Gordon Research Conferences
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Conference Program
 
Pancreatic Diseases
From Molecules to Patients
July 21-26, 2013
Mount Holyoke College
South Hadley, MA
Chair:
Marco Falasca

Vice Chair:
Michele Solimena

The 2013 Gordon Conference on Pancreatic Diseases will present cutting-edge research on the clinical, molecular and cellular perspective of functional and pathological aspects of pancreas biology. The broad scope of this conference is to support the development of a multi-disciplinary research community addressing medical, biological, chemical and pharmacological topics related to the diversity and complexity of pancreatic diseases.

Invited speakers represent a variety of scientific disciplines, including disparate research communities of basic scientists, endocrinologists, oncologists and surgeons specializing in the cell biology, pancreas development, pathogenesis, diagnosis, prevention, and treatment of diabetes, cancer and pancreatitis.

The Conference will provide a forum for communication of original works on the developmental, biological and pathophysiological relationship between the exocrine and endocrine component of the pancreas.

Through the contribution of leading experts, we expect to identify novel concepts for the pharmacological and cell-based treatment of pancreatic diseases.

The Conference will bring together an array of investigators who are at the forefront of their field, and will provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field. Some poster presenters will be selected for short talks.

The atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an avenue for scientists from different disciplines to brainstorm and promotes cross-disciplinary collaborations in the various research areas represented.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmCurrent status of Pancreatic diseases and challenges
Discussion Leader: Marco Falasca (Barts and The London)
7:40 pm - 8:20 pmJohn Neoptolemos (University of Liverpool)
"New strategies in pancreatic cancer"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmMatthias Hebrok (UCSF)
"Generating β cells from stem cells"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:45 amGroup Photo
9:00 am - 12:30 pmPancreatic Models
Discussion Leader: Sunil Hingorani (Fred Hutchinson Cancer Research Center)
9:00 am - 9:30 amOwen Sansom (Beatson Institute Glasgow)
"Using genetically engineered mouse models to test novel therapeutic targets in PDAC"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amFranco Folli (University of Texas Health S. C. at San Antonio)
"Pancreatic Pleiotropic Effects of Exenatide/Exendin-4, a GLP-1 receptor Agonist in the Baboon, a non-Human Primate Model of Obesity and Type 2 Diabetes Mellitus"
9:55 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:00 amPiero Marchetti (University of Pisa)
"The β cell in human type 2 diabetes"
11:00 am - 11:10 amDiscussion
11:10 am - 11:40 amManuel Hidalgo (Spanish National Cancer Research Centre (CNIO))
"Personalized tumorgrafts"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmJonathan Brody (Thomas Jefferson University)
"HuR post-transcriptionally regulates WEE1: implications for the DNA damage response in pancreatic cancer cells"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmStephan Speier (Technische Universität Dresden)
"Pancreas tissue slice culture facilitates long-term studies of exocrine and endocrine cell physiology in situ"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCell-cell interactions in pancreas
Discussion Leader: Bernard Thorens (Lausanne University)
7:30 pm - 8:00 pmChristofer Wright (Vanderbilt University)
"Pancreas Development"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmDafna Bar-Sagi (New York University)
"Small GTPases signaling in pancreatic cancer"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmFarzad Esni (University of Pittsburgh)
"Macrophage polarization is a necessary element of pancreatic regeneration"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmPeter Storz (Mayo Clinic Florida)
"Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia"
9:25 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMolecular mechanisms of pancreatic diseases
Discussion Leader: Maureen Gannon (Vanderbilt University)
9:00 am - 9:30 amDonghui Li (University of Texas)
"Obesity and Diabetes as risk factors for pancreatic cancer"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amJanel Kopp (University of California San Diego)
"Cellular Origins of Pancreatic Ductal Adenocarcinoma"
9:55 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:00 amAnil Bhushan (UCLA)
"Regeneration of pancreatic islets"
11:00 am - 11:10 amDiscussion
11:10 am - 11:40 amFred Gorelick (Yale University)
"Effects of extracellular metabolic factors on acute pancreatitis"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmBeatriz Sosa-Pineda (St. Jude Children's Research Hospital)
"Prox1 activity is essential for exocrine pancreas development and homeostasis"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmDonalyn Scheuner (Eli Lilly & Company)
"Stress Signaling in Beta Cell Function and Metabolic Disease"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNovel Signaling mechanisms in pancreatic diseases
Discussion Leader: Michael German (UCSF)
7:30 pm - 8:00 pmPer Olof Berggren (Karolinska Institute)
"The Pancreatic Islet as a Signaling Hub"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmSusumu Seino (Kobe University)
"Mechanisms of cell signaling in insulin secretion"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmPatrick Jacquemin (Université Catholique De Louvain)
"Role of Sox9 in pancreatic cancer"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmGeorge Holz (SUNY Upstate Medical University)
"Molecular Basis of Epac2 Action In Pancreatic Beta Cells"
9:25 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSignaling pathways in pancreatic diseases
Discussion Leader: Michele Solimena (University of Dresden)
9:00 am - 9:30 amGuy Rutter (Imperial College London)
"Signal Transduction in the pancreatic β cell in health and disease"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amChanse Fyffe (Blizard Institute)
"Pharmacological inhibition of PI3K/PDK1 signaling prevents pancreatic cancer tumor growth"
9:55 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:00 amBen Stanger (University of Pennsylvania)
"Pancreatic cancer progression"
11:00 am - 11:10 amDiscussion
11:10 am - 11:40 amHoward Crawford (Mayo Clinic Florida)
"Signal transduction pathways in pancreatitis"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmAndrea Loipetzberger (University of Salzburg)
"Hedgehog/GLI - EGFR cooperation response genes in tumor-initiating pancreatic cancer cells"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmJen Morton (Cruk Beatson Institute)
"Targeting LOX in Pancreatic Cancer"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmTherapies and clinical aspects
Discussion Leader: Tania Maffucci (Queen Mary University of London)
7:30 pm - 8:00 pmVolker Ellenrieder (University of Marburg)
"NFATc1 transcription factor links inflammation and carcinogenesis in the pancreas"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmGianfranco Delle Fave (University of Rome)
"Pancreatic endocrine tumors"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmBrittany Allen (OHSU)
"Phosphatase activation and kinase inhibition as a novel therapeutic strategy for pancreatic cancer"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmKimberly Tremblay (University of Massachusetts, Amherst)
"Identification and assessment of tissues involved in dorsal pancreas specification"
9:25 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPancreatic stem cells
Discussion Leader: Rohit Kulkarni (Joslin Diabetes Center)
9:00 am - 9:30 amAnne Grapin-Botton (Copenaghen University)
"From pancreas progenitors to beta cells: better in 3 dimensions?"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amGabriele Capurso (S. Andrea Hospital, University Of Rome)
"Mechanisms of resistance to targeted therapy in pancreatic endocrine tumours"
9:55 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:00 amSarah Thayer (Harvard Medical School)
"Pancreatic Duct Glands (PDG): An epithelial progenitor stem cell compartment important in regeneration and cancer"
11:00 am - 11:10 amDiscussion
11:10 am - 11:40 amDiane Simeone (University of Michigan)
"Pancreatic cancer stem cells and relevance to cancer treatments"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmLuis Filgueira (University of Fribourg)
"Expression of stem cell markers in beta cells"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmDanwei Huangfu (Sloan-Kettering Institute)
"Precision genetics in hPSCs for understanding pancreatic development and disease"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGenetic and epigenetic aspects
Discussion Leader: Channing Der (University of North Carolina)
7:30 pm - 8:00 pmJens Siveke (University of Munich)
"K-Ras driven pancreatic cancer"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmJorge Ferrer (Hospital Clinic Barcelona)
"The epigenetic landscape of beta cells"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmClara Lubeseder-Martellato (Klinikum Rechts Der Isar, Tu Munich)
"Endocytosis drives oncogenic Kras-dependent acinar-ductal metaplasia"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmThomas Wilkie (UT Southwestern Medical Center)
"RGS genes - HTS biomarkers for pancreas development, cancer and diabetes"
9:25 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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