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Conference Program
 
Oxidative Stress & Disease
The Metabolic-Inflammatory Axis in Brain Aging and Alzheimer's Disease
April 14-19, 2013
Les Diablerets Conference Center
Les Diablerets, Switzerland

Related Meeting Information
The Oxidative Stress & Disease Gordon Research Conference was held in conjunction with the Oxidative Stress & Disease Gordon Research Seminar. Please refer to the Oxidative Stress & Disease GRS web page for more information.

The 2013 GRC on Oxidative Stress and Disease, "The Metabolic Inflammatory Axis in Brain Aging and Alzheimer’s Disease", focuses on bioenergetic deficits, activation of inflammatory responses, and white matter metabolism in brain aging and Alzheimer’s. Dynamic interactions among these systems will be examined in terms of their causative or in-tandem occurrence and whether they occur in micro-environments that ultimately lead to global changes in brain. The themes of the conference are integrated in 9 sessions that include (a) Neurovascular and neurometabolic pathways in brain aging and Alzheimer’s disease; (b) Mitochondrial metabolism in brain aging and neurodegeneration; (c) functional metabolic parameters of brain aging and cognition; (d) Neuroinflammation, microglia aging, and Alzheimer’s disease; (f) Insulin resistance, diabetes, and the risk of Alzheimer’s disease; (g) Systemic environment in brain aging and Alzheimer’s, and (h) Age-related cognitive deficits. Two other sessions include a keynote presentation and oral presentations from young investigators from selected poster.

The Conference will bring together a distinguished cadre of investigators who are at the forefront of their field, and will provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field. Some poster presenters will be selected for short talks. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an avenue for scientists from different disciplines to brainstorm and promotes cross-disciplinary collaborations in the various research areas represented.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Presentations
Discussion Leader: TBA
7:40 pm - 8:20 pm Roberta Díaz Brinton (University of Southern California, USA)
"Sex differences in bioenergetic aging of brain and risk of Alzheimer's disease"
8:20 pm - 8:35 pm Discussion
8:35 pm - 9:15 pm Claudio Franceschi (University of Bologna, Italy)
"Biological parameters remodeling during human aging: complex regulation in longevity and in diabetes"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMitochondrial Function in Brain Aging and Neurodegeneration
Discussion Leader: LaDora Thompson (University of Minnesota, USA)
9:00 am - 9:30 amRussell H. Swerdlow (University of Kansas, USA)
"Brain aging, Alzheimer's disease, and mitochondria"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amAntonio Zorzano (University of Barcelona, Spain)
"Mitochondrial dynamics and its implications in metabolic dysregulation"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amDavid C. Rubinsztein (Cambridge Institute for Medical Research, UK)
"Control of autophagy as a therapy for neurodegenerative diseases"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmMichael Ristow (Swiss Federal Institute of Technology, CH)
"Promoting metabolic health by increasing oxidative stress: the concept of mitohormesis"
12:15 pm - 12:30 pmDiscussion
12:30 pmGroup Photo / Lunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmInsulin Resistance, Diabetes, and the Risk of Alzheimer's Disease
Discussion Leader: Efstathios S. Gonos (National Hellenic Research Foundation, Greece)
5:30 pm - 6:00 pm Suzanne Craft (Wake Forest School of Medicine, USA)
"Insulin resistance and pathological brain aging"
6:00 pm - 6:10 pm Discussion
6:10 pm - 6:40 pm Suzanne M. de la Monte (Brown University, USA)
"Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease"
6:40 pm - 6:50 pm Discussion
6:50 pm - 7:20 pm Fernanda G. De Felice (Federal University of Rio de Janeiro, Brazil)
"Molecular mechanisms underlying brain insulin resistance in Alzheimer's disease"
7:20 pm - 7:30 pm Discussion
8:00 pmDinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFunctional Metabolic Parameters of Brain Aging and Cognition
Discussion Leader: Bertrand Friguet (Université Pierre et Marie Curie, Paris, France)
9:00 am - 9:30 amEugenia Trushina (Mayo Clinic, USA)
"Metabolomic signatures in mouse models and patients with early Alzheimer's disease"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amGene L. Bowman (Oregon Health & Science University, USA)
"A platform for individualized nutritional therapy in dementia prevention"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amRima Kaddurah-Daouk (Duke Institute for Brain Research, USA)
"Metabolomics in early Alzheimer's disease"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmPierre Magistretti (École polytechnique fédérale de Lausanne, Switzerland and King Abdullah University of Science and Technology, Kingdom of Saudi Arabia)
"Brain energy metabolism and aging: focus on astrocyte-neuron metabolic cooperation"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 6:10 pmFunctional Metabolic Parameters of Brain Aging and Cognition (continued)
Discussion Leader: Bertrand Figuet (Université Pierre et Marie Curie, Paris, France)
5:30 pm - 6:00 pmOlivier Thibault (University of Kentucky, USA)
"Peripheral metabolic dysregulation and its impact on the brain: focus on calcium"
6:00 pm - 6:10 pmDiscussion
6:10 pm - 7:30 pmNeurovascular and Neurometabolic Pathways in Brain Aging and Alzheimer's Disease
Discussion Leader: José Viña (University of Valencia, Spain)
6:10 pm - 6:40 pmJoão Laranjinha (University of Coimbra, Portugal)
"Neurovascular and neurometabolic uncoupling in brain aging and neurodegeneration: a vascular nitric oxide-driven redox hypothesis"
6:40 pm - 6:50 pmDiscussion
6:50 pm - 7:20 pmHelena Chui (University of Southern California, USA)
"Vascular risk factors and Alzheimer's disease"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNeuroinflammation, Microglia Aging, and Alzheimer's Disease
Discussion Leader: Kelvin J.A. Davies (University of Southern California, USA)
9:00 am - 9:30 amMarina A. Lynch (Trinity College, Ireland)
"Age-related neuroinflammatory changes impact negatively on neuronal function"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amAgneta Nordberg (Karolinska Institute, Sweden)
"Inflammatory changes (astrocytosis) in brain by PET at different stages of Alzheimer's disease"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amLinda J. van Eldik (University of Kentucky, USA)
"Targeting inflammatory cytokine dysregulation in Alzheimer's disease"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmCatarina Oliveira (University of Coimbra, Portugal)
"Excitotoxicity and oxidative stress in early stages of Alzheimer's Disease"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 6:10 pmNeuroinflammation, Microglia Aging, and Alzheimer's Disease (continued)
Discussion Leader: Kelvin J.A. Davies (University of Southern California, USA)
5:30 pm - 6:00 pmRommy von Bernhardi (Universidad Catölica de Chile, Chile)
"Redox dysregulation and inflammatory mechanisms mediated by microglia aging in Alzheimer's disease"
6:00 pm - 6:10 pmDiscussion
6:10 pm - 7:30 pmAge-Related Cognitive Deficits
Discussion Leader: Giselle Petzinger (University of Southern California, USA)
6:10 pm - 6:40 pm Orly Lazarov (University of Illinois at Chicago, USA)
"Misregulation of neurogenesis in aging and Alzheimer's disease: Implications for cognitive function"
6:40 pm - 6:50 pm Discussion
6:50 pm - 7:20 pm Giuseppe Poli (University of Torino, Italy)
"Lipid oxidation, a link between altered cholesterol metabolism and Alzheimer's disease"
7:20 pm - 7:30 pm Discussion
7:30 pm - 8:00 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
8:00 pmDinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSystemic Environment in Brain Aging and Alzheimer's Disease
Discussion Leader: Tilman Grune (University of Jena, Germany)
9:00 am - 9:30 am Tony Wyss-Coray (Stanford University, USA)
"The systemic environment as a modulator of brain aging and Neurodegeneration"
9:30 am - 9:45 am Discussion
9:45 am - 10:15 am Mario F. Fraga (University of Oviedo, Spain)
"The role of epigenetics in aging and age-related diseases"
10:15 am - 10:30 am Discussion
10:30 am - 11:00 am Coffee Break
11:00 am - 11:30 am Vittorio Calabrese (University of Catania, Italy)
"Redox regulation of cellular stress response in aging and neurodegenerative disorders: Role of vitagens"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pm Rajiv R. Ratan (Weill Cornell Medical College, USA)
"Epigenetic modulation of oxidative death: HDACs and beyond"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmSelected Talks
Discussion Leaders: Rajiv Ratan (Weill Cornell Medical College, USA) and Deborah Ferrington (University of Minnesota, USA)
(Speakers TBA)
8:00 pmDinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible, in part by 1 R13 AG 044908-01 from the National Institute on Aging (NIA) and the National Institute of Neurological Disorders and Stroke (NINDS). 'The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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