental, and industrial scientists and allows for the free exchange of ideas, identification of new research opportunities, and initiation of cross-disciplinary collaborations. Contemporary themes will be explored to facilitate the discussion of these natural toxins and related topics of interest. Discussion sessions include: 1) frontiers in mycotoxin and phycotoxin research, 2) novel and emerging toxins and toxicities, 3) mechanisms of action, genomics, proteomics, and the phylogenetic basis of toxicity, 4) advances in analytical detection: use of analytical recognition elements, 5) advances in analytical detection: direct analysis of mycotoxins and phycotoxins, 6) outbreaks, exposure, and risk assessment, 7) evolution and ecological significance of mycotoxins and phycotoxins, 8) strategies and regulation for prevention and control, and 9) future perspectives and directions.

A primary goal of this unparalleled conference is to create a critical mass and atmosphere for cultivating the creative thinking necessary to advance knowledge of the complex challenges presented by naturally occurring toxigenic microbes and their toxins. The GRC brings together a diverse group of interdisciplinary scientists whose research ultimately contributes to ensuring the health of the environment and the safety and security of the food supply. Special attention will be given to strategies that improve interactions of junior and senior scientists during the conference. In keeping with the successful nature of Gordon Research Conferences, speaker presentations will provide the context for each session, yet vigorous discussion will be the key focus. Designated discussion leaders, recognized for their expertise in each particular area, will guide the audience-based discussions. Primary criteria used for selecting invited oral presenters are that the researcher (1) share new, cutting-edge research on mycotoxins and phycotoxins, and (2) deliver an engaging presentation to foster discussion of the presented material. Contributed poster sessions will also serve as an opportunity for lively and informal discussion.

The Gordon Research Seminar (GRS) will once again be held in conjunction with the 2013 GRC on Mycotoxins and Phycotoxins. The GRS, a two-day meeting immediately preceding the GRC (15-16 June 2013), is specifically designed for early career scientists, such as graduate students and post-doctoral researchers. This unique meeting offers an opportunity for junior investigators to present their work in a formal, highly stimulating, and non-intimidating environment with their peers. It is expected that GRS participants will remain to participate in the subsequent Mycotoxins and Phycotoxins GRC. The GRS provides an unmatched opportunity to promote interactions between junior scientists and those who are more established in the field.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmFrontiers in Mycotoxin and Phycotoxin Research
Discussion Leaders: Stacey DeGrasse (US Food & Drug Administration) and Gary Payne (North Carolina State University, US)
7:40 pm - 8:20 pmCorby Kistler (University of Minnesota, US)
"A toxic character: Cellular and genomic adaptations for trichothecene biosynthesis"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmKathi Lefebvre (NOAA Fisheries, US)
"Environmental algal toxin surveillance and diagnostic tools for detecting chronic disease"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNovel and Emerging Toxins and Toxicities
Discussion Leaders: James Pestka (Michigan State University, US) and Chris Miles (Norwegian Veterinary Institute, Norway)
9:00 am - 9:30 amThomas Massey (Queens University, Canada)
"Modification of DNA repair by aflatoxin B1"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amJames Metcalf (The Institute for Ethnomedicine, US)
"BMAA isomers in Cyanobacteria and invertebrates"
10:15 am - 10:30 amDiscussion
10:30 amGroup Photo / Coffee Break
11:00 am - 11:30 amJean-Denis Troadec (Universite Paul Cezanne, France)
"DON-induced anorexia and central inflammation"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmMichael Twiner (University of Michigan-Dearborn, US)
"The AZaspiracid story from A to Z: A mechanism of action revealed"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMechanisms of Action, Genomics, Proteomics, and the Phylogenetic Basis of Toxicity
Discussion Leaders: Ronald Riley (US Department of Agriculture) and Brett Neilan (University of New South Wales, Australia)
7:30 pm - 7:50 pmCharles Woloshuk (Purdue University, US)
"Pathogenesis and fumonisin biosyntheses in Fusarium verticilliodes"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmRalf Kellmann (University of Bergen, Norway)
"Saxitoxin biosynthesis in organisms from two kingdoms: A case study of horizontal gene transfer of an entire biosynthetic pathway"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmPaul Jennings (Innsbruck, Austria)
"Integration of omic technologies to uncover the mechanism of ochratoxin A induced nephrotoxicity and carcinogenicity"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmAllen Place (University of Maryland, Center of Environmental Science, US)
"Sorting the fatty acid chaff from the toxin wheat - Isolation of dinoflagellate multi-modular PKS & NRPS genes involved in toxin synthesis"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAdvances in Analytical Detection Methodologies: Analytical Recognition Elements
Discussion Leaders: David Miller (Carleton University, Canada) and Betsy Yakes (US Food & Drug Administration)
9:00 am - 9:30 amMaria De Rosa (Carleton University, Canada)
"Aptamers as mycotoxin recognition elements"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amJeffrey DeGrasse (US Food & Drug Administration)
"The rapid detection of saxitoxin using an aptamer toggle switch"
10:15 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:30 amChristopher Maragos (US Department of Agriculture)
"Signal amplification using colloidal gold in a biolayer interferometry-based immunosensor for the mycotoxin deoxynivalenol"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmJennifer McCall (University of North Carolina at Wilmington, US)
"Utilization of a fluorescence-based receptor binding assay to detect brevetoxins and ciguatoxins"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAdvances in Analytical Detection Methodologies: Direct Detection of Mycotoxins and Phycotoxins
Discussion Leaders: Andrew Turner (CEFAS, EU) and Benedikt Cramer (University of Muenster, Germany)
7:30 pm - 7:50 pmRudolf Krska (University of Natural Resources and Life Sciences, Vienna)
"Metabolomics of plant-fusarium interactions"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmElizabeth Hamelin (US Centers for Disease Control)
"Analytical approaches for the assessment of toxin exposures in clinical samples for continued public health response"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmCarmela Dell'Aversano and Martino Forino (University of Napoli "Federico II", Italy) "Hunting for toxins across the Mediterranean Sea: An analytical strategy for facing the impending palytoxins threat"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmMonica Campas (IRTA, Spain)
"Biosensors for phycotoxins: Innovations and applications"
9:20 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmOutbreaks, Exposures, and Risk Assessment
Discussion Leaders: Paul Turner (University of Maryland) and Betsy Hilborn (US EPA)
9:00 am - 9:30 amRebecca Stoltzfus (Cornell University, US)
"Mycotoxins in pregnancy and early childhood: potential consequences for child health and survival"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amVera Trainer (US National Oceanic and Atmospheric Administration)
"Diarrhetic shellfish poisoning: why now?"
10:15 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:30 amManfred Metzler (Karlsruhe Institute of Technology, Germany)
"Alternaria toxins: Novel aspects of genotoxicity and metabolism"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmJudy Kleindinst (Woods Hole Oceanographic Institute, US)
"Categorizing the severity of paralytic shellfish poisoning outbreaks in the Gulf of Maine for forecasting and management"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmEvolution and Ecological Significance of Mycotoxins and Phycotoxins
Discussion Leaders: Naresh Magan (Cranfield University) and Sibel Bargu Ates (Louisiana State University, US)
7:30 pm - 7:40 pmTBA (Short Talk: Best junior scientist GRS speaker - Mycotoxins)
7:40 pm - 7:50 pmDiscussion
7:50 pm - 8:00 pmTBA (Short Talk: Best junior scientist GRS speaker - Phycotoxins)
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmChris Schardl (University of Kentucky, US)
"Evolution and ecology of bioprotective alkaloids produced by epichloae, fungal symbionts of grasses"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmHans Dam (University of Connecticut, US)
"Evolutionary ecology of phycotoxin-mediated attack and defense"
9:15 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStrategies and Regulation for Prevention and Control
Discussion Leaders: Deepak Bhatnagar (US Department of Agriculture) and Quay Dortch (US National Oceanic and Atmospheric Administration)
9:00 am - 9:30 amBurton Bluhm (University of Arkansas, US)
"RNAi-based approaches to control mycotoxins in corn"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amKevin Sellner (Chesapeake Research Consortium, US)
"Local to international realities of prevention, control, and mitigation of Microcystis"
10:15 am - 10:30 amDiscussion
10:30 amCoffee Break
11:00 am - 11:30 amHokyoung Son (Seoul National University, Korea)
"Functional analysis of transcription factors in the cereal head blight fungus, Fusarium graminearum"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmMelissa (Lizzie) Evans (US Food & Drug Administration)
"Validations and approval strategies for toxin methods that are to be used for prevention and control in regulatory environments: Practical applications to theoretical science"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmFuture Perspectives and Directions
Discussion Leaders: Genevieve Bondy (Health Canada) and Gregory Boyer (State University of New York, US)
7:30 pm - 7:40 pmTBA (Hot Topic)
7:40 pm - 7:50 pmDiscussion
7:50 pm - 8:00 pmTBA (Hot Topic)
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:20 pmTBA (Hot Topic)
8:20 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmChris Elliott (Queen's University Belfast, UK)
"Measuring emerging mycotoxins and phycotoxins: Biology versus chemistry"
9:10 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13ES022898-01 from the National Institute of Environmental Health Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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