Gordon Research Conferences
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Conference Program
 
Natural Products
Current State of the Art in Natural Product Synthesis, Isolation, Structure Elucidation, and Application in Drug Discovery
July 28 - August 2, 2013
Proctor Academy
Andover, NH
Chair:
Rajinder Singh

Vice Chair:
Michael Calter

The 62nd Gordon Research Conference on Natural Products will continue the practice of featuring vibrant and diverse presentations on the leading edge of natural products synthesis, methodology development, isolation, structure elucidation and importance in drug discovery. This premier conference will feature speakers and attendees from academia and industry to share insights in the latest developments in the field of natural products synthesis and progress in synthetic methodology, application to drug discovery, chemical biology, and broadly the field of organic synthesis. The Natural Products conference provides an ideal opportunity towards presenting unpublished work by both established and emerging young investigators; the outstanding list of speakers for 2013 will continue to reinforce this aspect.

The meeting will be held in the same location as last year, Proctor Academy in Andover, New Hampshire. The site offers a relaxed and comfortable setting that is ideally suited for rigorous scientific discussions as well as abundant opportunity for recreation.

Consistent with previous meetings, poster sessions will be held on consecutive days, and represent an indispensable constituent of the scientific success and social dialogue at the Natural Products GRC. Thus, all conferees are encouraged to submit abstracts for poster presentation. Abstracts (1 page maximum) with title, authors and affiliation(s)/address(es) should be submitted to the 2013 Chair, Rajinder Singh, and the 2013 Vice Chair, Michael Calter as part of formal application through the GRC online site. Posters will be selected for short talks to be presented by their primary authors during the conference.

The Chair and Vice Chair look forward to your involvement at this highly anticipated and important meeting. Your valuable and scientifically stimulating interactions will further enrich the reputation of the NP GRC and continue the proud tradition of this meeting.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmTotal Synthesis of Natural Products
Discussion Leader: Robert Williams (Colorado State University)
7:40 pm - 8:15 pmStephen Martin (University of Texas, Austin)
"Recent Progress in the Total Synthesis of Heterocyclic Natural Products"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:40 pmJeremy May (University of Houston)
"Synthetic Discoveries from Polycyclic Natural Products"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 9:25 pmRick Danheiser (Massachusetts Institute of Technology)
"New Cycloaddition Strategies Based on Strained and Unusual Molecules"
9:25 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:10 amNovel Technologies in the Discovery of Natural Products from Marine Sources
Discussion Leader: Kerry McPhail (Oregon State University)
9:00 am - 9:25 amRoger Linington (University of California, Santa Cruz)
"Function-First Approaches to Natural Products Discovery Through Image-Based High Content Screening"
9:25 am - 9:30 amDiscussion
9:30 am - 10:05 amHendrik Luesch (University of Florida)
"Marine Cyanobacterial Natural Products as Starting Points for Drug Discovery"
10:05 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 12:30 pmCatalysis and Synthetic Methodology
Discussion Leader: Uttam Tambar (UT Southwestern Medical)
10:40 am - 11:10 amOhyn Kwon (University of California, Los Angeles)
"Phosphine Catalysis - Old and New"
11:10 am - 11:15 amDiscussion
11:15 am - 11:45 amAlison Frontier (University of Rochester)
"Cyclization Strategies for the Synthesis of Natural Products"
11:45 am - 11:50 amDiscussion
11:50 am - 12:25 pmF. Dean Toste (University of California, Berkeley)
"Asymmetric Catalysis with Cations and Anions"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSynthesis of Heterocyclic Natural Products and Chemical Biology
Discussion Leader: Brian Albrecht (Constellation Pharmaceuticals)
7:30 pm - 8:05 pmMarco Ciufolini (University of British Columbia)
"Synthetic Studies on Heterocyclic Natural Products"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmSteven Olson (Amgen)
"Structure-Based Design of Novel Piperidinone Inhibitors of the MDM2-p53 Interaction"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 9:25 pmDirk Trauner (Ludwig-Maximilians-Universität, Munich)
"The Fascinating Chemistry of Red Colorants"
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 10:10 amNew Methods and Biomimetic Synthesis of Biologically Active Natural Products
Discussion Leader: Cameron Smith (Merck)
9:00 am - 9:25 amArmen Zakarian (University of California, Santa Barbara)
"Enantioselective Synthesis and Glucokinase Activating Properties of Tatanans A-C"
9:25 am - 9:30 amDiscussion
9:30 am - 10:05 amJeremy Robertson (University of Oxford)
"One Thing Leads to Another... The Interplay of Heterocyclic Natural Product Synthesis and New Reaction Development"
10:05 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 12:30 pmProcess Development and Biomimetic Inspired Synthesis of Natural Products
Discussion Leader: Guangbin Dong (University of Texas, Austin)
10:40 am - 11:10 amMark Kerr (Eli Lilly)
"Development of a Glucagon Receptor Antagonist"
11:10 am - 11:15 amDiscussion
11:15 am - 11:45 amJonathan Reeves (Boehringer Ingleheim)
"New Strategies for Chiral Amine Synthesis"
11:45 am - 11:50 amDiscussion
11:50 am - 12:25 pmMatthew Shair (Harvard University)
"Assembling Highly Complex Organic Molecules Using Hints From Nature"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStrategies for Synthesis of Natural Products Leading to Probes to Investigate Biological Function
Discussion Leader: Eric Bercot (Suterra)
7:30 pm - 8:05 pmScott Snyder (Columbia University)
"Exploring Chemoselectivity through Natural Product Total Synthesis"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmMartin Burke (University of Illinois, Urbana-Champaign)
"Making Molecular Prosthetics"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 9:25 pmViresh Rawal (University of Chicago)
"Recent Developments in Alkaloids Total Synthesis"
9:25 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:10 amSynthetic Methods and Natural Products
Discussion Leader: Joie Garfunkle (Merck)
9:00 am - 9:25 amEric Ferreira (Colorado State University)
"Platinum Catalysis toward the Synthesis of Natural Products"
9:25 am - 9:30 amDiscussion
9:30 am - 10:05 amRichard Hsung (University of Wisconsin-Madison)
"Tandem Cascades for Natural Products Synthesis"
10:05 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 12:30 pmInnovations in Discovery and Investigation of Biologically Active Natural Products
Discussion Leader: John MacMillan (UT Southwestern Medical)
10:40 am - 11:10 amKerry McPhail (Oregon State University)
"Structure and Function of Microbial Natural Products from 'Unique' Marine Environments"
11:10 am - 11:15 amDiscussion
11:15 am - 11:45 amMandë Holford (Hunter College, CUNY)
"Building a Better M.O.U.S.E. (Marine Organisms Used in Shuttle Encapsulation) Trap"
11:45 am - 11:50 amDiscussion
11:50 am - 12:25 pmWilliam Fenical (Scripps Institution of Oceanography, UCSD)
"Marine Microbial Metabolites Provide Access to Mechanistically-novel Antitumor Drugs"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmNew Methods in Synthesis, Bioactive Natural Products, Drug Discovery and Function
Discussion Leader: Jennifer Stockdill (Wayne State University)
7:30 pm - 8:05 pmGary Sulikowski (Vanderbilt University)
"Synthesis and Study of Bioactive Natural Products"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmJosé R. Tormo (Fundación MEDINA)
"Challenges in Drug Discovery from Natural Products Libraries"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 9:25 pmAmir H. Hoveyda (Boston College)
"New Catalytic Processes for Synthesis of Natural Products"
9:25 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:45 amDiversity Oriented Synthesis in Medicinal Chemistry and Natural Products
Discussion Leader: Simon Shaw (Rigel)
9:00 am - 9:30 amLisa Marcaurelle (H3 Biomedicine)
"Structural Complexity: Hype or Hope"
9:30 am - 9:35 amDiscussion
9:35 am - 10:10 amDerek Tan (Sloan-Kettering Institute)
"Natural Product-based Strategies in Diversity-Oriented Synthesis"
10:10 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 12:30 pmProcess Development, Biosynthesis, and New Reactions for Natural Product Synthesis
Discussion Leader: Steven Olson (Amgen)
10:45 am - 11:15 amQinghao Chen (Merck)
"Chemical Process Development of Omarigliptin"
11:15 am - 11:20 amDiscussion
11:20 am - 11:40 amWendy Kelly (Georgia Institute of Technology)
"Biosynthetic Engineering to Access Thiostrepton Derivatives"
11:40 am - 11:45 amDiscussion
11:45 am - 12:25 pmJón Njarðarson (University of Arizona)
"Natural Products and New Synthetic Methods"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTotal Synthesis of Bioactive Natural Products
Discussion Leader: Michael Luzzio (Novartis)
7:30 pm - 8:20 pmAnthony Barrett (Imperial College London)
"Recent Advances in the Synthesis of Resorcylate Natural Products"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 9:20 pmAndrew Myers (Harvard University)
"Bringing the Full Power of Chemical Synthesis to Bear on the Discovery of New Antibiotics"
9:20 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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