| SUNDAY |
| 4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:45 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:45 pm - 9:15 pm | NO and Immunity |
| Discussion Leaders: Timothy Billiar (University of Pittsburgh) and Anje Cauwels (University of Ghent) |
| 7:45 pm - 8:15 pm | Laurel Lenz (National Jewish Health)
"Nitric oxide and the evolution of pathogen intercellular spread"
|
| 8:15 pm - 8:30 pm | Discussion |
| 8:30 pm - 9:00 pm | Gary Loake (University of Edinburgh)
"A central role for S-nitrosylation in plant immunity" |
| 9:00 pm - 9:15 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Chemical Biology of NO and Related Species |
| Discussion Leaders: Jack Lancaster Jr. (University of Alabama at Birmingham) and Jon Fukuto (Sonoma State University) |
| 9:00 am - 9:30 am | Douglas Thomas (University of Illinois at Chicago)
"Nitric oxide is an epigenetic regulator: the role of mononuclear non-heme enzymes"
|
| 9:30 am - 9:45 am | Discussion |
| 9:45 am - 10:15 am | Bernadette Fernandez (University of Southampton)
"Chemical biology of the interaction of sulfide and nitric oxide"
|
| 10:15 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Group Photo / Coffee Break |
| 11:00 am - 11:30 am | Dario Vitturi (University of Pittsburgh)
"Generation, metabolism and enzymatic inactivation of anti-inflammatory nitroalkenes"
|
| 11:30 am - 11:45 am | Discussion |
| 11:45 am - 12:15 pm | Des R. Richardson (University of Sydney)
"A common currency of NO transport and storage: dinitrosyl dithiol iron complexes"
|
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | NO and Oxidative Stress |
| Discussion Leaders: Victor Darley-Usmar (University of Alabama at Birmingham) and Bruce Freeman (University of Pittsburgh) |
| 7:30 pm - 8:00 pm | Mattias Carlström (Karolinska Institutet)
"Oxidative stress, NO, nitrite and renal function"
|
| 8:00 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:45 pm | Ingrid Fleming (University of Frankfurt)
"eNOS tyrosine phosphorylation and oxidative stress"
|
| 8:45 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:30 pm | Special Lecture: Jack Lancaster, Jr. (University of Alabama at Birmingham)
"Insights from a Career: The Most Important Scientific Constant is Change" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Regulation of eNOS in Health and Disease |
| Discussion Leaders: William Sessa (Yale University) and Dennis Stuehr (Cleveland Clinic Foundation) |
| 9:00 am - 9:30 am | Miriam Cortese-Krott (University of Düsseldorf)
"Significance of red cell eNOS in health and disease"
|
| 9:30 am - 9:45 am | Discussion |
| 9:45 am - 10:15 am | Adam Straub (University of Virginia)
"Mechanisms of NO regulation by hemoglobin alpha in the endothelium"
|
| 10:15 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:30 am | Arnab Ghosh (Cleveland Clinic Foundation)
"NO and heat shock protein 90 regulate maturation of NOS and soluble guanylyl cyclase in animal cells"
|
| 11:30 am - 11:45 am | Discussion |
| 11:45 am - 12:15 pm | Jay Zweier (Ohio State University)
"S-glutathionylation uncouples eNOS regulating its cellular and vascular function"
|
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | NO and Cardiovascular Regulation |
| Discussion Leaders: Martin Feelisch (University of Southampton) and Malte Kelm (University of Düsseldorf) |
| 7:30 pm - 8:00 pm | Annarita diLorenzo (Weill Cornell Medical College)
"Role of NO in vascular permeability"
|
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | John Pernow (Karolinska Institutet)
"Targeting arginase in cardiovascular disease"
|
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Stefan Offermanns (Max Planck Institute, Bad Nauheim)
"G-protein-mediated regulation of vascular function"
|
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | The Nitrate-Nitrite-NO Pathway |
| Discussion Leaders: Eddie Weitzberg (Karolinska Institutet) and Mark Gladwin (Univerity of Pittsburgh) |
| 9:00 am - 9:30 am | Courtney Sparacino-Watkins (University of Pittsburgh)
"Exploration of novel mammalian nitrite reductases"
|
| 9:30 am - 9:45 am | Discussion |
| 9:45 am - 10:15 am | Christopher Kevil (Louisiana State University)
"Nitrite therapy for peripheral artery disease" |
| 10:15 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:30 am | Sruti Shiva (University of Pittsburgh)
"Nitrite mediates NO-dependent and independent regulation of mitochondrial function"
|
| 11:30 am - 11:45 am | Discussion |
| 11:45 am - 12:15 pm | Tienush Rassaf (University of Düsseldorf)
"Novel therapeutic role of dietary nitrate in cardiovascular dysfunction" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
| 7:30 pm - 9:30 pm | Keynote Lecture and Hot Topics |
| Discussion Leader: Harry Ischiropoulos (University of Pennsylvania) |
| 7:30 pm - 8:30 pm | TBA (3-5 talks selected from abstracts submitted on site)
|
| 8:30 pm - 9:20 pm | Keynote Lecture: Louis J. Ignarro (Univerity of California Los Angeles)
"What the Nobel Prize means to me"
|
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Therapeutic Opportunities: To Stimulate or Block NO? |
| Discussion Leaders: Amrita Ahluwalia (William Harvey Research Institute) and Sruti Shiva (University of Pittsburgh) |
| 9:00 am - 9:30 am | Christian Heiss (University of Düsseldorf)
"Understanding the role of eNOS in vascular effects of dietary flavanols"
|
| 9:30 am - 9:45 am | Discussion |
| 9:45 am - 10:15 am | Anje Cauwels (University of Ghent)
"NO and sGC in inflammation-induced shock: mediator and/or protector"
|
| 10:15 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:30 am | Lusiane Bendhack (University of São Paulo)
"Vascular cell signaling pathways induced by nitric oxide donors"
|
| 11:30 am - 11:45 am | Discussion |
| 11:45 am - 12:15 pm | TBA |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | NO and Cancer |
| Discussion Leader: David Wink (National Institute of Health) |
| 7:30 pm - 8:00 pm | David Wink (National Institute of Health)
"An overview of the role of NO in cancer"
|
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Christoffer Switzer (National Institute of Health)
"The role of nitric oxide signaling in breast cancer progression and therapeutic implications"
|
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Anita Hjelmeland (Cleveland Clinic)
"Just say NO to brain tumors: Targeting glioblastoma stem cells"
|
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |