Gordon Research Conferences
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Conference Program
 
Proteins
June 16-21, 2013
Holderness School
Holderness, NH

Protein science has undergone a revolution in the last decade. The elucidation of molecular structures at high resolution has become routine, vast amounts of genomic information now inform our analyses of protein structure, function and biology, and cutting edge technologies provide stunning glimpses into details of mechanism at ever higher resolution and shorter timescale. The 2013 Proteins Gordon Research Conference will bring together experimental and computational biochemists, biophysicists, chemists, biologists and engineers who study diverse aspects of proteins science, including protein structure, function, dynamics, thermodynamics, and evolution. The meeting will include sessions focused on the mechanical properties of proteins, which can be probed with exquisite single-molecule techniques, and the origins of stability, which can be examined using high-throughput random mutagenesis and deep sequencing. The controversial roles of water and cavities in defining the sensitivity of proteins to pressure will be discussed. There will also be talks about intricate molecular machines, and sessions that focus on large assemblies, membrane proteins, and the evolution of proteins and their interactions. Invited speakers will highlight a wide range of approaches for addressing fundamental and emerging problems in protein science. Speaking slots have also been reserved so that late-breaking results can be presented in short talks, and poster sessions will provide an opportunity for broad dissemination of participants’ research. In the relaxed, beautiful setting of Holderness, New Hampshire, ideas will flow between sub-disciplines and generations during collegial formal discussions, informal discussions, poster sessions, social events and afternoon recreational activities. Exciting recent advances in protein science and the strong historical tradition of this meeting promise an outstanding conference experience for participants at all career stages.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmImaging and Modeling Large Assemblies
Discussion Leader: Bertrand García-Moreno (Johns Hopkins)
7:40 pm - 8:10 pmShu-ou Shan (Caltech)
"ATPase and GTPase tangos during intracellular protein targeting"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:25 pmKeynote Introduction
8:25 pm - 9:10 pmKeynote Lecture: Eva Nogales (U.C. Berkeley)
"Visualizing the molecular machinery controlling human gene expression"
9:10 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmProtein Interactions
Discussion Leader: Amy Keating (MIT)
9:05 am - 9:35 amBarry Honig (Columbia)
"Structure-based prediction of protein-protein interactions on a genome-wide scale"
9:35 am - 9:45 amDiscussion
9:45 am - 10:15 amJacob Corn (Genentech)
"Conformational selection of therapeutically important protein-protein interactions"
10:15 am - 10:25 amDiscussion
10:25 am - 10:50 amCoffee Break
10:50 am - 11:05 amIvan Korendovych (Syracuse University)
"Design and directed evolution of allosterically regulated protein catalysts"
11:05 am - 11:10 amDiscussion
11:10 am - 11:40 amMadeline Shea (U. Iowa)
"Calcium-triggered conformational switching of calmodulin on ion channels"
11:40 am - 11:50 amDiscussion
11:50 am - 12:20 pmPeter S. Kim (Merck)
"Toward an HIV vaccine"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmWater and Pressure
7:30 pm - 7:45 pmDiscussion Leader: George Makhatadze (Rensselaer Polytechnic Institute)
"Introduction: Dancing under Pressure"
7:45 pm - 8:10 pmCatherine Royer (Center for Structural Biochemistry, Montpellier)
"How can pressure boil an egg? The physical basis for pressure unfolding of proteins"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmWoody Sherman (Schrödinger)
"Thermodynamic characterization of water molecules at the surface of proteins and implications for protein-protein interaction inhibitors"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmA. Joshua Wand (U. Pennsylvania)
"Resolving the dance of protein and solvent by solution NMR"
9:20 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMembrane Proteins
Discussion Leader: Bertrand García-Moreno (Johns Hopkins)
9:05 am - 9:35 amPeter Hegemann (Humboldt University)
"Engineered channelrhodopsins as new optogenetic tools"
9:35 am - 9:45 amDiscussion
9:45 am - 10:15 amOlga Boudker (Cornell Medical College)
"Dance lessons for proteins: the dynamics of a glutamate transporter homologue"
10:15 am - 10:25 amDiscussion
10:25 am - 10:50 amCoffee Break
10:50 am - 11:05 amAlessandro Senes (U. Wisconsin-Madison)
"Structural analysis of transmembrane proteins of the bacterial divisome"
11:05 am - 11:10 amDiscussion
11:10 am - 11:25 amAriane Briegel (Caltech)
"Electron cryotomography of bacterial chemoreceptor arrays"
11:25 am - 11:30 amDiscussion
11:30 am - 12:00 pmRon Dror (D.E. Shaw Research)
"How drugs bind and control their targets: characterizing GPCR signaling through long-timescale simulation"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmElsa Yan (Yale)
"An Unusual Arrhenius Pre-factor of 1070 s-1 in the Thermal Reactions of Rhodopsin"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmMechanical Properties of Proteins
Discussion Leader: Dan Raleigh (Stony Brook)
7:30 pm - 8:00 pmFrauke Gräter (Heidelberg Institute for Theoretical Studies)
"How proteins are designed for mechanical function: from unfolding kinetics to force sensors"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmMatthias Rief (Technische Universität, Munich)
"Single molecule mechanics and dynamics of proteins"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmJohn Karanicolas (U. Kansas)
"Small-molecule modulators of protein interactions"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmStephen Sprang (U. Montana)
"Dangerous Dancing: Catalysis of GDP release from Gai1 by the exchange factor Ric-8A"
9:25 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmProtein Evolution
Discussion Leader: Karyn O'Neil (Centyrex)
9:05 am - 9:35 amJoseph Thornton (U. Oregon)
"Reconstructing the evolution of ancient proteins"
9:35 am - 9:45 amDiscussion
9:45 am - 10:15 amMatthew Cordes (U. Arizona)
"Evolution of foldability"
10:15 am - 10:25 amDiscussion
10:25 am - 10:50 amCoffee Break
10:50 am - 11:20 amMichael Laub (MIT)
"Systematic mapping of the sequence space of a protein-protein interaction"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amMargaret Glasner (Texas A & M)
"Identifying structural and mechanistic features of enzymes that promote evolvability"
11:45 am - 11:50 amDiscussion
11:50 am - 12:20 pm David Liu (Harvard)
"Continuous directed evolution of proteins"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmDynamic Protein Assemblies
Discussion Leader: Steven Kazmirski (AstraZeneca)
7:30 pm - 8:00 pmGideon Schreiber (Weizmann Institute)
"Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmMatteo Dal Peraro (École Polytechnique Fédérale de Lausanne)
"Swirling into the membrane: integrative dynamic modeling of aerolysin pores"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmEric Estrin (Berkeley)
"Coordinated destruction: Architecture and dynamics of the 26S proteasome"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmKlaus Schulten (U. Illinois at Urbana-Champaign)
"Experimental-computational study of virus capsid structure and dynamics"
9:20 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
9:00 am - 12:30 pmFolding and Stability
Discussion Leader: Jane Clarke (University of Cambridge)
9:05 am - 9:35 amSusan Marqusee (U.C. Berkeley)
"Sequence determinants of the energy landscape"
9:35 am - 9:45 amDiscussion
9:45 am - 10:15 amRaghavan Varadarajan (Indian Institute of Science, Bangalore)
"Residue specific contributions to stability and binding inferred from saturation mutagenesis and deep sequencing"
10:15 am - 10:25 amDiscussion
10:25 am - 10:50 amCoffee Break
10:50 am - 11:20 amVijay Pande (Stanford)
"Some surprises in the biophysics of protein dynamics"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amScott Showalter (Pennsylvania State University)
"Quantitative Biophysical Characterization of Intrinsically Disordered Proteins"
11:45 am - 11:50 amDiscussion
11:50 am - 12:20 pm C. Robert Matthews (U. Mass Medical School)
"The roles of sequence and chain connectivity in the folding of CheY"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmDestruction and Disassembly
Discussion Leader: Amy Keating (MIT)
7:40 pm - 8:25 pmKeynote Lecture: Robert Sauer (MIT)
"Anatomy of an ATP-fueled molecular machine"
8:25 pm - 8:45 pmDiscussion
8:45 pm - 9:15 pmEnrique De La Cruz (Yale)
"How cells use chemistry and physics to break the bones that power their movement"
9:15 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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