Gordon Research Conferences
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Conference Program
 
Physical Virology
January 20-25, 2013
Ventura Beach Marriott
Ventura, CA

Related Meeting Information
The Physical Virology Gordon Research Conference was held in conjunction with the Physical Virology Gordon Research Seminar. Please refer to the Physical Virology GRS web page for more information.

As physical manifestations - in size, structure, molecular composition, and function - of the boundary between chemistry and biology, viruses receive ever-increasing attention in fundamental science and applied technology. The Physical Virology GRC covers viruses as paradigms for nanoscale self-assembly, genomic packaging and delivery, materials development, and interactions among biological systems. These fields are investigated by mathematicians, physicists, chemists, material scientists, and biologists, providing outstanding opportunities but also challenges in communication between disciplines. The goal of this conference is to bring together leading scientists and young investigators with the molecular, theoretical, materials-oriented, and biological perspectives that are rapidly shaping the study and use of virus-based and virus-inspired functional systems.


Contributors

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmLessons from Nature, Part 1
Discussion Leader: William Gelbart (UCLA)
7:40 pm - 8:10 pmMichael Buchmeier (UC Irvine)
"Functional and Structural Proteomics of the SARS CoV: Modeling a Rational Response to Emerging Infectious Diseases"
8:10 pm - 8:25 pmDiscussion
8:25 pm - 8:55 pmJames Bryers (University of Washington)
"Non-viral Delivery Vehicles for pDNA and mRNA Vaccines"
8:55 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmMichael Hagan (Brandeis University)
"Thermodynamic and Kinetic Constraints on Viral Packaging of ssRNA"
9:25 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmProtein Nanoparticles for Biomedicine, Part 1
Discussion Leader: Marianne Manchester (UCSD)
9:00 am - 9:30 amCarston Wagner (University of Minnesota)
"From Drug Delivery to Engineered Cell Surfaces by Chemically Self-Assembled Antibody Nanostructures (CSANS)"
9:30 am - 9:45 amDiscussion
9:45 am - 9:55 amQian Wang (University of South Carolina)
"Rapid Osteoinduction by Tobacco Mosaic Virus Substrate"
9:55 am - 10:00 amDiscussion
10:00 am - 10:30 amGroup Photo / Coffee Break
10:30 am - 11:00 amAravind Asokan (University of North Carolina)
"Reengineering the Virion Shell"
11:00 am - 11:15 amDiscussion
11:15 am - 11:45 amDavid Peabody (University of New Mexico)
"Bacteriophage MS2 VLPs for vaccine discovery"
11:45 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmJinny Liu (Naval Research Laboratory)
"Phage-based NPs for Protein and DNA delivery: Cellular Uptake of Bacteriophage T4 DNA Packaging and Protein Encapsulation Nanoparticles (NP)"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmDustin Patterson (Montana State University)
"Biomimetic Display of Conserved Antigens Towards Directing Protective Immunologic Responses to Influenza"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmVirus Assembly
Discussion Leader: Peter Stockley (University of Leeds)
7:30 pm - 8:00 pmCarolyn Teschke (University of Connecticut)
"Structure and Function of the Telokin-like Domain Inserted into Phage P22's Coat Protein"
8:00 pm - 8:15 pmDiscussion
8:15 pm - 8:45 pmLindsay Black (University of Maryland)
"Capsid Packaging and Unpackaging of Proteins and DNAs"
8:45 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmDennis Rappaport (Bar-Ilan University)
"Learning about Self-Assembly Dynamics from Simple Models"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmVirus Structure and Dynamics
Discussion Leader: Nicole Steinmetz (Case Western Reserve University)
9:00 am - 9:30 amBrian Bothner (Montana State University)
"Did You See That? It Moved! I Swear That Capsid Protein Just Moved All the Way Over There"
9:30 am - 9:45 amDiscussion
9:45 am - 10:05 amIan Molineux (University of Texas at Austin)
"The Bacteriophage T7 Virion Undergoes Extensive Structural Remodeling during Infection"
10:05 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:15 amSusan Schroeder (University of Oklahoma)
"Advancing Viral RNA Structure Prediction"
11:15 am - 11:30 amDiscussion
11:30 am - 12:00 pmAlasdair Steven (National Institutes of Health)
"Capsids as Compartments"
12:00 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmYi-Ju Chen (CalTech)
"A Single Molecule Hershey-Chase Experiment"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmProtein Nanoparticles for Biomedicine, Part 2
Discussion Leader: Matthew Francis (UC Berkeley)
7:30 pm - 8:00 pmAnnette Schneemann (Scripps Research Institute)
"Novel Approaches for Vaccine Development Using Antigen Display on Icosahedral Virus-like Particles"
8:00 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmIssac Carrico (Stony Brook University)
"Expanding the Therapeutic Potential of Mammalian Viruses via Chemoselective Modification"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 9:00 pmLaura Palomares (Universidad Nacional Autonoma de Mexico)
"Viral Protein Assemblies as Vaccines"
9:00 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmZhenning Tan (Indiana University)
"Regulation of Hepatitis B virus assembly and replication by core protein interface"
9:25 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmVirus Based Materials
Discussion Leader: Trevor Douglas (Montana State University)
9:00 am - 9:30 amJunghae Suh (Rice University)
"Reprogramming Virus Nanoparticles for Biomedical Applications"
9:30 am - 9:45 amDiscussion
9:45 am - 9:55 amGregory Bedwell (University of Alabama at Birmingham)
"Selective Biotemplated Mineralization of TiO2 Inside of the Bacteriophage P22"
9:55 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:00 amJames Culver (University of Maryland)
"An Infectious Approach to Biofabrication"
11:00 am - 11:15 amDiscussion
11:15 am - 11:45 amBogdan Dragnea (Indiana University)
"On the Measurement of Virion Variability by Single-particle Methods"
11:45 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmRik Rurip (University of Twente)
"Loading Capsids: Less is More"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmJoost Snijder (Utrecht University)
"Native Ion Mobility Mass Spectrometry as a Tool to Study Virus Assembly and Cargo Encapsulation"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmProtein Cages and Cargo, Natural and Engineered
Discussion Leader: Jeroen Cornelissen (University of Twente)
7:30 pm - 8:00 pmAkif Tezcan (UCSD)
"Metal-Directed Assembly of Protein Cages and Tubes - Bottom-Up and Top-Down"
8:00 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmJeff Glasgow (University of California Berkley)
"Encapsulation of Enzymes in Bacteriophage MS2 Viral Capsids"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 9:00 pmDonald Hilvert (ETH Zürich)
"Directed Evolution of Artificial Protein Containers"
9:00 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmPedro De Pablo (Universidad Autonoma de Madrid)
"Monitoring Disassembly of Individual Adenovirus Particles Shows Stepwise Dismantling and Core Uncoating in Real Time"
9:25 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
9:00 am - 12:30 pmProduction and Self-Assembly
Discussion Leader: Mavis Agbandje-McKenna (University of Florida)
9:00 am - 9:30 amReidun Twarock (University of York)
"Evolutionarily Tunable Packaging Signals Control ssRNA Virus Assembly"
9:30 am - 9:45 amDiscussion
9:45 am - 9:55 amDavid Regura (Universitat de Barcelona)
"Physical Ingredients Controlling the Polymorphism and Stability of Viral Capsids"
9:55 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:00 amPhilip Santanelo (Georgia Inst. of Technology)
"Interrogating Virus Entry, Assembly, and Production with Single Molecule Sensitive Probes"
11:00 am - 11:15 amDiscussion
11:15 am - 11:25 amGheorghe Chistol (UC Berkeley)
"Phi29 Packaging Motor Employs Several Throttle Controls as DNA Fills the Viral Capsid"
11:25 am - 11:30 amDiscussion
11:30 am - 12:00 pmJames Swartz (Stanford University)
"Cell-free Construction of Artificial Viruses and Domain Specific Viral Antigens"
12:00 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShawn Douglas (UCSF)
"A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmLessons from Nature, Part 2
Discussion Leader: Jack Johnson (Scripps Research Institute)
7:30 pm - 8:00 pmTodd Yeates (UCLA)
"Non-viral Protein capsids in Nature and by Protein Engineering"
8:00 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmIrina Tsvetkova (Indiana University)
"Effects of Fluorescent Protein Fusion on Early Sindbis Virus Entry Events"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 9:00 pmGeorge Lomonossoff (John Innes Centre)
"CPMV Empty Nanoshells - a Tool for the Delivery of Foreign Materials and for Unravelling the Tangled Process of Virus Replication and Assembly"
9:00 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmLuigi Perotti (UCLA)
"Capsid Symmetry and Conformational Change during Maturation"
9:25 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible [in part] by 1 R13 AI104198-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

 
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